[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"malocclusion-angle-class-iii\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:malocclusion-angle-class-iii":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,43,73],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":4},"100599024","3d-printed-occlusal-splints-for-intraoperative-use-100599024",false,"NCT07079111","3D Printed Occlusal Splints for Intraoperative Use","Inclusion Criteria:\n\n* Patients of any age who require any orthognathic surgery (including, but not limited to, facial fracture reduction and fixation, mandibular or maxillary reconstruction, cranial vault reconstruction, mandibular osteotomies, maxilla osteotomies) at Johns Hopkins Hospital.\n\nExclusion Criteria:\n\n* Patients who are non-English speaking.\n* Surgeons who do not perform orthognathic surgery with occlusal splints.","ALL","0 Years","80 Years",{"count":19,"type":20},70,"ESTIMATED","INTERVENTIONAL",[23],"NA","A 3D printed intraoperative occlusal splint is a custom-made biocompatible resin guide that allows surgeons properly align a patient's upper and lower dentition during surgery. This alignment further places maxilla and mandible into proper position. An occlusal splint contains outlines maxillary and mandibular dentition allowing the teeth to lock into place with correct alignment.\n\nAt Johns Hopkins, traditionally hand-made and industry-made 3D printed splints have been used safely. However, prior studies have demonstrated the ability of in-house 3D prints to save time and money compared to industry. In-house models are similarly produced with FDA-clear, biocompatible resin for 3D printing, and maintain equivalent safety for patients compared to industry-made models.",[26,27,28],"Malocclusion, Angle Class I","Malocclusion, Angle Class II","Malocclusion, Angle Class III",[30],"malocclusion","NOT_YET_RECRUITING","2026-04-09",{"date":34,"type":35},"2026-04-13","ACTUAL",{"date":37,"type":20},"2026-08-30",{"date":39,"type":20},"2030-08-30",{"name":41,"class":42},"Johns Hopkins University","OTHER",{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":49,"sex":15,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":21,"phases":54,"briefSummary":55,"conditions":56,"keywords":57,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":72},"100502439","evaluation-of-surgical-outcomes-of-patients-treated-with-the-surgery-first-approach-and-aligners-100502439","NCT05822271","Evaluation of Surgical Outcomes of Patients Treated With the Surgery First Approach and Aligners","Inclusion Criteria:\n\n* Adults;\n* Skeletal malocclusion;\n* ANB Angle zero or negative;\n* Witts negative;\n* Etiology: mandibular excess, a maxillary deficiency, or a combination of both;\n* Indication for bimaxillary surgery;\n\nExclusion Criteria:\n\n* Previous orthodontic treatment;\n* Craniofacial anomaly or previous fracture of the facial bones;\n* Total edentulism;\n* Deep curve of Spee;\n* Vertical asymmetry;\n* Any medication use that contraindicates surgical treatment.",true,"17 Years","35 Years",{"count":53,"type":20},20,[23],"The purpose of this prospective study is to compare treatment outcomes and the quality of life of skeletal Class III patients treated with conventional fixed appliances and aligners undergoing Surgery-first approach. Data will be collected through validated questionnaires: OQLQ (Orthognathic Quality of Life Questionnaire), OHIP-14 (Oral Health Impact Profile), SF-36 (Medical Outcomes Study 36 - Item Short-Form Health Survey) and IOTN (Index of Orthodontic Treatment Need).",[28],[58,59,60,61],"Surgery-First","Orthognathic","Aligner","Aesthetic Treatment","RECRUITING","2024-11-28",{"date":65,"type":35},"2024-12-02",{"date":67,"type":35},"2022-01-30",{"date":69,"type":20},"2025-10",{"name":71,"class":42},"Rio de Janeiro State University",1,{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":4,"eligibilityCriteria":79,"healthyVolunteers":11,"sex":15,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":4,"studyType":21,"phases":84,"briefSummary":85,"conditions":86,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":4},"100547029","comparison-of-customized-and-standard-facemasks-for-early-treatment-of-class-iii-malocclusion-100547029","NCT06402656","Comparison of Customized and Standard Facemasks for Early Treatment of Class III Malocclusion","Comparison of Customized and Standard Facemasks for Early Treatment of Class III Malocclusion: Randomized Crossover Study","Inclusion Criteria:\n\n* Age between 5 and 12 years;\n* Class III malocclusion, for which early orthopedic treatment with rapid maxillary expander and facemask is indicated.\n* signing of informed consent\n\nExclusion Criteria:\n\n* Cleft lip and\u002For palate.\n* Craniofacial syndromes.","5 Years","12 Years",{"count":83,"type":20},24,[23],"The aim of the study is to compare a customized facemask for the treatment of Class III malocclusion in the prepubertal growing patient (patients between the ages of 5 and 12 years) versus a standard commercial facemask. Specifically, preference, pain, difficulty in sleeping, time of use, and possible complications for the two types of facemasks will be analyzed.\n\nThis is a single-center, national, controlled, superiority, randomized, crossover, open-label study.\n\nEach patient will be treated with both the customized facemask and the standard commercial facemask. Each patient will wear one type of facemask for 2 months and the other type of facemask for the next 2 months. After 2 weeks and at the end of therapy with each of the facemask types, the patient, with the possible help of the parents, will have to answer a questionnaire about pain and difficulty sleeping and report any complications. In addition, after completing both phases (fourth month), the patient should indicate a preference for one of the two types of mask with which to complete therapy for an additional 6 months.",[28,87],"Extraoral Traction Appliances","2024-07-30",{"date":90,"type":35},"2024-07-31",{"date":92,"type":20},"2024-09-01",{"date":94,"type":20},"2026-01-01",{"name":96,"class":42},"Azienda Ospedaliero-Universitaria Careggi"]