[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"male\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:male":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,47,96,125,152,176],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100639423","randomized-non-inferiority-within-patient-trial-of-density-gradient-processing-of-sequential-ejaculates-versus-centrifugation-free-sperm-separation-device-for-icsi-in-men-with-elevated-sperm-dna-fragmentation-100639423",false,"NCT07626359","Randomized Non-inferiority Within-Patient Trial of Density Gradient Processing of Sequential Ejaculates Versus Centrifugation-free Sperm Separation Device for ICSI in Men With Elevated Sperm DNA Fragmentation.","SE","Inclusion Criteria:\n\n* • Elevated SDF defined as DFI \\>20 %measured by the sperm chromatin dispersion (SCD) test performed in a participating center's andrology laboratory, using a harmonized protocol under standardized conditions after 2-3 days of ejaculatory abstinence, and within 90 days (≤3 months) prior to enrollment.\n\n  * Male partners 21-45 years;\n  * Female partners 21-35 years.\n  * Undergoing IVF\u002FICSI.\n  * No known genetic or chromosomal abnormalities.\n  * Minimum 4 MII oocyte patients shall be included\n\nExclusion Criteria:\n\n* Azoospermia or severe oligoasthenozoospermia (\\\u003C1 million motile sperm\u002FmL).\n* Significant systemic disease (e.g., uncontrolled diabetes, malignancy).\n* History of a prior ICSI cycle with no embryo development.\n* Relevant female factors: untreated adnexal pathology ,a history of a thin endometrium (\\\u003C7 mm) following endometrium preparation for embryo transfer","ALL","21 Years","45 Years",{"count":20,"type":21},830,"ESTIMATED","INTERVENTIONAL",[24],"NA","Elevated SDF can adversely impact fertilization, embryo development, and pregnancy outcomes in IVF-ICSI cycles. Two pragmatic strategies aim to reduce SDF on the day of ICSI: (i) obtaining a second ejaculate shortly after the first to reduce oxidative damage and transit time; and (ii) selecting sperm via centrifugation-free sperm separation device, which enriches for motile sperm with intact DNA. There are limited direct comparisons between these strategies; this study addresses that gap.",[27],"Male",[29,30,31,32,33],"pregnancy rate","Second Ejaculate","Abstinence","Microfluidic","CA0","NOT_YET_RECRUITING","2026-05-30",{"date":37,"type":38},"2026-06-04","ACTUAL",{"date":40,"type":21},"2026-08-05",{"date":42,"type":21},"2028-03-25",{"name":44,"class":45},"Indira IVF Hospital Pvt Ltd","OTHER",9,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":18,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":58,"conditions":59,"keywords":75,"overallStatus":85,"whyStopped":4,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":95},"100572617","wild-blueberries-for-gut-brain-and-heart-health-in-adults-with-high-blood-pressure-100572617","NCT06735599","Wild Blueberries for Gut, Brain, and Heart Health in Adults With High Blood Pressure","Effects of Wild Blueberry Consumption on Gut, Brain, and Cardiovascular Health in Non-Hispanic Black and White Adults With High Blood Pressure","Inclusion Criteria:\n\n* Individuals 45-65 years of age\n* Diagnosis of elevated blood pressure or stage 1 hypertension (systolic blood pressure = 120-139 mmHg and\u002For diastolic blood pressure = 80-89 mmHg) for at least 6 months\n* BMI 25-35 kg\u002Fm2 via anthropometric measurements.\n* Ability to give consent\n\nExclusion Criteria:\n\n* Allergies to berries\n* Use of one hypertensive drug for less than three months\n* Use of more than one anti-hypertensive or statin drug, insulin, antibiotics, and anti-inflammatory drugs, active cancer, gastrointestinal, renal, cardiovascular, thyroid, and neurological disorders or severe head injury\n* Smoking\n* Alcohol consumption (\\>2 drinks\u002Fday)\n* Consuming antioxidant, probiotic, and prebiotic supplements\n* Pregnant or lactating\n* Participating in a weight loss program","65 Years",{"count":56,"type":21},40,[24],"The purpose of the study is to determine the