[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"malnutrition-child\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:malnutrition-child":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,19,0,[8,46,78,91,119,146,158,177,208,238,266,294,324,346,369,388,414,440,471],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100053232","nutritional-care-after-discharge-in-children-term-born-18years-old-100053232",false,"NCT06414200","Nutritional Care After Discharge in Children Term Born-18years Old","Nutritional Care After Hospital Discharge (NutriCAD): A Stepped Wedged Multicentre Randomized Controlled Trial in Paediatrics","NutriCAD","Inclusion Criteria:\n\n* Children term born neonates till 18 years old\n* Admitted with newly initiated nutritional support(oral and\u002For enteral nutritional support) during hospitalization\n* Nutritional Support continues at home after discharge.\n\nExclusion Criteria:\n\n* Children with existing nutritional support upon admission\n* Children in need of parenteral nutrition at discharge\n* Children with DSM-5 diagnosed feeding disorders such as anorexia\n* Absence of written informed consent","ALL","7 Days","18 Years",{"count":21,"type":22},260,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this stepped wedge cluster randomized trial is to compare nutritional care after discharge to an intervention in children term born - 18 years old discharged with newly initiated nutritional care.\n\nThe main question it aims to answer is:\n\nTo investigate whether a tailored nutritional care follow-up program in children who are being discharged from the hospital with nutritional support improves nutritional intake and status as well as feeding behavior and quality of life (QoL) in children and their parents. Furthermore, the effect on parental stress, anxiety, depression, and post-traumatic stress (PTSD) as well as QoL will be assessed with and without a tailored nutritional care follow-up program",[28],"Malnutrition, Child",[30,31,32],"Nutritional care","After discharge","Pediatric","RECRUITING","2026-07-10",{"date":36,"type":37},"2026-07-13","ACTUAL",{"date":39,"type":37},"2024-04-23",{"date":41,"type":22},"2027-12-31",{"name":43,"class":44},"Erasmus Medical Center","OTHER",6,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":54,"sex":17,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":23,"phases":59,"briefSummary":60,"conditions":61,"keywords":64,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":77},"100053887","expanding-coverage-of-severe-acute-malnutrition-sam-treatment-in-kenya-100053887","NCT06441305","Expanding Coverage of Severe Acute Malnutrition (SAM) Treatment in Kenya","Assessing the Impact, Implementation and Cost of Empowering Community Health Promoters to Improve Wasting Treatment Coverage in Turkana County Through Family-led MUAC Scale-up, Weight-for-age Screening, and Defaulters' Follow-up","R-SWITCH","Inclusion Criteria:\n\n* Household in a village of the study area covered by a CHP (although the child may or may not be registered by a CHP) AND\n* Child is 6-59.9 months of age AND\n* Caregiver consents to be part of the study AND\n* any of the following:\n\n  * WHZ \\\u003C -3 (relative to WHO 2006 reference) OR\n  * MUAC \\\u003C115 mm OR\n  * Presence of bilateral edema OR\n  * receiving treatment as follow-up for an initial SAM condition on the way to full recovery\n\nexclusion criteria is:\n\n* Congenital malformation that makes anthropometric measurements impossible.\n* Length is below 54 cm or height is above 120cm.",true,"6 Months","5 Years",{"count":58,"type":22},1600,[25],"Child wasting is a type of malnutrition which occurs when a child becomes too thin. This medical condition increases the risk of becoming sick or dying. A child with severe wasting needs to be seen in a medical consultation to check on health status and to receive some medicine and a medical food supplement for daily consumption until cured. Yet, only a small proportion of children suffering from severe wasting are presently receiving appropriate treatment.\n\nIn Kenya, there is an opportunity to build on the existing network of community health promoters (CHPs) to increase the number of children with wasting who are identified and treated. In intervention areas, CHPs will be equipped with smartphones and an application which provides guidance on household members to visit and simple actions to take, related to health. CHPs will distribute color-coded mid-upper arm circumference tapes to households with young children and train caregivers on how to use it. After training, CHPs will send Short Message Services (SMS) to remind caregivers to regularly measure the arm circumference of the child. In addition, CHPs will receive a scale to measure the weight of children every month. Finally, wasted children registered in the treatment program who fail to attend a planned consultation will be flagged to their CHP through the phone application, and CHPs will conduct a specific home visit to investigate and help solve potential issues.\n\nThe study will assess whether this community intervention (called SWITCH) allows to identify and treat more children suffering from severe wasting. Before the start of the intervention, the proportion of wasted children receiving treatment in 40 community units in Turkana South, Turkana East and Aroo will be assessed. After this survey, a computer will randomly select 20 community units where the intervention will be scaled up. The survey will be repeated after 2 years to assess if the proportion of severely wasted children receiving treatment is higher in the area where the intervention was scaled up compared to the area where it was not scaled up.\n\nIn addition, after 1 year of implementation, the study will assess how the intervention was scaled up, what are the main challenges, and what are the overall perceptions on the intervention in the community among those who receive it and those who deliver it. Finally, costs of the various components of the intervention will be measured for all actors involved, including for caregivers.",[62,28,63],"Acute Malnutrition, Severe","Wasting",[65,66,67,63,68],"Outpatient Therapeutic Feeding Program","Treatment","Screening","Severe acute malnutrition","2026-07-09",{"date":36,"type":37},{"date":72,"type":37},"2024-06-03",{"date":74,"type":22},"2027-07-30",{"name":76,"class":44},"International Food Policy Research Institute",1,{"id":79,"slug":4,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":80,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":81,"targetDuration":4,"studyType":23,"phases":82,"briefSummary":26,"conditions":83,"keywords":84,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":88,"completionDateStruct":89,"leadSponsor":90,"locationsCount":77},"100547917","Nutritional Care After Hospital