[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"major-trauma\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:major-trauma":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,46,85,125],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100619170","blood-storage-related-mortality-and-adverse-effects-in-trauma-patients-100619170",false,"NCT07341139","Blood Storage Related Mortality and Adverse Effects in Trauma Patients","Is Long-Term Blood Storage Related With Increased Mortality and Adverse Effects in Severely Injured Trauma Patients?","Inclusion Criteria:\n\n* Patients between 18-75 years of age,\n* Injury Severity Score\\>15 and have received massive blood transfusions in our hospital from 1 January 2015 to 31 December 2025\n* The patients admitted because of trauma and undergoing surgery\n\nExclusion Criteria:\n\n* Patients with known cardiac or vascular diseases such as heart failure or malignant hypertension, those under anticoagulant treatment\n* Patients with known serious kidney (on dialysis), lung, liver diseases, those under anticoagulant treatment\n* Super obese patients with body mass index (BMI) 50 or above","ALL","18 Years","75 Years",{"count":20,"type":21},300,"ESTIMATED","OBSERVATIONAL","The purpose of this retrospective study is to examine the following factors related to blood storage time in severely injured trauma patients who received large blood transfusions:\n\n1. The effect of blood storage time on the patient's 28-day mortality rate.\n2. The relationship between storage time and other health problems that the patient may develop (such as heart disease, vascular occlusion, respiratory failure, infection, and organ failure).\n\nFor this purpose, patients aged 18-75 who were admitted directly from the scene of injury and received large transfusions at Jacksonville Shands Hospital between January 1, 2023, and October 1, 2025, will be included. Data will be obtained from hospital information systems and anesthesia records",[25,26,27],"Transfusion Adverse Reaction","Major Trauma","Blood Product Transfusion for All Conditions",[29,30,31,32],"blood storage","Transfusion","Trauma","Red Blood Cell","RECRUITING","2026-02-12",{"date":36,"type":37},"2026-02-17","ACTUAL",{"date":39,"type":37},"2026-01-17",{"date":41,"type":21},"2026-06-01",{"name":43,"class":44},"Kocaeli City Hospital","OTHER_GOV",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":54,"targetDuration":4,"studyType":56,"phases":57,"briefSummary":59,"conditions":60,"keywords":67,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":84},"100407660","phase-3-erythropoietin-alfa-to-prevent-mortality-and-reduce-severe-disability-in-critically-ill-trauma-patients-100407660","NCT04588311","ErythroPOietin Alfa to Prevent Mortality and Reduce Severe Disability in Critically Ill TRAUMA Patients","A Randomised, Double-blind, Placebo-controlled Trial of Erythropoietin Alfa Versus Placebo in Mechanically Ventilated Critically Ill Patients Following Traumatic Injury","EPO-TRAUMA","Inclusion Criteria: Patients with trauma admitted to the ICU who:\n\n* Are ≥ 18 to ≤ 75 years of age\n* Are \\\u003C 24 hours since primary traumatic injury\n* Are invasively mechanically ventilated\n* Are expected to stay in the ICU ≥ 48 hours\n* Have a haemoglobin not exceeding the upper limit of the applicable normal (ULN) reference range in clinical use at the treating institution\n* Have informed consent from a legal surrogate according to local law\n\nExclusion Criteria: Patients will be excluded from the study if any of the following criteria apply:\n\n* GCS = 3 and fixed dilated pupils\n* Recent history of DVT, PE or other thromboembolic event (within previous 12 months or receiving concomitant anticoagulant treatment for this indication)\n* A chronic hypercoagulable disorder, including known malignancy\n* Treatment with EPO in the last 30 days\n* First dose of study drug unable to be given within 24 hours of primary injury\n* Pregnancy or lactation or 3 months postpartum\n* Expected to die imminently (\\\u003C 24 hours)\n* Known sensitivity to mammalian cell derived products\n* Known contraindication to epoetin alfa\n* End stage renal failure (receives chronic dialysis)\n* Severe pre-existing physical or mental disability or severe co-morbidity that may interfere with the assessment of outcome\n* The treating physician believes it is not in the best interest of the patient to be randomised to this trial",{"count":55,"type":21},2500,"INTERVENTIONAL",[58],"PHASE3","The EPO-TRAUMA study is a prospective, multi-centre, double-blind, phase III, randomised controlled trial evaluating the efficacy of epoetin alfa compared to placebo in reducing mortality and severe disability at six months in critically ill trauma patients.