[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"major-adverse-cardiovascular-events\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:major-adverse-cardiovascular-events":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,47,80,106,131],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":4},"100054311","how-institutional-guidelines-for-urgent-inpatient-surgeries-affect-intensity-of-perioperative-cardiovascular-testing-100054311",false,"NCT07692503","How Institutional Guidelines for Urgent Inpatient Surgeries Affect Intensity of Perioperative Cardiovascular Testing","PERLHS: How Institutional Guidelines for Urgent Inpatient Surgeries Affect Intensity of Perioperative Cardiovascular Testing: A PrePost Study","Inclusion Criteria:\n\n* Adults age 18 years or older\n* Admitted through the Emergency Department at Johns Hopkins Hospital or Johns Hopkins Bayview Medical Center Undergoing urgent inpatient surgery during the index hospitalization\n\nExclusion Criteria:\n\n* Elective surgeries,\n* Outpatient procedures,\n* Procedures followed only by observation or extended-stay recovery rather than inpatient admission,\n* Patients younger than 18 years old","ALL","18 Years",{"count":19,"type":20},3000,"ESTIMATED","INTERVENTIONAL",[23],"NA","This study will evaluate the impact of implementing an educational clinical decision support (CDS) tool designed to guide perioperative cardiovascular evaluation for adults undergoing urgent inpatient surgery. The CDS tool, integrated within the Epic electronic health record via AgileMD, provides evidence-informed recommendations regarding perioperative cardiac testing and specialty consultation based on American Heart Association guidance and multidisciplinary institutional consensus. The investigators will conduct a retrospective and prospective pre-post observational cohort study comparing perioperative cardiovascular testing intensity, consultation patterns, time to operating room, and clinical outcomes before and after implementation of the tool among adult patients admitted through the emergency department at Johns Hopkins Hospital and Johns Hopkins Bayview Medical Center who undergo urgent surgery. Data will be obtained from the Core for Clinical Research Data Acquisition (CCDA) and Epic electronic health record, with case-level chart review performed as needed to validate rare outcomes such as major adverse cardiac events.",[26,27],"Major Adverse Cardiovascular Events","Cardiovascular Testing and Consultation Intensity",[29,30,31,32,33,34],"Perioperative Care","Preoperative Care","Clinical Decision Support Systems","Hospital Medicine","High Value Care","Testing intensity","NOT_YET_RECRUITING","2026-07-09",{"date":38,"type":39},"2026-07-13","ACTUAL",{"date":41,"type":20},"2026-12",{"date":43,"type":20},"2028-06",{"name":45,"class":46},"Johns Hopkins University","OTHER",{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":21,"phases":56,"briefSummary":57,"conditions":58,"keywords":63,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":79},"100540586","predictive-value-of-systolic-rise-time-of-the-plantar-arch-on-the-risk-of-major-adverse-limb-events-male-and-major-adverse-cardiovascular-events-mace-in-peripheral-artery-disease-pad-at-critical-ischaemia-stage-100540586","NCT06318767","Predictive Value of Systolic Rise Time of the Plantar Arch on the Risk of Major Adverse Limb Events (MALE) and Major Adverse Cardiovascular Events (MACE) in Peripheral Artery Disease (PAD) at Critical Ischaemia Stage","TAMIS","Inclusion Criteria:\n\n* patients at least 18 years old,\n* willing and able to provide written informed consent,\n* with documented atherosclerosis critical limb ischemia (pain rest and\u002For ulcer and gangrene manifestations)\n* with hemodynamic measures (ankle pressure less than 50mmHg and\u002For TBI less than 30mmHg and\u002For TcPO2 less than 30 mmHg),\n* followed or send to CHU Amiens Picardie, and eligible to chirurgical revascularization.\n\nExclusion Criteria:\n\n* with non atherosclerosis arteriopathy,\n* ineligible to the gold standard treatment such as the chirurgical revascularization,\n* with life expectancy less than 3 months.",{"count":55,"type":20},134,[23],"Peripheral artery disease (PAD), vascular disease of atheromatous origin, is a frequent pathology, with a steady and significant increase in prevalence over the last decades. It has various symptoms ranging from mild arterial claudication to critical limb ischemia. The critical ischaemia stage in PAD is defined by rest pain or trophic disorders and is a special situation because of the number of cardiovascular deaths at 1 year (25%), 60% at 5 years and acute ischaemic recurrence at 1 year (25%).