Discharge",{"count":21,"type":22},[25],[28],[30,31,32],"2026-06-02",{"date":87,"type":37},"2026-06-04",{"date":39,"type":37},{"date":41,"type":22},{"name":43,"class":44},{"id":92,"slug":93,"hasResults":11,"nctId":94,"briefTitle":95,"officialTitle":95,"acronym":4,"eligibilityCriteria":96,"healthyVolunteers":11,"sex":17,"minAge":55,"maxAge":4,"enrollmentInfo":97,"targetDuration":4,"studyType":23,"phases":99,"briefSummary":100,"conditions":101,"keywords":104,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":118},"100634523","evaluation-of-7-day-vs-1-day-packaging-of-small-quantity-lipid-based-nutrition-supplementation-sq-lns-100634523","NCT07540793","Evaluation of 7-day vs 1-day Packaging of Small Quantity Lipid-based Nutrition Supplementation (SQ-LNS)","Inclusion Criteria (must meet all):\n\n* Written informed consent from head of household\n* Household within the study area\n* Available for the full 8-week study period\n* 1 child aged 6-22 months in the household at time of enrollment\n* Child has MUAC ≥ 12.5cm\n* Child does not have any clinical complications requiring inpatient treatment or referral to the health post, according to Ethiopian malnutrition treatment guidelines\\*\\*\n* Child is not allergic to peanuts, milk, or soy\n* Household does not have multiple children within the eligible age range\n\nExclusion Criteria (any excludes):\n\n* Head of household declines to sign written informed consent\n* Household is outside of the study area\n* Not available for the full 8-week study period\n* House has either multiple children aged 6-22 months in the household at time of enrollment, or 0 children aged 6-22 months at time of enrollment\n* Child has MUAC \\\u003C 12.5cm\n* Child has any clinical complications requiring inpatient treatment or referral to the health post, according to Ethiopian malnutrition treatment guidelines\n* Child is allergic to peanuts, milk, or soy",{"count":98,"type":22},100,[25],"Small Quantity Lipid-based Nutrient Supplements (SQ-LNS), are fortified, lipid-based nutritional supplements that were specifically designed for children 6-24 months to prevent malnutrition. Recent research has shown reductions in mortality, severe wasting, severe stunting, iron deficiency anemia, and developmental delays.\n\nSQ-LNS is currently available in individual daily dose packets of 20g. Healthy children age 6-24 months receive 1 packet per day (1dp), and are typically given a 1- or 2- month supply at a time (30-60 packets).\n\nRecently, Nutriset Développement has developed a new packaging design for SQ-LNS that reduces the cost by over 15% overall, through production efficiency with 40% less packaging, and improved transportation efficiency by 20%. This new packaging is a 140g packet that will allow 20g to be dispensed daily for 7 days (7dp). The packaging has a chamber that will allow for accurate 10g dosing (either twice daily, or twice at once). Users of the packaging will also be able to close the spout to minimize risk of microbiological contamination.\n\nEdesia Nutrition is working with Nutriset to conduct field testing of this new packaging for SQ-LNS, and this mixed-methods study in North Shoa Zone, Amhara Region, Ethiopia, will help inform recommendations for the future use of the package. The study seeks to determine (1) the acceptability of integrating SQ-LNS distribution into the malnutrition program; (2) whether adherence to the 2 different package types differs, and if there are differences in usage; (3) and how the packages perform over time, their perceived safety and functionality, and how they are stored.\n\nEducational and communication tools will be developed and pre-tested as part of this study, and will become part of the final deliverable package to Edesia Nutrition, in addition to final recommendations on the product packaging, findings about how the packages are used, and behavior change and nutrition education strategies.\n\nThe primary outcome of the quantitative evaluation will be adherence, calculated as the number of delivered doses of SQ-LNS divided by the number of expected doses per week (7).\n\nAdherence will be measured via weekly self-report via caregiver interview and counts of return of used and unused packages during weekly home visits. The percentage of children who receive a dose during structured observation periods will be calculated. Each adherence outcome will be analyzed separately.",[102,28,103],"Prevention","Nutrition",[105,106,107],"Small Quantity Lipid-based Nutrient Supplement","Child nutrition","Malnutrition prevention","NOT_YET_RECRUITING","2026-05-11",{"date":111,"type":37},"2026-05-14",{"date":113,"type":22},"2026-05",{"date":115,"type":22},"2026-12",{"name":117,"class":44},"University of California, San Francisco",3,{"id":120,"slug":121,"hasResults":11,"nctId":122,"briefTitle":123,"officialTitle":124,"acronym":4,"eligibilityCriteria":125,"healthyVolunteers":11,"sex":17,"minAge":55,"maxAge":126,"enrollmentInfo":127,"targetDuration":4,"studyType":23,"phases":129,"briefSummary":130,"conditions":131,"keywords":134,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":137,"lastUpdatePostDateStruct":138,"startDateStruct":140,"completionDateStruct":142,"leadSponsor":144,"locationsCount":77},"100619535","treatment-of-severe-acute-malnutrition-in-children-6-to-59-months-old-with-standard-ready-to-use-therapeutic-food-compared-to-a-newly-formulated-lipid-optimized-ready-to-use-therapeutic-food-100619535","NCT07345884","Treatment of Severe Acute Malnutrition in Children 6 to 59 Months Old With Standard Ready To Use Therapeutic Food Compared to a Newly Formulated Lipid Optimized Ready To Use Therapeutic Food","Comparison of Treatment of Severe Acute Malnutrition in Children 6 to 59 Months Old With Standard Ready To Use Therapeutic Food and Newly Formulated Lipid Optimized Ready To Use Therapeutic Food an Individual Randomized Double Blind Controlled Trial","Inclusion Criteria:\n\n* Children aged 6-59 months with severe acute malnutrition, i.e., MUAC \\\u003C11.5 cm, and\u002For weight-for-height\u002Flength z-score \\\u003C -3, and\u002For with bilateral pitting edema, with an appetite to completely consume a 30 g test feeding, and without medical complications presenting at selected rural therapeutic feeding health facilities\n\nExclusion Criteria:\n\n* Children that are simultaneously involved in another research trial or supplemental feeding program, are developmentally delayed, have vision or hearing deficits, or have a history of milk or peanut allergy.\n* Chronic diseases such as malabsorption, chronic kidney disease, inflammatory bowel disease, congenital heart disease, endocrine disorders (e.g., hypothyroidism, growth hormone deficiencies), recurrent infections (e.g., pneumonia, cough, fever, pharyngitis), chronic respiratory diseases (e.g., asthma, lung diseases), congenital or acquired immunodeficiency, and neurological disorders","59 Months",{"count":128,"type":22},125,[25],"The goal of this randomized clinical trial is to learn if a newly formulated Lipid-Optimized Ready-to-Use Therapeutic Food (LO-RUTF) can treat severe acute malnutrition in children aged 6 to 59 months. The main questions it aims to answer are:\n\n1. Does LO-RUTF impact physical recovery from severe acute malnutrition in participants?\n2. Does LO-RUTF impact neurocognitive performance after 8 and 12 weeks of treatment?