[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"major-surgery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:major-surgery":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,43,80,117,145,179],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":25,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100641089","postoperative-complications-in-major-surgery-100641089",false,"NCT07621198","Postoperative Complications in Major Surgery","Prediction of Postoperative Complications in Major Surgery: A Prospective, Multicenter, Cohort Study in Low- and Middle-income Settings","SURGCOM","Inclusion Criteria:\n\n* Major surgery\n* Adult or pediatric patients\n* Emergency or elective surgery\n* Ambulatory or hospitalized patients\n\nExclusion Criteria:\n\n* Patients derived to other institution","ALL",{"count":19,"type":20},364,"ESTIMATED","OBSERVATIONAL","The primary objective of this study is to develop and validate a multivariable risk prediction model for 30-day major postoperative complications and mortality in patients undergoing major surgery across participating international centers. Despite advancements in perioperative care, surgical complications remain a leading cause of global morbidity and preventable death, particularly in resource-limited or low- and middle-income country (LMIC) settings.\n\nThis study utilizes a prospective, multicenter, international cohort design. Data will be collected on patient-level risk factors (e.g., age, frailty, comorbidities), hospital-level infrastructure (e.g., nurse-to-patient ratios, rescue capacity), and perioperative safety processes (e.g., adherence to the WHO Surgical Safety Checklist). Patients will be followed prospectively for up to 30 days post-surgery. The collected data will be used to construct robust predictive models to identify individual patient risk and uncover actionable system-level factors to optimize surgical safety globally.",[24],"Major Surgery",[24,26,27,28,29],"Operative Procedures","Developing Countries","Patient Safety","Surgery Complications","NOT_YET_RECRUITING","2026-05-27",{"date":33,"type":34},"2026-06-02","ACTUAL",{"date":36,"type":20},"2026-08-01",{"date":38,"type":20},"2027-08-30",{"name":40,"class":41},"Hospital Departamental de Villavicencio","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":17,"minAge":51,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":54,"phases":55,"briefSummary":57,"conditions":58,"keywords":64,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":42},"100605891","phase-4-landiolol-to-avoid-tachycardia-in-patients-at-risk-for-cardiovascular-events-undergoing-major-non-cardiac-surgery-100605891","NCT07168421","LANdiolol to Avoid TAchycardia in Patients at Risk for Cardiovascular Events Undergoing Major Non-cardiac Surgery","LANdiolol to Avoid TAchycardia in Patients at Risk for Cardiovascular Events Undergoing Major Non-cardiac Surgery: a Feasibility Trial","LANTA-P","Inclusion Criteria:\n\n* Patients undergoing elective non-cardiac surgery defined as intermediate or high-risk by the 2022 european society of cardiology (ESC) guidelines\n* surgery performed under general anesthesia;\n* expected length of hospital stay ≥ 24 hours;\n* age ≥ 45 years;\n* at least two of the following risk factors:\n\n  * age ≥ 75 years\n  * arterial hypertension;\n  * ischemic heart disease (history of myocardial infarction or positive exercise test, current complaint of chest pain considered to be secondary to myocardial ischemia, use of nitrates, pathological Q waves, prior coronary revascularization);\n  * history of congestive heart failure;\n  * history of cerebrovascular disease;\n  * peripheral artery disease;\n  * diabetes mellitus;\n  * GFR ≤ 59 ml\u002Fmin pro 1.73 m2;\n  * pre-operative NTproBNP \\> 200 pg\u002Fml;\n* excessive sympathetic outflow as proven by exercise testing:\n\n  * impaired heart rate recovery (≤ 12 bpm within 1 minute after cessation of exercise); OR\n  * exaggerated heart rate response (≥ 12 bpm after 3 minutes of unloaded pedalling);\n\nExclusion Criteria:\n\n* unable to consent or follow study procedures;\n* absolute contraindications for exercise testing;\n* pregnancy or intention to become pregnant;\n* active cardiac conditions (such as unstable coronary syndromes, decompensated heart failure, significant arrhythmias, severe valvular disease);\n* urgent \u002F emergency surgery;\n* already on β-blocker (within the last 30 days prior to