[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"malnutrition-or-risk-of-malnutrition\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:malnutrition-or-risk-of-malnutrition":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,52,88,114,145,176,203],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100626308","partial-enteral-nutrition-to-prevent-weight-loss-and-sarcopenia-in-ibd-patients-at-nutritional-risk---simba-100626308",false,"NCT07433946","Partial Enteral Nutrition to Prevent Weight Loss and Sarcopenia in IBD Patients at Nutritional Risk - SIMBA","Partial Enteral Nutrition Effects on Weight Loss and Sarcopenia in Patients With IBD at Risk of Caloric-Protein Malnutrition - SIMBA","SIMBA","Inclusion Criteria:\n\n* Age 18-65 years\n* Diagnosis of Crohn's Disease or Ulcerative Colitis\n* At risk of malnutrition according to the Malnutrition Universal Screening Tool (MUST)\n* Ability to provide informed consent\n* Women of childbearing potential must use effective contraception\n\nExclusion Criteria:\n\n* Following an exclusion diet (CDED)\n* Current hospitalization\n* Pregnancy\n* Requirement for a low-protein diet","ALL","18 Years","65 Years",{"count":21,"type":22},146,"ESTIMATED","INTERVENTIONAL",[25],"NA","This is a multicenter, open-label, randomized two-arm interventional nutritional study evaluating the effects of partial enteral nutrition (LH VIOLA) in patients with Inflammatory Bowel Disease (IBD) at risk of malnutrition. A total of 146 patients (73 per arm) will be enrolled across 4 centers.\n\nIBD, including Crohn's Disease and Ulcerative Colitis, is associated with malabsorption, weight loss, sarcopenia, and malnutrition, which negatively impact quality of life and treatment outcomes. Nutritional assessment using the Malnutrition Universal Screening Tool (MUST) will identify patients at risk.\n\nParticipants will be randomized to receive either nutritional counseling alone or counseling plus oral LH VIOLA supplementation (≥412 kcal\u002Fday) for 16 weeks. The primary objective is to evaluate maintenance or recovery of body weight at 16 weeks. Secondary objectives include assessment of weight at 24 weeks, muscle strength (handgrip), body composition and metabolic parameters (BIA\u002FBIVA, vitamin B12\u002FD, pre-albumin), quality of life (SF-12), economic impact, adherence, gastrointestinal tolerability, and reduction in malnutrition risk (MUST score).\n\nThe study duration per patient is 24 weeks (16 weeks of intervention plus 8 weeks follow-up), with a total study duration of 18 months. The sample size is powered to detect an increase from 40% to 65% in patients achieving weight maintenance or gain at 16 weeks, accounting for a 15% dropout rate.",[28,29,30,31],"Ulcerative Colitis (Disorder)","Crohn Disease","Malnutrition or Risk of Malnutrition","IBD",[31,33,34,35,36,37,38],"Malnutrition","Sarcopenia","ONS","enteral nutrition","weight loss","clinical nutrition","RECRUITING","2026-06-22",{"date":42,"type":43},"2026-06-25","ACTUAL",{"date":45,"type":43},"2026-03-09",{"date":47,"type":22},"2027-01-31",{"name":49,"class":50},"Lionhealth Srl Società Benefit","INDUSTRY",4,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":60,"sex":61,"minAge":19,"maxAge":62,"enrollmentInfo":63,"targetDuration":4,"studyType":23,"phases":65,"briefSummary":66,"conditions":67,"keywords":69,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":87},"100642924","the-savor-study-appetite-and-physiological-responses-100642924","NCT07636369","The SAVOR Study: Appetite and Physiological Responses","Seniors' Appetite: Vibrant Opportunities for Revitalization (SAVOR)","SAVOR","Inclusion Criteria:\n\n* Postmenopausal female\n* Aged 65-74 years\n* Habitual breakfast consumer (consumes breakfast between 7am to 10am)\n* Willingness to consume meals and follow intervention protocol\n* English speaking\n\nExclusion Criteria:\n\n* BMI ≥ 27.5\n* Diagnosed with medical condition that may influence appetite or microbiome (e.g. diabetes, thyroid disorders, gastrointestinal diseases)\n* Currently taking any medications or supplements that may influence appetite or the microbiome (e.g. probiotics, antibiotics, appetite stimulants\u002Fsuppressants) one month prior to their first visit in consultation with study physician, PI and study team\n* Following a special