\n\nIt is a medico-surgical pathology. A haemodynamic marker is needed to monitor patients, as it is predictive of limb progression, cardiovascular events and mortality. The Systolic Rise Time (SRT) of the plantar footpad is a recently described haemodynamic measurement of proven value in the diagnosis of PAD. The aim of this study is to show the prognostic value of the Systolic Rise Time on Major Adverse Limb Events (MALE).",[59,26,60,61,62],"Major Adverse Limb Events","Peripheral Artery Disease","Critical Limb Ischemia","Hemodynamic Measure",[64,65,66,67,68],"major adverse limb events","major adverse cardiovascular events","peripheral artery disease","critical limb ischemia","hemodynamic measure","RECRUITING","2026-06-12",{"date":72,"type":39},"2026-06-15",{"date":74,"type":39},"2024-03-07",{"date":76,"type":20},"2026-09",{"name":78,"class":46},"Centre Hospitalier Universitaire, Amiens",1,{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":4,"eligibilityCriteria":86,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":87,"enrollmentInfo":88,"targetDuration":4,"studyType":90,"phases":4,"briefSummary":91,"conditions":92,"keywords":4,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":79},"100584152","prediction-of-lvar-and-mace-in-stemi-though-plasma-multiomics-analysis-100584152","NCT06885619","Prediction of LVAR and MACE in STEMI Though Plasma Multiomics Analysis","Prediction of Left Ventricular Adverse Remodeling and Major Adverse Cardiovascular Events in Patients With Acute ST-segment Elevation Myocardial Infarction Though Plasma Multiomics Analysis","Inclusion Criteria:\n\n1. Age ≥18 years and ≤80 years.\n2. Definite diagnosis of STEMI according to ESC\u002FACC guidelines:\n\n   * Chest pain lasting \\>30 minutes, and\n   * ST-segment elevation in at least two contiguous leads: ≥0.2 mV in leads V2-V3 (≥0.2 mV for men, ≥0.15 mV for women) or ≥0.1 mV in other leads, or new-onset left bundle branch block.\n3. Reperfusion therapy: Symptom onset to first medical contact ≤12 hours, and successful primary PCI (culprit vessel opened, post-procedure TIMI flow grade 3).\n4. First STEMI (no prior history of myocardial infarction).\n5. Left ventricular ejection fraction (by echocardiography within 24-48 hours after admission) ≥35%.\n6. Informed consent: Signed informed consent obtained, with willingness to undergo serial blood sampling and echocardiographic follow-up.\n\nExclusion Criteria:\n\n1. Non-atherosclerotic MI: coronary embolism, spasm, aortic dissection, myocarditis, Takotsubo.\n2. Severe comorbidities:\n\n   * Prior HF (NYHA ≥II);\n   * Severe CKD (eGFR \\\u003C30 mL\u002Fmin\u002F1.73m² or dialysis);\n   * Severe liver disease (Child-Pugh B\u002FC);\n   * Active malignancy (life expectancy \\\u003C1 year);\n   * Severe hematologic disorders (thrombocytopenia, coagulopathy, active bleeding).\n3. Fibrinolysis-followed-by-PCI.\n4. Primary PCI complications:\n\n   * No-reflow\u002Fslow-flow (final TIMI \\\u003C2);\n   * Cardiogenic shock or mechanical complication within 7 days;\n   * In-hospital repeat revascularization.\n5. Inability to complete 6-month follow-up.\n6. Factors affecting blood sampling\u002Fexosome\u002Fimmune\u002Fproteome assays:\n\n   * Blood transfusion within 1 month;\n   * Known hemolytic disorder;\n   * Inadequate venous access.\n7. Pregnancy or lactation.","80 Years",{"count":89,"type":20},1000,"OBSERVATIONAL","To identify plasma multi-omics biomarkers that predict left ventricular adverse remodeling (LVAR) and major adverse cardiovascular events (MACE) in patients with acute ST-segment elevation myocardial infarction, and to investigate the molecular pathways linked to LVAR and MACE.",[93,94,95,96,26],"Left Ventricular Remodeling","Plasma Multi-Omics","Acute ST-segment Elevation Myocardial Infarction","Immunomics","2026-05-07",{"date":99,"type":39},"2026-05-12",{"date":101,"type":39},"2025-05-01",{"date":103,"type":20},"2027-12-31",{"name":105,"class":46},"Beijing Anzhen Hospital",{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":4,"eligibilityCriteria":112,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":87,"enrollmentInfo":113,"targetDuration":4,"studyType":21,"phases":115,"briefSummary":116,"conditions":117,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":79},"100597378","total-arterial-vs-mixed-grafting-in-left-coronary-cabg-100597378","NCT07057713","Total Arterial vs. Mixed