[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"macular-hole-surgery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:macular-hole-surgery":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,47,71],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":4,"maxAge":4,"enrollmentInfo":16,"targetDuration":4,"studyType":19,"phases":20,"briefSummary":22,"conditions":23,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100643696","comparison-between-outcomes-of-closure-of-idiopathic-macular-hole-using-autologus-tenon-capsule-graft-and-internal-limiting-membrane-flap-techniques-pilot-study-100643696",false,"NCT07633457","Comparison Between Outcomes of Closure of Idiopathic Macular Hole Using Autologus Tenon Capsule Graft and Internal Limiting Membrane Flap Techniques (Pilot Study)","Inclusion Criteria:\n\n* Patients diagnosed with idiopathic full-thickness macular hole\n* ≥400 µm in horizontal diameter\n\nExclusion Criteria:\n\n* Media opacity preventing adequate OCT\u002FOCTA imaging\n* Other retinal vascular pathology as retinal vascular occlusion\n* Intraoperative complications\n* Signal noise ratio using OCTA \\\u003C6\\\\10\n* Poor fixation of the patient","ALL",{"count":17,"type":18},20,"ESTIMATED","INTERVENTIONAL",[21],"NA","The aim of this study is to compare the functional visual outcomes, anatomical closure rate and macular perfusion changes assessed by OCT and OCTA after surgical repair of macular hole using Tenon capsule graft versus ILM flap.",[24,25,26,27,28],"Macular Hole Surgery","ILM Peeling","Tenon Capsule","ILM Flap","Macular Hole",[30,31,32,33],"Macular hole","ILM flap","Tenon capsule","Graft","RECRUITING","2026-06-04",{"date":37,"type":38},"2026-06-08","ACTUAL",{"date":40,"type":38},"2025-11-09",{"date":42,"type":18},"2028-01-01",{"name":44,"class":45},"Ain Shams University","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":15,"minAge":55,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":19,"phases":57,"briefSummary":58,"conditions":59,"keywords":60,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":46},"100617464","autologous-tenons-capsule-graft-for-refractory-macular-holes-100617464","NCT07318961","Autologous Tenon's Capsule Graft for Refractory Macular Holes","Visual and Anatomical Outcomes of Autologous Tenon's Capsule Graft for Refractory Macular Holes","ATCG-RMH","Inclusion Criteria:\n\n* Age 18 years or older\n* Refractory full-thickness macular hole defined as:\n* Chronic macular hole \\>400 µm, or\n* Persistent macular hole following prior vitrectomy with ILM peeling and gas tamponade\n* Clear ocular media and adequate fixation for OCT imaging\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Active ocular infection or inflammation\n* Advanced glaucoma or optic neuropathy\n* History of intraocular tumors\n* Severe proliferative vitreoretinopathy\n* Significant systemic diseases likely to affect visual recovery","18 Years",{"count":17,"type":18},[21],"This prospective interventional study evaluates the anatomical and functional outcomes of autologous Tenon's capsule grafting in patients with refractory full-thickness macular holes. Eligible patients include those with chronic large macular holes (\\>400 µm) or persistent holes following prior pars plana vitrectomy with internal limiting membrane peeling and gas tamponade. Anatomical closure will be assessed using spectral-domain optical coherence tomography, and functional outcomes will be evaluated by best-corrected visual acuity over a 3-month follow-up period.",[24],[61,28],"Autologous Tenon's Capsule Graft","2025-12-21",{"date":64,"type":38},"2026-01-06",{"date":66,"type":38},"2025-12-14",{"date":68,"type":18},"2026-06-03",{"name":70,"class":45},"Benha University",{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":15,"minAge":55,"maxAge":4,"enrollmentInfo":79,"targetDuration":4,"studyType":19,"phases":81,"briefSummary":82,"conditions":83,"keywords":84,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":5},"100585934","no-endotamponade-for-macular-hole-repair-the-nemar-study-100585934","NCT06908824","No Endotamponade for Macular Hole Repair: the NEMAR Study","The No Endotamponade for Macular Hole Repair (NEMAR) Study: An International Multi-center Randomized Controlled Trial Comparing Macular Hole Closure Using Internal Limiting Membrane Flap Without Endotamponade Versus Conventional Surgery","NEMAR","Inclusion Criteria:\n\n* Age \\>= 18 years\n* Presence of full thickness macular hole in one eye (defined as full thickness discontinuity of neuro-sensory retina at the macula on optical coherence tomography)\n* Able to comply to post-operative posture\n* VA ≥0.05 and ≤0.8\n\nExclusion Criteria:\n\n* Fellow eye enrolled in the study\n* Eyes that underwent previous macular surgery\n* Presence of maculopathy other than macular hole, epi-retinal membrane or myopic maculopathy. For example, age-related macular degeneration, diabetic macular edema or pre-existing macular scar\n* Axial length \\>\u002F= 28mm or presence of significant myopic chorio-retinal atrophy involving the fovea\n* Minimum linear diameter \\>\u002F=800µm\n* Presence of contraindications to intraocular gas, such as advanced glaucoma or uncontrolled glaucoma\n* Significant macular puckering (Govetto staging ≥ stage 2)\n* Patients who are unable to give informed consent\n* Patients who are pregnant",{"count":80,"type":18},180,[21],"Full-thickness macular hole (MH) is a common sight threatening macular condition with a prevalence of 3.3 per 1000 individuals. Prompt surgical repair of MH is imperative in preventing irreversible vision loss from MH as the majority of patients would experience progressive loss of central vision, often resulting in visual acuity (VA) of 20\u002F200 or worse and the spontaneous closure rate is less than 10%.\n\nPars plana vitrectomy (PPV) with internal limiting membrane (ILM) peeling (with or without ILM flap) and gas tamponade, herein referred to as conventional surgery, is the current standard-of-care surgical technique in repairing MH.\n\nRecently, a novel surgical technique that omits the need of gas tamponade to repair MH has been proposed, early results from retrospective studies were encouraging.\n\nThe purpose of this prospective international multi-centre randomised controlled study is to compare the efficacy and safety of two surgical techniques in treating MH:\n\n1. Conventional surgery: PPV with ILM peeling and gas or silicone oil tamponade\n2. ILM flap with no gas tamponade surgery: PPV with ILM flap with no gas tamponade",[28,24],[28,85,86,87,88],"Vitrectomy","Macular surgery","Internal limiting membrane peeling","Gas tamponade","2025-09-26",{"date":91,"type":38},"2025-09-30",{"date":93,"type":38},"2025-09-16",{"date":95,"type":18},"2027-12-31",{"name":97,"class":45},"Chinese University of Hong Kong"]