[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"magnesium-sulphate\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:magnesium-sulphate":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,46,74],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100644957","hemodynamic-effect-of-dexmedetomidine-versus-magnesium-sulphate-as-an-adjuvant-to-lidocaine-in-preemptive-peribulbar-block-in-patients-undergoing-dacryocystorhinostomy-under-general-anesthesia-100644957",false,"NCT07675616","Hemodynamic Effect of Dexmedetomidine Versus Magnesium Sulphate as an Adjuvant to Lidocaine in Preemptive Peribulbar Block in Patients Undergoing Dacryocystorhinostomy Under General Anesthesia","Hemodynamic Effect of Dexmedetomidine Versus Magnesium Sulphate as an Adjuvant to Lidocaine in Preemptive Peribulbar Block in Patients Undergoing Dacryocystorhinostomy Under General Anesthesia: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age ≥ 18 years.\n* Both sexes.\n* American Society of Anesthesiologists (ASA) physical status I or II.\n* Undergoing elective Dacryocystorhinostomy (DCR) surgery under general anesthesia.\n\nExclusion Criteria:\n\n* Patients have local infection.\n* Allergic reaction or complications of the local anaesthesia (LA).\n* Coagulopathy defined as international normalized ratio (INR) \\> 1.5, platelet count \\\u003C 100,000\u002Fmm³, or ongoing anticoagulant therapy not adequately discontinued.\n* Uncontrolled systemic disease, defined as poorly controlled hypertension \\[systolic blood pressure (SBP) \\> 160 mmHg\\], uncontrolled diabetes mellitus (HbA1c \\> 8.5%), unstable ischemic heart disease, or decompensated hepatic or renal disease.\n* Uncooperative patients.","ALL","18 Years",{"count":19,"type":20},60,"ESTIMATED","INTERVENTIONAL",[23],"NA","This study aims to compare the hemodynamic effect of dexmedetomidine and magnesium sulphate as an adjuvant to lidocaine in preemptive peribulbar block in patients undergoing Dacryocystorhinostomy (DCR) under general anaesthesia (GA) .",[26,27,28,29,30,31,32],"Hemodynamic Effect","Dexmedetomidine","Magnesium Sulphate","Lidocaine","Peribulbar Block","Dacryocystorhinostomy","General Anesthesia","RECRUITING","2026-06-27",{"date":36,"type":37},"2026-06-30","ACTUAL",{"date":39,"type":37},"2026-05-16",{"date":41,"type":20},"2026-12-01",{"name":43,"class":44},"Cairo University","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":21,"phases":56,"briefSummary":57,"conditions":58,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":45},"100603669","dexamethasone-versus-magnesium-sulphate-as-an-adjuvant-to-bupivacaine-in-ultrasound-guided-erector-spinae-plane-block-for-postoperative-analgesia-in-elective-caesarean-section-under-spinal-anesthesia-100603669","NCT07139522","Dexamethasone Versus Magnesium Sulphate as an Adjuvant to Bupivacaine in Ultrasound Guided Erector Spinae Plane Block for Postoperative Analgesia in Elective Caesarean Section Under Spinal Anesthesia","The Efficacy of Dexamethasone Versus Magnesium Sulphate as an Adjuvant to Bupivacaine in Ultrasound Guided Erector Spinae Plane Block for Postoperative Analgesia in Elective Caesarean Section Under Spinal Anesthesia: A Randomized Controlled Trial.","Inclusion Criteria:\n\n* Age from 18 to 35 years.\n* Full-term, singleton, pregnant women.\n* American Society of Anesthesiologists (ASA) physical status II.\n* Scheduled for elective cesarean delivery under spinal anesthesia.\n\nExclusion Criteria:\n\n* Refusal of the patient.\n* Emergency caesarean sections.\n* Patients having chronic diseases as asthma, cardiovascular disorders (Significant arrhythmias, Severe Valvular diseases, congenital heart diseases, ischemic heart disease, cardiomyopathy, deep venous thrombosis ,and pulmonary embolism)\n* Renal impairment (Creatinine level ≥ 2mg\u002Fdl, urea ≥ 25mg\u002FdL), liver impairment \\[Alanine aminotransferase (ALT) \\\u003C 45 U\u002FL, Aspartate aminotransferase (AST) \\\u003C 45 U\u002FL\\].\n* Allergy to the drug enrolled in the study.\n* Body mass index (BMI) ≥ 35 kg\u002Fm2.\n* Hypertensive disorders of pregnancy.\n* Contraindication to spinal anesthesia, such as coagulopathy \\[platelet count \\\u003C150.000, international normalized ratio (INR) \\> 1.2\\], or local infection.