[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"males\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:males":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,52,84],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":33,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100603043","interaction-between-inorganic-nitrate-supplementation-and-metformin-in-individuals-with-prediabetes-100603043",false,"NCT07131384","Interaction Between Inorganic Nitrate Supplementation and Metformin in Individuals With Prediabetes","The Interaction Between Inorganic Nitrate Supplementation and Metformin on Exercise Capacity, Vascular Function, and Insulin Sensitivity in Individuals With Pre-Diabetes","NO3-PreDM","Inclusion Criteria:\n\n* Individuals who can communicate meaningfully with the investigator and can provide written consent.\n* Confirmed prediabetic individuals (ages 18-60 years old) (2-hour glucose of 140-199 mg\u002FdL following OGTT test or HbA1c between 5.7-6.4% tested on two occasions within 6 months).\n* Taking metformin (stable dose for at least a week) or naïve to metformin\n* Sedentary (\\\u003C1 day\u002Fweek of structured exercise)\n* Be able to perform exercise on a cycle ergometer without assistance\n* Stable medication regimen for the last 6 months\n* If female, have a normal menstrual cycle\n\nExclusion Criteria:\n\n* Estimated Glomerular filtration rate (GFR) ≤ 45\n* Body mass index ≥ 40 Kg\u002Fm2\n* HbA1c \\> 6.4%\n* Smokers within the last 5 years\n* Has experienced significant weight loss \\~3 kg in the last three months or is taking any weight loss drugs\n* Current medical condition that prohibits exercising at high intensities\n* Currently on hormone replacement of any kind\n* History of myocardial infarction, cerebrovascular event, acute or unstable disease other than pre-diabetes or obesity\n* Currently taking any of the following medications (calcium channel blockers, statins, ACE or renin inhibitors, angiotensin receptor blockers, organic nitrates (e.g., nitroglycerine) or recent regular use of inorganic nitrates, alpha- or beta-blockers, diuretics, proton pump inhibitors, PDE-5 inhibitors (e.g.,: Cialis, Viagra), or xanthine oxidase inhibitors (e.g.,: Allopurinol))\n* Oral antibiotic use within the previous four weeks, including over-the-counter antibacterial mouthwash or a mouthwash containing chlorhexidine and unwilling to discontinue use\n* Oral cancer\u002Fsevere oral disease\n* Uncontrolled hypertension (\\>140\u002F90)\n* Had hysterectomy or oophorectomy\n* Fetuses, neonates, children, prisoners, cognitively impaired, non-English speaking participants","ALL","18 Years","60 Years",{"count":21,"type":22},24,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study is examining whether short-term supplementation with inorganic nitrate, in the form of beetroot juice, can enhance blood vessel health, insulin sensitivity, and exercise capacity in individuals with prediabetes. We will be comparing the responses in individuals who are taking metformin to those who are naive to metformin. The results from this study may help identify non-pharmacological interventions in prediabetes.",[28,29,30,31,32],"Males","Females","Sedentary","Metformin","Prediabetes",[34,35,36,37,38],"Prediabetic Individuals","Exercise Capacity","Vascular health","Inorganic nitrate","Insulin Sensitivity","RECRUITING","2026-06-02",{"date":42,"type":43},"2026-06-03","ACTUAL",{"date":45,"type":43},"2026-01-01",{"date":47,"type":22},"2027-06-30",{"name":49,"class":50},"University of Virginia","OTHER",1,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":60,"sex":17,"minAge":61,"maxAge":4,"enrollmentInfo":62,"targetDuration":4,"studyType":23,"phases":64,"briefSummary":65,"conditions":66,"keywords":69,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":4},"100601332","the-effects-of-vitamin-c-on-acute-exercise-in-postmenopausal-females-100601332","NCT07109115","The Effects of Vitamin C on Acute-Exercise in Postmenopausal Females","The Effects of Vitamin C on Exercise-Induced Oxidative Stress in Postmenopausal Females","PM-VitC","Inclusion Criteria:\n\n* Post-menopausal (for females; defined as no menstrual cycle for 1-year)\n* Sedentary (\\\u003C150min of moderate-intensity exercise per week or not engaged in a regular exercise program)\n* Non-smoking\n* Weight stable (+\u002F-3 kg over the past 3 months)\n\nExclusion Criteria:\n\n* Overt CVD\n* Any condition or medication contraindicating safe exercise\n* Hormone replacement therapy (last 3-months)\n* Use of vasoactive medications (e.g., calcium channel blockers, statins, ACE inhibitors, ARBs, nitrates, alpha-\u002Fbeta-blockers, diuretics), diabetes, or unstable medication regimens\n* Diabetes\n* Oral antibiotic use within previous four weeks\n* Oral disease or poor oral health as determined by the Oral Health Questionnaire\n* Using an antibacterial mouthwash or a mouthwash containing chlorhexidine and unwilling to discontinue use\n* Cancer diagnosis",true,"45 Years",{"count":63,"type":22},30,[25],"This study is looking at whether vitamin C can help improve oxidative stress and blood vessel health in females after menopause. We will see if taking different amounts of vitamin C for a few days changes how the body handles stress from exercise. This could lead to safer ways to protect females from heart disease without using hormone therapy.",[29,28,67,30,68],"Menopause","Healthy Participants",[70,71,72,73,74],"Vitamin C","Postmenopausal Females","Exercise","Oxidative Stress","Vascular Health","NOT_YET_RECRUITING","2025-07-30",{"date":78,"type":43},"2025-08-07",{"date":80,"type":22},"2025-09-01",{"date":82,"type":22},"2027-09-01",{"name":49,"class":50},{"id":85,"slug":86,"hasResults":11,"nctId":87,"briefTitle":88,"officialTitle":89,"acronym":4,"eligibilityCriteria":90,"healthyVolunteers":11,"sex":91,"minAge":4,"maxAge":61,"enrollmentInfo":92,"targetDuration":4,"studyType":94,"phases":4,"briefSummary":95,"conditions":96,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":51},"100598844","serum-testosterone-level-on-angiographic-complexity-of-coronary-lesions-in-premature-ischemic-egyptian-males-100598844","NCT07076771","Serum Testosterone Level on Angiographic Complexity of Coronary Lesions in Premature Ischemic Egyptian Males","Impact of Serum Testosterone Level on Angiographic Complexity of Coronary Lesions in Premature Ischemic Egyptian Males","Inclusion Criteria:\n\n* Male patients aged \\\u003C45 years.\n* Diagnosed with premature ischemic heart disease.\n* Undergoing elective coronary angiography for suspected coronary artery disease (CAD) .\n\nExclusion Criteria:\n\n* History of acute coronary syndrome within the preceding 3 months.\n* Prior diagnosis of hypogonadism or history of testosterone replacement therapy or anabolic steroid use.\n* Active neoplasm or history of chemotherapy.\n* Known hepatic cirrhosis, chronic kidney disease, or end-stage renal disease.\n* Use of medications known to affect sex hormone levels (e.g., spironolactone, ketoconazole).\n* Endocrine disorders such as sickle cell anemia or celiac disease.","MALE",{"count":93,"type":22},50,"OBSERVATIONAL","This study aims to investigate the association between serum testosterone levels and the angiographic complexity of coronary artery lesions in male patients under 45 years of age presenting with premature ischemic heart disease.",[97,98,99,100,28],"Testosterone","Angiographic Complexity","Coronary Lesion","Premature Ischemia","2025-07-12",{"date":103,"type":43},"2025-07-22",{"date":105,"type":43},"2025-01-01",{"date":107,"type":22},"2025-08-01",{"name":109,"class":50},"Sohag University"]