diet for weight management (e.g. low-calorie, low carbohydrate)\n* History of bariatrics surgery\n* Intentional attempt to change body weight or composition\n* History of severe vasovagal syncope (blackouts or near faints) following blood draw\n* Drug abuse within last 5 years\n* Excessive alcoholic beverage consumption \\> 2 servings per day (1 serving defined as 360 mL beer, 150 mL wine or 45 mL distilled spirits)\n* Smoking (cigarette, e-cigarette, cigar, pipe, vape)\n* Engaging in habitual vigorous physical activity (as defined by physical activity questionnaire-PAQ)\n* Loose teeth or jaw pain\n* Not missing \\> 2 non-wisdom molars\n* Involvement in other clinical studies that may influence the outcome of the study\n* A study team member or their immediate family member",true,"FEMALE","74 Years",{"count":64,"type":22},20,[25],"The study aims to identify key physiological factors that differentiate older adults with healthy appetites from those experiencing appetite decline. The investigators hypothesize that seniors experiencing appetite decline will exhibit distinct oro-sensory, gastrointestinal, and hormonal profiles compared to seniors with healthy appetites, suggesting underlying biological mechanisms contributing to reduced appetite.",[68,30],"Anorexia of Aging",[70,71,72,73,74,75],"appetite decline","elderly","anorexia of aging","malnutrition","Asian seniors","appetite regulation","NOT_YET_RECRUITING","2026-06-03",{"date":79,"type":43},"2026-06-09",{"date":81,"type":22},"2026-06",{"date":83,"type":22},"2026-10",{"name":85,"class":86},"Singapore Institute of Food and Biotechnology Innovation","OTHER_GOV",1,{"id":89,"slug":90,"hasResults":11,"nctId":91,"briefTitle":92,"officialTitle":92,"acronym":93,"eligibilityCriteria":94,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":95,"targetDuration":4,"studyType":23,"phases":97,"briefSummary":98,"conditions":99,"keywords":100,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":87},"100612539","long-term-muscle-synthetic-effects-of-intradialytic-parenteral-nutrition-in-chronic-hemodialysis-patients-100612539","NCT07254897","Long-term Muscle Synthetic Effects of Intradialytic Parenteral Nutrition in Chronic Hemodialysis Patients","LOTUS","Inclusion Criteria:\n\n* Age above 18 years\n* Receiving HD treatment over 3 months\n* Receiving HD treatment 3 times per week for at least 4 hours per session\n* 24-hour urine production \\\u003C 100 mL\n* Adequate dialysis dose (eKt\u002FV over 1.2)\n* AV fistula with blood flow (measured invasively or by Doppler ultrasound) over 750 mL\u002Fmin\n\nExclusion Criteria:\n\n* Occurrence of intradialytic hypotension in the last month, defined by systolic blood pressure \\\u003C 90 mm Hg combined with a nursing intervention\n* Hospitalization \\\u003C 3 months before inclusion\n* Active infection or inflammation at randomization\n* Use of oral or intravenous corticosteroids\n* Incapacitation\n* Patients who are not expected to be able to complete the study protocol (e.g., due to a planned kidney transplantation within the planned study time frame)\n* Pregnancy\n* Use of oral anticoagulants or antiplatelet agents that cannot be safely stopped during the study\n* Diabetes mellitus\n* AV fistula with recirculation",{"count":96,"type":22},16,[25],"This study examines the effects of intradialytic parenteral nutrition (IDPN) on muscle growth and blood pressure in patients undergoing chronic hemodialysis.",[30],[101,102,103],"hemodialysis","myofibrillar fractional synthetic rate","intradialytic parenteral nutrition","2025-11-20",{"date":106,"type":43},"2025-11-28",{"date":108,"type":22},"2026-01-01",{"date":110,"type":22},"2027-09-01",{"name":112,"class":113},"Erasmus Medical Center","OTHER",{"id":115,"slug":116,"hasResults":11,"nctId":117,"briefTitle":118,"officialTitle":119,"acronym":120,"eligibilityCriteria":121,"healthyVolunteers":60,"sex":17,"minAge":122,"maxAge":123,"enrollmentInfo":124,"targetDuration":4,"studyType":23,"phases":126,"briefSummary":127,"conditions":128,"keywords":133,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":137,"lastUpdatePostDateStruct":138,"startDateStruct":139,"completionDateStruct":141,"leadSponsor":143,"locationsCount":87},"100562162","mother-screening-for-relapse-using-mid-upper-arm-circumference-among-children-recovered-from-severe-acute-malnutrition-full-scale-trial-100562162","NCT06599580","Mother