\n\nResearchers will compare LO-RUTF to standard RUTF see if our energy-dense food compares to standard issue RUTF in terms of promoting recovery from severe acute malnutrition.\n\nParticipants will\n\n* Take a one-week ration of LO-RUTF or standard RUTF based on the participant's weight\n* Return every week for checkups, tests and to receive the next ration of assigned RUTF if eligible\n* Be assessed for neurocognitive function through Malawi Developmental Assessment Tool (MDAT) at three time points (before treatment, 4 weeks, 12 weeks)",[132,28,133],"Severe Acute Malnutrition in Childhood","Neurocognition, Child",[135,136],"RUTF","Ready-to-use therapeutic food","2026-04-20",{"date":139,"type":37},"2026-04-22",{"date":141,"type":22},"2026-06",{"date":143,"type":22},"2026-10",{"name":145,"class":44},"University of California, Los Angeles",{"id":147,"slug":4,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":54,"sex":17,"minAge":55,"maxAge":56,"enrollmentInfo":148,"targetDuration":4,"studyType":23,"phases":149,"briefSummary":60,"conditions":150,"keywords":151,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":152,"lastUpdatePostDateStruct":153,"startDateStruct":155,"completionDateStruct":156,"leadSponsor":157,"locationsCount":77},"100549995",{"count":58,"type":22},[25],[62,28,63],[65,66,67,63,68],"2026-03-25",{"date":154,"type":37},"2026-03-27",{"date":72,"type":37},{"date":74,"type":22},{"name":76,"class":44},{"id":159,"slug":160,"hasResults":11,"nctId":161,"briefTitle":162,"officialTitle":163,"acronym":52,"eligibilityCriteria":164,"healthyVolunteers":54,"sex":17,"minAge":55,"maxAge":56,"enrollmentInfo":165,"targetDuration":4,"studyType":23,"phases":167,"briefSummary":168,"conditions":169,"keywords":170,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":152,"lastUpdatePostDateStruct":171,"startDateStruct":172,"completionDateStruct":174,"leadSponsor":176,"locationsCount":77},"100545330","increasing-the-coverage-of-severe-acute-malnutrition-sam-treatment-in-ethiopia-100545330","NCT06380504","Increasing the Coverage of Severe Acute Malnutrition (SAM) Treatment in Ethiopia","Effect of Leveraging Community-level Structures to Strengthen Prevention, Screening and Treatment of Severe Acute Malnutrition in Ethiopia","Inclusion Criteria:\n\n* Child 6-59 months of age\n* Suffering from SAM (defined as MUAC \\\u003C 115mm or presence of bilateral pitting edema or Weight-for-Length Z-score \\\u003C-3) OR currently enrolled in SAM OTP\n\nExclusion Criteria:\n\n\\- Anthropometric malformation or being handicapped which hampers anthropometric measurements.",{"count":166,"type":22},1080,[25],"The R-SWITCH intervention aims to address the low coverage of treatment for severe wasting (SAM) by leveraging existing community groups to deliver an integrated package focused on prevention, screening, referral, and treatment of SAM. It includes behavior change communication on child nutrition and health, active screening, improved passive screening at health posts, and follow-up of referred cases and those enrolled in outpatient treatment programs (OTP). The primary objectives of the R-SWITCH studies are to assess the intervention's impact on OTP coverage, identify implementation barriers and facilitators, and evaluate its cost-efficiency and cost-effectiveness.",[62,28,63],[65,66,67,63,68],{"date":154,"type":37},{"date":173,"type":37},"2024-05-02",{"date":175,"type":22},"2027-06-30",{"name":76,"class":44},{"id":178,"slug":179,"hasResults":11,"nctId":180,"briefTitle":181,"officialTitle":181,"acronym":182,"eligibilityCriteria":183,"healthyVolunteers":11,"sex":17,"minAge":184,"maxAge":185,"enrollmentInfo":186,"targetDuration":4,"studyType":23,"phases":188,"briefSummary":189,"conditions":190,"keywords":194,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":198,"lastUpdatePostDateStruct":199,"startDateStruct":201,"completionDateStruct":203,"leadSponsor":205,"locationsCount":207},"100509320","the-effect-of-high-caloric-oral-nutritional-supplements-on-growth-and-development-of-malnourished-children-100509320","NCT05911893","the Effect of High Caloric Oral Nutritional Supplements on Growth and Development of Malnourished Children","EHCONSGDMC","Inclusion Criteria:\n\n* Aged 1-3 years\n* BMI for Age Z-score\\\u003C-2\n* Height-for-age z score\\\u003C-2\n* Total daily energy intake\\\u003C75% of recommended nutrient intake\n* The child's guardian is willing to participate in this study and sign an informed consent form.\n\nExclusion Criteria:\n\n* Chronic or severe infectious disease (e.g., chronic hepatitis, HIV or tuberculosis infection)\n* Certain congenital or genetic diseases affecting physical growth and development (congenital heart disease, Down's syndrome, infantile anorexia nervosa, etc.), malignancies and use of drugs (diuretics, appetite stimulants, steroids and growth hormones, etc.)\n* Severe gastrointestinal disorders (e.g., celiac disease, short bowel syndrome, inflammatory bowel disease, etc.)\n* Acute and chronic respiratory\u002Fdigestive tract infections within 2 weeks prior to enrollment\n* Allergy or contraindication to any of the ingredients in the high-energy total nutrition formula used in this study\n* Have used high-energy enteral nutrition preparations for the last 3 months","1 Year","3 Years",{"count":187,"type":22},200,[25],"The goal of this clinical trial is to investigate the effect of high caloric oral nutritional supplements on body proportion, weight, linear growth pattern, neuropsychological development level and related health aspects (gut health, immune function, quality of life, etc.) in participants aged 1 to 3 years who are malnourished (underweight and wasting),as well as to evaluate the safety of applying high caloric oral nutritional supplements. Participants will receive nutritional education and daily high caloric oral nutritional supplements(experimental group),or will receive nutritional education and dietary instruction(control group).This study may provide data to support the development of clinical intervention strategies for malnourished Chinese children.",[28,191,192,193],"Malnourishment","Nutritional Deficiency","Undernutrition",[195,196,197],"Oral Nutritional Supplements","Physique Growth","Neuropsychological Development","2026-03-16",{"date":200,"type":37},"2026-03-18",{"date":202,"type":37},"2024-06-17",{"date":204,"type":22},"2026-03-10",{"name":206,"class":44},"Children's Hospital of Chongqing Medical University",13,{"id":209,"slug":210,"hasResults":11,"nctId":211,"briefTitle":212,"officialTitle":213,"acronym":4,"eligibilityCriteria":214,"healthyVolunteers":11,"sex":17,"minAge":56,"maxAge":215,"enrollmentInfo":216,"targetDuration":4,"studyType":23,"phases":218,"briefSummary":219,"conditions":220,"keywords":223,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":229,"lastUpdatePostDateStruct":230,"startDateStruct":232,"completionDateStruct":234,"leadSponsor":236,"locationsCount":77},"100627920","from-kitchen-to-clinic-100627920","NCT07454902","From Kitchen to Clinic","From Kitchen to Clinic: A Family-Centered, Food-As-Medicine Approach Using Medically Tailored Meals and Caregiver Coaching in Pediatric Oncology Care","Patient Inclusion Criteria:\n\n1. Receiving cancer treatment for any cancer diagnosis\n2. Within the first 3-6 weeks of diagnosis i. Diagnosis date is defined as the date of the family meeting relaying diagnosis to the patient\u002Fcaregiver\u002Ffamily\n3. At least 5-21 years of age at the time of enrollment\n4. English-speaking\n5. Approved to participate by both their oncologist and RDN\n6. Must anticipate to live in the same household as the designated caregiver for the duration of the study\n\nPatient Exclusion Criteria:\n\n1. Experiencing swallowing or digestive diseases\u002Ffood allergies (e.g. celiacs, lactose intolerance, nut allergy), or specific food preferences that cannot be accommodated by MANNA.