Grafting in Left Coronary CABG","A Prospective, Randomized, Double-Blind Controlled Trial Comparing Total Arterial Grafting Versus Conventional Mixed Grafting in the Left Coronary Artery System During Coronary Artery Bypass Grafting (CABG)","Inclusion Criteria:\n\n1. Age ≥ 18 years\n2. Diagnosed with multivessel coronary artery disease\n3. Indicated for elective coronary artery bypass grafting (CABG) involving ≥3 coronary vessels\n4. Right coronary artery stenosis \\>75%\n5. Able and willing to provide written informed consent\n\nExclusion Criteria:\n\n1. Scheduled for concurrent cardiac procedures (e.g., valve surgery, congenital heart disease repair, aortic dissection surgery, atrial fibrillation ablation)\n2. Severe stenosis of left or right subclavian artery\n3. Unsuitable saphenous veins (e.g., bilateral varicosities)\n4. Unsuitable radial artery as assessed preoperatively\n5. History of intracranial hemorrhage or ischemic stroke within the past 14 days\n6. Severe hepatic or renal insufficiency\n7. Acute myocardial infarction within 72 hours prior to surgery\n8. History of prior CABG or other cardiac surgery",{"count":114,"type":20},400,[23],"This is a prospective, randomized, double-blind controlled trial comparing the clinical efficacy of total arterial grafting (internal thoracic artery and radial artery) versus conventional mixed grafting (internal thoracic artery and great saphenous vein) in the left coronary artery system during coronary artery bypass grafting (CABG). A total of 400 patients undergoing elective CABG at the Second Hospital of Jilin University will be enrolled and randomized into two groups. The primary endpoint is graft patency at 12 months postoperatively, evaluated by coronary angiography or CT angiography. Secondary outcomes include perioperative complications, major adverse cardiovascular events (MACE), and long-term clinical prognosis. The study aims to provide evidence-based guidance on optimal graft selection in CABG.",[118,119,120,121,26],"Coronary Artery Disease","Coronary Artery Bypass Grafting","Arterial Graft","Graft Patency","2026-04-21",{"date":124,"type":39},"2026-04-23",{"date":126,"type":20},"2026-08-01",{"date":128,"type":20},"2027-12-30",{"name":130,"class":46},"Second Hospital of Jilin University",{"id":132,"slug":133,"hasResults":11,"nctId":134,"briefTitle":135,"officialTitle":136,"acronym":137,"eligibilityCriteria":138,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":139,"targetDuration":141,"studyType":90,"phases":4,"briefSummary":142,"conditions":143,"keywords":4,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":149,"lastUpdatePostDateStruct":150,"startDateStruct":152,"completionDateStruct":154,"leadSponsor":156,"locationsCount":158},"100415546","ccta-improves-clinical-management-of-stable-chest-pain-100415546","NCT04691037","CCTA Improves Clinical Management of Stable Chest Pain","Improving the Clinical Management of Stable Chest Pain Based on Imaging: a Registry of Computed Tomography Coronary Angiography","CICM-SCP","Inclusion Criteria:\n\n* symptomatic patients with SCP suspected of obstructive CAD.\n* referred for CCTA for the assessment of SCP.\n* ≥18 years of age.\n* signed informed consent.\n\nExclusion Criteria:\n\n* acute coronary syndromes\n* previous CAD or coronary revascularization\n* nonsinus rhythm\n* cardiomyopathy, valvular disease, congenital heart disease or left cardiac insufficiency because of other reasons",{"count":140,"type":20},50000,"3 Years","The investigator aims to prospectively enroll patients who were referred for coronary computed tomography angiography (CCTA) for the assessment of stable chest pain (SCP) suspected of obstructive coronary artery disease (CAD). All patients underwent CCTA according to established guidelines and local institutional protocols. The imaging data were evaluated using different image post-processing software to comprehensively analyse anatomical, functional and histological information of coronary. This study will determine if CCTA-based imaging evaluation can provide more informaton to improve clinical management for SCP, including fewer MACE and better decision-making of downstream investigations and therapeutic interventions.",[144,145,146,147,148,26,118],"Coronary Computed Tomography Angiography","Stable Chest Pain","Optimal Medical Therapy","Invasive Coronary Angiography","Revascularization","2024-03-26",{"date":151,"type":39},"2024-03-28",{"date":153,"type":39},"2016-01-01",{"date":155,"type":20},"2030-01-01",{"name":157,"class":46},"Tianjin Chest Hospital",4]