Screening for Relapse Using Mid-upper Arm Circumference Among Children Recovered From Severe Acute Malnutrition (Full Scale Trial)","Mother Screening for Relapse Using Mid-upper Arm Circumference Among Children Recovered From Severe Acute Malnutrition (MAMAN)","MAMAN","Inclusion Criteria:\n\n* Caregiver's aged 18 years old or older or a legal guardian or a relative aged 18 or older\n* Child aged 6-54 months\n* Child has recovered from an episode of severe acute malnutrition per Burkinabè national guidelines (weight-for-height ≥ -2 and\u002For mid-upper arm circumference ≥ 12.5 cm in the past month, with the criterion used for admissions corresponding to the original admission criteria)\n* Family is planning to stay in the study area for 6 months\n* Appropriate consent from the caregiver or guardian.\n\nExclusion Criteria:\n\n* Caregiver age under 18 years old, or legal guardian or relatives under 18 years old\n* Child age \\\u003C 6 months or \\> 54 months\n* Twins\u002Fmultiple births\n* Children with feeding issues\n* Did not recover from severe acute malnutrition in the past month\n* Family is planning to move out of the study area in the next 6 months\n* Caregiver or guardian refuses to provide consent","6 Months","54 Months",{"count":125,"type":22},2400,[25],"A 1:1:1 individually randomized unmasked controlled trial is proposed in which caregivers will be trained to screen their children who have recovered from an episode of SAM (severe acute malnutrition) using MUAC (mid-upper arm circumference) tapes. One arm will include caregiver screening with a mid-upper arm circumference tape and usual monthly follow-up schedule for the first 3 months post enrollment and a final follow-up at 6 months. Another arm will include caregiver screening with a mid-upper arm circumference tape and a reduced follow-up schedule for one visit at 3 months and a final visit at 6 months. The third arm will adhere to the current standard of care, which is no caregiver training to conduct mid-upper arm circumference screenings and monthly clinic-based follow-up appointments for 3 months with a final visit at 6 months post enrollment. Children aged 6-54 months with a documented recovery from uncomplicated severe acute malnutrition that was managed in a participating outpatient nutritional program and their caregivers will be eligible for inclusion in the trial. Caregivers will be trained to screen their children weekly for 6 months following discharge from the nutritional program and will be counseled to bring their child back to the nutritional program should their mid-upper arm circumference value fall in the red zone of the mid-upper arm circumference tape (\\\u003C 11.5 cm). All children will be seen at 3 and 6 months for the primary outcome assessment. By conducting this study, our primary goal is to determine if training caregivers to screen their children for relapse to MAM (moderate acute malnutrition) or SAM (severe acute malnutrition) using mid-upper arm circumference tapes following recovery from SAM (severe acute malnutrition) will reduce the risk of relapse. An additional aim is to assess the level of acceptability of caregivers screening children for malnutrition using mid-upper arm circumference tapes from both a clinic and caregiver perspective.",[129,130,30,131,132],"Malnutrition, Child","Malnutrition, Infant","Hemoglobin Level Measurement","Anemia",[134,135,73,136],"MUAC (mid-upper arm circumference)","Caregiver screening","home based malnutrition screening","2025-11-17",{"date":104,"type":43},{"date":140,"type":43},"2025-03-20",{"date":142,"type":22},"2027-11",{"name":144,"class":113},"University of California, San Francisco",{"id":146,"slug":147,"hasResults":11,"nctId":148,"briefTitle":149,"officialTitle":150,"acronym":151,"eligibilityCriteria":152,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":153,"targetDuration":4,"studyType":23,"phases":155,"briefSummary":156,"conditions":157,"keywords":159,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":167,"lastUpdatePostDateStruct":168,"startDateStruct":170,"completionDateStruct":172,"leadSponsor":174,"locationsCount":87},"100599674","short-term-nutritional-enhancement-combined-with-health-education-in-postoperative-colorectal-cancer-patients-a-randomized-controlled-trial-100599674","NCT07087561","Short-Term