[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"malocclusion\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:malocclusion":28},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,33,0,25,[9,56,77,109,137,172,199,224,252,284,307,338,372,398,420,440,464,486,511,533,558,582,605,625,658],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":18,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":44,"lastUpdatePostDateStruct":45,"startDateStruct":48,"completionDateStruct":50,"leadSponsor":52,"locationsCount":55},"100642058","comparison-of-patient-reported-comfort-between-two-clear-aligner-trimming-line-designs-a-split-mouth-study-100642058",false,"NCT07660809","Comparison of Patient-Reported Comfort Between Two Clear Aligner Trimming-Line Designs: A Split-Mouth Study","Comparison of Patient-Reported Comfort Between Supragingival and Juxtagingival Clear Aligner Trimming-Line Designs: A Cross-Sectional, Within-Subject Split-Mouth Study","COMFORT-ALIGN","Inclusion Criteria:\n\n* Adolescent or adult patient (aged 15 years or older)\n* Active orthodontic treatment with clear aligners, including finishing (refinement) aligners\n* Wearing two clear aligners with different trimming-line designs, one per dental arch: a supragingival design on one arch and a juxtagingival design on the contralateral arch\n* At least 4 weeks of wear of the two designs at the time of questionnaire completion\n* Good treatment compliance\n* Willing and able to complete the online questionnaire and provide the required consent\n\nExclusion Criteria:\n\n* Mixed orthodontic treatment (aligners combined with fixed appliances)\n* Pre-existing neurological, cognitive, or speech disorders\n* Systemic conditions affecting the oral cavity (e.g., xerostomia, mucosal disorders)",true,"ALL","15 Years",{"count":22,"type":23},70,"ESTIMATED","OBSERVATIONAL","* The trimming-line design of clear aligners (supragingival versus juxtagingival) is a routine clinical decision whose influence on patient-reported comfort has not been established; available evidence on aligner comfort derives almost exclusively from comparisons with fixed appliances.\n* This observational, cross-sectional study compares two clear aligner trimming-line designs with respect to patient-reported comfort: a supragingival design, whose edge rests on the marginal gingiva, and a juxtagingival design, whose edge follows the gingival contour without covering it. Because the two designs sit differently against the gingival soft tissue, they may be experienced differently during wear.\n* Participants are patients already wearing one trimming-line design on one dental arch and the other on the contralateral arch; each participant thus serves as their own control. After a minimum of four weeks of wear, participants complete a 20-item questionnaire once, rating the frequency of defined oral experiences for the maxillary and mandibular arch separately on a three-point ordinal scale (0 = none, 1 = occasional, 2 = frequent).\n* The questionnaire is anonymous; the design worn on each arch is identified from which of two identical forms a participant completes. Responses for the two designs are compared within each participant. The study evaluates whether trimming-line design is associated with differences in patient-reported comfort.",[27,28,29],"Patient Comfort","Malocclusion","Oral Health",[31,32,33,34,35,36,37,38,39,40,41,42],"clear aligners","trimming-line design","gingival margin","supragingival","juxtagingival","split-mouth design","patient-reported outcome","comfort","oral health-related quality of life","questionnaire","orthodontics","finishing orthodontic treatment","NOT_YET_RECRUITING","2026-06-18",{"date":46,"type":47},"2026-06-23","ACTUAL",{"date":49,"type":23},"2026-07",{"date":51,"type":23},"2026-08",{"name":53,"class":54},"George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures","OTHER",1,{"id":57,"slug":58,"hasResults":12,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":4,"eligibilityCriteria":62,"healthyVolunteers":18,"sex":19,"minAge":4,"maxAge":4,"enrollmentInfo":63,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":65,"conditions":66,"keywords":4,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":4},"100644428","postural-assessment-in-patients-with-malocclusions-100644428","NCT07664059","Postural Assessment in Patients With Malocclusions","Postural Assessment Using 3D Spine Analysis in Patients With Malocclusions","Inclusion Criteria:\n\n* Patients referred for orthodontic evaluation\n* Presence of skeletal malocclusion\n* Availability