effectiveness of wild blueberries on cardiovascular health, cognitive function, and gut microbiota composition in non-Hispanic Black and White adults with elevated blood pressure.",[60,61,27,62,63,64,65,66,67,68,69,70,71,72,73,74],"Hypertension (Without Type 2 Diabetes Mellitus)","High Blood Pressure","Female","Adult","Cognition","Endothelial Function (Reactive Hyperemia)","Oxidative Stress","Diet","Overweight","Body Composition Measurement","Gut Microbiome","Arterial Stiffness","Caucasian Whites","Inflammation","Microvascular Function",[76,77,68,61,78,79,80,81,82,83,84],"Blueberries","Hypertension","Endothelial Function","Cognitive Function","Dietary intervention","functional foods","gut microbiota","arterial stiffness","microvascular function","RECRUITING","2026-03-23",{"date":88,"type":38},"2026-03-27",{"date":90,"type":38},"2024-09-17",{"date":92,"type":21},"2027-01-01",{"name":94,"class":45},"Georgia State University",1,{"id":97,"slug":98,"hasResults":11,"nctId":99,"briefTitle":100,"officialTitle":101,"acronym":4,"eligibilityCriteria":102,"healthyVolunteers":103,"sex":16,"minAge":104,"maxAge":4,"enrollmentInfo":105,"targetDuration":4,"studyType":107,"phases":4,"briefSummary":108,"conditions":109,"keywords":112,"overallStatus":85,"whyStopped":4,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":124},"100567670","clinical-performance-of-urine-hpv-testing-in-males-100567670","NCT06671210","Clinical Performance of Urine HPV Testing in Males","Clinical Evaluation of Self-collected Urine Samples for the Detection of Human Papillomavirus in Males","Inclusion Criteria:\n\n* Be at least 18 years old and have had sexual experience;\n\n  * After one year or more of regular, unprotected sexual activity without pregnancy in married couples； ③Voluntarily participate in this study after communication and sign an informed consent form.\n\nExclusion Criteria:\n\n* Samples that cannot obtain valid nucleic acid test results, including but not limited to samples with human errors in clinical trial testing process or samples with insufficient volume to complete a valid test; ② Incomplete demographic information and laboratory test related information of the subjects.",true,"18 Years",{"count":106,"type":21},150,"OBSERVATIONAL","Human papillomavirus (HPV) infection is one of the most prevalent viral infections of the genital tract, primarily transmitted through sexual contact. Research indicates that individuals engaging in sexual activity have a lifetime probability of HPV infection as high as 85% to 90%. While extensive and in-depth investigations have been conducted on HPV infection in women, epidemiological studies focusing on male HPV infection remain relatively scarce. Many men with HPV are asymptomatic; reports suggest that approximately 10.5% of men in China are infected with HPV, yet only about 1% exhibit related symptoms. This substantial population of asymptomatic and unaware patients poses significant challenges for the prevention and control efforts regarding HPV in China. Furthermore, evidence suggests an association between HPV infection and conditions such as condyloma acuminatum, penile intraepithelial neoplasia (PeIN), penile cancer (PA), and even infertility among male patients. In current clinical practice, detection of HPV typically involves collecting exfoliated cells from the external genitalia via swabs. The discomfort associated with this sampling method and its procedural complexity often deter many asymptomatic men from undergoing penile swab testing for HPV, resulting in low compliance rates. Self-sampling urine tests offer advantages including convenience, ease of use, painlessness, and non-invasiveness; thus they may serve as a viable alternative approach. In prior research endeavors, we successfully established a detection system utilizing female urine samples for identifying HPV presence. Consequently, this study aims to further refine this detection system to develop a stable and reliable methodology for detecting HPV using self-collected urine samples from males. Through this investigation