[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"major-noncardiac-surgery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:major-noncardiac-surgery":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,40,72],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100624425","risk-prediction-model-for-older-adults-undergoing-noncardiac-surgery-100624425",false,"NCT07409467","Risk Prediction Model for Older Adults Undergoing Noncardiac Surgery","Development of a Surgical Risk Prediction Model for Older Adults Undergoing Major Noncardiac Surgery: A Prospective Cohort Study","Inclusion Criteria:\n\n* Patients aged 65 years or older scheduled for elective surgery who visit the preoperative assessment clinic.\n* Patients scheduled for major non-cardiac surgery.\n* Patients who voluntarily provide written informed consent.\n\nExclusion Criteria:\n\n* Patients unable to communicate.\n* Patients unable to complete questionnaires or perform physical function tests.\n* Patients with implanted electronic medical devices, such as cardiac pacemakers or implantable patient monitoring devices.\n* Patients whose scheduled surgery is cancelled.\n* Patients with underlying medical or psychiatric conditions that may affect the study outcomes.\n* Any other reason that, in the opinion of the investigator, makes the patient unsuitable for participation.","ALL","65 Years",{"count":19,"type":20},520,"ESTIMATED","OBSERVATIONAL","This prospective observational study aims to develop and evaluate predictive models for postoperative complications in patients aged 65 years or older scheduled for elective major surgery. The investigators will recruit 520 eligible patients visiting the preoperative assessment clinic.\n\nThe study involves the prospective collection of comprehensive preoperative data using specific validated tools:\n\n* Physical Activity: Assessed using the Saltin-Grimby Physical Activity Scale (SGPAS) to categorize physical activity intensity.\n* Nutritional Risk: Screened using the Nutritional Risk Screening 2002 (NRS-2002) tool.\n* Psychological Status: Evaluated for anxiety and depression using the Hospital Anxiety and Depression Scale (HADS).\n* Body Composition: Measured using a portable bioelectrical impedance analysis (BIA) device (BWA2.0S, InBody) to assess muscle mass, body fat\u002Fwater, and phase angle.\n* Physical Function: Assessed via the short physical performance battery (SPPB) using electronic measurement devices (AndanteFit, DYPHI) to calculate frailty index and physical age.\n\nThe primary endpoint is the occurrence and severity of postoperative complications within 30 days, evaluated using both the Clavien-Dindo Classification and the Comprehensive Complication Index (CCI). Using the collected dataset, the investigators will develop prediction models using both classical regression analysis and machine learning algorithms to compare their predictive performance.",[24,25,26],"Major Noncardiac Surgery","Geriatric Anesthesia","Postoperative Complications","NOT_YET_RECRUITING","2026-02-08",{"date":30,"type":31},"2026-02-13","ACTUAL",{"date":33,"type":20},"2026-02-19",{"date":35,"type":20},"2027-02-28",{"name":37,"class":38},"Seoul National University Hospital","OTHER",1,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":46,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":48,"targetDuration":4,"studyType":50,"phases":51,"briefSummary":53,"conditions":54,"keywords":57,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":71},"100515383","phase-4-the-effect-of-desflurane-versus-sevoflurane-versus-propofol-on-postoperative-delirium-100515383","NCT05990790","The Effect of Desflurane Versus Sevoflurane Versus Propofol on Postoperative Delirium","The Effect of Desflurane Versus Sevoflurane Versus Propofol on Postoperative Delirium in Elderly Patients Undergoing Moderate- to High-risk Major Noncardiac Surgery - a Prospective, Observer-blinded, Randomized, Clinical Trial","RAPID-II","Inclusion Criteria:\n\n* Provide written informed consent\n* ≥65 years of age\n* Scheduled for elective major noncardiac surgery with estimated time of surgery ≥ 2 hours\n\nExclusion Criteria:\n\n* Patients undergoing emergency surgery\n* BMI \\> 45 kg\u002Fm\\^2\n* History of diagnosed dementia\n* Language, vision, or hearing impairments that may compromise cognitive assessments\n* History of malignant hyperthermia\n* History of structural muscle disease\n* History of organ transplantation (kidney, liver, lung, heart)\n* Patients