\n\n2500 mechanically ventilated ICU patients admitted with a primary trauma diagnosis presenting to the ICU will be recruited into the study from participating study centres in Australia, New Zealand, Europe, and Saudi Arabia.",[31,61,62,63,64,65,26,66],"Traumatic Injury","Traumatic Brain Injury","Wounds and Injuries","Penetrating Injury","Blunt Injury","Multiple Trauma",[68,31,69,70,71,72,73],"Intensive Care Unit","Major trauma","Traumatic injury","EPO","Erythropoietin","Epoetin alfa","2025-07-14",{"date":76,"type":37},"2025-07-16",{"date":78,"type":37},"2020-11-09",{"date":80,"type":21},"2027-08-31",{"name":82,"class":83},"Australian and New Zealand Intensive Care Research Centre","OTHER",41,{"id":86,"slug":87,"hasResults":11,"nctId":88,"briefTitle":89,"officialTitle":90,"acronym":4,"eligibilityCriteria":91,"healthyVolunteers":92,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":93,"targetDuration":95,"studyType":22,"phases":4,"briefSummary":96,"conditions":97,"keywords":105,"overallStatus":115,"whyStopped":4,"lastUpdateSubmitDate":116,"lastUpdatePostDateStruct":117,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":4},"100571890","the-nrc-dataset-developing-a-minimum-dataset-for-multidisciplinary-rehabilitation-a-modified-e-delphi-study-100571890","NCT06726135","The NRC Dataset. Developing a Minimum Dataset for Multidisciplinary Rehabilitation: a Modified E-Delphi Study","The National Rehabilitation Centre Dataset. Development of a Minimum Dataset for Multidisciplinary Rehabilitation: a Modified E-Delphi Study","Inclusion Criteria:\n\nThe panel will aim to include clinicians with a minimum of 5 years' experience from a variety of professional backgrounds within the following specialist areas:\n\n* Neuro Rehab\n* Trauma Rehab\n* Community Rehab\n* Outpatient Rehabilitation services\n* Defence medical services\n* Psychology services\n* Amputee Rehab\n* Speech and Language therapy\n* Emergency department\n* Critical Care\n* Trauma and Orthopaedics\n* Rehabilitation Medicine\n\nIt is expected that the expert panel will include:\n\n* Medical Doctors\n* Dietitians\n* Physiotherapists\n* Psychologists\n* Prosthetists\n* Occupational therapists\n* Speech and Language therapists\n* Data-base managers\n* Researchers\u002FAcademics\n* Commissioners\n* Local service managers\n* A department of work and pensions representative\n* An epidemiologist\u002Fdata-scientist with healthcare financial modelling experience\n\nExclusion Criteria:\n\nIndividuals will be excluded from the expert panel for any of the following reasons:\n\n1. They do not have 5 years' experience in their specialist field\n2. They do not have an understanding of various health indicators and the appropriate outcome measure instruments required to evaluate these health indicators.\n3. They have no understanding of how demographic and socio-economic variables impact health outcomes\n4. They have no understanding of how to evaluate clinical effectiveness and cost efficiency of inpatient rehabilitation services.\n5. Their professional background is not represented in the above noted specialist areas",true,{"count":94,"type":21},50,"6 Months","Several rehabilitation datasets are presently in use for specific patient groups in England. The 'National Clinical Audit of Specialist Rehabilitation for patients with complex needs following major injury' (NCASRI) evaluated outcomes within a cohort of Major Trauma patients between 2015 and 2018 using data from two of these datasets. The NCASRI project outlined some of the shortcomings of the pre-existing datasets and highlighted the need for a single National Rehabilitation Dataset to provide long term evaluation of a variety of patient presentations.\n\nThe proposed study will seek to develop such a dataset by means of an E-delphi study. This study will seek consensus from a panel of experts on the data items required to measure the effectiveness and socio-economic impact of multidisciplinary inpatient rehabilitation. Providing commissioners, researchers and clinicians with the data required to improve patient care, conduct research and develop rehabilitation services.