recruitment);\n* contraindication for β-blocker therapy (bradycardia (HR \\\u003C 55 bpm), hypotension (systolic blood pressure \\\u003C 100 mmHg), severe peripheral vascular disease, severe asthma, allergy, higher-degree atrioventricular block);\n* severe preoperative anaemia (haemoglobin \\\u003C 100 g\u002FL) unless there is a plan set up and followed for correction prior to surgery;\n* planned intermediate care or intensive care admission;\n* prior enrolment in this trial.","45 Years",{"count":53,"type":20},114,"INTERVENTIONAL",[56],"PHASE4","Limiting perioperative tachycardia (aiming for a heart rate \\\u003C90 beats per minute throughout the perioperative period) using the ultra-short acting beta-blocker landiolol in patients with cardiovascular risk factors undergoing major surgery might lower the incidence of perioperative myocardial injury. Feasibility of the intervention needs to be proven prior to conduction of a larger trial.",[59,60,61,24,62,63],"Perioperative Myocardial Injury","Autonomic Dysfunction","Cardiovascular (CV) Risk","Beta Blocker","Myocardial Injury After Non-cardiac Surgery",[65,66,67,68,69],"perioperative myocardial injury","major surgery","beta blocker","myocardial injury after non-cardiac surgery","autonomic dysfunction","RECRUITING","2026-05-04",{"date":73,"type":34},"2026-05-05",{"date":75,"type":34},"2026-04-24",{"date":77,"type":20},"2028-03-01",{"name":79,"class":41},"Insel Gruppe AG, University Hospital Bern",{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":4,"eligibilityCriteria":86,"healthyVolunteers":87,"sex":17,"minAge":88,"maxAge":4,"enrollmentInfo":89,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":91,"conditions":92,"keywords":100,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":42},"100623641","submental-tissue-oxygenation-and-arterial-lactate-in-major-surgery-100623641","NCT07399275","Submental Tissue Oxygenation and Arterial Lactate in Major Surgery","Relationship Between Submental Tissue Oxygenation, Microvascular Reactivity, and Arterial Lactate During Major Surgical Procedures","Inclusion Criteria:\n\n* Adults aged 18 years and older\n* Scheduled for major surgical procedures under general anesthesia\n* Major surgery defined as procedures associated with a risk of significant blood loss and\u002For impaired tissue perfusion, requiring invasive arterial blood pressure monitoring and hourly arterial blood gas analysis\n* Planned intraoperative arterial catheter placement as part of routine clinical care\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Age younger than 18 years\n* Refusal or inability to provide informed consent\n* Absence of invasive arterial blood pressure monitoring\n* Known pregnancy\n* Severe peripheral vascular disease affecting upper extremities\n* Anatomical abnormalities or skin conditions preventing placement of NIRS sensors on the submental or thenar regions\n* Emergency surgery requiring immediate intervention\n* Preoperative severe metabolic acidosis (arterial pH \\\u003C 7.20)",true,"18 Years",{"count":90,"type":20},150,"During major surgical procedures performed under general anesthesia, changes in blood flow and oxygen delivery to tissues may occur due to blood loss, hemodynamic fluctuations, and anesthesia-related physiological effects. These changes can lead to impaired tissue perfusion, which is commonly reflected by increased arterial lactate levels. However, lactate measurements are intermittent and may not detect early perfusion abnormalities.\n\nThis prospective observational study aims to investigate the relationship between submental tissue oxygenation measured by near-infrared spectroscopy (NIRS), microvascular reactivity assessed by the vascular occlusion test, and arterial lactate levels during major surgery. Adult patients undergoing major abdominal, neurosurgical, or orthopedic procedures will be monitored intraoperatively using non-invasive NIRS techniques, while arterial blood gas analyses will be performed as part of routine clinical care.