[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"malnutrition-severe\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:malnutrition-severe":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,48,79,103,131],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":31,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100639425","optimax-will-test-whether-sq-lns-incentivises-vaccination-uptake-in-rural-chad-and-niger-with-a-cost-effectiveness-analysis-it-will-also-look-at-whether-having-received-sq-lns-before-becoming-malnourished-leads-to-better-outcomes-for-children-treated-under-the-optima-protocol-100639425",false,"NCT07592260","OptiMAx Will Test Whether SQ-LNS Incentivises Vaccination Uptake in Rural Chad and Niger, With a Cost Effectiveness Analysis. It Will Also Look at Whether Having Received SQ-LNS Before Becoming Malnourished Leads to Better Outcomes for Children Treated Under the OptiMA Protocol.","OptiMAx: Incentivizing EPI Vaccination Via Distribution of SQ-LNS Nutritional Supplementation to Children From Age 6-11 Months Until 18 Months of Age in Rural Chad and Niger, With a Cost Effectiveness Analysis Protocol for a Research Study Nested in the OptiMA Research Study in Ngouri Health District, Lake Region, Chad and Mirriah Health District, Zinder Region, Niger","OptiMAx","Inclusion Criteria:\n\n* All non-malnourished children between 6 and 12 months of age will be eligible for SQ-LNS supplementation until they reach 18 months of age.\n\nFor the annual household surveys,\n\n* Children aged 6 to 59 months will be surveyed on MUAC status and other malnutrition-related issues, while the immunization analysis will focus on children aged 12 to 23 months;\n* With the informed oral consent of the parents or legal guardian ;\n* Reside in the neighborhoods included in the study.\n\nFor the mixed-methods process evaluation and gender sub-study (to be carried out in the months following implementation).\n\nInclusion criteria\n\n* OptiMAx intervention personnel (e.g. healthcare staff)\n* A group of mothers of children benefiting from the intervention\n* Male partners\u002Fspouses of parents\n* Community members from the sites targeted by the intervention will be recruited for the focus groups.\n* Non-adherents or parents who choose not to continue nutritional supplementation and\u002For vaccination despite their availability under the program will be recruited for interviews.\n* Husbands\u002Fmale partners of non-members will also be surveyed.\n\nExclusion Criteria:\n\n* Age-eligible children with MUAC \\\u003C125 or edema will first be treated for acute malnutrition with OptiMA and then resume supplementation with SQ-LNS.\n\nThere is no exclusion criteria for the annual household surveys\n\nExclusion criteria for the mixed-methods process evaluation\n\n\\- Parents or guardians under 15 years of age.",true,"ALL","6 Months","59 Months",{"count":22,"type":23},20000,"ESTIMATED","INTERVENTIONAL",[26],"NA","Malnutrition and infectious disease form a vicious circle, posing a double threat to vulnerable children in low- and middle-income countries. Malnutrition makes children more vulnerable to infectious diseases, while infectious diseases increase the risk of malnutrition. When caught in this cycle, children are far more likely to die or suffer adverse effects on their health and development. High rates of wasting and low immunization coverage also constitute a weakening double burden for already fragile health systems. Every year in these contexts, hundreds of thousands of children are treated for severe wasting, while at the same time suffering repeated and prolonged epidemics of vaccine-preventable diseases such as measles. Rural areas of Chad and Niger are at the heart of this dynamic, recording some of the worst indicators of malnutrition and low vaccination coverage rates.\n\nSmall-quantity lipid-based nutritional supplements (SQ-LNS) are a category of ready-to-use, nutrient-dense food supplements fortified with micronutrients, designed to prevent malnutrition and improve child survival, growth and development. A recent meta-analysis on SQ-LNS reveals that giving a child just one sachet of SQ-LNS a day for a year can reduce the risk of mortality by 27%, iron-deficiency anemia by 64%, severe wasting by 31% and severe stunting by 17%. The recent World Health Organization (WHO) guideline on complementary feeding of infants and young children aged 6 to 23 months recently recommended the use of SQ-LNS in certain contexts of food insecurity, based on evidence deemed \"very safe\".