[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"macromastia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:macromastia":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,49],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100571838","npwt-reduction-mammaplasty-100571838",false,"NCT06725459","NPWT Reduction Mammaplasty","Assessing the Application of Closed Incision Negative Pressure Wound Therapy to Reduction Mammaplasty","Inclusion Criteria:\n\n* Female patients\n* Age 18 years or older\n* Scheduled to undergo bilateral reduction mammaplasty with a Wise pattern (anchor) incision and a superomedial, inferior, or central mound pedicle at MedStar Georgetown University Hospital or MedStar Good Samaritan Hospital\n* Able to comply with study procedures and follow-up visits\n\nExclusion Criteria:\n\n* Younger than 18 years of age\n* Biologically male patients\n* Scheduled to undergo unilateral breast mammaplasty\n* Currently pregnant or lactating\n* Use of steroids or other immune modulators known to affect wound healing\n* Current smokers who have not paused for a minimum of 4 weeks prior to surgery\n* History of breast cancer\n* History of oncologic or reconstructive breast surgery\n* History of radiation to the breast\n* History of chemotherapy or hormone therapy\n* Tattoos in the area of skin incision\n* Skin conditions known to affect wound healing or scarring of the breast (e.g., cutis laxa)\n* Significant history of scar problems (e.g., hypertrophic scarring or keloids) post-surgical incisions with active bleeding\n* Exposure of blood vessels, organs, bone, or tendon at the base of the reference wound\n* Known allergies to product components (e.g., medical or NPWT tape)\n* Unable to comply with NPWT requirements, including those unable to present for postoperative follow-up\n* Lactating at the time of surgery\n* Require deviation from standard operative or closure techniques (e.g., staples, free nipple grafts)\n* Considered part of a vulnerable population (adults unable to consent, infants, children, teenagers, pregnant women, prisoners)\n* Experience intraoperative complications due to surgical complications not related to the NPWT instrumentation (e.g., expanding hematoma)","FEMALE","18 Years",{"count":19,"type":20},92,"ESTIMATED","INTERVENTIONAL",[23],"NA","In this prospective, randomized, split-body control trial, we aim to compare complications, patient-reported outcomes, and cost differentials following reduction mammaplasty with prophylactic closed incision negative pressure wound therapy versus standard adhesive dressing.",[26,27,28,29,30],"Healthy","Macromastia","Negative Pressure Therapy","Mammaplasty","Wound Healing",[32,33,34,35],"mammaplasty","macromastia","breast reduction","negative pressure therapy","RECRUITING","2025-10-24",{"date":39,"type":40},"2025-10-27","ACTUAL",{"date":42,"type":40},"2024-12-17",{"date":44,"type":20},"2026-11-01",{"name":46,"class":47},"Medstar Health Research Institute","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":56,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":21,"phases":61,"briefSummary":63,"conditions":64,"keywords":66,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":5},"100508259","phase-4-subpectoral-bupivacaine-for-pain-management-in-adolescent-reduction-mammaplasty-100508259","NCT05898087","Subpectoral Bupivacaine for Pain Management in Adolescent Reduction Mammaplasty","Inclusion Criteria:\n\n1. Female\n2. Age 13-25 at the time of surgery\n3. Undergoing bilateral reduction mammaplasty at Connecticut Children's from 1\u002F1\u002F2022-12\u002F31\u002F2025.\n4. Ability of child's parent\u002Flegal guardian to understand and the willingness to sign a written informed consent document.\n\nExclusion Criteria:\n\n1. Patients with history of substance use disorder or \"chronic pain\" defined as pain requiring management and treatment by a pain management specialist.\n2. Patients already taking narcotics at the time of surgery.\n3. Patients with a history of hepatic or renal dysfunction.\n4. Patients with known allergy to bupivacaine.\n5. Patients who are pregnant, determined by urine testing in pre-operative area.\n6. Patients who are non-verbal or have developmental delays that would result in inability to report reliable pain scores.\n7. Patients with significant post-operative complications\n8. Patients not meeting inclusion criteria.\n9. Patients lost to follow-up- they must be seen within 1 week and 4 weeks post-operatively",true,"ALL","13 Years","25 Years",{"count":60,"type":20},128,[62],"PHASE4","The main question this randomized control trial aims to answer is:\n\n• Is the use of intraoperative subpectoral bupivacaine associated with decreased post-operative pain in adolescent patients who undergo bilateral reduction mammaplasty\n\nParticipants will be randomized into the study group that intraoperatively receives 30cc of subpectoral bupivacaine injections or into the control group that intraoperatively receives 30cc of injectable saline subpectorally. All participants will keep a pain log and pain medication log at home for the first week following surgery.\n\nResearchers will compare to see if patients who receive subpectoral bupivacaine have lower pain scores in the PACU, and lower use of narcotics post-operatively when compared to the control group who receive injectable saline.",[27,65],"Post-operative Pain",[33,67,68],"post-operative pain","bupivacaine","2025-05-23",{"date":71,"type":40},"2025-05-29",{"date":73,"type":40},"2022-04-01",{"date":75,"type":20},"2026-04-01",{"name":77,"class":47},"Connecticut Children's Medical Center"]