of lateral cephalometric radiograph\n* Ability to undergo three-dimensional postural assessment using the Spine 3D system\n* Patients of any age and sex\n* Provision of written informed consent by the participant or by parents\u002Flegal guardians in case of minors\n\nExclusion Criteria:\n\n* Previous orthodontic treatment\n* Previous orthopaedic treatment affecting posture\n* Presence of craniofacial syndromes or congenital anomalies\n* History of spinal surgery\n* Significant musculoskeletal disorders\n* Neurological conditions affecting posture\n* Use of medications affecting musculoskeletal function\n* Inability to undergo postural assessment\n* Lack of written informed consent",{"count":64,"type":23},64,"This observational cross-sectional study aims to investigate the association between skeletal malocclusions and body posture using three-dimensional postural analysis. Patients will undergo cephalometric assessment, temporomandibular disorder evaluation using the Helkimo index, and non-invasive postural evaluation using the Spine 3D system, based on rasterstereography technology. Postural parameters, including thoracic kyphosis, lumbar lordosis, trunk inclination, pelvic asymmetry, and spinal deviations, will be analysed in relation to skeletal malocclusion classes and temporomandibular disorders. The study seeks to improve the understanding of the potential interactions between the stomatognathic system and global body posture and to support a multidisciplinary diagnostic approach in orthodontic patients.",[28,67,68],"Temporomandibular Disorder","Postural; Defect","2026-06-17",{"date":46,"type":47},{"date":72,"type":23},"2026-09-01",{"date":74,"type":23},"2028-09-30",{"name":76,"class":54},"Andrea Scribante",{"id":78,"slug":79,"hasResults":12,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":18,"sex":19,"minAge":85,"maxAge":86,"enrollmentInfo":87,"targetDuration":4,"studyType":89,"phases":90,"briefSummary":92,"conditions":93,"keywords":96,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":55},"100641094","micro-osteoperforation-versus-photobiomodulation-therapy-for-accelerating-maxillary-canine-retraction-100641094","NCT07658235","Micro-osteoperforation Versus Photobiomodulation Therapy for Accelerating Maxillary Canine Retraction","Micro-osteoperforation Versus Photobiomodulation Therapy for Accelerating Maxillary Canine Retraction: A Three-Arm Parallel Randomized Controlled Clinical Trial.","MOP-PBMT","Inclusion Criteria:\n\n* Age 18 to 40 years at the time of enrollment\n* Systemically healthy with no chronic medical conditions affecting bone metabolism or wound healing\n* Requiring bilateral maxillary first premolar extraction as part of a comprehensive fixed orthodontic treatment plan\n* Class I or mild Class II malocclusion requiring maximum anchorage canine retraction\n* Fully erupted maxillary permanent dentition with no missing teeth other than planned extraction teeth\n* Good oral hygiene (Plaque Index ≤ 1) and healthy periodontal status (probing depth ≤ 3 mm, no bleeding on probing)\n* No previous orthodontic treatment\n* Willing to attend all scheduled appointments and comply with study protocol\n* Able to provide written informed consent\n\nExclusion Criteria:\n\n* Systemic diseases affecting bone metabolism including osteoporosis, osteopenia, diabetes mellitus, thyroid disorders, or autoimmune conditions\n* Current use of medications affecting bone remodeling including corticosteroids, bisphosphonates, non-steroidal anti-inflammatory drugs (NSAIDs), or vitamin D supplements\n* Current or recent smokers (within the past 6 months)\n* Pregnant or breastfeeding women\n* History of head and neck radiation therapy\n* Periodontal disease or active dental infection at the time of enrollment\n* Skeletal Class III malocclusion or severe Class II requiring surgical intervention\n* Previous orthodontic treatment or orthognathic surgery\n* Craniofacial syndromes or cleft lip and palate\n* Photosensitivity disorders or use of photosensitizing medications (relevant to LLLT group)\n* Coagulation disorders or anticoagulant therapy (relevant to MOP group)\n* Uncooperative patients or those unable to maintain adequate oral hygiene throughout treatment\n* Parafunctional habits such as severe bruxism or tongue thrusting'","18 Years","40 Years",{"count":88,"type":23},75,"INTERVENTIONAL",[91],"NA","Orthodontic treatment often requires moving the upper canine teeth (the pointed teeth) into the spaces left after removing premolar teeth. This process is usually slow and can take many months, making the total treatment time longer.This study will compare two techniques that may speed up this tooth movement:\n\nMicro-osteoperforation (MOP): A minimally invasive procedure in which a small device is used to create tiny holes in the jawbone near the canine tooth under local anesthesia. These micro-perforations stimulate the bone to remodel faster, which allows the tooth to move more quickly.