\n\nThe distribution of SQ-LNS is also promising as an incentive for vaccination, as well as for other health services, such as participation in infant growth monitoring programs. Various operational experiences suggest that it is likely to have an impact on increasing vaccination coverage, and a modeling simulation suggests that it would lead to a significant reduction in measles morbidity and mortality.\n\nThe main objective of OptiMAx is to estimate the effectiveness of a mass SQ-LNS supplementation program coupled with the routine immunization program compared with the routine immunization program alone in terms of vaccination coverage against pentavalent 1 (Niger) and measles 1 (Chad), after 12 months of program implementation, in children aged 12 to 23 months as part of an annual cross-sectional household survey.\n\nSecondary objectives include:\n\n* Estimate the effectiveness of a mass SQ-LNS supplementation program combined with the routine Essential Program on Immunization (EPI) compared with the routine EPI alone in children aged 6-18 months, after 12 months of program implementation, in terms of 1) coverage of pentavalent 3 vaccine, malaria and other childhood vaccines, 2) on-time immunization for age-eligible children.\n* Evaluate the feasibility and reliability of combining measles and pentavalent coverage measurements during annual MUAC-family training campaigns;.\n* Evaluate outcomes of acutely malnourished children who received SQ-LNS supplementation prior to RUTF treatment (as part of their inclusion in the OptiMA study) versus those who did not receive SQ-LNS supplementation\n\nThe specific objectives of the process evaluation (with a sub-study on gender), modeling and economic evaluation are as follows:\n\n1. Conduct a process evaluation of the OptiMAx intervention to understand how it works, for whom and where;\n2. Understand to what extent and how gender-related facilitations and barriers affect the interaction and uptake of intervention, both on the demand side (health-seeking\u002Fintervention behaviors) and the supply side (provision of intervention services).\n3. Estimate the health impact of the OptiMAx intervention, in terms of nutrition and vaccine-preventable diseases, using mathematical modeling approaches.\n4. Quantify the relative costs associated with the OptiMAx intervention compared with the costs associated with existing vaccination activities in Mirriah, Niger, and Ngouri, Chad.\n5. Estimate the cost-effectiveness of the OptiMAx intervention in Mirriah, Niger, and Ngouri, Chad.",[29,30],"Malnutrition Severe","Vaccination",[32,33,34],"routine immunization","SQ-LNS supplementation","acute malnutrition","RECRUITING","2026-05-11",{"date":38,"type":39},"2026-05-18","ACTUAL",{"date":41,"type":39},"2025-05-01",{"date":43,"type":23},"2026-12",{"name":45,"class":46},"Alliance for International Medical Action","OTHER",2,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":18,"minAge":55,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":58,"phases":4,"briefSummary":59,"conditions":60,"keywords":63,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":78},"100631415","multimodal-nutritional-and-sarcopenia-assessment-for-risk-stratification-in-lung-cancer-surgery-100631415","NCT07500376","Multimodal Nutritional and Sarcopenia Assessment for Risk Stratification in Lung Cancer Surgery","Prognostic Value of Multimodal Nutritional Status and Sarcopenia Assessment for Postoperative Risk Stratification in Patients Undergoing Lung Cancer Surgery: A Prospective Cohort Study","Inclusion Criteria:\n\n* Age ≥18 years\n* Patients undergoing anatomical lung resection (lobectomy or segmentectomy) for primary lung cancer\n* Availability of preoperative thoracic computed tomography (CT) within 30 days before surgery\n* Completion of preoperative nutritional assessment and ultrasonographic muscle measurements\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Receipt of neoadjuvant chemotherapy, immunotherapy, or radiotherapy\n* Emergency