\n2. Receiving nutrition via nasogastric or gastric tube feedings\n3. Bone marrow transplant patient","21 Years",{"count":217,"type":22},120,[25],"Children receiving cancer treatment often experience nutrition-related challenges, such as changes in appetite, weight, and food intake, due to treatment side effects and the demands placed on families during care. These challenges can increase caregiver stress, reduce diet quality, and contribute to short- and long-term health risks for children. While medically tailored meals have been shown to improve nutrition and reduce burden in adults with serious illness, their use in pediatric cancer care has not been well studied. This pilot study will evaluate the feasibility and acceptability of a 12-week, family-centered food-as-medicine program for children undergoing active cancer treatment and their caregivers. The program combines weekly delivery of medically tailored meals with individualized caregiver coaching provided by registered dietitian nutritionists. During the first eight weeks, families receive full meal support and weekly coaching sessions, followed by a four-week transition period with tapered meal delivery and bi-weekly coaching to support sustainable nutrition practices. A total of 60 pediatric patients and their caregivers will be enrolled at the Children's Hospital of Philadelphia. The study will assess whether families can be successfully recruited and retained, whether they are able to participate in study activities, and whether the program is acceptable and usable during cancer treatment. The study will also explore preliminary effects on children's dietary intake, weight and growth patterns, treatment tolerance, household nutrition security, and caregiver stress and burden.",[221,28,222],"Pediatric Cancer","Caregiver Burden",[224,225,226,227,228],"Pediatric oncology","Nutrition intervention","Medically tailored meals","Feasibility studies","Caregivers","2026-03-05",{"date":231,"type":37},"2026-03-09",{"date":233,"type":22},"2026-03",{"date":235,"type":22},"2028-12",{"name":237,"class":44},"Drexel University",{"id":239,"slug":240,"hasResults":11,"nctId":241,"briefTitle":242,"officialTitle":243,"acronym":4,"eligibilityCriteria":244,"healthyVolunteers":54,"sex":245,"minAge":19,"maxAge":246,"enrollmentInfo":247,"targetDuration":4,"studyType":23,"phases":249,"briefSummary":250,"conditions":251,"keywords":253,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":257,"lastUpdatePostDateStruct":258,"startDateStruct":260,"completionDateStruct":262,"leadSponsor":264,"locationsCount":77},"100484615","efficacy-of-mobile-health-application-in-promotion-of-exclusive-breast-feeding-and-young-child-feeding-practices-in-pakistan-100484615","NCT05590351","Efficacy of Mobile Health Application in Promotion of Exclusive Breast Feeding and Young Child Feeding Practices in Pakistan","Efficacy of Mobile Health Application in Promotion of Exclusive Breast Feeding and Young Child Feeding Practices in Pakistan: A Randomized Controlled Trial","Inclusion Criteria:\n\n1. Pregnant women in the third trimester at 36 +\u002F- 1 week of gestation.\n2. Planned to stay in their respective areas for at least 1 year after delivery\n3. Planned to get the infant immunized from the respective FHC of the hospitals.\n4. Have access to smart phones with internet connection.\n5. Registered and planning to deliver to any of the Secondary Care Hospitals\n6. Can read and write in local language (English and\u002For Urdu).\n7. Consent to participate and remain in the study until 1 year of child age\n\nExclusion Criteria:\n\n1. High-risk including maternal neurological\u002Fheart\u002F autoimmune\u002Frenal disease, preeclampsia, placenta previa, multiple gestations (twins\u002Ftriplets), fetal structural\u002Fgenetic anomalies, fetal growth restrictions, and birth trauma\u002Frequiring NICU admission.\n2. Women who plan to move to different location after delivery","FEMALE","48 Years",{"count":248,"type":22},300,[25],"Early life nutrition is the key modifiable determinant of child growth, development, survival and diseases of adult onset. Pakistan ranks highest for neonatal mortality rate (44.2\u002F1000 live births (LBs)) globally. One third of under-five deaths (74.9\u002F1000 LBs) are attributable to high prevalence of stunting (38%), underweight (23%) and wasting (7%), greatly related to feeding practices. Given the low prevalence of exclusively breast fed (EBF) (48%) and use of minimum acceptable diet (13%), mitigation of early life nutritional risk through promotion of EBF and Young Child Feeding Practices (YCFP) provides a critical window of opportunity for intervention. Secondary Care Hospitals (SCH) of the Aga Khan Health Services Pakistan provide essential maternal and child health services for low-middle income population. Babies born at these SCHs are followed up for vaccination, growth-monitoring and other services at the closely affiliated Family Health Centers (FHCs) run by Lady Health Visitors (LHVs). We aim to examine the effectiveness of a locally designed m-Health application for empowering mothers for child nutritional care as a potentially sustainable approach. The first six months of formative research would identify perceptions, barriers and facilitators for EBF and YCFP using self-determination behavioral theory, among multi-parous pregnant mothers enrolled at three SCHs of Karachi. A randomization trial would be conducted during next 18 months among near-term pregnant women who have access to smart-phones. A culturally appropriate mhealth application called first diet would be developed to provide personalized push messages delivered weekly by the LHVs. Non-intervention group will receive face-face nutritional counselling by the research staff at FHC following routine vaccination and growth-monitoring schedule. Mothers would followed-up from one month prior to expected delivery to child's first birthday. We expect 20% improvement in rates of EBF and YCFP with m-Health intervention. If proven effective, m-health would be incorporated in routine child care provision by LHVs.",[252,28],"Malnutrition, Infant",[254,255,256],"infant & young child feeding