[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"magnesium-sulfate\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:magnesium-sulfate":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,43,72,105,136,159,182],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":4},"100603694","magnesium-sulfate-for-prevention-of-emergence-agitation-in-lumbar-disc-surgery-100603694",false,"NCT07139847","Magnesium Sulfate for Prevention of Emergence Agitation in Lumbar Disc Surgery","Effect of Intraoperative Magnesium Infusion on Postoperative Emergence Agitation in Patients Undergoing Lumbar Microdiscectomy","Inclusion Criteria:\n\nAge between 18 and 70 years\n\nASA physical status classification I or II\n\nScheduled for elective single-level lumbar microdiscectomy under general anesthesia\n\nAbility to provide written informed consent\n\nExclusion Criteria:\n\nSevere cardiovascular disease\n\nHistory of psychiatric disorder\n\nNeuromuscular disease\n\nPregnancy or breastfeeding\n\nHepatic or renal dysfunction\n\nCurrent use of calcium channel blockers, hypnotics, anxiolytics, or antipsychotic medications\n\nKnown allergy to magnesium sulfate or study-related medications\n\nRefusal to participate in the study","ALL","18 Years","70 Years",{"count":20,"type":21},70,"ESTIMATED","1 Month","OBSERVATIONAL","In this retrospective study, the effect of intraoperative magnesium sulfate infusion on the incidence of postoperative emergence agitation was evaluated in adult patients who underwent elective lumbar microdiscectomy under general anesthesia. The medical records of patients aged 18-70 years with an ASA physical status of I-II were retrospectively reviewed. Patients were evaluated according to whether they received intraoperative magnesium sulfate infusion as part of anesthetic management. The primary outcome measure was the incidence of emergence agitation in the post-anesthesia care unit; this assessment was based on Ramsay Sedation Scale scores recorded in the post-anesthesia care unit at admission and at 5, 10, 15, and 30 minutes. Secondary outcome measures included postoperative pain scores assessed using the Numeric Rating Scale, intraoperative remifentanil consumption, recovery and extubation times, tramadol requirement in the post-anesthesia care unit, and possible adverse events related to magnesium infusion.",[26,27,28],"Lumbar Disc Herniation","Emergence Agitation","Magnesium Sulfate",[28,26,30],"Postoperative Complications","NOT_YET_RECRUITING","2026-06-20",{"date":34,"type":35},"2026-06-25","ACTUAL",{"date":37,"type":21},"2026-07-05",{"date":39,"type":21},"2026-09-30",{"name":41,"class":42},"Ondokuz Mayıs University","OTHER",{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":53,"phases":54,"briefSummary":56,"conditions":57,"keywords":59,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":71},"100434562","phase-4-effect-of-magnesium-sulfate-bolus-on-intraoperative-neuromonitoring-100434562","NCT04938765","Effect of Magnesium Sulfate Bolus on Intraoperative Neuromonitoring","Randomized and Placebo Controlled Study to Evaluate the Effect of Magnesium Sulfate on Intraoperative Neuromonitoring.","Inclusion Criteria.\n\n* Patients aged 18 to 80 years\n* Belonging to American Society of Anesthesiologists physical status (ASA) I, II\n* Undergoing elective spine or cranial surgery where intraoperative neuromonitoring including short latency somatosensory evoked potentials (SSEP or SEP) and transcranial electrical muscle motor evoked potentials recording from muscles (TceMEP or TcMEP or mMEP or MEP) is planned.\n\nExclusion Criteria:\n\n* Magnesium use within the last 2 days, either intravenous or oral supplements.\n* Patients with known electrolyte imbalances (Sodium \\\u003C135 or \\>145 mmol\u002FL OR Potassium \\\u003C 3.5 or \\> 5.0 mmol\u002FL, Magnesium \\>1.2 mmol\u002FL.\n* Severe cardiac or cardiac conduction disorders.\n* Severe pulmonary disease.\n* Patients with significant neuromuscular disorders or preexisting motor or sensory deficits other than focal upper limb neuropathy or focal cervical radiculopathy or mild cervical myelopathy.\n* Severe Renal disease - serum creatinine of \\> 2 mg\u002Fdl.\n* Pregnant or breastfeeding patients.\n* Unable to obtain adequate baseline SSEPs and MEPs.","80 Years",{"count":52,"type":21},50,"INTERVENTIONAL",[55],"PHASE4","Magnesium Sulfate(MgSo4) is increasingly being used as part of the multimodal pain regimen in the perioperative period. The intraoperative neurophysiological monitoring (IONM) is utilized in complex spine and cranial surgeries to assess the functional integrity of the neural pathways. The effect of Magnesium sulfate on IONM has not been studied.