[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"malnourished-children\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:malnourished-children":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,38,69,95],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":27,"lastUpdatePostDateStruct":28,"startDateStruct":31,"completionDateStruct":33,"leadSponsor":35,"locationsCount":4},"100631140","unveiling-the-role-of-intestinal-parasitic-infections-in-childhood-malnutrition-in-assiut-governorate-100631140",false,"NCT07496801","Unveiling the Role of Intestinal Parasitic Infections in Childhood Malnutrition in Assiut Governorate.","Inclusion Criteria:\n\n* Children aged 2-15 years of both sexes.\n\n  * Children whose parents provide informed written consent.\n  * Malnourished children identified based on anthropometric measurements according to the growth standards of the World Health Organization. Height-for-Age, Weight-for-Age and Weight-for-Height were \\\u003C-2 standard deviation (SD) were classified as stunted, wasted, and underweight, respectively.\n  * Apparently healthy control children of similar age groups\n\nExclusion Criteria:\n\n* • Children with chronic systemic diseases (e.g., chronic renal, hepatic, cardiac, or endocrine disorders).\n\n  * Children with known genetic or congenital disorders affecting growth.\n  * Children who received micronutrient supplementation (omega 3, zinc, vitamin D) within the last 3 months.\n  * Children who received antiparasitic treatment within the last 3 months.",true,"ALL","2 Years","15 Years",{"count":20,"type":21},116,"ESTIMATED","OBSERVATIONAL","Intestinal parasitic infections (IPIs) are highly prevalent worldwide, particularly among children living in lowresource settings. (1) These infections pose a significant public health challenge due to their widespread distribution and their impact on vulnerable populations, especially preschool and school-aged children. (2) Common intestinal parasites include protozoa such as Giardia lamblia and Entamoeba histolytica, as well as helminths like Ascaris lumbricoides, Trichuris trichiura, and hookworms.(3) IPIs contribute to a range of health problems in children, including diarrhea, anemia, general weakness, and impaired physical development. These infections often cause malabsorption of nutrients and chronic blood loss, which can severely affect children's growth and overall health status. (2) Malnutrition has been defined by the World Health Organization as a major global health challenge with significant implications for morbidity and mortality worldwide.(4) It is characterized by conditions such as stunting, wasting, and underweight, all of which reflect inadequate nutrition and impaired growth. . (Yoseph \\& Beyene, 2020).Malnutrition is influenced by multiple interconnected factors including socioeconomic status, inadequate feeding practices, lack of exclusive breastfeeding, recurrent infections, limited healthcare access, and poor environmental conditions such as unsafe water and sanitation. (5) Persistent and\u002For recurring IPIs are considered important contributors to adverse developmental outcomes depending on parasite species and infection dynamics.(6) They may contribute to malnutrition through both direct and indirect mechanisms. Directly, they can induce chronic subclinical systemic inflammation and modulate the host immune response to ensure persistence, resulting in adverse effects on growth.(7) For example, infection with Cryptosporidium spp.\n\nhas been linked to reduced length-for-age, mediated by increased systemic inflammation and decreased circulating IGF-1 concentrations.(8) Indirectly, they may promote environmental enteric dysfunction (EED), which is subclinical disorder of the small intestine that can contribute to malnutrition. It involves villous atrophy and crypt hyperplasia, reducing nutrient absorption, and infections such as G. lamblia may play a key role in its development.(6) Additionally IPIs may interact with the normal gut microbiota, with each influencing the other's pathogenic potential, and this interaction can contribute to malnutrition.(7) IPIs can reduce food intake by causing illness, abdominal discomfort, or altering appetite regulation.(8) They may affect neuroendocrine signals, modifying taste perception and satiety hormones, such as elevated leptin levels observed in children infected with E. histolytica, Strongyloides spp., and G. lamblia. Infections like Trichuris trichiura have also been linked to lower intake of protein, energy, iron and riboflavin.(6) While parasites like hookworm directly cause nutrient loss through blood and iron depletion, often resulting in anaemia. (1) Deficiencies in zinc, vitamin D and omega-3 fatty acids are common in children affected by malnutrition and parasitic infections. Zinc and vitamin D is essential for gut integrity, immune function, and growth, while omega-3 fatty acids support intestinal structure and have anti-inflammatory effects. Low levels of these nutrients may worsen intestinal dysfunction, including EED, and contribute to impaired growth.(9) In the light of the previously discussed mechanisms, a strong bidirectional relationship exists between parasitic infections and malnutrition, whereby each condition aggravates the other, forming a vicious cycle that increases the risk of stunting, poor growth, anaemia, and impaired immune function.(3)",[25],"Malnourished Children","NOT_YET_RECRUITING","2026-03-23",{"date":29,"type":30},"2026-03-27","ACTUAL",{"date":32,"type":21},"2026-04",{"date":34,"type":21},"2027-12",{"name":36,"class":37},"Assiut University","OTHER",{"id":39,"slug":40,"hasResults":11,"nctId":41,"briefTitle":42,"officialTitle":42,"acronym":43,"eligibilityCriteria":44,"healthyVolunteers":11,"sex":16,"minAge":45,"maxAge":46,"enrollmentInfo":47,"targetDuration":4,"studyType":49,"phases":50,"briefSummary":52,"conditions":53,"keywords":54,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":68},"100587859","effects-of-channa-striata-extract-on-intestinal-inflammation-and-nutritional-status-in-malnutritional-toddlers-after-albendazole-therapy-in-south-bangka-district-100587859","NCT06933862","Effects of Channa Striata Extract on Intestinal Inflammation and Nutritional Status in Malnutritional Toddlers After Albendazole Therapy in South Bangka District","Striatin1","Inclusion Criteria:\n\n* Malnourished children aged 1.5-5 years (-3SD to \\\u003C -2 SD)\n* Parents or guardians are willing to participate in the study\n* Parents or guardians can read and fill out the questionnaire\n\nExclusion Criteria:\n\n* Children with chronic diseases such as tuberculosis, congenital heart disease, diabetes, cancer, epilepsy, HIV Aids, sickle cell anemia, and mental illness.