Nutritional Enhancement Combined With Health Education in Postoperative Colorectal Cancer Patients: A Randomized Controlled Trial","The Effects and Mechanisms of Short-Term Nutritional Enhancement Combined With Health Education on Clinical Outcomes in Postoperative Patients With Colorectal Cancer: A Multicenter, Open-Label, Randomized Controlled Trial","NUTRI-CRC","Inclusion Criteria:\n\n* Signed informed consent\n* Age ≥ 18 years\n* Pathologically confirmed diagnosis of colon or rectal cancer\n* Mentally alert and capable of communication\n* Willing to participate in follow-up, with an estimated life expectancy of more than 6 months\n* Cancer stage IIa, IIb, or IIIa\n\nExclusion Criteria:\n\n* Nutritional risk screening score of mPG-SGA \\\u003C 2 or NRS-2002 \\\u003C 3\n* Diagnosed with AIDS\n* History of organ transplantation\n* Pregnant or breastfeeding women\n* Concurrent participation in another interventional clinical trial\n* Inability to care for oneself independently\n* Inability to engage in physical activity during the perioperative period\n* Severe comorbid conditions (e.g., uncontrolled cardiovascular disease, severe hepatic or renal dysfunction)\n* Known allergy or intolerance to components of the nutritional supplements used in the study",{"count":154,"type":22},360,[25],"This clinical study aims to evaluate whether short-term personalized nutritional support, when combined with structured health education, can improve nutritional status, quality of life, and clinical outcomes in patients who have undergone surgery for colorectal cancer (CRC). Colorectal cancer is one of the most common cancers worldwide, and many patients experience malnutrition and poor physical condition during treatment, which can negatively affect recovery and long-term survival.\n\nIn this multicenter, randomized, controlled clinical trial, approximately 360 postoperative CRC patients will be enrolled and randomly assigned to one of four groups: (A) nutritional enhancement combined with health education, (B) health education alone, (C) nutritional enhancement alone, or (D) standard care (control group). Nutritional support will include individualized diet counseling and oral nutritional supplements tailored to each patient's needs. Health education will be delivered using an \"Internet Plus\" approach, including weekly educational videos and expert consultations focusing on nutrition, physical activity, and mental health.\n\nThe primary objectives are to determine whether these interventions can improve patients' short-term nutritional status and quality of life. Secondary outcomes include the impact of interventions on long-term survival, treatment-related side effects, patient adherence to nutrition recommendations, and psychological well-being.\n\nThis study will also investigate the biological mechanisms underlying the clinical effects by analyzing changes in the gut microbiome, blood-based metabolic profiles, and immune responses. Blood, stool, and tumor tissue samples will be collected and analyzed using advanced techniques, including untargeted metabolomics, metagenomics, and single-cell sequencing.\n\nThis trial is designed to provide evidence for the integration of nutritional strategies into routine cancer care, and to guide the development of more personalized, effective nutrition-based therapies for colorectal cancer patients. Participants will be followed for up to annually up to 5 years to evaluate both clinical outcomes and biological markers of response.",[158,30],"Colorectal Cancer (Diagnosis)",[160,161,162,163,164,165,166],"Colorectal Cancer","Nutrition Support","Health Education","Patient-Reported Outcomes","Nutritional Risk","Cancer Rehabilitation","Randomized Controlled Trial","2025-07-18",{"date":169,"type":43},"2025-07-28",{"date":171,"type":43},"2024-10-10",{"date":173,"type":22},"2030-10-10",{"name":175,"class":113},"Xiaoqin Luo",{"id":177,"slug":178,"hasResults":11,"nctId":179,"briefTitle":180,"officialTitle":181,"acronym":182,"eligibilityCriteria":183,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":184,"targetDuration":4,"studyType":186,"phases":4,"briefSummary":187,"conditions":188,"keywords":190,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":194,"lastUpdatePostDateStruct":195,"startDateStruct":197,"completionDateStruct":199,"leadSponsor":201,"locationsCount":87},"100573031","nutritional-intake-in-patients-on-noninvasive-ventilation-a-prospective-observational-study-100573031","NCT06740981","Nutritional