\n\nThis is a prospective, double blind, randomized placebo controlled trial to study the effect of Magnesium sulfate bolus on the amplitude and latency of somatosensory(SSEPs) and motor evoked potentials(MEPs) in patients undergoing surgery requiring IONM.",[58,28],"Intraoperative Neurophysiological Monitoring",[60],"multimodal analgesia","RECRUITING","2026-04-21",{"date":64,"type":35},"2026-04-24",{"date":66,"type":35},"2022-03-18",{"date":68,"type":21},"2027-03",{"name":70,"class":42},"Loma Linda University",1,{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":78,"eligibilityCriteria":79,"healthyVolunteers":11,"sex":80,"minAge":17,"maxAge":4,"enrollmentInfo":81,"targetDuration":4,"studyType":53,"phases":83,"briefSummary":85,"conditions":86,"keywords":92,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":4},"100633586","phase-2-mag-pain---magnesium-for-postoperative-analgesia-in-the-newly-delivered-100633586","NCT07528612","MAG-PAIN - MAGnesium for Postoperative Analgesia In the Newly Delivered","Effect of Intravenous Magnesiumsulfate on Postoperative Pain in Patients Undergoing Cesarean Section: The Magnesium for Postoperative Analgesia In the Newly Delivered, The MAG-PAIN Randomized Controlled Trial.","MAG-PAIN","Inclusion Criteria:\n\n* Adult\n* Planned or non-urgent c-section in regional anesthesia\n* Ability to read, speak and understand infromation in Swedish\n* Oral and written consent\n\nExclusion Criteria:\n\n* Contraindications for spinal anesthesia\n* Moderate to severe kidney failure\n* Need of translator\n* Ongoing treatment with magnesium-infusion\n* Myastenia Gravis","FEMALE",{"count":82,"type":21},150,[84],"PHASE2","The study aims to investigate whether a commonly used medicine, magnesium, can help reduce pain after a Caesarean section. A total of 150 participants will be included. Their usual medical care will not change, and participation is entirely voluntary. The purpose of the study is to determine whether magnesium can improve pain relief after surgery and support faster recovery and bonding with the newborn.\n\nBefore the operation, potential participants will receive a text message containing a short questionnaire about their background and their expectations regarding postoperative pain. On the day of surgery, all patients will receive two intravenous lines as part of routine care. Those who participate in the study will be asked to rate how painful this insertion was on a scale from one to ten. The participants will then be randomly assigned to receive either magnesium or a saltwater solution through a 100 ml drip, which is administered after the baby is born. Neither participants nor the clinical staff will know which solution has been given, and no blood samples will be collected. After the procedure, participants will be asked several times about their pain level.\n\nDuring the first three days after the operation, each participant will receive one text message per day with a short questionnaire about their pain, general recovery, and early bonding with their newborn. Fourteen days after the operation, and again three months later, they will receive additional questionnaires similar to the earlier ones. Each questionnaire takes approximately five to seven minutes to complete, and no extra hospital visits are required.\n\nMagnesium can cause side effects, but the risks associated with the dose used in the study are low. The most common side effect is a brief burning sensation at the infusion site, which is not harmful. Magnesium is widely used in medical care, including in pregnant patients, and the study team considers the treatment safe. Because the medication is administered after birth, it does not affect the baby and does not increase risks during breastfeeding.\n\nAll collected information will be handled securely and confidentially. Data will be coded so that individual participants cannot be directly identified, and only the research team will have access to the key linking codes to individuals. Participants have the right to access their data, request corrections, ask for deletion of their information, or limit how their data is used. The study has been approved by the Swedish Ethical Review Authority, and results will be published in a scientific journal without identifying any participant. No financial compensation is provided, but participants are covered by the usual patient and medication insurance.\n\nTo ensure that the study is conducted correctly, authorized monitors or authorities may compare study data with medical records. These individuals must sign confidentiality agreements. By giving consent to participate, individuals allow this review. All data will be stored according to legal archiving requirements.