[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"malocclusion-angle-class-i\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:malocclusion-angle-class-i":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,49,76],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":4},"100639211","treatment-outcome-of-elastomeric-and-nickel-titanium-separators-in-tooth-separation-100639211",false,"NCT07591454","Treatment Outcome of Elastomeric and Nickel-Titanium Separators in Tooth Separation","Comparison Between The Efficiency Of Elastomeric And Nickel-Titanium Separators In Tooth Separation, Pain Perception, And Gingival Inflammation - A Randomized Controlled Trial","Inclusion Criteria:\n\n* Class I skeletal and dental malocclusion.\n* No history of previous orthodontic treatment.\n* All permanent teeth in both arches, except third molars.\n* Good oral hygiene and periodontal health.\n* Good interproximal tooth contacts at the site of separator placement as\n* checked by interdental floss.\n* No caries or restorations on the proximal surfaces of first and second permanent molars, and second premolars.\n\nExclusion Criteria:\n\n* Patients presenting with restorations or carious lesions on the proximal surfaces of the first or second molars or the second premolars.\n* Patients with uncontrolled gingival or periodontal inflammation.\n* Patients with a history of previous orthodontic treatment.\n* Patients are skeletally classified as Class II or Class III.\n* Patients are currently using opioid analgesics or have chronic pain conditions requiring regular analgesic intake.","ALL","16 Years","25 Years",{"count":20,"type":21},30,"ESTIMATED","INTERVENTIONAL",[24],"NA","Patients seeking fixed orthodontic treatment that requires band placement will be enrolled in this study. This trial aims to compare the efficiency of rectangular cross-section nickel-titanium separators with elastomeric separators in creating sufficient interdental space for orthodontic band placement. In addition, the impact of both separator types on pain perception and gingival health during a 3-day placement period will be evaluated. Participants will be allocated to two groups in a split-mouth design. On the experimental side, nickel-titanium separators will be used, while elastomeric separators will be used as the control on the other side. Outcomes will include separation efficacy, pain perception over time, gingival inflammation, analgesic consumption, and separator loss.",[27,28],"Dental Crowding","Malocclusion, Angle Class I",[30,31,32,33,34,35,36],"Orthodontic separators","Nickel-Titanium","Elastomeric","Tooth separation","Pain perception","VAS","Gingival inflammation","NOT_YET_RECRUITING","2026-05-13",{"date":40,"type":41},"2026-05-15","ACTUAL",{"date":43,"type":21},"2026-06-01",{"date":45,"type":21},"2027-02-01",{"name":47,"class":48},"3D-Aligners","INDUSTRY",{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":16,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":22,"phases":59,"briefSummary":60,"conditions":61,"keywords":64,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":4},"100599024","3d-printed-occlusal-splints-for-intraoperative-use-100599024","NCT07079111","3D Printed Occlusal Splints for Intraoperative Use","Inclusion Criteria:\n\n* Patients of any age who require any orthognathic surgery (including, but not limited to, facial fracture reduction and fixation, mandibular or maxillary reconstruction, cranial vault reconstruction, mandibular osteotomies, maxilla osteotomies) at Johns Hopkins Hospital.\n\nExclusion Criteria:\n\n* Patients who are non-English speaking.\n* Surgeons who do not perform orthognathic surgery with occlusal splints.","0 Years","80 Years",{"count":58,"type":21},70,[24],"A 3D printed intraoperative occlusal splint is a custom-made biocompatible resin guide that allows surgeons properly align a patient's upper and lower dentition during surgery. This alignment further places maxilla and mandible into proper position. An occlusal splint contains outlines maxillary and mandibular dentition allowing the teeth to lock into place with correct alignment.\n\nAt Johns Hopkins, traditionally hand-made and industry-made 3D printed splints have been used safely. However, prior studies have demonstrated the ability of in-house 3D prints to save time and money compared to industry. In-house models are similarly produced with FDA-clear, biocompatible resin for 3D printing, and maintain equivalent safety for patients compared to industry-made models.",[28,62,63],"Malocclusion, Angle Class II","Malocclusion, Angle Class III",[65],"malocclusion","2026-04-09",{"date":68,"type":41},"2026-04-13",{"date":70,"type":21},"2026-08-30",{"date":72,"type":21},"2030-08-30",{"name":74,"class":75},"Johns Hopkins University","OTHER",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":16,"minAge":83,"maxAge":4,"enrollmentInfo":84,"targetDuration":4,"studyType":22,"phases":86,"briefSummary":87,"conditions":88,"keywords":89,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":100},"100564334","effect-of-different-grafting-material-following-surgically-facilitated-orthodontics-therapy-100564334","NCT06627829","Effect of Different Grafting Material Following Surgically Facilitated Orthodontics Therapy","Effect of Different Grafting Material Following Surgically Facilitated Orthodontics Therapy: a Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* American Society of Anesthesiologists (ASA) I\u002FII\n* Periodontal diagnosis of clinical gingival health or gingivitis on intact\u002Freduced periodontium per 2017 American Academy of Periodontology (AAP) classification\n* No history of periodontitis.\n* Class I malocclusion\n* Crowding of 4 mm or less on mandibular anterior incisors\n* Incisor mandibular plane angle between 90-100 degrees\n* No extractions indicated as part of the orthodontic treatment plan\n* Keratinized tissue of at least 3mm\n\nExclusion Criteria:\n\n* Patients who are current smokers\n* Pregnancy\n* Uncontrolled diabetes or other metabolic systemic conditions\n* Presence of open bite or deep bite\n* Spacing\n* Excessive retroclined mandibular incisors\n* Any contraindication to treatment or the material used if in the experimental groups","18 Years",{"count":85,"type":21},24,[24],"The purpose of this study is to quantitatively investigate the radiographic changes of alveolar bone, and gingival tissue changes of the mandibular anterior teeth in experimental group A receiving SFOT using freeze-dried allograft with a collagen membrane, experimental group B receiving SFOT using particulate xenograft covered by a collagen membrane and control group receiving only orthodontics therapy.",[28],[90],"orthodontic treatment","2024-10-02",{"date":93,"type":41},"2024-10-04",{"date":95,"type":21},"2025-01-06",{"date":97,"type":21},"2027-01-06",{"name":99,"class":75},"The University of Texas Health Science Center, Houston",1]