undergoing hyperthermic intraperitoneal chemotherapy\n* ICU patients undergoing surgery",{"count":49,"type":20},1332,"INTERVENTIONAL",[52],"PHASE4","Patients over the age of 65 years are at increased risk for developing delirium after noncardiac surgeries, resulting in increased morbidity and mortality. The prevention of postoperative delirium has been classified as a public health priority. However, so far data regarding possible intraoperative interventions to reduce the incidence of postoperative delirium is very scarce. Due to the more rapid wash-in and wash-out times of desflurane as compared to sevoflurane or propofol it seems reasonable that desflurane might be beneficial for the prevention of postoperative delirium. Therefore, we evaluate the effect of maintenance of anesthesia using desflurane, sevoflurane or propofol on postoperative delirium in elderly patients undergoing moderate- to high-risk major noncardiac surgery.",[55,24,56],"Postoperative Delirium","Postoperative Cognitive Dysfunction",[58,59,60],"Propofol","Sevoflurane","Desflurane","RECRUITING","2025-04-27",{"date":64,"type":31},"2025-04-30",{"date":66,"type":31},"2023-09-03",{"date":68,"type":20},"2028-12-31",{"name":70,"class":38},"Medical University of Vienna",2,{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":4,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":16,"minAge":79,"maxAge":4,"enrollmentInfo":80,"targetDuration":4,"studyType":50,"phases":82,"briefSummary":83,"conditions":84,"keywords":89,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":99,"leadSponsor":101,"locationsCount":39},"100582175","phase-4-dexmedetomidine-esketamine-combination-and-sleep-disturbances-after-major-noncardiac-surgery-100582175","NCT06859892","Dexmedetomidine-Esketamine Combination and Sleep Disturbances After Major Noncardiac Surgery","Effect of Dexmedetomidine-esketamine Combination on Sleep Disturbances After Major Noncardiac Surgery: a Single-center, Randomised, Double-blind, Placebo-controlled Trial","Inclusion Criteria:\n\n1. Aged ≥18 years.\n2. Scheduled for major noncardiac surgery (≥60 minutes) under general anesthesia with an expected end of surgery no later than 18:00 pm.\n3. Required patient-controlled intravenous analgesia after surgery.\n\nExclusion Criteria:\n\n1. Emergency surgery, transurethral surgery, organ transplantation.\n2. Pregnant or lactating women.\n3. Patients who need hypnotics for sleep disturbance or antidepressants for depression prior to surgery.\n4. History of schizophrenia, epilepsy, Parkinson's disease, or myasthenia gravis.\n5. Inability to communicate due to coma, severe dementia, or speech disorders, endured hypoxic encephalopathy or traumatic brain injury, or after neurosurgery.\n6. Comorbid with hyperthyroidism and pheochromocytoma.\n7. Preoperative left ventricular ejection fraction \\\u003C30%, sick sinus syndrome, severe sinus bradycardia (heart rate \\\u003C50 beats\u002Fmin), atrioventricular block of degree II or higher without pacemaker implantation, or systolic blood pressure below 90 mmHg despite use of vasopressors.\n8. Diagnosed as sleep apnea, or judged to be at high risk of moderate-to-severe sleep apnea as assessed by STOP-Bang.\n9. Severe hepatic dysfunction (Child-Pugh class C), severe renal dysfunction (on dialysis), or ASA classification ≥IV.\n10. Hypersensitive to dexmedetomidine and\u002For esketamine.\n11. Other conditions that are deemed unsuitable for study participation.","18 Years",{"count":81,"type":20},476,[52],"Sleep disturbances are common early after major surgery, and are associated with delayed recovery. A previous study showed that dexmedetomidine-esketamine combination as a supplement to patient-controlled intravenous analgesia improved postoperative analgesia and subjective sleep quality in patients after scoliosis correction surgery. The purpose of this trial is to test the hypothesis that dexmedetomidine-esketamine combination used as a supplement during general anesthesia and postoperative intravenous analgesia may reduce sleep disturbances in adult after major noncardiac surgery.",[85,24,86,87,88],"Adults","Dexmedetomidine","Esketamine","Postoperative Sleep Disturbances",[90,91,92,93,94],"adults","major noncardiac surgery","dexmedetomidine","esketamine","postoperative sleep disturbances","2025-03-18",{"date":97,"type":31},"2025-03-19",{"date":95,"type":31},{"date":100,"type":20},"2026-12",{"name":102,"class":38},"Peking University First Hospital"]