[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"male-with-sex-chromosome-mosaicism\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:male-with-sex-chromosome-mosaicism":35},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":36,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":69},"100316207","the-extroardinary-babies-study-natural-history-of-health-and-neurodevelopment-in-infants-and-young-children-with-sex-chromosome-trisomy-100316207",false,"NCT03396562","The eXtroardinarY Babies Study: Natural History of Health and Neurodevelopment in Infants and Young Children With Sex Chromosome Trisomy","Inclusion Criteria:\n\n1. Prenatal diagnosis of sex chromosome aneuploidy (by cfDNA, chorionic villi sampling, and\u002For amniocentesis)\n2. Postnatal confirmatory karyotype of XXY, XYY, XXX, XXYY, XYYY, XXXY, XXXX, XXXXX, XXXXY, XXXYY, XXYYY, XYYYY (including any mosaicism with \\\u003C80% 46,XX or 46,XY cell line)\n3. English or Spanish speaking\n4. Age 6 weeks to 12 months 30 days on enrollment\n\nExclusion Criteria:\n\n1. Previous diagnosis of a different genetic or metabolic disorder with neurodevelopmental or endocrine involvement\n2. Prematurity less than 34 weeks gestational age\n3. Complex congenital malformation not previously associated with sex chromosome aneuploidy\n4. History of significant neonatal complications (ie intraventricular hemorrhage, meningitis, hypoxic-ischemic encephalopathy)\n5. Known complex Central Nervous System (CNS) malformation identified by neuroimaging","ALL","6 Weeks","13 Months",{"count":19,"type":20},300,"ESTIMATED","OBSERVATIONAL","This study is designed to research the natural history of neurodevelopment, health and early hormonal function in infants with XXY\u002FKlinefelter syndrome, XYY, XXX and other sex chromosome variations in an effort to identify early predictors of developmental and health outcomes. The Investigators will also evaluate different developmental screening tools in infants with sex chromosome variations so the investigators can develop recommendations for pediatrician caring for infants and young children with XXY\u002FKlinefelter syndrome, XYY, XXX, and other sex chromosome variations.",[24,25,26,27,28,29,30,31,32,33,34,35],"Klinefelter Syndrome","Trisomy X","XYY Syndrome","XXXY and XXXXY Syndrome","Xxyy Syndrome","Xyyy Syndrome","Xxxx Syndrome","Xxxxx Syndrome","Xxxyy Syndrome","Xxyyy Syndrome","Xyyyy Syndrome","Male With Sex Chromosome Mosaicism",[37,38,39,25,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56],"body composition","klinefelter syndrome","XXY","XXX","XYY","XXYY","XXXY","XXXXY","sex chromosome variation","sex chromosome aneuploidy","sex chromosome trisomy","testosterone","XYYY","XXXX","XXXXX","XXXYY","XXYYY","XYYYY","developmental delay","speech development","RECRUITING","2024-05-07",{"date":60,"type":61},"2024-05-09","ACTUAL",{"date":63,"type":61},"2017-09-29",{"date":65,"type":20},"2028-03-01",{"name":67,"class":68},"University of Colorado, Denver","OTHER",2]