[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"magnetic-resonance\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:magnetic-resonance":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,47,75],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":31,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100610916","presence-of-dural-pulsation-in-patients-diagnosed-with-lumbar-spinal-stenosis-100610916",false,"NCT07233798","Presence of Dural Pulsation in Patients Diagnosed With Lumbar Spinal Stenosis","Correlation of the Presence of Dural Pulsation With Clinical and Radiological Parameters in Patients Diagnosed With Lumbar Spinal Stenosis","Inclusion criteria\n\n* Aged between 18 and 85 years\n* Patients experiencing low back and\u002For leg pain attributable to lumbar spinal stenosis\n* Presence of lumbar spinal stenosis at least at one level consistent with clinical symptoms on lumbar MRI\n* Willingness to participate in the study Exclusion criteria\n* Body Mass Index (BMI) ≥ 35 kg\u002Fm²\n* Patients with radiculopathy due to lumbar disc herniation\n* Patients with axial low back pain caused by facet syndrome, sacroiliac dysfunction, or discogenic pain\n* History of lumbar spine surgery\n* Individuals with mental retardation\n* Patients with major psychiatric comorbidities\n* Patients with congenital spinal anomalies\n* Inflammatory rheumatic diseases characterized by osteophyte formation and ligament calcification, such as ankylosing spondylitis and diffuse idiopathic skeletal hyperostosis (DISH)\n* Pregnancy\n* Patients with heart failure","ALL","18 Years","85 Years",{"count":20,"type":21},100,"ESTIMATED","1 Year","OBSERVATIONAL","Lumbar spinal stenosis is defined as the narrowing of the spinal canal resulting from degenerative changes in the spinal joints, intervertebral discs, and the ligamentum flavum.\n\nPressure fluctuations within the cerebral and spinal vascular systems lead to the formation of pulsations. The periodic occurrence of these pulsations in the dura mater is referred to as spinal dural pulsation.The vibratory movements of the dura mater have been interpreted as an indicator that the spinal cord is freely mobile within the subarachnoid space and not subjected to any external compression.This study aims to investigate whether the presence of dural pulsation is associated with clinical and radiological parameters in patients diagnosed with lumbar spinal stenosis",[26,27,28,29,30],"Lumbar Spinal Stenosis","Numerical Rating Scale","Disability Physical","Magnetic Resonance","Claudication",[32,33],"Dural Pulsation","oswestry disability index","RECRUITING","2026-03-09",{"date":37,"type":38},"2026-03-11","ACTUAL",{"date":40,"type":38},"2025-12-07",{"date":42,"type":21},"2026-12-30",{"name":44,"class":45},"Marmara University","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":57,"phases":58,"briefSummary":60,"conditions":61,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":46},"100513707","multicentre-rct-of-awake-versus-asleep-tractography-based-dbs-for-et-100513707","NCT05968976","Multicentre RCT of Awake Versus Asleep Tractography Based DBS for ET","The TREMBLE Study: Multicentre Randomized Controlled Trial of Awake Versus Asleep Tractography Based Deep Brain Stimulation for Essential Tremor","TREMBLE","Inclusion Criteria:\n\n* Age \\> 18 years;\n* Idiopathic essential tremor\n* Disabling tremor despite optimal pharmacological treatment\n* A life expectancy of at least two years\n\nExclusion Criteria:\n\n* Legally incompetent adults;\n* Previous tremor-neurosurgery (e.g., DBS, thalamotomy);\n* Contraindications for DBS surgery, such as a physical disorder making surgery hazardous;\n* Psychosis;\n* Current depression;\n* Unable to provide written informed consent.",{"count":56,"type":21},110,"INTERVENTIONAL",[59],"NA","Rationale: Deep brain stimulation (DBS) of the thalamus is an effective surgical treatment for patients with disabling essential tremor, despite optimal pharmacological treatment. To date, the standard DBS procedure is performed under local anesthesia which is very burdensome for patients. It is now possible to directly visualize the target (motor) area in the thalamus due to advances in modern imaging techniques. DBS surgery could be performed under general anesthesia (asleep).\n\nObjective: The primary objective of the study is to determine whether asleep thalamic DBS surgery provides an equal tremor reduction compared to awake thalamic DBS surgery, measured by the clinically validated Essential Tremor Rating Assessment Scale after six months of DBS.\n\nSecondary outcomes are: disease related daily functioning, adverse effects, operation time, quality of life, patient satisfaction with treatment outcome and patient evaluation of treatment burden.\n\nStudy design: The study will be a multicentre prospective randomized open label blinded (PROBE) endpoint trial comparing thalamic DBS under general versus local anesthesia.\n\nStudy population: A total of 110 patients with disabling essential tremor despite optimal pharmacological treatment will be randomized.