[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"malalignment-bone\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:malalignment-bone":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,42,71],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":23,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100551633","clinical-and-radiological-results-of-long-term-tibial-and-femoral-osteotomy-in-knee-ostheoarthritis-with-concomitant-lower-limb-malalignement-100551633",false,"NCT06462625","Clinical and Radiological Results of Long Term Tibial and Femoral Osteotomy in Knee Ostheoarthritis With Concomitant Lower Limb Malalignement","Long-term Clinical and Radiographic Outcomes of Different Knee Osteotomy Techniques for the Treatment of Compartmental Knee Osteoarthritis With Lower Limb Malalignment.","KNEE OSTEOTOMY","Inclusion Criteria:\n\n1. Patients undergoing corrective knee osteotomy and any associated procedures such as meniscal repair\u002Fresection\u002Freplacement, ligament reconstruction, chondral treatment, or regenerative infiltrative treatment;\n2. Patients aged between 18 and 70 years at the time of surgical intervention;\n3. Patients with isolated compartmental osteoarthritis;\n4. Patients with a varus or valgus knee alignment defect of at least 3° compared to mechanical neutrality.\n\nExclusion Criteria:\n\n1. Patients with advanced multicompartimental osteoarthritis;\n2. Patients who are no longer reachable;\n3. Women of childbearing age who cannot exclude pregnancy;\n4. Patients unable to give informed consent or patients unwilling to sign the informed consent form.","ALL","18 Years","70 Years",{"count":21,"type":22},150,"ESTIMATED","2 Years","OBSERVATIONAL","The present study aims to evaluate the long-term and medium-term outcomes of different knee osteotomy techniques in the treatment of knee osteoarthritis in patients with lower limb malalignment. This evaluation is necessary in the current context of research on the treatment and prevention of knee osteoarthritis through treatments that do not involve or allow for the postponement of prosthetic replacement. Among the biological treatments performed in orthopedic clinical practice, osteotomy is one of the most promising. However, further long-term evaluations are needed to more clearly determine the indications and potential of this type of intervention, considering the various surgical procedures described for performing it.",[27,28],"Knee Osteoarthritis","Malalignment, Bone","RECRUITING","2026-01-28",{"date":32,"type":33},"2026-01-29","ACTUAL",{"date":35,"type":33},"2023-01-12",{"date":37,"type":22},"2027-10",{"name":39,"class":40},"Istituto Ortopedico Rizzoli","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":17,"minAge":49,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":53,"phases":54,"briefSummary":56,"conditions":57,"keywords":59,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":41},"100503870","knee-osteotomy-associated-with-allograft-meniscus-transplantation-100503870","NCT05840887","Knee Osteotomy Associated With Allograft Meniscus Transplantation","Knee Osteotomy Associated With Allograft Meniscus Transplantation in Patients With Altered Mechanical Axis, Meniscectomy Outcomes, and Osteoarthritis: Clinical, Biomechanical, and Biological Evaluation","Inclusion Criteria:\n\n1. Male or female patients aged between 20 and 60 years;\n2. Single-compartment tibiofemoral osteoarthritis (Kellgren-Lawrence grade ≤ 3);\n3. Surgical indication of corrective osteotomy (axial deviation of lower extremities \\> 5°);\n4. Meniscal deficit of the compartment affected by the overload due to malalignment;\n5. Ability and consent of patients to actively participate in the rehabilitation protocol and clinical and radiological follow-up (RX and MRI)\n6. Signature of informed consent\n\nExclusion Criteria:\n\n1. Patients who are incapacitated or have neurological disorders that may invalidate the research protocol;\n2. Diagnosis of neoplastic diseases;\n3. Diagnosis of rheumatoid arthritis, Reiter's syndrome, psoriatic arthritis, gout, ankylosing spondylitis or arthritis resulting from another inflammatory disease; human immunodeficiency virus (HIV) infection, viral hepatitis; chondrocalcinosis;\n4. Patients with uncontrolled diabetes mellitus;\n5. Patients with uncontrolled thyroid metabolic disorders;\n6. Patients abusing alcoholic beverages, drugs or medications;\n7. Body Mass Index \\> 40;\n8. Pregnancy or lactation status or intention to become pregnant during the period of study participation;\n9. Patients undergoing knee surgery in the previous 12 months.","20 Years","60 Years",{"count":52,"type":22},52,"INTERVENTIONAL",[55],"NA","This is a prospective randomized double-blind controlled clinical trial with parallel arms and 1:1 allocation.\n\nThe main objective of the BIOMAT project is to demonstrate, through an RCT, whether the combined approach by knee osteotomy and MAT can provide clinical improvement over knee osteotomy alone for the treatment of patients with monocompartmental knee OA associated with meniscal insufficiency and lower extremity malalignment. Secondary objectives are to demonstrate whether the addition of MAT to knee osteotomy in patients with monocompartmental OA can improve biomechanical parameters and whether this treatment has protective effects on the joint environment and cartilage degeneration.",[28,58],"Osteoarthritis, Knee",[60,61,62],"knee osteotomy","MAT","meniscal allograft transplatation","2025-12-03",{"date":65,"type":33},"2025-12-04",{"date":67,"type":33},"2023-08-30",{"date":69,"type":22},"2026-06",{"name":39,"class":40},{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":78,"targetDuration":4,"studyType":53,"phases":80,"briefSummary":81,"conditions":82,"keywords":4,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":4},"100535338","comparison-between-tomofix-and-bodycad-fine-osteotomy-100535338","NCT06250530","Comparison Between TOMOFIX and BodyCAD Fine Osteotomy","Do Patient Specific Implants Improve Accuracy of Correction With MOWHTO. A Pilot Study for a Definitive Randomised Trial Comparing TOMOFIX and BodyCAD Fine Osteotomy.","Inclusion Criteria:\n\n* aged 18-70 years old\n* have medial compartment osteoarthritis, with varus alignment, deemed suitable for a MOWHTO\n* able to speak, read and understand English\n\nExclusion Criteria:\n\n* found to have a cruciate ligament deficiency\n* require multiplanar or rotational alignment correction\n* have greater than 5 degrees fixed flexion deformity\n* unable to have CT scans for follow up\n* evidence of tricompartmental osteoarthritis\n* evidence of lateral compartment osteoarthritis on arthroscopy\n* received injection therapy within 3 months of surgery on the operative knee\n* have a medical history of inflammatory arthropathy, diabetes\n* actively smoke",{"count":79,"type":22},40,[55],"This is a single centre, randomised, patient blinded pilot study that will assign 40 participants with medial knee osteoarthritis undergoing medial opening wedge high tibial osteotomy (MOWHTO) to either current standard of care with TOMOFIX plating system, or utilise patient specific instrumentation and custom-made plate development, with BodyCAD Fine Osteotomy. If the definitive study is deemed feasible, an additional 110 participants will be randomized, for a total of 150 participants.",[83,28,58],"Osteotomy","NOT_YET_RECRUITING","2024-04-24",{"date":87,"type":33},"2024-04-26",{"date":89,"type":22},"2024-07",{"date":91,"type":22},"2027-06",{"name":93,"class":40},"Western University, Canada"]