not only do we seek to validate the feasibility of employing self-collected urine samples for detecting male HPV infections but also assess the accuracy and practicality of home-based self-testing methods among subjects-ultimately providing novel strategies for male-specific HPV detection",[110,111,27],"HPV","Self-sampling",[113,110,114],"urine","male","2024-11-03",{"date":117,"type":38},"2024-11-05",{"date":119,"type":38},"2024-11-04",{"date":121,"type":21},"2025-04-30",{"name":123,"class":45},"Peking University People's Hospital",2,{"id":126,"slug":127,"hasResults":11,"nctId":128,"briefTitle":129,"officialTitle":130,"acronym":131,"eligibilityCriteria":132,"healthyVolunteers":11,"sex":16,"minAge":104,"maxAge":4,"enrollmentInfo":133,"targetDuration":4,"studyType":107,"phases":4,"briefSummary":135,"conditions":136,"keywords":138,"overallStatus":85,"whyStopped":4,"lastUpdateSubmitDate":143,"lastUpdatePostDateStruct":144,"startDateStruct":146,"completionDateStruct":148,"leadSponsor":150,"locationsCount":95},"100558730","sex-specific-differences-in-cardiac-surgery-patients-secs-100558730","NCT06554925","SEx-specific Differences in Cardiac Surgery Patients (SECS).","SEx-specific Differences in Cardiac Surgery Patients (SECS). A Retrospective Registration and Evaluation of Characteristics and Perioperative Management of Cardiac Surgery Patients","SECS","Inclusion Criteria:\n\n* Patients \\> 18 years\n* All patients who underwent cardiac surgery from 1 January 1998 in the AUMC, location VUmc, until 1 June 2021.\n\nExclusion Criteria:\n\n* None",{"count":134,"type":21},10000,"The aim of this study is to evaluate the differences between females and males undergoing cardiac surgery. The investigators will look at perioperative factors such as adaption of body weight, previous medical history, pharmacokinetics, transfusion, coagulation, cardiopulmonary bypass (CPB) related factors, cardiac function, inotropic requirements, risk, and outcome scores as well as morbidity and mortality at sort-term (within 30 days) and long-term (90 days and 1 year).",[62,27,137],"Surgery, Cardiac",[139,140,141,142],"anesthesia","sex-specific differences","cardiac surgery","care pathways","2024-08-12",{"date":145,"type":38},"2024-08-15",{"date":147,"type":38},"2022-03-01",{"date":149,"type":21},"2031-03-01",{"name":151,"class":45},"Jennifer Breel",{"id":153,"slug":154,"hasResults":11,"nctId":155,"briefTitle":156,"officialTitle":157,"acronym":158,"eligibilityCriteria":159,"healthyVolunteers":11,"sex":16,"minAge":104,"maxAge":4,"enrollmentInfo":160,"targetDuration":4,"studyType":107,"phases":4,"briefSummary":162,"conditions":163,"keywords":165,"overallStatus":85,"whyStopped":4,"lastUpdateSubmitDate":168,"lastUpdatePostDateStruct":169,"startDateStruct":171,"completionDateStruct":173,"leadSponsor":175,"locationsCount":95},"100529582","towards-a-sex-specific-female-enhanced-recovery-after-cardiac-surgery-f-eras-pathway-100529582","NCT06175650","Towards a Sex-specific \"Female Enhanced Recovery After Cardiac Surgery'' (F-ERAS) Pathway:","Towards a Sex-specific \"Female Enhanced Recovery After Cardiac Surgery'' (F-ERAS) Pathway: An Observational Registration and Evaluation of Characteristics and Perioperative Management of Cardiac Surgery Patients","F-ERAS","Inclusion Criteria:\n\n* Patients \\> 18 years\n* All patients who underwent cardiac surgery from 1 January 2016 to the start of the study, in either of the centres (AMC or VUmc) (retrospective)\n* All patients undergoing cardiac surgery from the start of the study (\\~March 2022) until approximately 2032\n\nExclusion Criteria:\n\n• Patients who object to the re-use of their care data or do not give consent",{"count":161,"type":21},5500,"The aim of this study is to evaluate the differences between men and women undergoing cardiac surgery. We will look at perioperative factors such as body weight, body surface area, previous medical history, pharmacokinetics, transfusion, coagulation, cardiopulmonary bypass (CPB) related factors, cardiac function, inotropic requirements, risk, and