surgery\n* Pneumonectomy\n* Combined resection of another organ during the same procedure\n* Inadequate or non-evaluable imaging or measurement data\n* Immunosuppressive therapy or presence of advanced\u002Fmetastatic disease\n* Significant thoracic deformity or prior conditions interfering with muscle measurements\n* Refusal or inability to provide informed consent","18 Years",{"count":57,"type":23},142,"OBSERVATIONAL","This prospective observational cohort study aims to evaluate the prognostic value of multimodal nutritional status and sarcopenia assessment in patients undergoing lung cancer surgery. Postoperative complications, mortality, and prolonged hospital stay remain major clinical concerns in thoracic surgery. Although malnutrition and sarcopenia are recognized as important determinants of surgical outcomes, their combined and multidimensional evaluation has not been sufficiently studied.\n\nAdult patients undergoing anatomical lung resection for primary lung cancer will be included. Nutritional status will be assessed using serum biomarkers, inflammatory indices, and validated clinical nutritional scores. Sarcopenia will be evaluated using computed tomography-based muscle mass and density measurements, as well as ultrasonographic muscle thickness.\n\nThese parameters will be analyzed in relation to postoperative complications, intensive care unit (ICU) requirement, length of hospital stay, and mortality. Multivariable analyses will be performed to identify independent predictors, and a combined risk stratification model will be developed.\n\nThis study aims to improve preoperative risk assessment and to support personalized perioperative management strategies, including identification of patients who may benefit from targeted nutritional optimization and prehabilitation.",[61,62,29],"Lung Cancer (Non-Small Cell)","Sarcopenia",[64,65,66,67,68],"lung cancer surgery","sarcopenia","nutritional status","malnutrition","risk stratification","2026-03-24",{"date":71,"type":39},"2026-03-30",{"date":73,"type":39},"2026-03-15",{"date":75,"type":23},"2026-07-15",{"name":77,"class":46},"Ondokuz Mayıs University",1,{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":4,"eligibilityCriteria":85,"healthyVolunteers":11,"sex":18,"minAge":55,"maxAge":86,"enrollmentInfo":87,"targetDuration":4,"studyType":58,"phases":4,"briefSummary":89,"conditions":90,"keywords":4,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":4},"100595437","impact-of-sleep-deprivation-on-malnutrition-in-icu-intensive-care-unit-patients-100595437","NCT07032441","Impact of Sleep Deprivation on Malnutrition in ICU (Intensive Care Unit) Patients","Association Between Sleep Deprivation and Malnutrition in Intensive Care Unit Patients: A Prospective Observational Cohort Study","Inclusion Criteria:\n\n* Adult ICU patients (≥18 years)\n* Expected length of stay ≥5 days\n* No severe liver or kidney failure (to avoid confounding in nutritional metabolism)\n\nExclusion Criteria:\n\n* Pre-existing malnutrition upon admission (e.g., BMI \\\u003C18.5 or weight loss \\>10% within 6 months)\n* Neuromuscular diseases affecting metabolic assessment","80 Years",{"count":88,"type":23},150,"Study Design This study is a prospective cohort design conducted at Zhongshan Hospital affiliated with Fudan University. It will involve systematic assessments of sleep quality, nutritional status, and associated clinical outcomes in adult ICU patients over a defined observation period.\n\nSample Size: An estimated 150 adult patients (≥18 years) will be recruited from the ICU.\n\nAssessments 1. Sleep Quality Assessment:\n\n1. Polysomnography (PSG): Sleep quality and duration will be quantified using PSG, which records brain waves, blood oxygen levels, heart rate, and breathing, as well as eye and leg movements. This will provide a comprehensive picture of sleep architecture and disturbances.\n2. Sleep Quality Index: In addition to PSG data, the Pittsburgh Sleep Quality Index (PSQI) will be administered to assess subjective sleep quality, sleep latency, duration, habitual sleep efficiency, sleep disturbances, and daytime dysfunction.\n\n2\\. Nutritional Status Evaluation:\n\n1. Nutritional Risk Screening Tools: The Nutritional Risk Screening (NRS-2002) and the Malnutrition Universal Screening Tool (MUST) will be applied to assess nutritional risk and identify malnutrition.