\n\nPhotobiomodulation therapy (PBMT) \u002F Low-Level Laser Therapy (LLLT): A painless, non-invasive technique that uses a low-power laser light applied to the gum tissue near the canine tooth. The laser energy stimulates cells in the bone and supporting tissues to accelerate tooth movement without any cutting or drilling.\n\nThis trial will randomly assign eligible patients into one of three groups: MOP, LLLT, or a control group receiving standard orthodontic treatment only. Each group will contain 25 participants (75 total). The main goal is to measure and compare how fast the upper canine tooth moves in each group over the first month and until the space is fully closed. The study will also measure the effect of age and sex on the results. The findings will help orthodontists choose the best, fastest, and most comfortable method for each patient to shorten overall treatment time",[28,94,95],"Orthodontic Tooth Movement","Maxillary Canine Retraction",[97,98,99,100],"Micro-osteoperforation","Photobiomodulation therapy","low-level laser therapy","acceleration of tooth movement","2026-06-16",{"date":44,"type":47},{"date":104,"type":23},"2026-07-01",{"date":106,"type":23},"2027-05-28",{"name":108,"class":54},"Kufa University",{"id":110,"slug":111,"hasResults":12,"nctId":112,"briefTitle":113,"officialTitle":114,"acronym":115,"eligibilityCriteria":116,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":117,"targetDuration":4,"studyType":89,"phases":119,"briefSummary":120,"conditions":121,"keywords":123,"overallStatus":130,"whyStopped":4,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":133,"completionDateStruct":134,"leadSponsor":136,"locationsCount":55},"100641544","effect-of-finishing-clear-aligner-marginal-termination-design-supragingival-vs-juxtagingival-on-aligner-color-stability-after-14-days-of-wear-a-split-mouth-study-100641544","NCT07628491","Effect of Finishing Clear Aligner Marginal Termination Design (Supragingival vs Juxtagingival) on Aligner Color Stability After 14 Days of Wear: A Split-Mouth Study","Colorimetric Stability of Finishing Clear Aligners According to Marginal Termination Design (Supragingival Versus Juxtagingival) After 14 Days of Intraoral Wear During Orthodontic Treatment: A Prospective Split-Mouth Study","SPECTRO-ALIGN","Inclusion Criteria:\n\n* Adolescent and adult patients (age 15 years or older at enrollment)\n* Undergoing a finishing (refinement) stage of clear aligner therapy, with only small residual tooth movements remaining, including both patients completing active orthodontic treatment and patients with prior orthodontic treatment who require additional refinement (e.g., minor relapse or loss of retention)\n* Adherence to the prescribed oral hygiene instructions\n* Written informed consent; for participants aged 15-17 years, written consent from a parent or legal guardian\n\nExclusion Criteria:\n\n* Deficient oral hygiene\n* Excessive consumption of intensely staining beverages (coffee, tea, red wine, colored carbonated drinks)\n* Systemic conditions or medications that may affect salivary secretion or tooth color\n* Non-compliance with the aligner \u002F orthodontic appliance wear protocol",{"count":118,"type":23},50,[91],"* The goal of this clinical study is to learn whether the gumline edge design of a finishing orthodontic clear aligner affects how much the aligner's color changes after 14 days of wear.\n* The main question is: does a supragingival edge design - a straight edge covering about 2 mm of gum tissue - lead to a different amount of color change in the aligner compared with a juxtagingival edge design that follows the gumline exactly, after 14 days of wear?\n* Each participant wears finishing clear aligners with both edge designs at the same time - one design on the upper jaw and the other on the lower jaw - and serves as their own comparison (split-mouth). This within-person approach removes differences between individuals in oral hygiene, diet, and saliva.