\n\nParticipation in the study is completely voluntary. Individuals may withdraw at any time, and if they do, their collected data will be deleted. Their medical care before, during, and after the operation will not be affected by their decision to participate or withdraw.",[87,88,89,28,90,91],"Postoperative Pain","Quality of Recovery (QoR-15)","Pain Prediction","Pain Interference","Self-Efficacy",[93,94,95],"Postoperative pain after Caesarean section","Postoperative core outcome set for postoperative pain","NMDA-antagonism","2026-04-14",{"date":98,"type":35},"2026-04-17",{"date":100,"type":21},"2026-04-02",{"date":102,"type":21},"2028-12-31",{"name":104,"class":42},"Region Halland",{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":110,"acronym":4,"eligibilityCriteria":111,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":112,"enrollmentInfo":113,"targetDuration":4,"studyType":53,"phases":114,"briefSummary":116,"conditions":117,"keywords":126,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":131,"completionDateStruct":132,"leadSponsor":134,"locationsCount":71},"100606900","anesthesia-techniques-neuroprotection-and-surgical-field-in-fess-under-controlled-hypotension-100606900","NCT07181564","Anesthesia Techniques, Neuroprotection and Surgical Field in FESS Under Controlled Hypotension","FUNCTIONAL ENDOSCOPIC NASAL AND SINUS SURGERY AND ANESTHESIA: Study of Hemodynamic Parameters During General Anesthesia Compared to the Surgical Field, as Well as Assessment of Cerebral Ischemia Intraoperatively by Measurement of S100B Protein and Specific Neuronal Enolase (NSE).","Inclusion Criteria :\n\nAdult patients (≥18 years old). Scheduled for F.E.S.S (Functional endoscopic sinus surgery ) under general anesthesia.\n\nAble to provide informed consent\n\nExclusion Criteria:\n\nEmergency surgery. ASA physical status IV-V. Severe hepatic or renal dysfunction. Known allergy or contraindication to study drugs. Pregnant or lactating women. unable to provide informed consent\n\nPatients unwilling or unable to provide consent.","90 Years",{"count":82,"type":21},[115],"NA","This prospective, randomized controlled trial investigates the effect of four different anesthetic maintenance techniques on surgical field conditions, hemodynamic stability, and neuroprotection during functional endoscopic sinus surgery (FESS) performed under controlled hypotension. Patients are randomly assigned to receive either total intravenous anesthesia with propofol-remifentanil, propofol-remifentanil with adjunct ketamine and magnesium, sevoflurane-remifentanil, or sevoflurane-remifentanil with adjunct ketamine and magnesium. Primary outcomes include serum biomarkers of neuronal injury (S100B and neuron-specific enolase, NSE) measured perioperatively, as well as surgical field visibility and intraoperative bleeding scores. Secondary outcomes include recovery profile and postoperative pain.",[28,118,119,120,121,122,123,124,125],"Remifentanil","S 100beta","S100 Beta Protein, Human","Neuron-Specific Enolase","Brain Ischemia","Sevoflurane Anaesthesia","Propofol\u002FRemifentanil","Ketamine",[127],"\"Anesthesia\", \"Controlled Hypotension\", \"FESS\", \"S100B\", \"Neuron-Specific Enolase\"","2025-09-11",{"date":130,"type":35},"2025-09-18",{"date":128,"type":35},{"date":133,"type":21},"2026-03-20",{"name":135,"class":42},"University General Hospital of Patras",{"id":137,"slug":138,"hasResults":11,"nctId":139,"briefTitle":140,"officialTitle":141,"acronym":4,"eligibilityCriteria":142,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":143,"enrollmentInfo":144,"targetDuration":4,"studyType":53,"phases":145,"briefSummary":146,"conditions":147,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":151,"lastUpdatePostDateStruct":152,"startDateStruct":154,"completionDateStruct":155,"leadSponsor":157,"locationsCount":71},"100590369","intraoperative-combination-of-ketamine-and-magnesium-sulfate-infusions-on-postoperative-analgesia-in-open-rhinoplasty-100590369","NCT06966518","Intraoperative Combination of Ketamine and Magnesium Sulfate Infusions on Postoperative Analgesia in Open Rhinoplasty","Effectiveness of Intraoperative Combination of Ketamine and Magnesium Sulfate Infusions on Postoperative Analgesia in Patients Undergoing Open Rhinoplasty: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age from 18 to 65 years.\n* Both sexes.\n* American Society of Anesthesiologists (ASA) physical status I - II.\n* Scheduled for rhinoplasty under general anesthesia.\n\nExclusion Criteria:\n\n* Receiving analgesic or any medications since 48 hours before the surgery.\n* Drug addiction.\n* Cardiovascular disease.\n* Respiratory disease, renal, liver, metabolic and neurological disease.\n* Pregnancy or breast feeding.