practices","stunting","wasting","2026-02-10",{"date":259,"type":37},"2026-02-12",{"date":261,"type":37},"2026-02-02",{"date":263,"type":22},"2027-12",{"name":265,"class":44},"Aga Khan University",{"id":267,"slug":268,"hasResults":11,"nctId":269,"briefTitle":270,"officialTitle":271,"acronym":4,"eligibilityCriteria":272,"healthyVolunteers":11,"sex":17,"minAge":273,"maxAge":274,"enrollmentInfo":275,"targetDuration":4,"studyType":23,"phases":276,"briefSummary":278,"conditions":279,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":283,"lastUpdatePostDateStruct":284,"startDateStruct":286,"completionDateStruct":288,"leadSponsor":290,"locationsCount":293},"100519909","phase-4-safety-study-of-smoflipid-to-evaluate-the-risk-of-developing-efad-andor-pnac-in-pediatric-and-adult-patients-100519909","NCT06049680","Safety Study of SMOFlipid to Evaluate the Risk of Developing EFAD and\u002For PNAC in Pediatric and Adult Patients","A Single-arm Open-label Safety Study of SMOFlipid to Evaluate the Risk of Developing Essential Fatty Acid Deficiency (EFAD) and\u002For Parenteral Nutrition-associated Cholestasis (PNAC) in Pediatric Patients 1 Month to 17 Years of Age and in Adult Patients, Who Are Anticipated to Need 8 Weeks or Longer of Parenteral Nutrition Treatment","Age Limits: and Adults\n\nInclusion Criteria:\n\n1. Male or female patients, at least 1 month of age.\n2. Patients who require PN for at least 5 days\u002Fweek.\n3. Patients who receive 80% or more of their total energy requirements as PN at enrollment and who are expected to receive 80% or more of their total energy requirements as PN for at least 56 days.\n4. Written informed consent. In case of pediatric patients, informed consent must be obtained from parent(s) or legal representatives. If possible, the assent of the pediatric patient must also be obtained (according to local law).\n\nExclusion Criteria:\n\n1. Use of any other lipid injectable emulsion than SMOFlipid within 6 months prior to study participation\n2. Known hypersensitivity to fish, egg, soybean, or peanut proteins, or to any of the active ingredients or excipients of SMOFlipid.\n3. Hyperlipidemia or disorders of lipid metabolism characterized by hypertriglyceridemia (serum triglyceride concentration \\>250 mg\u002FdL in infants or \\>400 mg\u002FdL in older pediatric and adult patients).\n4. Inborn errors of amino acid metabolism.\n5. Cardiopulmonary instability (including pulmonary edema, cardiac insufficiency, myocardial infarction, acidosis and hemodynamic instability requiring significant vasopressor support).\n6. Hemophagocytic syndrome.\n7. Liver enzymes (either AST, or ALT, or GGT) exceeding 2 x upper limit of normal range\n8. Direct bilirubin exceeding 2 x upper limit of normal range\n9. INR exceeding 2 x upper limit of normal range and patient not receiving oral anticoagulants.\n10. Any known hepatic condition outside of IFALD that will increase direct bilirubin ≥2.0 mg\u002FdL.\n11. Clinically significant abnormal levels of any serum electrolyte (sodium, potassium, magnesium, calcium, chloride, phosphate).\n12. Active bloodstream infection demonstrated by positive blood culture at screening.\n13. Severe renal failure (eGFR \\\u003C15 ml\u002Fmin per 1.73 m2) including patients on renal replacement therapy.\n14. Abnormal blood pH, oxygen saturation, or carbon dioxide.\n15. Pregnancy or lactation.\n16. Participation in another interventional clinical study.\n17. Unlikely to survive longer than 56 days.","1 Month","17 Years",{"count":98,"type":22},[277],"PHASE4","Evaluate the risk of developing EFAD and\u002For PNAC in adult and pediatric patients 1 month of age and older, who are anticipated to need 8 weeks or longer of parenteral nutrition treatment with SMOFlipid.",[28,280,281,282],"Malnutrition","Essential Fatty Acid Deficiency (EFAD)","Parenteral Nutrition Associated Cholestasis","2025-12-03",{"date":285,"type":37},"2025-12-04",{"date":287,"type":37},"2024-10-28",{"date":289,"type":22},"2026-09",{"name":291,"class":292},"Fresenius Kabi","INDUSTRY",5,{"id":295,"slug":296,"hasResults":11,"nctId":297,"briefTitle":298,"officialTitle":299,"acronym":300,"eligibilityCriteria":301,"healthyVolunteers":54,"sex":17,"minAge":55,"maxAge":302,"enrollmentInfo":303,"targetDuration":4,"studyType":23,"phases":305,"briefSummary":306,"conditions":307,"keywords":311,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":316,"lastUpdatePostDateStruct":317,"startDateStruct":319,"completionDateStruct":321,"leadSponsor":323,"locationsCount":77},"100562162","mother-screening-for-relapse-using-mid-upper-arm-circumference-among-children-recovered-from-severe-acute-malnutrition-full-scale-trial-100562162","NCT06599580","Mother Screening for Relapse Using Mid-upper Arm Circumference Among Children Recovered From Severe Acute Malnutrition (Full Scale Trial)","Mother Screening for Relapse Using Mid-upper Arm Circumference Among Children Recovered From Severe Acute Malnutrition (MAMAN)","MAMAN","Inclusion Criteria:\n\n* Caregiver's aged 18 years old or older or a legal guardian or a relative aged 18 or older\n* Child aged 6-54 months\n* Child has recovered from an episode of severe acute malnutrition per Burkinabè national guidelines (weight-for-height ≥ -2 and\u002For mid-upper arm circumference ≥ 12.5 cm in the past month, with the criterion used for admissions corresponding to the original admission criteria)\n* Family is planning to stay in the study area for 6 months\n* Appropriate consent from the caregiver or guardian.\n\nExclusion Criteria:\n\n* Caregiver age under 18 years old, or legal guardian or relatives under 18 years old\n* Child age \\\u003C 6 months or \\> 54 months\n* Twins\u002Fmultiple births\n* Children with feeding issues\n* Did not recover from severe acute malnutrition in the past month\n* Family is planning to move out of the study area in the next 6 months\n* Caregiver or guardian refuses to provide consent","54 Months",{"count":304,"type":22},2400,[25],"A 1:1:1 individually randomized unmasked controlled trial is proposed in which caregivers will be trained to screen their children who have recovered from an episode of SAM (severe acute malnutrition) using MUAC (mid-upper arm circumference) tapes. One arm will include caregiver screening with a mid-upper arm circumference tape and usual monthly follow-up schedule for the first 3 months post enrollment and a final follow-up at 6 months. Another arm will include caregiver screening with a mid-upper arm circumference tape and a reduced follow-up schedule for one visit at 3 months and a final visit at 6 months. The third arm will adhere to the current standard of care, which is no caregiver training to conduct mid-upper arm circumference screenings and monthly clinic-based follow-up appointments for 3 months with a final visit at 6 months post enrollment. Children aged 6-54 months with a documented recovery from uncomplicated severe acute malnutrition that was managed in a participating outpatient nutritional program and their caregivers will be eligible for inclusion in the trial. Caregivers will be trained to screen their children weekly for 6 months following discharge from the