Intake in Patients on Noninvasive Ventilation: a Prospective Observational Study","Nutrition in Critically Ill Patients Undergoing Non-Invasive Ventilation: a Prospective Single-Center Study","PRO-NUTRINIV","Inclusion Criteria:\n\n* Age of 18 years or more\n* Hospitalization in the participant ordinary wards, intermediate care units and intensive care unit at the Maggiore della Carità University Hospital, Novara, Italy\n* Admission for acute respiratory failure of any cause requiring noninvasive ventilation treatment within 24 hours from hospital admission\n\nExclusion Criteria:\n\n* Palliative noninvasive ventilation treatment\n* Contraindication to oral nutrition from hospital admission\n* Patients admitted for surgical or gastroenterological diagnosis\n* Severe immunocompromised patients or patients undergoing therapies contraindicating oral nutrition",{"count":185,"type":22},126,"OBSERVATIONAL","The primary objective is to quantify the caloric and protein intake in adult participants with acute respiratory failure who start a noninvasive ventilation treatment. The main question is:\n\n\\- Are participants meeting their caloric and protein target during noninvasive ventilation treatment? Participants will complete a five-day food diary collection starting from the initiation of noninvasive ventilation treatment.",[30,189],"Acute Respiratory Failure",[191,192,193],"noninvasive ventilation","nutrition","critical illness","2024-12-19",{"date":196,"type":43},"2024-12-27",{"date":198,"type":22},"2024-12-16",{"date":200,"type":22},"2027-12",{"name":202,"class":113},"Università degli Studi del Piemonte Orientale Amedeo Avogadro",{"id":204,"slug":205,"hasResults":11,"nctId":206,"briefTitle":207,"officialTitle":208,"acronym":209,"eligibilityCriteria":210,"healthyVolunteers":60,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":211,"targetDuration":4,"studyType":186,"phases":4,"briefSummary":213,"conditions":214,"keywords":216,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":219,"lastUpdatePostDateStruct":220,"startDateStruct":222,"completionDateStruct":224,"leadSponsor":226,"locationsCount":228},"100564221","screening-for-malnutrition-in-obese-patients-100564221","NCT06626360","Screening for Malnutrition in Obese Patients","SCreening fOr Malnutrition and Obesity in Patients With COVID-19 and Other Diseases","SCOOP","Inclusion Criteria:\n\n* Age 18 years or older\n* Overweight (BMI of 25 kg\u002Fm² or higher)\n\nExclusion Criteria:\n\n* Physically or mentally unable to participate.\n* Severe cognitive disorder or severe emotional instability, as assessed by the attending nurse or physician.\n* Insufficient proficiency in the Dutch language to express themselves properly and no interpreter or assistant to help.\n* Patient resides in a nursing or care home.",{"count":212,"type":22},2000,"More than half of the Dutch population is overweight or obese, which is associated with an increased risk of COVID-19 and worse outcomes during a COVID-19 infection. In addition, malnutrition and loss of muscle mass are often reported with COVID-19, as well as with cancer and other diseases. Malnutrition and overweight or obesity can coexist, even within the same individual. It is still unclear which mechanisms contribute to the worse outcomes of COVID-19 and other diseases in case of overweight, malnutrition, and a combination of both. The aim of this study is to identify which parameters are associated with worse disease outcomes through literature research and database research (COVID-19 and cancer, more than 150.000 participants). In addition, a clinical study will be conducted aiming to develop a simple screening tool for the recognition of the coexistence of malnutrition and overweight or obesity in clinical practice.",[215,30],"Overweight and Obese Adults",[217,218,33],"Overweight","Obesity","2024-11-07",{"date":221,"type":43},"2024-11-08",{"date":223,"type":43},"2024-10-02",{"date":225,"type":22},"2025-08-31",{"name":227,"class":113},"HAN University of Applied Sciences",3]