\n* Asthma.","65 Years",{"count":52,"type":21},[115],"The study aims to evaluate the effectiveness of intraoperative combination of ketamine and magnesium sulfate infusions on postoperative analgesia in patients undergoing open rhinoplasty.",[148,125,28,149,150],"Intraoperative","Postoperative Analgesia","Rhinoplasty","2025-05-12",{"date":153,"type":35},"2025-05-13",{"date":151,"type":35},{"date":156,"type":21},"2025-10-01",{"name":158,"class":42},"Ain Shams University",{"id":160,"slug":161,"hasResults":11,"nctId":162,"briefTitle":163,"officialTitle":164,"acronym":4,"eligibilityCriteria":165,"healthyVolunteers":166,"sex":80,"minAge":17,"maxAge":4,"enrollmentInfo":167,"targetDuration":4,"studyType":53,"phases":169,"briefSummary":170,"conditions":171,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":173,"lastUpdatePostDateStruct":174,"startDateStruct":176,"completionDateStruct":178,"leadSponsor":180,"locationsCount":71},"100571226","magnesium-sulfate-and-postoperative-hypercoagulability-in-laparoscopic-gynecological-surgeries-100571226","NCT06717490","Magnesium Sulfate and Postoperative Hypercoagulability in Laparoscopic Gynecological Surgeries","Effect of Magnesium Sulfate on Postoperative Hypercoagulability Using Thromboelastometry in Laparoscopic Gynecological Surgeries","Inclusion Criteria:\n\n* ASA I and II patients\n* Laparoscopic gynecological surgeries\n* age \\>18 years\n* Patients receiving prophylactic anticoagulant therapy 12 hours before surgery based on the Caprini score\n* Patients receiving prophylactic anticoagulant therapy 12 hours postoperatively based on the Caprini score.\n\nExclusion Criteria:\n\n* ASA ≥ III\n* age \\\u003C18 years\n* BMI \\>40 kg\u002Fm²\n* Pregnancy\n* Known hematologic disorders\n* Liver\u002Fkidney\u002Fcardiovascular disease\n* Severe anemia (6,5- 7,9 g\u002Fdl)\n* Inability or refusal to provide informed consent",true,{"count":168,"type":21},60,[115],"This will be a prospective randomized, double-blind study, aiming at investigating the effects of magnesium sulfate on postoperative hypercoagulability in patients undergoing laparoscopic gynecological surgeries under general anesthesia",[28,172],"Thromboelastometry","2024-11-30",{"date":175,"type":35},"2024-12-05",{"date":177,"type":21},"2024-12",{"date":179,"type":21},"2025-11",{"name":181,"class":42},"Marianna Mavromati",{"id":183,"slug":184,"hasResults":11,"nctId":185,"briefTitle":186,"officialTitle":186,"acronym":4,"eligibilityCriteria":187,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":188,"enrollmentInfo":189,"targetDuration":4,"studyType":53,"phases":191,"briefSummary":192,"conditions":193,"keywords":196,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":198,"lastUpdatePostDateStruct":199,"startDateStruct":201,"completionDateStruct":203,"leadSponsor":205,"locationsCount":4},"100568782","phase-4-comparative-study-between-intrathecal-magnesium-sulfate-neostigmine-and-fentanyl-as-adjuvant-for-bubivacaine-in-postoperative-analgesia-in-lower-abdominal-surgeries-100568782","NCT06685705","Comparative Study Between Intrathecal Magnesium Sulfate, Neostigmine and Fentanyl as Adjuvant for Bubivacaine in Postoperative Analgesia in Lower Abdominal Surgeries","Inclusion Criteria:\n\n* • the American Society of Anesthesiologists (ASA) classification I-II\n\n  * Age \\>18 up to 55 years old\n  * Both sex\n  * Patients who will undergo lower abdominal surgeries\n\nExclusion Criteria:\n\n* • Patients' refusal.\n\n  * Patients with morbid obesity, cardiac diseases, hepatic diseases, renal diseases, diabetes mellitus with polyneuritis.\n  * Patients who were in risk-scoring groups American Society of Anesthesia III-IV.\n  * Hypertensive patients receiving therapy with adrenergic receptor antagonist, calcium channel blocker and\u002For angiotensin converting enzyme inhibitor.\n  * Patients with coagulation disorders, those receiving any anticoagulants.\n  * Any history of allergy to local anesthetic or other drugs used in the study, patients on examining drugs.\n  * Any contraindication to spinal anesthesia ( infection at puncture site and increased intracranial tension and Patients with psychiatric illness and neurologic diseases.","55 Years",{"count":190,"type":21},66,[55],"Lower abdominal surgeries often result in severe pain, which in turn can cause rapid and shallow breathing, retention of secretions and poor patient compliance. Justifiably, apart from the fear for the surgery outcome, patients are concerned mainly with postoperative pain. If treated inadequately, acute pain can have serious consequences for patient health mainly with postoperative complications, prolonged recovery and increased length of hospital stay. Higher levels of postoperative pain and pain distress are associated with increased morbidity, poorer functional recovery, and reduced quality of life.\n\nAim of the study To compare the duration, quality of analgesia, and side effects between intrathecal Magnesium sulfate, neostigmine and fentanyl as adjuvant for bubivacaine as postoperative analgesia in lower abdominal surgeries",[28,194,195],"Neostigmine","Fentanyl",[197],"lower abdominal surgeries","2024-11-11",{"date":200,"type":35},"2024-11-12",{"date":202,"type":21},"2024-12-01",{"date":204,"type":21},"2026-01-01",{"name":206,"class":42},"Assiut University"]