[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"lymphedema-due-to-radiation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:lymphedema-due-to-radiation":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,39,68],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":27,"lastUpdatePostDateStruct":28,"startDateStruct":31,"completionDateStruct":33,"leadSponsor":35,"locationsCount":38},"100615847","prospective-study-on-icg-lymphoscintigraphy-changes-before-and-after-radiotherapy-in-breast-cancer-patients-100615847",false,"NCT07297927","Prospective Study on ICG Lymphoscintigraphy Changes Before and After Radiotherapy in Breast Cancer Patients","ICG_prepostRT","Inclusion Criteria:\n\n* Female, ≥18 years old Pathologically confirmed stage I-III breast cancer Scheduled to receive postoperative radiotherapy (RT)\n\nExclusion Criteria:\n\n* Previous or current lymphedema Prior radiotherapy to the ipsilateral breast or axilla History of neoadjuvant chemotherapy Severe systemic diseases (heart, renal, hepatic failure) Active infection Pregnancy or lactation Allergy to indocyanine green (ICG) or iodine-based contrast agents","FEMALE","18 Years",{"count":19,"type":20},40,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to learn how the lymphatic system changes before and after radiotherapy in female patients with breast cancer. The study aims to understand early lymphatic changes that may lead to breast-cancer-related lymphedema (BCRL) and to help identify patients who might benefit from early preventive rehabilitation.\n\nThe main questions it aims to answer are:\n\nHow does lymphatic flow and vessel function change after radiotherapy, as measured by indocyanine green (ICG) lymphography?\n\nCan early imaging changes on ICG lymphography predict later swelling or lymphedema symptoms in the arm?\n\nThere is no comparison or treatment group, since all participants will receive radiotherapy as part of their standard breast cancer care.\n\nParticipants will:\n\nUndergo ICG lymphography before radiotherapy and again within 4-6 weeks after completing radiotherapy\n\nReceive a small injection of ICG dye under the skin and have near-infrared imaging to visualize lymphatic flow\n\nComplete follow-up assessments (for some participants) at 3, 6, or 12 months to monitor long-term lymphatic changes\n\nContinue their usual standard medical and rehabilitation care throughout the study\n\nThis study will include 40 female participants, aged 18 years or older, who have been diagnosed with stage I-III breast cancer and are scheduled for postoperative radiotherapy. Participants with a history of lymphedema, prior radiotherapy, severe organ disease, or known ICG\u002Fiodine allergy will not be included.\n\nThe information collected will include imaging findings from ICG lymphography, arm circumference and volume measurements, and patient-reported outcomes on arm discomfort or swelling. These data will help researchers identify early imaging biomarkers of radiation-induced lymphatic dysfunction.\n\nThe study does not involve any experimental treatment or random assignment. All procedures are routine diagnostic or rehabilitation methods that are already approved for clinical use. The ICG test uses a very small amount of dye and is considered safe, with allergic reactions being rare.\n\nThe findings of this study may provide new insights into how radiotherapy affects the lymphatic system and may contribute to developing personalized strategies to prevent or minimize lymphedema after breast cancer treatment.",[24,25],"Breast Neoplasms","Lymphedema Due to Radiation","RECRUITING","2025-12-09",{"date":29,"type":30},"2025-12-22","ACTUAL",{"date":32,"type":30},"2025-11-05",{"date":34,"type":20},"2028-10-18",{"name":36,"class":37},"Inah Kim","OTHER",1,{"id":40,"slug":41,"hasResults":11,"nctId":42,"briefTitle":43,"officialTitle":44,"acronym":45,"eligibilityCriteria":46,"healthyVolunteers":11,"sex":47,"minAge":17,"maxAge":4,"enrollmentInfo":48,"targetDuration":4,"studyType":49,"phases":50,"briefSummary":52,"conditions":53,"keywords":57,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":38},"100609483","manual-lymph-drainage-for-external-lymphedema-100609483","NCT07215169","Manual Lymph Drainage for External Lymphedema","The Effect of Manual Lymph Drainage for Cancer Treatment-related External Lymphedema in the Head and Neck - a Pilot and Feasibility Study of a Randomized Controlled Trial","MLD-HN","Inclusion Criteria:\n\n* • a previous diagnosis of oropharyngeal cancer (all histological types are accepted)\n\n  * curative treatment with (chemo)radiotherapy to at least 68Gy at the primary site completed no more than 1 year before the study inclusion\n  * age \\>18 years\n  * ability to give written and informed consent.