\n2. Biochemical Assessment: Blood samples will be collected to measure biochemical indicators such as serum albumin, transferrin, prealbumin, and other relevant markers of nutritional status.\n3. Anthropometric Measurements: Body mass index (BMI) and muscle mass assessments will be conducted using bioelectrical impedance analysis (BIA) or dual-energy X-ray absorptiometry (DEXA) to quantify body composition.\n\n3\\. Physiological Monitoring:\n\n1. Continuous monitoring of vital signs, including heart rate, blood pressure, and respiratory rate, will be performed.\n2. Assessment of immune function through laboratory tests, including white blood cell count and levels of inflammatory markers (C-reactive protein).\n\n4\\. Complications Tracking:\n\n1\\. Data on complications such as infections, delayed wound healing, and respiratory failure will be systematically recorded throughout the ICU stay.\n\nThis study aims to elucidate the complex interplay between sleep deprivation and malnutrition in ICU patients. By identifying key associations and influencing factors, we hope to inform targeted clinical interventions that can improve patient care, recovery, and quality of life. The findings will serve as a foundation for future research exploring the intricate relationships between sleep and nutritional status in critical care settings.",[91,92,29],"ICU Hospitalization","Sleep Deprivation","NOT_YET_RECRUITING","2025-06-18",{"date":96,"type":39},"2025-06-24",{"date":98,"type":23},"2025-08-01",{"date":100,"type":23},"2026-12-31",{"name":102,"class":46},"Shanghai Zhongshan Hospital",{"id":104,"slug":105,"hasResults":11,"nctId":106,"briefTitle":107,"officialTitle":108,"acronym":109,"eligibilityCriteria":110,"healthyVolunteers":11,"sex":18,"minAge":55,"maxAge":4,"enrollmentInfo":111,"targetDuration":4,"studyType":24,"phases":113,"briefSummary":114,"conditions":115,"keywords":117,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":78},"100591161","management-of-undernutrition-on-discharge-from-hospital-by-dieticians-and-physical-activity-teachers-at-home-100591161","NCT06976827","Management of Undernutrition on Discharge From Hospital by Dieticians and Physical Activity Teachers at Home","Prise en Charge de la dénutrition en Sortie d'Hospitalisation Par Des diététiciennes et Des Enseignants en activité Physique adapté à Domicile : étude de faisabilité (DENUTADOM)","DENUTADOM","Inclusion Criteria:\n\n* Moderately or severely malnourished adult patient according to HAS diagnostic criteria: At least one phenotypic criterion: weight loss (\\> 5% in 1 month, \\> 10% in 6 months or relative to pre-disease weight), BMI \\\u003C 18.5 in \\\u003C 70 years or BMI \\\u003C 22 in ≥ 70 years, reduced muscle mass and\u002For function AND At least one etiological criterion: reduction in food intake \\> 50% for \\> 7 days or \\> 14 days regardless of reduction, reduced absorption, aggressive situation with hypercatabolism\n* Patient with an attending physician wishing to participate in the study\n* Patient wishing to be followed by a private dietician participating in the study\n\nExclusion Criteria:\n\n* Patients with cognitive disorders\n* Patients with eating disorders\n* Pregnant or breast-feeding patient\n* Patient with an estimated life expectancy of less than 6 months (at investigator's discretion)\n* Patient under legal protection\n* Patient not affiliated to the social security system\n* Patient who has not signed a free, written and informed consent form",{"count":112,"type":23},27,[26],"The DENUTADOM study is a single-center feasibility study. It is an interventional research project involving human subjects (RIPH2), which will lead to a change in the care and treatment of adult patients diagnosed as suffering from moderate to severe undernutrition during hospitalization. The aim of this study was to assess patient compliance with a new undernutrition management program (diet and physical activity) at discharge from hospital.\n\nIn this study, during hospitalization, patients may be included in the study if they meet the inclusion criteria. To this end, the physician will offer to participate in the study, and will provide the patient with an information document. If the patient agrees to take part, he or she will be included in the study after signing the consent form. Participation will last 3 months.