\n* Requirement for conversion to general anesthesia after spinal anesthesia will also be excluded.","35 Years",{"count":55,"type":20},150,[23],"This study aims to compare the efficacy of adding dexamethasone and magnesium sulfate as an adjuvant to bupivacaine in bilateral erector spinae block in postoperative pain control in patients undergoing caesarean section under spinal anesthesia.",[59,28,60,61,62,63,64,65],"Dexamethasone","Adjuvant","Ultrasound","Erector Spinae Plane Block","Postoperative Analgesia","Cesarean Section","Spinal Anesthesia","2025-08-18",{"date":68,"type":37},"2025-08-24",{"date":70,"type":37},"2023-12-01",{"date":72,"type":20},"2025-12-01",{"name":43,"class":44},{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":16,"minAge":81,"maxAge":82,"enrollmentInfo":83,"targetDuration":4,"studyType":21,"phases":85,"briefSummary":87,"conditions":88,"keywords":4,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":45},"100590337","phase-4-lidocaine-infusion-versus-magnesium-infusion-in-decreasing-fentanyl-requirements-in-endoscopic-sinus-surgeries-100590337","NCT06966102","Lidocaine Infusion Versus Magnesium Infusion in Decreasing Fentanyl Requirements in Endoscopic Sinus Surgeries","Evaluating the Effect of Lidocaine Infusion Versus Magnesium Sulfate Infusion on Decreasing Total Fentanyl Requirements in Patients Undergoing Functional Endoscopic Sinus Surgeries: a Randomized Controlled Study","Inclusion Criteria:\n\n* Age from 21 to 60 years.\n* Both genders.\n* American society of Anesthesiologist (ASA) physical status I-II\n* Scheduled for functional endoscopic sinus surgery under general anesthesia.\n\nExclusion Criteria:\n\n* Patients with prolonged QT interval.\n* Patients with renal disease.\n* Patients with a history of allergy to lidocaine or magnesium sulfate.\n* American Society of Anesthesiologists class higher than II.\n* Patient refusal","21 Years","60 Years",{"count":84,"type":20},156,[86],"PHASE4","Enhanced recovery after ear, nose and throat surgery is based on multimodal and multidisciplinary perioperative interventions to decrease postoperative pain. Functional endoscopic sinus surgery is a surgical management for chronic rhinosinusitis. Although a common procedure, there is a lack of knowledge about perioperative pain and specific pain management after such a procedure. Most of recommendations given in guidelines for postoperative pain management in nasal surgery and sinus surgery are subsumed under head and neck surgery. Head and neck surgery is a wide field covering widely variable surgical procedures. So, postoperative pain management guidelines may not meet the requirements for pain management during and after endoscopic sinus surgery.\n\nVarious medications have been used to improve the surgical field and postoperative pain including intravenous clonidine, dexmedetomidine, lidocaine, and magnesium.\n\nLidocaine has been used considering its analgesic, immuno-modulating, and anti-inflammatory properties. The opioid sparing effect of lidocaine is supported by a high level of evidence. The effectiveness of lidocaine infusion in obtaining reduction of postoperative pain, gastrointestinal recovery time, postoperative nausea and vomiting, and shortening the hospital length of stay, was demonstrated principally in major gastro-intestinal surgery.\n\nMagnesium sulfate is a good option in multimodal analgesia, as it stabilizes the cell membrane and intracytoplasmic organelles by mediating the activation of Na+-K+ ATPase and Ca++ ATPase enzymes, which have an important role in transmembrane ion exchange during the depolarization and repolarization phases. Moreover, magnesium inhibits the release of norepinephrine by blocking the N-type Ca++ channels at nerve endings.\n\nMany studies were designed to prove the role of the analgesic effect of lidocaine and magnesium infusion. However, this is the first randomized controlled study to assess the effect of lidocaine infusion versus magnesium sulphate infusion on decreasing total fentanyl requirements in patients undergoing functional endoscopic sinus surgery.\n\nThis randomized controlled trial was designed to compare the efficacy of lidocaine hydrochloride infusion versus magnesium sulphate infusion in controlling perioperative pain in patients undergoing functional endoscopic sinus surgery.",[89,90,29,28,91],"Enhanced Recovery","Functional Endoscopic Sinus Surgery","Perioperative Pain","NOT_YET_RECRUITING","2025-05-03",{"date":95,"type":37},"2025-05-11",{"date":97,"type":20},"2025-05-10",{"date":99,"type":20},"2025-07-30",{"name":43,"class":44}]