\n* The aligner's color over six selected teeth (three upper, three lower) is measured with a dental spectrophotometer (VITA Easyshade V) at placement (day 0) and after 14 days. Each measurement is repeated three times under standardized optical conditions. The amount of color change is expressed as a color-difference value (ΔE).\n* The study hypothesis is that marginal termination design (supragingival versus juxtagingival) is associated with a difference in the 14-day colorimetric change (ΔE00) of the finishing aligner.\n* The study is carried out during the finishing (refinement) stage of orthodontic treatment, when only small residual tooth movements remain, so that color changes can be attributed to wear and edge design rather than to tooth movement.",[28,122],"Esthetics, Dental",[31,124,125,126,127,128,129,36,42],"color stability","spectrophotometry","CIELAB","CIEDE2000","trimming line","marginal termination design","RECRUITING","2026-06-15",{"date":69,"type":47},{"date":131,"type":47},{"date":135,"type":23},"2026-08-15",{"name":53,"class":54},{"id":138,"slug":139,"hasResults":12,"nctId":140,"briefTitle":141,"officialTitle":142,"acronym":143,"eligibilityCriteria":144,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":86,"enrollmentInfo":145,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":147,"conditions":148,"keywords":158,"overallStatus":130,"whyStopped":4,"lastUpdateSubmitDate":163,"lastUpdatePostDateStruct":164,"startDateStruct":166,"completionDateStruct":168,"leadSponsor":170,"locationsCount":55},"100371514","orthognathic-speech-pathology-phonetic-contrasts-of-patients-with-dental-discrepancies-pre--and-post-treatment-analyses-100371514","NCT04117360","Orthognathic Speech Pathology: Phonetic Contrasts of Patients With Dental Discrepancies Pre- and Post-Treatment Analyses","Orthognathic Speech Pathology: Phonetic Contrasts of Patients With Dentofacial Discrepancies With Pre- and Post-Treatment Analyses","OSP","Inclusion Criteria:\n\n* Jaw surgery patient at UNC with a skeletal open bite, underbite or overjet greater than 5mm.\n* Age 15-40 years\n\nExclusion Criteria:\n\n* Hearing loss\n* Learned English as a second language\n* Significant regional accent, as characterized by a speech pathologist\n* Developmental delay, performing several grade levels below age bracket\n* history of craniofacial disorder\n* genetic syndrome associated with known craniofacial presentation\n* history of craniofacial trauma\n* history of prior craniofacial surgery (excluding extractions and dental procedures)\n* Jaw surgery without fixed orthodontic appliances",{"count":146,"type":23},180,"The investigators are studying how speech is effected by jaw and tooth position in jaw surgery patients. Eighty percent of our jaw surgery patients have speech pathologies, compared to five percent of the general population, but speech pathologists do not understand why. The investigators hypothesize that open bites and underbites prevent most patients from being able to pronounce words normally and surgical correction will lead to improvement in speech. Patients will be audio recorded speaking and patients' tongue gestures ultrasound recorded before and after their jaw surgeries to observe what changes occur in their speech and tongue movements.",[149,150,151,28,152,153,154,155,156,157],"Dentofacial Abnormalities","Dentofacial Deformities","Dentofacial Anomalies, Including Malocclusion","Malocclusion in Children","Dentofacial Disharmony","Skeletal Malocclusion","Skeletal Malformation","Speech Sound Disorder","Speech Disorders",[153,159,156,160,161,162],"Skeletal malocclusion","Spectral Moment Analysis","Tongue Ultrasound","Orthognathic Surgery","2026-06-10",{"date":165,"type":47},"2026-06-12",{"date":167,"type":47},"2019-09-11",{"date":169,"type":23},"2028-03",{"name":171,"class":54},"University of North Carolina, Chapel Hill",{"id":173,"slug":174,"hasResults":12,"nctId":175,"briefTitle":176,"officialTitle":177,"acronym":4,"eligibilityCriteria":178,"healthyVolunteers":18,"sex":19,"minAge":20,"maxAge":179,"enrollmentInfo":180,"targetDuration":4,"studyType":89,"phases":182,"briefSummary":183,"conditions":184,"keywords":185,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":191,"lastUpdatePostDateStruct":192,"startDateStruct":194,"completionDateStruct":195,"leadSponsor":197,"locationsCount":4},"100643580","comparison-of-acupressure-ibuprofen-and-chewing-gum-for-the-management-of-post-archwire-orthodontic-pain-100643580","NCT07638644","Comparison of Acupressure, Ibuprofen, and Chewing Gum for the Management of Post-Archwire Orthodontic Pain","Comparative Efficacy of Acupressure, Ibuprofen, and Chewing Gum in Managing Post-Archwire Orthodontic Pain: A Three-Arm