outcome scores as well as morbidity and mortality at 30 and 90 days, 1, 5, and 10 years.",[62,27,164],"Surgery,Cardiac",[166,167],"Anesthesia","Quality of Life","2023-12-18",{"date":170,"type":38},"2023-12-19",{"date":172,"type":38},"2023-11-21",{"date":174,"type":21},"2026-11-21",{"name":151,"class":45},{"id":177,"slug":178,"hasResults":11,"nctId":179,"briefTitle":180,"officialTitle":181,"acronym":4,"eligibilityCriteria":182,"healthyVolunteers":11,"sex":16,"minAge":104,"maxAge":183,"enrollmentInfo":184,"targetDuration":4,"studyType":22,"phases":186,"briefSummary":187,"conditions":188,"keywords":195,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":201,"lastUpdatePostDateStruct":202,"startDateStruct":204,"completionDateStruct":206,"leadSponsor":208,"locationsCount":4},"100471348","efficacy-of-transcutaneous-vagus-nerve-stimulation-paired-with-tailor-made-notched-music-therapy-versus-tailor-made-notched-music-training-for-chronic-subjective-tinnitus-100471348","NCT05417711","Efficacy of Transcutaneous Vagus Nerve Stimulation Paired With Tailor-Made Notched Music Therapy Versus Tailor-made Notched Music Training for Chronic Subjective Tinnitus","Efficacy of Transcutaneous Vagus Nerve Stimulation Paired With Tailor-Made Notched Music Therapy Versus Tailor-made Notched Music Training for Chronic Subjective Tinnitus: A Multicenter, Randomized, Double-blind, Controlled Clinical Trial","Inclusion Criteria:\n\n* Patients with tinnitus as the main complaint: the patients subjectively feel the sound in the ear or deep part of the head without internal or external sound stimulation, and therefore seek medical treatment\n* Chronic (≥ 6 months) and tonal tinnitus\n* Age 18-60\n* Tinnitus frequency is 125-8000 Hz\n* Hearing threshold at each frequency shall not exceed 70 dB HL\n\nExclusion Criteria:\n\n* Patients with conductive deafness, history of middle ear surgery, pulsatile tinnitus caused by vascular distortion and tinnitus caused by Meniere disease\n* History of head trauma, central nervous system diseases, mental diseases and drug abuse","60 Years",{"count":185,"type":21},388,[24],"This clinical study is a prospective, multicenter, randomized, controlled, double-blind clinical study. Sun Yat Sen Memorial Hospital of Sun Yat sen University was the central unit, and Nanjing First Hospital, Sun Yat Sen people's Hospital, Guanfzhou Panyu central Hospital and Zhuhai integrated traditional Chinese and Western medicine hospital were the cooperative units. In this study, 388 patients with chronic subjective tinnitus were recruited. In view of chronic subjective tinnitus, a common ear disease, the study gave the patients three months of treatment with transcutaneous vagus nerve stimulation paired with tailor-made notched music therapy or tailor-made notched music training alone. By comparing the changes of subjective scale scores related to tinnitus before and after treatment in patients receiving two different therapies, such as THI, VAS, BAI, BDI, PSQI, to evaluate the efficacy of the two therapies, so as to judge whether transcutaneous vagus nerve stimulation paired with tailor-made notched music therapy is better than tailor-made notched music training alone. In addition, the study will continue to follow up the patients after the treatment for one year to observe the difference in the long-term sustained efficacy of the two therapies. This clinical study will also evaluate the two therapies from the perspective of compliance and safety, and explore the factors that affect the efficacy of the two therapies.",[189,190,191,192,62,27,193,194],"Tinnitus, Subjective","Vagus Nerve Stimulation","Music Therapy","Double-Blind Method","Humans","Treatment Outcome",[196,197,198,199,200],"Chronic subjective tinnitus","Tailor-made notched music training","Vagus nerve stimulation","Electroencephalogram","Clinical trial","2023-11-22",{"date":203,"type":38},"2023-11-27",{"date":205,"type":21},"2023-11-23",{"date":207,"type":21},"2026-09-01",{"name":209,"class":45},"Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University"]