nutritional program and will be counseled to bring their child back to the nutritional program should their mid-upper arm circumference value fall in the red zone of the mid-upper arm circumference tape (\\\u003C 11.5 cm). All children will be seen at 3 and 6 months for the primary outcome assessment. By conducting this study, our primary goal is to determine if training caregivers to screen their children for relapse to MAM (moderate acute malnutrition) or SAM (severe acute malnutrition) using mid-upper arm circumference tapes following recovery from SAM (severe acute malnutrition) will reduce the risk of relapse. An additional aim is to assess the level of acceptability of caregivers screening children for malnutrition using mid-upper arm circumference tapes from both a clinic and caregiver perspective.",[28,252,308,309,310],"Malnutrition or Risk of Malnutrition","Hemoglobin Level Measurement","Anemia",[312,313,314,315],"MUAC (mid-upper arm circumference)","Caregiver screening","malnutrition","home based malnutrition screening","2025-11-17",{"date":318,"type":37},"2025-11-20",{"date":320,"type":37},"2025-03-20",{"date":322,"type":22},"2027-11",{"name":117,"class":44},{"id":325,"slug":326,"hasResults":11,"nctId":327,"briefTitle":328,"officialTitle":329,"acronym":330,"eligibilityCriteria":331,"healthyVolunteers":11,"sex":17,"minAge":55,"maxAge":126,"enrollmentInfo":332,"targetDuration":4,"studyType":23,"phases":334,"briefSummary":335,"conditions":336,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":338,"lastUpdatePostDateStruct":339,"startDateStruct":341,"completionDateStruct":343,"leadSponsor":345,"locationsCount":77},"100516913","phase-4-azithromycin-as-adjunctive-treatment-for-uncomplicated-severe-acute-malnutrition-100516913","NCT06010719","Azithromycin as Adjunctive Treatment for Uncomplicated Severe Acute Malnutrition","Azithromycin as Adjunctive Treatment for Uncomplicated Severe Acute Malnutrition: the AMOUR Trial","AMOUR","Children with uncomplicated SAM per Burkina Faso's national guidelines who present to an eligible enrollment site during the study period and meet all of the eligibility criteria below will be considered for enrollment:\n\nInclusion criteria:\n\n* Age 6-59 months\n* WHZ\\\u003C-3 SD or MUAC\\\u003C115 mm\n* Primary residence within a catchment area of an enrollment site\n* Available for full 8-week study (primary endpoint)\n* Not admitted to a nutritional program for SAM treatment in the previous 2 weeks\n* No edema\n* No antibiotic use in the past 7 days\n* No clinical complications requiring antibiotic or inpatient treatment\\*\\*\n* No congenital abnormality or chronic debilitating illness that would lead to predictable growth faltering or reduce likelihood of SAM treatment benefit (such as cerebral palsy, Down syndrome, congenital heart disease, cleft lip\u002Fpalate, etc)\n* No known allergies to macrolides\u002Fazalides or amoxicillin\u002Fpenicillin\n* Sufficient appetite according to a feeding test with RUTF\n* Written informed consent from at least one parent or guardian\n\nExclusion criteria:\n\n* Age less than 6 month or more than 59 months\n* WHZ\\>-3 SD or MUAC\\>115 mm\n* Primary residence is not within a catchment area of an enrollment site\n* Not Available for full 8-week study (primary endpoint)\n* Admitted to a nutritional program for SAM treatment in the previous 2 weeks\n* Edema\n* Antibiotic use in the past 7 days\n* Clinical complications requiring antibiotic or inpatient treatment\\*\\*\n* Congenital abnormality or chronic debilitating illness that would lead to predictable growth faltering or reduce likelihood of SAM treatment benefit (such as cerebral palsy, Down syndrome, congenital heart disease, cleft lip\u002Fpalate, etc)\n* Known allergies to macrolides\u002Fazalides or amoxicillin\u002Fpenicillin\n* No Sufficient appetite according to a feeding test with RUTF\n* No Written informed consent from at least one parent or guardian\n\n  * Per Burkinabé guidelines, children any of the following conditions will not be eligible for the trial and will be referred to an inpatient facility: MUAC \\\u003C115 mm with complications; MUAC \\\u003C115 mm plus edema; bipedal pitting edema; anorexia or no appetite for RUTF; diarrhea and dehydration; unable to ingest anything without vomiting; severe pneumonia; open cutaneous lesions; hypothermia (35\\*C); fever (38.5\\*C); paleness suggesting severe anemia; hypoglycemia; very weak, lethargic, or unconscious; convulsions; signs of vitamin A deficiency; or a condition requiring IV infusion or an NG tube.",{"count":333,"type":22},3000,[277],"Amoxicillin is recommended by the World Health Organization (WHO) as adjunctive therapy for the treatment of uncomplicated severe acute malnutrition (SAM). Because children with uncomplicated SAM may have asymptomatic infection due to immune suppression, presumptive treatment with a broad-spectrum antibiotic may be beneficial by clearing any existing infection and improving outcomes. Two randomized placebo-controlled randomized trials have evaluated amoxicillin for uncomplicated SAM and have found conflicting results. These results may indicate either that antibiotics are not helpful for the management of uncomplicated SAM, or that a better antibiotic is needed. Recently, the investigators demonstrated that biannual mass azithromycin distribution as a single oral dose reduces all-cause child mortality in sub-Saharan Africa. Children with uncomplicated SAM, who have an elevated risk of mortality relative to their well-nourished peers, may particularly benefit from presumptive azithromycin treatment. Our pilot data demonstrated feasibility in rapid enrollment of children with uncomplicated SAM in our study area, and showed no significant difference between azithromycin and amoxicillin, demonstrating equipoise for a full-scale trial. Here, the investigators propose an individually randomized trial in which children will be randomized to a) azithromycin, b) amoxicillin, or c) placebo, and evaluated for differences in weight gain, nutritional recovery, and the gut microbiome. The results of this study will strengthen the evidence base for policy related to the use of antibiotics as part of the management of uncomplicated SAM, including additional evidence of amoxicillin versus placebo as well as evaluation of an antibiotic class that has not been considered for uncomplicated SAM, which may lead to changes in guidelines for treatment.",[28,337],"Severe Acute Malnutrition","2025-10-13",{"date":340,"type":37},"2025-10-15",{"date":342,"type":37},"2024-10-23",{"date":344,"type":22},"2028-12-29",{"name":117,"class":44},{"id":347,"slug":348,"hasResults":11,"nctId":349,"briefTitle":350,"officialTitle":350,"acronym":4,"eligibilityCriteria":351,"healthyVolunteers":54,"sex":17,"minAge":55,"maxAge":352,"enrollmentInfo":353,"targetDuration":4,"studyType":23,"phases":355,"briefSummary":357,"conditions":358,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":360,"lastUpdatePostDateStruct":361,"startDateStruct":363,"completionDateStruct":365,"leadSponsor":366,"locationsCount":368},"100479151","phase-3-lactoferrin-and-lysozyme-supplementation-for-long-term-diarrhea-sequelae-100479151","NCT05519254","Lactoferrin