\n\nThe study does not involve any changes to standard anesthesia or surgical management. All treatments and clinical decisions will be made by the responsible care team according to routine practice. By evaluating non-invasive indicators of tissue oxygenation and microvascular function, this study aims to improve the understanding of early intraoperative tissue perfusion changes and their association with metabolic markers.",[93,94,95,96,97,98,99,24],"Microcirculatory Dysfunction","Tissue Hypoperfusion","Microcirculatory Status","Microvascular Circulation","Near Infrared Spectroscopy","Vascular Occlusion Test","Lactate Blood Increase",[101,102,103,104,105,106],"tissue hypoperfusion","microvascular circulation","Near infrared spectroscopy","vascular occlusion","lactate blood increase","Major surgery","2026-02-03",{"date":109,"type":34},"2026-02-10",{"date":111,"type":20},"2026-02-15",{"date":113,"type":20},"2027-02-15",{"name":115,"class":116},"Bursa Sevket Yilmaz Training and Research Hospital","OTHER_GOV",{"id":118,"slug":119,"hasResults":11,"nctId":120,"briefTitle":121,"officialTitle":122,"acronym":123,"eligibilityCriteria":124,"healthyVolunteers":11,"sex":17,"minAge":88,"maxAge":4,"enrollmentInfo":125,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":127,"conditions":128,"keywords":129,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":136,"lastUpdatePostDateStruct":137,"startDateStruct":139,"completionDateStruct":141,"leadSponsor":143,"locationsCount":42},"100473087","morbidity-and-mortality-surgery-and-standardized-transmission-in-operating-room-100473087","NCT05440331","Morbidity and Mortality: Surgery and Standardized Transmission in Operating Room","Morbidity and Mortality in Operating Room: Surgery and Standardized Communication","HIATUS","Inclusion Criteria:\n\n* Patient aged \\> 18 years;\n* Patients with score ASA I-IV;\n* Requiring urgent or planned surgery;\n* Major surgery (duration of surgery \\> 2 hours, requiring a hospital stay of at least 1 night): orthopedics, cardiac, vascular, thoracic, visceral, ENT, plastic surgery;\n* Handover between two anesthesists defined as a definitive relay between one physician anaesthesist and another in operating room;\n* Intensive care anesthesists and nurse anaesthetist working in investigator center during the study;\n* Affiliated to a social security system;\n* No-opposition to participating to the study.\n\nExclusion Criteria:\n\n* Transmission between physician anaesthesist and nurse anaesthetist;\n* Medical transmission occurs out of anesthesia care out of operating room;\n* Medical transmission occurs in transitory manner (for example: coffee time, lunch time);\n* Patients enrolled in an another ongoing study of surgical intervention.",{"count":126,"type":20},1120,"The primary objective of the study is to evaluate the efficacy of standard handover with AnesList© between physician anesthesists in operating room, for a complete transmission for a patient, on the occurence of event as death, serious complications or rehospitalization in month of postoperative after major surgery.",[24],[106,130,131,132,133,134,135],"Morbility","Mortality","Training in peroperative","Handover","Anaesthetist","Nurse anaesthetist","2025-11-18",{"date":138,"type":34},"2025-11-19",{"date":140,"type":34},"2023-09-08",{"date":142,"type":20},"2026-10",{"name":144,"class":41},"Assistance Publique - Hôpitaux de Paris",{"id":146,"slug":147,"hasResults":11,"nctId":148,"briefTitle":149,"officialTitle":150,"acronym":4,"eligibilityCriteria":151,"healthyVolunteers":87,"sex":17,"minAge":88,"maxAge":4,"enrollmentInfo":152,"targetDuration":4,"studyType":54,"phases":154,"briefSummary":155,"conditions":156,"keywords":159,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":170,"lastUpdatePostDateStruct":171,"startDateStruct":173,"completionDateStruct":175,"leadSponsor":177,"locationsCount":42},"100575591","phase-4-analgesic-efficacy-of-intravenous-ketamine-as-a-continuous-infusion-vs-pca-in-the-management-of-acute-postoperative-pain-in-major-orthopedic-surgery-100575591","NCT06774274","Analgesic Efficacy of Intravenous Ketamine as a Continuous Infusion vs PCA in the Management of Acute Postoperative Pain in Major Orthopedic Surgery.","Analgesic Efficacy of Intravenous Ketamine as a Continuous Infusion vs PCA in the Management of Acute Postoperative Pain in Major Orthopedic Surgery: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Patients over 18 years of age\n* Elective major orthopedic surgery.\n* ASA (American Association of Anesthesiology) classification 1, 2 or 3.\n\nExclusion Criteria:\n\n* Patients with a diagnosis of perioperative kidney injury or hepatic failure\n* Patients with active cardiac conditions\n* Patients with any cognitive impairment that disables the patient from operating the PCA pump or impedes the postoperative interview\n* Patients with scheduled ICU admission with invasive ventilatory support\n* Patients with known hypersensitivity to opioid medications\n* Patients with past medical history of severe adverse reactions to opioids or ketamine.