Randomized Clinical Trial","Inclusion Criteria:\n\n* Age 15 to 35 years\n* Complete permanent dentition\n* Undergoing comprehensive fixed orthodontic treatment\n* Scheduled for initial archwire placement\n* Ability to comply with study procedures\n* Written informed consent provided (or parental\u002Fguardian consent for participants younger than 18 years)\n\nExclusion Criteria:\n\n* Pregnant or lactating\n* Systemic disorders that may affect pain perception\n* Periodontal disease\n* Neurological abnormalities that may affect pain perception\n* Known sensitivity to chewing gum\n* Documented allergy to ibuprofen\n* Use of adjunctive orthodontic appliances\n* Use of analgesics, anti-inflammatory medications, or other medications that may affect pain perception within 24 hours before enrollment","35 Years",{"count":181,"type":23},105,[91],"The goal of this clinical trial is to find out which method works best to reduce pain after braces are adjusted for the first time (when the first archwire is placed). The study will compare three approaches: acupressure (applying pressure on a specific point on the hand), ibuprofen (a pain-relief medicine), and chewing sugar-free gum. It will also check how safe these methods are and whether patients need extra pain medicine.\n\nThe main questions the researchers want to answer are:\n\nWhich method reduces orthodontic pain the most after the first archwire is placed? Do patients need extra painkillers in any of the groups? Are there any problems with braces (such as loose brackets or wire issues) within the first week?\n\nResearchers will compare the three groups to see which option gives the best pain relief during the first few days after braces are activated.\n\nParticipants will:\n\nBe placed into one of three groups: acupressure, ibuprofen, or chewing gum Use their assigned method after their first orthodontic wire is placed Rate their pain at different time points using a simple pain scale (VAS) Report if they take any extra pain medicine Be checked for any brace-related problems for up to 7 days\n\nThis study may help improve comfort and pain management for patients starting orthodontic treatment.",[28],[186,187,188,189,190],"Post-archwire orthodontic pain","Fixed orthodontic treatment","Chewing gum pain relief","Ibuprofen analgesia","Acupressure LI4 Hegu point","2026-06-09",{"date":193,"type":47},"2026-06-11",{"date":104,"type":23},{"date":196,"type":23},"2027-07-01",{"name":198,"class":54},"Bahria University",{"id":200,"slug":201,"hasResults":12,"nctId":202,"briefTitle":203,"officialTitle":204,"acronym":4,"eligibilityCriteria":205,"healthyVolunteers":12,"sex":19,"minAge":85,"maxAge":206,"enrollmentInfo":207,"targetDuration":4,"studyType":89,"phases":209,"briefSummary":210,"conditions":211,"keywords":212,"overallStatus":130,"whyStopped":4,"lastUpdateSubmitDate":215,"lastUpdatePostDateStruct":216,"startDateStruct":218,"completionDateStruct":220,"leadSponsor":222,"locationsCount":55},"100601801","bromelain-for-post-surgery-facial-swelling-100601801","NCT07115212","Bromelain for Post-surgery Facial Swelling","Effectiveness of Bromelain Supplement in Reduction of Facial Swelling Caused by Orthognathic Surgery","Inclusion Criteria:\n\n* undergoing orthognathic surgery\n\nExclusion Criteria:\n\n* craniofacial anomalies\n* incomplete patient data\n* systemic disease that could affect healing\n* allergy to latex or pineapple\n* under 18 years of age\n* non english speaking","65 Years",{"count":208,"type":23},200,[91],"The goal of this clinical trial is to learn if Bromelain Supplement works to decrease the amount of swelling or the amount of time swelling is present following jaw surgery. It will also learn about the safety of Bromelain supplement. The main questions it aims to answer are:\n\nDoes Bromelain decrease facial swelling following orthognathic, or jaw, surgery? Does Bromelain supplement decrease the amount of time that patients are swollen following orthognathic, or jaw, surgery?\n\nParticipants will:\n\nTake Bromelain supplement once daily for 9 days total. Take 2 days before surgery and 7 days following surgery.\n\nKeep a log of when the bromelain supplement is taken as well as another other medications.