and Lysozyme Supplementation for Long-term Diarrhea Sequelae","Inclusion Criteria:\n\n* Age 6-24 months\n* Managed as an outpatient or inpatient for diarrhea at one of the recruiting sites\n* MUAC \\\u003C12.5 cm at the time of screening\n* Plan to stay within the study area for the next 6 months or greater\n\nExclusion Criteria:\n\n* Age younger than 6 months or older than 24 months\n* Caregiver does not provide consent to study participation\n* History of 2 or more blood transfusions in the past 12 months\n* Exclusively breastfeeding at the time of enrollment\n* History of congenital defect or syndrome that prevents age-appropriate feeding (e.g. cleft palate)\n* History of allergy to dairy products\n* Child is not ready to return home (is not yet discharged), or discharged against medical advice\n* Unwilling to participate in the dual sugar permeability sub-study if selected\n* Enrollment in another study","24 Months",{"count":354,"type":22},600,[356],"PHASE3","Children in low- and middle-income countries who are hospitalized for diarrhea and also have malnutrition are at high risk for illness and death in the 6 months period following treatment for diarrhoea despite receiving current guideline recommended diarrhea management (such as oral rehydration solution, or \"ORS\"). This study will test whether nutritional supplements made from milk (lactoferrin or lysozyme) or a combination of the two (lactoferrin and lysozyme) will prevent children from having repeated diarrhea episodes and help improve their nutrition by improving their stomach health or preventing new disease during this 6-month period. The study is taking place at 7 hospitals in Western Kenya. Six hundred participants will be enrolled if they provide informed consent to participate, are aged 6-24 months, were hospitalized with diarrhea and malnutrition and have been managed by the facility nutritionists and ready to return home. Participation in the study will entail providing information on the child's health history, collection of stool samples, blood, and potentially urine. The caregiver will be provided sachets of the investigational product to take home and mix daily with their child's porridge or other complimentary food, and asked to return to the clinic 4 times in the subsequent 6 months, and also consent to having a community health worker visit their home every two weeks for a follow up visit. The risks to the participant and their caregiver are minimal. The information gained in this study will help us create new treatments and develop new strategies to treat sick children to prevent death and illness.",[359,63,28],"Diarrhea","2025-09-04",{"date":362,"type":37},"2025-09-11",{"date":364,"type":37},"2023-03-10",{"date":115,"type":22},{"name":367,"class":44},"University of Washington",4,{"id":370,"slug":371,"hasResults":11,"nctId":372,"briefTitle":373,"officialTitle":373,"acronym":4,"eligibilityCriteria":374,"healthyVolunteers":11,"sex":17,"minAge":55,"maxAge":56,"enrollmentInfo":375,"targetDuration":4,"studyType":376,"phases":4,"briefSummary":377,"conditions":378,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":379,"lastUpdatePostDateStruct":380,"startDateStruct":382,"completionDateStruct":384,"leadSponsor":386,"locationsCount":77},"100571116","prevalence-of-intestinal-parasitic-infections-in-under-five-children-with-malnutrition-in-sohag-egypt-100571116","NCT06716060","Prevalence of Intestinal Parasitic Infections in Under-Five Children With Malnutrition in Sohag, Egypt","Inclusion Criteria:\n\n\\- 100 children aged between 6 months and 5 years, having malnutrition symptoms (growth retardation, failure to thrive, lethargy, generalized weakness, xerophthalmia, etc.) will be randomly recruited from pediatric outpatient clinics, Faculty of medicine, Sohag University.\n\nExclusion Criteria:\n\n* children who took specific anthelmintic, antiprotozoal, purgatives or anti-diarrheal drugs three weeks before the stool sampling.",{"count":98,"type":22},"OBSERVATIONAL","This study aims to estimate the prevalence of intestinal parasitic infections in under-five children with malnutrition.",[28],"2024-11-29",{"date":381,"type":37},"2024-12-04",{"date":383,"type":37},"2024-08-20",{"date":385,"type":22},"2025-08-01",{"name":387,"class":44},"Sohag University",{"id":389,"slug":390,"hasResults":11,"nctId":391,"briefTitle":392,"officialTitle":393,"acronym":4,"eligibilityCriteria":394,"healthyVolunteers":54,"sex":17,"minAge":55,"maxAge":352,"enrollmentInfo":395,"targetDuration":4,"studyType":23,"phases":397,"briefSummary":398,"conditions":399,"keywords":400,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":405,"lastUpdatePostDateStruct":406,"startDateStruct":408,"completionDateStruct":410,"leadSponsor":412,"locationsCount":77},"100417860","hens-hatching-hope-100417860","NCT04721197","Hens Hatching Hope","Program Evaluation: Eggs Hatching Hope. Providing Egg Vouchers to Women With Young Children in Rural Honduras.","Inclusion Criteria:\n\n* Healthy children ages 6 to 24 months at the time the study begins\n* No cerebral palsy, birth defect or condition that may affect their growth or development.\n* Children living in the department of Intibucá, Honduras\n\nExclusion Criteria:\n\n* Children from families that are considering leaving the region within the next 12 months\n* Known egg allergy",{"count":396,"type":22},400,[25],"The study is a prospective community-cluster non-randomized trial that will evaluate the effectiveness of a program that will provide 30-day egg vouchers to mothers of 6 to 24 month-old children living in rural areas of Intibucá, Honduras.",[28],[401,402,403,404],"Stunting","Eggs","diarrhea","complementary foods","2024-09-24",{"date":407,"type":37},"2024-09-25",{"date":409,"type":37},"2021-01-23",{"date":411,"type":22},"2026-01-22",{"name":413,"class":44},"Georgia Southern University",{"id":415,"slug":416,"hasResults":11,"nctId":417,"briefTitle":418,"officialTitle":418,"acronym":4,"eligibilityCriteria":419,"healthyVolunteers":11,"sex":17,"minAge":55,"maxAge":420,"enrollmentInfo":421,"targetDuration":4,"studyType":23,"phases":423,"briefSummary":424,"conditions":425,"keywords":426,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":432,"lastUpdatePostDateStruct":433,"startDateStruct":435,"completionDateStruct":436,"leadSponsor":438,"locationsCount":77},"100545511","effectiveness-of-a-microbiome-directed-food-to-promote-programmatic-and-sustained-nutritional-recovery-among-children-with-uncomplicated-acute-malnutrition-100545511","NCT06382857","Effectiveness of a Microbiome-directed Food to Promote Programmatic and Sustained Nutritional Recovery Among Children With Uncomplicated Acute Malnutrition","Inclusion Criteria:\n\n* for children with Severe Acute Malnutrition (SAM): MUAC \\\u003C 115 mm and\u002For WLZ \\\u003C -3 and\u002For mild (+) or moderate (++) edema\n* for children with Moderate Acute Malnutrition (MAM): 115 mm ≤ MUAC \\\u003C 125 mm