\n* Pregnant patients\n* Patients undergoing continuous regional anesthetic techniques including peripheral nerve catheters or continuous epidural catheters\n* Patient refusal to participate in the study",{"count":153,"type":20},120,[56],"The goal of this clinical trial is to determine whether treating pain after surgery with ketamine is more effective when administered intravenously as a continuous infusion or through a patient-controlled analgesia (PCA) pump. This study focuses on adult volunteers following major orthopedic surgery. We have two main questions to address:\n\n* Is a continuous intravenous infusion of ketamine as effective as ketamine administered through a PCA pump for managing pain after major orthopedic surgery.\n* Does a continuous intravenous infusion of ketamine result in lower opioid requirements compared to ketamine delivered through a PCA pump for pain management after major orthopedic surgery?\n\nParticipants will be divided into two groups. One group will receive ketamine via continuous infusion, while the other will receive it through a PCA pump. Both groups will also receive a placebo (a substance that looks like the drug but contains no active ingredients), ensuring that neither group knows whether they are receiving ketamine through the PCA pump (which always contains a painkiller) or as a continuous infusion.\n\nParticipants will be assigned to one of the two groups and will receive their assigned treatment for 48 hours while hospitalized. Researchers will visit participants during their first three days in the hospital to assess their pain levels and monitor for any side effects.",[157,158,24],"Pain, Postoperative","Opioid Use",[160,161,162,163,66,164,165,166,167,168,169],"postoperative pain","ketamine","patient controlled analgesia","continuous infusion","pain","abdominal surgery","thoracic surgery","spine surgery","opioid","major orthopedic surgery","2025-04-08",{"date":172,"type":34},"2025-04-11",{"date":174,"type":34},"2025-03-01",{"date":176,"type":20},"2027-06-15",{"name":178,"class":41},"Universidad de Antioquia",{"id":180,"slug":181,"hasResults":11,"nctId":182,"briefTitle":183,"officialTitle":184,"acronym":185,"eligibilityCriteria":186,"healthyVolunteers":11,"sex":17,"minAge":187,"maxAge":4,"enrollmentInfo":188,"targetDuration":4,"studyType":54,"phases":190,"briefSummary":192,"conditions":193,"keywords":195,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":197,"lastUpdatePostDateStruct":198,"startDateStruct":200,"completionDateStruct":202,"leadSponsor":204,"locationsCount":42},"100397913","multimodal-prehabilitation-for-surgery-in-the-elderly-a-randomised-prospective-multicenter-multidisciplinary-trial-100397913","NCT04461301","Multimodal Prehabilitation for Surgery in the Elderly: a Randomised, Prospective, Multicenter, Multidisciplinary Trial","Multimodal Prehabilitation for Major Surgery in Elderly Patients to Lower Complications and to Increase Cost Effectiveness: a Randomised, Prospective, Multicenter, Multidisciplinary Trial (PREHABIL Trial).","PREHABIL","Inclusion Criteria:\n\n* Written informed consent\n* comorbid (≥ASA 3)\n* pre-existing fitness deficit: AT\\\u003C11ml\u002Fkg\u002Fmin respectively VO2peak\\\u003C14ml\u002Fkg\u002Fmin if AT unavailable or VE\u002FVCO2 slope \\> 33\n* scheduled for major urologic, thoracic, visceral, orthopaedic or cardiovascular surgery\n* screening at least 2 weeks prior to surgery\n\nExclusion Criteria:\n\n* Paralysis or patients with mobility problems (who are unable to exercise),\n* Premorbid conditions or orthopaedic impairments that contraindicate exercise,\n* Cognitive disabilities,\n* Chronic renal failure (need for dialysis)\n* Emergency procedures.","65 Years",{"count":189,"type":20},466,[191],"NA","This multicentric, randomised controlled trial is to the investigators knowledge the first implementation of a multimodal, multidisciplinary prehabilitation approach using knowledge from different specialties to lower complications and to increase cost effectiveness after major surgery in elderly, frail patients.",[194,24],"Frail Elderly Syndrome",[196],"Comprehensive Complication Index","2024-10-29",{"date":199,"type":34},"2024-11-01",{"date":201,"type":34},"2022-02-01",{"date":203,"type":20},"2026-12-30",{"name":79,"class":41}]