\n\nThere are three potential phases to this study:\n\n* Phase one involves the establishment of a core domain set, outlining what information (data) should be included in the NRC core dataset.\n* Phase one will consist of at least 2 rounds of voting, with successive rounds of voting undertaken until an a-priori consensus of 70% is reached for all core data items marked as mandatory\u002Fcritical data in fitting OMERACT guidelines.\n* After 2 rounds, any data item that have reached consensus will be included in the final dataset. These core domain (data items) will then be excluded from subsequent rounds of voting.\n* A maximum of 4 rounds will be allowed in Phase 1. At which point the highest-ranking data items remaining with a consensus above 60% from each of the pre-identified categories will be included in the final dataset.\n* Phase two will explore what tools should be used to collect the core domains (outcome measure instruments) for each category outlined in phase 1.\n* Phase 2 will follow the same protocol for including outcome measure instruments into the core outcome set as were required to include core data items from phase 1.\n* If a consensus of equal or greater than 60% cannot be reached using an E-Delphi method in either phase 1 or phase 2 then a virtual meeting will be held amongst all expert panel members to reach consensus using a nominal group technique (phase 3).",[98,62,26,99,100,101,102,103,104],"Pain","Multiple Sclerosis","Amputees \u002F Rehabilitation","Spinal Cord Injuries (SCI)","Functional Neurological Disorder","Intensive Care Unit (ICU) Acquired Weakness (ICU - AW)","Trauma Related Injuries",[106,107,108,109,110,111,112,113,114],"E-delphi","Delphi","Multidisciplinary","Rehabilitation","Core outcome set","Dataset","national rehabilitation centre","outcome measure instruments","inpatient","NOT_YET_RECRUITING","2024-12-15",{"date":118,"type":37},"2024-12-19",{"date":120,"type":21},"2025-01",{"date":122,"type":21},"2025-06",{"name":124,"class":83},"ThomasCorbett",{"id":126,"slug":127,"hasResults":11,"nctId":128,"briefTitle":129,"officialTitle":130,"acronym":4,"eligibilityCriteria":131,"healthyVolunteers":11,"sex":16,"minAge":132,"maxAge":4,"enrollmentInfo":133,"targetDuration":4,"studyType":56,"phases":135,"briefSummary":137,"conditions":138,"keywords":140,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":142,"lastUpdatePostDateStruct":143,"startDateStruct":145,"completionDateStruct":147,"leadSponsor":149,"locationsCount":45},"100473794","vitamin-d-for-critically-traumatic-patients-100473794","NCT05449522","Vitamin D for Critically Traumatic Patients","Effects of High Doses of Liquid Vitamin D Supplementation on Clinical Outcomes in Critically Traumatic Patients.","Inclusion Criteria:\n\n* Major trauma adult (\\> 20 years old) with Injury Severity Score equal or higher than 9, who is admitted to ICU\n\nExclusion Criteria:\n\nPatients with the following conditions:\n\n* Chronic liver disease\n* Contraindication to enteral feeds\n* Hypercalcemia\n* Current use of vitamin D, estrogen, or medications for bone disease\n* High risk of hypercalcemia, ex. metastatic cancer, primary hyperparathyroidism, sarcoidosis, multiple myeloma","20 Years",{"count":134,"type":21},100,[136],"NA","Trauma has been an important global public health issue. Yet it is the sixth cause of death in Taiwan, trauma brings great negative impact to national productivity since it presents specifically as the leading cause of death for the population aged below 40 years. According to the national databank from Formosa Association for the Surgery of Trauma, mortality rate in critically traumatic patients with injury severity score (ISS) ≥ 25 is as high as 23%. Vitamin D, a pleiotropic hormone, regulates directly functions of most organs and immune system. It has been proven that vitamin D insufficiency or deficiency would deteriorate survival of critically ill patients, while supplementation of high-dose vitamin D ameliorates the clinical outcomes. This study investigates whether multiple high doses of vitamin D supplementation in one week can decrease the mortality and morbidity in critically traumatic patients. The serum levels of calcidiol and PTH will be measured on Day 0, Day 3, Day 10, Day 15, Day 30 and Day 60 before and after vitamin D supplementation.",[139,26],"Vitamin D Deficiency",[141,26],"Vitamin D","2024-08-14",{"date":144,"type":37},"2024-08-16",{"date":146,"type":37},"2018-05-01",{"date":148,"type":21},"2026-07-01",{"name":150,"class":83},"National Taiwan University Hospital"]