\n\nIntervention (if applicable): Patients will be randomized for asleep DBS or awake DBS. According to the standard DBS procedure, two brain-electrodes are connected to an implanted neurostimulator, which is placed subcutaneously in the subclavicular area\n\nMain study parameter\u002Fendpoints: The primary outcome measure is the change in tremor score on the Essential Tremor Rating Assessment Scale after 6 months of thalamic DBS.\n\nThe secondary outcome measures are the Amsterdam Linear Disability Score for functional health status, Quality of Life in Essential Tremor Questionnaire, patient satisfaction with the treatment, patient evaluation of treatment burden, operating time, hospitalization time, change of tremor medication, side effects and complications.\n\nNature and extent of the burden and risks associated with participation, benefit and group relatedness: Awake DBS at present is very burdensome and by many patients and health care providers considered to be an overly invasive treatment for essential tremor. Through this trial, we aim to investigate whether asleep DBS in essential tremor can become the new treatment standard. This is expected to increase the accessibility for DBS and subsequently would allow more people with essential tremor to be helped, as well as in an earlier stage of their disease than currently; more patients will benefit for a longer time period from DBS. Asleep DBS will have a shorter procedure length. The proposed research project involves treatment options that are standard care in daily practice. The therapies will not be combined with other research products. Both treatments have a low risk of serious complications and a higher risk of minor side effects. Regular follow up will be used. Participation in this study constitutes moderate risk according to NFU criteria for human research.",[62,63,64,29,65],"Essential Tremor","Deep Brain Stimulation","Diffusion Tensor Imaging","Central Nervous System Diseases","2025-04-10",{"date":68,"type":38},"2025-04-13",{"date":70,"type":38},"2024-02-01",{"date":72,"type":21},"2028-07-01",{"name":74,"class":45},"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)",{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":83,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":85,"conditions":86,"keywords":90,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":46},"100572611","cardiac-magnetic-resonance-stress-perfusion-study-in-patinets-with-fontan-circulation-100572611","NCT06735521","Cardiac Magnetic Resonance Stress-perfusion Study in Patinets with Fontan Circulation","Att Överleva Och Leva Som Vuxen Med Enkammarhjärta I Sverige","CMR_TCPC","Inclusion Criteria:\n\n* Patients who had undergone total cavo-pulmonary connection (TCPC) surgery resulting in Fontan circulation.\n* NYHA (New York Heart Assosiation) class I-II.\n* Understanding the study information (signed informed consent).\n* \\>18 years old.\n\nExclusion Criteria:\n\n* Device therapy (pacemaker, ICD).\n* Failing Fontan (NYHA III-IV).\n* Kidney failure (GFR\\\u003C30ml\u002Fh).\n* Arrythmia (atrial fibrillation).\n* Pregnancy.",{"count":84,"type":21},30,"Univentricular heart (UVH) is a severe congenital heart disease. Accurate advanced non-invasive diagnostic methods is limited. Cardiovascular magnetic resonance (CMR) imaging has evolved as a particularly useful tool for the study of patients with adult congenital heart disease (ACHD) considering its ability to determine detailed anatomy and detect early cardiac dysfunction without the need for radiation exposure. Most of contemporary treatment recommendations are based on consensus opinions\u002Fdocuments and small studies from local, or national registries. Improved knowledge is needed in all these areas to facilitate clinical decisions regarding treatment, monitoring and follow-up.\n\nThis study seeks to answer if early detection of deterioration in cardiac function, venous pressure and microvascular dysfunction can identify patients before the symptoms progress and thus help to initiate early treatment. The hypothesis is that quantitative myocardial stress-perfusion maps improves the pathophysiological insight in patients with UVH.\n\nThe overall goal with this research proposal is to implement combined advanced CMR imaging for a comprehensive non-invasive mapping of functional cardiovascular behavior in patients with complex UVH disease. The outcome of this research may benefit this young adult patient population due to early detection of cardiac disease, less hospitalizations because of heart failure, and eventually decrease morbidity and mortality.",[87,88,89,29],"Univentricular Heart","Microvascular Dysfunction","Heart Failure",[91,92,93,94,95,96],"Fontan circulation","CMR","stress-perfusion","tissue characterization","univentricle heart","TCPC","2024-12-13",{"date":99,"type":38},"2024-12-16",{"date":101,"type":38},"2024-04-15",{"date":103,"type":21},"2025-09-01",{"name":105,"class":45},"Karolinska Institutet"]