and\u002For -3 ≤ WHZ \\\u003C -2\n* Caregiver providing informed consent\n\nExclusion Criteria:\n\n* Medical complications requiring inpatient treatment, as identified by the national protocol\n* Not eating\u002Flack of appetite (as informed by appetite test and investigator judgement)\n* Re-admission into the program within 2 months of previous default\n* for children with Severe Acute Malnutrition (SAM): Referral from inpatient care (therapeutic feeding center, TFC) or supplementary feeding program (SFP)\n* for children with Moderate Acute Malnutrition (MAM): Referral from SAM treatment (TFC or OTP)\n* Presence of congenital abnormality or underlying chronic disease that may affect growth or risk of infection\n* Known contraindication\u002F hypersensitivity\u002Fallergy to study interventions (chickpea\u002Fsoy flour, banana, peanut)\n* Residence outside the study catchment area or in a non-fixed (e.g. nomadic) community","23 Months",{"count":422,"type":22},7356,[25],"This study is an individually randomized controlled trial comparing microbiome-directed foods to standard nutritional therapy among children aged 6 to \\\u003C 24 months with uncomplicated acute malnutrition in terms of programmatic recovery by 12 weeks from admission and sustained recovery at 24 weeks from admission.",[28],[280,427,428,429,430,431],"SAM","MAM","Child","MDF","Microbiome","2024-08-26",{"date":434,"type":37},"2024-08-27",{"date":173,"type":37},{"date":437,"type":22},"2026-02-01",{"name":439,"class":44},"Epicentre",{"id":441,"slug":442,"hasResults":11,"nctId":443,"briefTitle":444,"officialTitle":445,"acronym":446,"eligibilityCriteria":447,"healthyVolunteers":11,"sex":17,"minAge":448,"maxAge":56,"enrollmentInfo":449,"targetDuration":4,"studyType":23,"phases":451,"briefSummary":452,"conditions":453,"keywords":456,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":461,"lastUpdatePostDateStruct":462,"startDateStruct":464,"completionDateStruct":466,"leadSponsor":468,"locationsCount":470},"100500057","double-duty-interventions-and-its-impact-on-double-burden-of-malnutrition-in-children-under-five-years-100500057","NCT05791305","Double Duty Interventions and Its Impact on Double Burden of Malnutrition in Children Under Five Years","Double Duty Interventions and Its Impact on DBM Among Children Under Five Years Ethiopia: A Cluster Randomized Controlled Trial","DBM","Inclusion Criteria:\n\n* who attend the intervention\n\nExclusion Criteria:\n\n* who are not attended the intervention","2 Years",{"count":450,"type":22},456,[25],"Background: Double burden of malnutrition is an emerging public health problem among children under-five years due to the inevitable consequences of nutritional transition. Addressing these two contrasting forms of malnutrition (undernutrition and overnutrition) simultaneously brings an enormous challenge to the food and nutrition policies of developing countries like Ethiopia. Children under five ages are more vulnerable to DBM, especially during the first year of their life due to high growth and inadequate diet. Hence, there has been a paradigm shift in thinking to reduce its effect on the health of children. However, interventions that are used to address these different kinds of malnutrition are implemented through different governance and still, they are isolated and disintegrated each other. Therefore, double-duty interventions can tackle the risk of both nutritional problems simultaneously in an integrated approach through nutrition behavior change communication.\n\nObjective: Therefore, the main aim of this pilot study is to assess the effect of selected double-duty interventions on the double burden of malnutrition among children under five years in Debre Berhan City, Ethiopia.",[280,28,454,193,455],"Obesity","Thinness",[457,458,459,193,460],"Double burden of malnutrition","Double-duty interventions","Children under five years","Overnutrition","2024-08-07",{"date":463,"type":37},"2024-08-09",{"date":465,"type":37},"2023-04-10",{"date":467,"type":22},"2025-12-30",{"name":469,"class":44},"Debre Berhan University",2,{"id":472,"slug":473,"hasResults":11,"nctId":474,"briefTitle":475,"officialTitle":476,"acronym":4,"eligibilityCriteria":477,"healthyVolunteers":54,"sex":245,"minAge":19,"maxAge":478,"enrollmentInfo":479,"targetDuration":4,"studyType":23,"phases":481,"briefSummary":482,"conditions":483,"keywords":487,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":492,"lastUpdatePostDateStruct":493,"startDateStruct":495,"completionDateStruct":497,"leadSponsor":498,"locationsCount":77},"100503569","impact-of-benazir-nashonuma-program-bnp-on-maternal-and-child-nutritional-status-100503569","NCT05836961","Impact of Benazir Nashonuma Program (BNP) on Maternal and Child Nutritional Status","Evaluating Effectiveness of Benazir Nashonuma Program (BNP) on Maternal and Infant Outcomes: A Non-randomized Intervention Study in Sindh and Punjab","Inclusion Criteria:\n\nIntervention arm: All pregnant women in their first or second trimester, who are enrolled in Benazir Nashonuma Program (BNP).\n\nNon-intervention arm: All pregnant women in their first or second trimester, who are not enrolled in Benazir Nashonuma Program (BNP).\n\nExclusion Criteria:\n\n* Women who intend to migrate or relocate for more than 3 months during the study period will be excluded from the study.\n* Women in the non intervention group who are consuming specialized nutritious food (SNF) from any source at the time of enrollment will be excluded from the study.","49 Years",{"count":480,"type":22},5500,[25],"The purpose of this study is to evaluate the impact of Benazir Nashonuma Program (BNP) which includes specialized nutritious food (SNF) augmented with specific reproductive health interventions during pregnancy on proportion of low birthweight babies and stunting among children, in low income setting of Pakistan. The study aims to answer if:\n\n1. Utilization of Benazir Nashonuma Program (BNP) among pregnant women is effective in reducing the proportion of low birthweight babies, compared to pregnant women who are not utilizing the program, among low income setting population.\n2. Utilization of Benazir Nashonuma Program (BNP) is effective in reducing the proportion of stunting among children, compared to those not utilizing the program, among low income setting population.\n\nParticipants who are enrolled in the Benazir Nashonuma Program (receiving intervention) and those who are not enrolled (not receiving intervention) will be followed throughout pregnancy till delivery. After delivery mother-baby dyad will be followed for a period of 12 months. Compliance of supplementation will be measured, and outcomes (low birthweight and stunting) observed throughout the follow up.",[484,401,63,28,485,486],"Low Birthweight","Iron Deficiency Anemia","Dietary Habits",[488,489,490,491,401],"Intervention study","Maternal and child nutrition","Benazir Nashonuma Program (BNP)","Low birthweight","2023-04-28",{"date":494,"type":37},"2023-05-01",{"date":496,"type":37},"2023-02-01",{"date":289,"type":22},{"name":265,"class":44}]