\n\nOn inclusion, after seeing the physician, an adapted physical activity teacher (EAPA) and a hospital dietician will assess the patient's physical capacities and dietary needs, in order to draw up an adapted physical and dietary program. The CRA will assess the patient's quality of life using a questionnaire. When the patient is discharged, he will be given a notebook in which to keep track of appointments with healthcare professionals (GP, private dietician, EAPA). Patients are also asked to keep a record of their non-protocol care appointments and participation in physical activities.\n\nAfter hospitalization, the patient will have to follow a multi-professional program: dietetic by a private dietician (at D3-J5, at 3 weeks and then at 6 weeks), medical by the general practitioner (at 1 month), and adapted physical activity by the EAPA (during 3 months).\n\nAt three months, the patient will be seen again by the hospital's health professionals. The investigating physician will reassess nutritional status, and the EAPA will reassess physical capacity. The patient will be asked to return his diary so that data can be collected. They will also be given a quality of life and satisfaction questionnaire to complete.\n\nWhen all patients have completed their follow-up, a satisfaction questionnaire will be sent to each healthcare professional.\n\nCurrently, as part of standard care, , dietetics and physical rehabilitation are not reimbursed. As a result, although recommended, patients rarely benefit from a dietetic consultation and adapted physical activity follow-up following a diagnosis of undernutrition. We therefore hypothesize that early cooperative outpatient care, involving general practitioners, private dieticians and adapted physical activity teachers (EAPA), for adult patients diagnosed as moderately or severely malnourished during hospitalization will optimize the management of these patients.",[29,116],"Malnutrition; Moderate",[118,119,120,121],"moderate malnutrition","severe malnutrition","ambulatory care","discharge from hospital","2025-05-09",{"date":124,"type":39},"2025-05-16",{"date":126,"type":23},"2025-05-15",{"date":128,"type":23},"2025-12-31",{"name":130,"class":46},"Centre hospitalier Henri Mondor d'Aurillac",{"id":132,"slug":133,"hasResults":11,"nctId":134,"briefTitle":135,"officialTitle":136,"acronym":4,"eligibilityCriteria":137,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":138,"targetDuration":4,"studyType":24,"phases":140,"briefSummary":141,"conditions":142,"keywords":4,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":143,"lastUpdatePostDateStruct":144,"startDateStruct":146,"completionDateStruct":148,"leadSponsor":150,"locationsCount":4},"100566331","psychosocial-stimulations-and-treatment-outcome-of-severe-acute-malnourished-children-100566331","NCT06653790","PSYCHOSOCIAL STIMULATIONS AND TREATMENT OUTCOME OF SEVERE ACUTE MALNOURISHED CHILDREN","EFFECT OF PSYCHOSOCIAL STIMULATIONS ON TREATMENT OUTCOME OF SEVERE ACUTE MALNOURISHED CHILDREN","Inclusion Criteria:\n\n* All children aged 6m to 59 months admitted to stabilization centre fulfilling criteria of severe acute malnutrition will be included in study.\n\nExclusion Criteria:\n\n* Children with chronic diseases like cystic fibrosis, cerebral palsy, celiac disease, chronic kidney disease, chronic liver failure, congenital heart disease, inborn error of metabolism, cleft lip and palate will be excluded from study.",{"count":139,"type":23},800,[26],"A playroom and a playground are already part of the stabilization unit and are furnished with basic facilities for engaging the SAM children in play-based motor, language, and personal-social activities. The severely acute malnourished children in the intervention group will be sent to a development pediatrician who will do a developmental assessment of the child and stimulation. A sensory therapist, an occupational therapist, and a physiotherapist will also be available for sessions.",[29],"2024-10-21",{"date":145,"type":39},"2024-10-22",{"date":147,"type":23},"2024-11-10",{"date":149,"type":23},"2025-04-10",{"name":151,"class":46},"Universiti Putra Malaysia"]