\n\nExclusion Criteria:\n\n* • pregnancy\n\n  * surgery or Botox injections in the tissue of the head and neck area\n  * Locoregional deep infection i.e., suspected abscess at the scheduled time points for measurements.\n  * prior daily treatment with Self MLD\n  * other treatment of head and neck lymphedema, for example compression\n  * psychiatric disorders\n  * substance abuse problems","ALL",{"count":19,"type":20},"INTERVENTIONAL",[51],"NA","This study will evaluate the feasibility of a randomized controlled trial. The future randomized controlled trial will compare two groups following different intensities of manual lymphatic drainage for external head- and neck lymphedema among persons treated with radiotherapy for head- and neck cancer.",[54,55,56,25],"Lymphedema of Face","Neoplasms","Radiotherapy Side Effect",[58],"Head and neck lymphedema management","2025-10-02",{"date":61,"type":30},"2025-10-10",{"date":63,"type":30},"2025-10-01",{"date":65,"type":20},"2027-06",{"name":67,"class":37},"Lund University",{"id":69,"slug":70,"hasResults":11,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":11,"sex":16,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":4,"studyType":49,"phases":80,"briefSummary":81,"conditions":82,"keywords":87,"overallStatus":97,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":4},"100606060","effectiveness-of-a-therapeutic-exercise-program-with-specific-upper-limb-exercises-to-reduce-lymphedema-and-neuropathy-in-breast-cancer-patients-a-pre-post-study-lynma-100606060","NCT07170631","Effectiveness of a Therapeutic Exercise Program With Specific Upper Limb Exercises to Reduce Lymphedema and Neuropathy in Breast Cancer Patients: A Pre-post Study (LYNMA)","Effectiveness of a General Therapeutic Exercise Program Including Specific Upper Limb Exercises to Reduce Lymphedema and Peripheral Neuropathy Secondary to Oncological Treatment in Patients With Breast Cancer: A Pre-post Intervention Study (LYNMA)","LYNMA","Inclusion Criteria:\n\n* Patients receiving treatment for breast carcinoma.reatments include surgical procedures (breast-conserving surgery or mastectomy), axillary lymph node dissection, sentinel lymph node biopsy, radiotherapy, chemotherapy, and hormone therapy.\n* Participants must provide authorization from their primary care physician and\u002For oncologist to perform therapeutic exercise.\n* Diagnosis of lymphedema associated with stage I or II breast cancer (Stage 1 or mild: circumference difference less than 4 cm \\[volume difference 10-25%\\] compared to the healthy arm; Stage 2 or moderate: circumference difference between 4 and 6 cm \\[volume difference 25-50%\\] compared to the healthy arm).\n* A score of 4 or higher on the DN4 questionnaire (neuropathic pain)\n\nExclusion Criteria:\n\n* Lack of medical authorization.\n* Pre-existing cardiac pathology prior to cancer diagnosis.\n* Exacerbation of comorbidities.\n* Travel time exceeding 45 minutes to the location where the therapeutic exercise program is conducted.","35 Years","70 Years",{"count":79,"type":20},30,[51],"This study aims to evaluate the effectiveness of a therapeutic exercise program designed specifically for women with breast cancer. The program includes general exercises along with specific movements for the upper limb to help reduce common side effects of cancer treatment such as lymphedema (swelling of the arm) and neuropathy (nerve pain or numbness). Participants will undergo the exercise program and be assessed before and after to determine improvements in their symptoms and overall quality of life. The goal is to provide evidence that targeted physical therapy can improve recovery and well-being in breast cancer survivors.",[83,25,84,85,86],"Lymphedema Arm","Lymphedema, Breast Cancer","Peripheral Neuropathy Due to Chemotherapy","Peripheral Neuropathy in Breast Cancer Patient",[88,89,90,91,92,93,94,95,96],"Therapeutic exercise","Breast cancer","Lymphedema","Peripheral neuropathy","Upper limb exercises","Oncology physiotherapy","Neural mobilization","Neurodynamic techniques","Peripheral nerve ultrasound","NOT_YET_RECRUITING","2025-09-12",{"date":100,"type":30},"2025-09-18",{"date":102,"type":20},"2026-01",{"date":104,"type":20},"2026-10",{"name":106,"class":37},"Universitat Internacional de Catalunya"]