\n* Children with history of snakehead fish allergy\n* Children with physical disabilities that complicate data collection","17 Months","60 Months",{"count":48,"type":21},122,"INTERVENTIONAL",[51],"NA","The goal of this clinical trial is to learn if intervention with channa striata extract or inbumin forte sachet as a food supplement can improve intestinal damage and nutritional status in malnourished children aged 1.5-5 years. The main questions it aims to answer are:\n\n* Whether there is a change in calprotectin and AAT levels after administration of snakehead fish extract of inbumin forte sachet?\n* Whether there is a difference in changes in nutritional status after administration of snakehead fish extract or inbumin forte sachet? Researchers will compare snakehead fish extract or inbumin forte sachet to a placebo (a look-alike substance that contains no drug) to see if snakehead fish extract or inbumin forte sachet works to treat children malnutrition.\n\nParticipants will take snakehead fish extract or inbumin forte sachet or placebo every day for 3 months. Researchers will visit study participants every month to check their weight and height and monitor vitamin administration through photos, notes and videos sent every day and records complaints or symptoms that may arise and at the end of 3 months, researchers will collect stool and blood samples and check nutritional status.",[25],[55,56,57,58],"snakehead fish extract","malnourished children","Calprotectin","striatin","2025-04-10",{"date":61,"type":30},"2025-04-18",{"date":63,"type":21},"2025-05-15",{"date":65,"type":21},"2026-06-30",{"name":67,"class":37},"Indonesia University",2,{"id":70,"slug":71,"hasResults":11,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":4,"eligibilityCriteria":75,"healthyVolunteers":15,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":76,"targetDuration":4,"studyType":49,"phases":78,"briefSummary":79,"conditions":80,"keywords":81,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":94},"100573220","enhancing-growth-monitoring-visits-in-joshipur-rural-municipality-kailai-nepal-100573220","NCT06743451","Enhancing Growth Monitoring Visits in Joshipur Rural Municipality, Kailai, Nepal","Enhancing Growth Monitoring Visits Through Health Workers Training on Growth Monitoring and Promotion, GMP Guideline a Community Health Volunteer Mobilization for Increasing Demand of GMP Through GMP Day in Joshipur Rural Municipality, Kailai, Nepal","Inclusion Criteria:\n\nFor Health Workers:\n\n1. Nutrition focal person of the health facility having primary engagement in growth monitoring and promotion.\n2. Trained on growth monitoring and promotion guideline.\n\nFor Female Community Health Volunteers 1. Active for inviting mothers and caretakers of the municipality\n\nFor Mothers and caretakers having under two years children\n\n1\\. Any mothers and caretakers having under two years children residing in Joshipur Rural Municipality during intervention.\n\nExclusion Criteria:\n\nWho not available during the time of data collection",{"count":77,"type":21},80,[51],"The goal of this clinical trial is to learn if health workers training on growth promotion and monitoring guideline and Female Community Health Volunteers mobilization for increasing demand for growth monitoring and promotion, GMP through growth monitoring and promotion day, GMP day) can enhance the growth monitoring and promotion practices in mothers and caretaker having under two years children. The main questions it aims to answer are:\n\n* Does health workers training on GMP guideline enhances the growth monitoring and promotion practices in mothers and caretakers having under two years children?\n* Does FCHV mobilization enhances growth monitoring and promotion practices in mothers and caretakers having under two years children? Participants will\n* Health workers of the Joshipur rural municipality will have to attend Training session on GMP guideline,\n* Mothers and caretakers having under two years children will have to visit to the nearest health facility for GMP visits for their children",[25],[82,83,84],"Nepal","Growth monitoring and Promotion","Malnutrition","2024-12-16",{"date":87,"type":30},"2024-12-19",{"date":89,"type":21},"2024-12",{"date":91,"type":21},"2025-08",{"name":93,"class":37},"Kathmandu University School of Medical Sciences",1,{"id":96,"slug":97,"hasResults":11,"nctId":98,"briefTitle":99,"officialTitle":100,"acronym":4,"eligibilityCriteria":101,"healthyVolunteers":15,"sex":16,"minAge":102,"maxAge":103,"enrollmentInfo":104,"targetDuration":106,"studyType":22,"phases":4,"briefSummary":107,"conditions":108,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":4},"100562729","effect-of-probiotics-supplementation-on-outcome-of-malnourished-children-100562729","NCT06606951","Effect Of Probiotics Supplementation on Outcome Of Malnourished Children","Effect Of Probiotics Supplementation on Outcome Of Malnourished Children Admitted at Assiut University Children's Hospital","Inclusion Criteria:\n\n1- Age group of children from 6 month up to 5 years\n\nExclusion Criteria:\n\n* age below 6 month and above 5 years","5 Months","5 Years",{"count":105,"type":21},102,"12 Months","The Outcome Of malnourished children who receive probiotics (Lactobacillus and Bifidobacterium",[25],"2024-09-18",{"date":111,"type":30},"2024-09-23",{"date":113,"type":21},"2025-01-01",{"date":115,"type":21},"2026-01-01",{"name":36,"class":37}]