\n\nVisit the clinic with pre and post surgical protocol",[28],[213,214],"Bromelain","Oral Supplements","2026-06-03",{"date":217,"type":47},"2026-06-05",{"date":219,"type":47},"2025-09-08",{"date":221,"type":23},"2028-05",{"name":223,"class":54},"Mohamed Bazina",{"id":225,"slug":226,"hasResults":12,"nctId":227,"briefTitle":228,"officialTitle":229,"acronym":4,"eligibilityCriteria":230,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":231,"targetDuration":4,"studyType":89,"phases":233,"briefSummary":234,"conditions":235,"keywords":236,"overallStatus":130,"whyStopped":4,"lastUpdateSubmitDate":243,"lastUpdatePostDateStruct":244,"startDateStruct":246,"completionDateStruct":248,"leadSponsor":250,"locationsCount":55},"100595947","evaluation-of-clinical-and-patient-reported-outcomes-of-laceback-100595947","NCT07039071","Evaluation of Clinical and Patient-Reported Outcomes of Laceback","Evaluation of Clinical and Patient-Reported Outcomes of Laceback: A Split-Mouth Randomised Controlled Trial","Inclusion Criteria:\n\nPatient factors\n\n* Age 15 and above\n* Medically fit and well\n* Good oral hygiene - no dental caries, Basic Periodontal Examination (BPE) score 0\n\nOrthodontic factors\n\n* Full upper and lower arch fixed orthodontic treatment (bonded till first permanent molars)\n* Pre-adjusted edgewise appliance with 0.022\" slot, MBT prescription, Master Series® brackets (American Orthodontics, USA)\n* Extraction of bilateral upper and lower permanent first\u002Fsecond premolars\n* No previous orthodontic treatment\n\nExclusion Criteria:\n\n* Craniofacial deformities\n* Mental or physical disability leading to impaired manual dexterity, difficulty in comprehending and following oral hygiene instructions\n* Underlying chronic medical illness, oral diseases",{"count":232,"type":23},38,[91],"The goal of this clinical trial is to evaluate oral hygiene status, archwire complications, laceback complications, and pain while using lacebacks in patients undergoing orthodontic fixed appliance treatment.\n\nThe main questions it aims to answer are:\n\n1. What is the effect of laceback on patient's oral hygiene during alignment phase of orthodontic fixed appliance treatment?\n2. What is the effect of laceback on the frequency of archwire complications during alignment phase of orthodontic fixed appliance treatment?\n3. What is the frequency of laceback complications during alignment phase of orthodontic fixed appliance treatment?\n4. What is the effect of laceback on pain during alignment phase of orthodontic fixed appliance treatment?\n\nFor each subject, researchers will randomly assign half of the oral cavity to receive laceback during orthodontic fixed appliance treatment, whereas the other half will not receive laceback. Researchers will then compare the effect of laceback on patient's oral hygiene, archwire complications, laceback complications, and pain.\n\nParticipants are required to carry out the usual oral hygiene practices after braces and laceback are being put up. During the observation period, they are required to notify the researcher if they suspect any breakages or loose components, so that they come to the clinic for emergency appointments. They are also required to fill up a pain diary.",[28],[237,238,239,240,241,242],"laceback","pain","plaque score","archwire","complication","breakage","2026-05-10",{"date":245,"type":47},"2026-05-13",{"date":247,"type":47},"2026-03-09",{"date":249,"type":23},"2027-09",{"name":251,"class":54},"International Islamic University Malaysia",{"id":253,"slug":254,"hasResults":12,"nctId":255,"briefTitle":256,"officialTitle":257,"acronym":258,"eligibilityCriteria":259,"healthyVolunteers":18,"sex":19,"minAge":260,"maxAge":261,"enrollmentInfo":262,"targetDuration":4,"studyType":89,"phases":264,"briefSummary":265,"conditions":266,"keywords":269,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":275,"lastUpdatePostDateStruct":276,"startDateStruct":278,"completionDateStruct":280,"leadSponsor":282,"locationsCount":55},"100633850","comparison-of-three-orthodontic-separators-for-pain-plaque-and-tooth-separation-100633850","NCT07532044","Comparison of Three Orthodontic Separators for Pain, Plaque, and Tooth Separation","Separation Effect, Plaque Score, Pain Perception, And Impact On Quality Of Life When Comparing Three Types Of Orthodontic Separators: A Randomized Controlled Trial","SEP-ORTHO","Inclusion Criteria:\n\n* Patients requiring fixed orthodontic appliance therapy with maxillary first molar banding\n* Age between 12 and 25 years\n* Good oral hygiene (Plaque Index score 0-1)\n* Good general oral health\n* No previous orthodontic treatment\n* No history of dental extractions\n* Presence of tight interproximal contacts at the site of separator placement (no spacing)\n\nExclusion Criteria:\n\n* Presence of interproximal restorations\n* Presence of interproximal caries\n* Missing maxillary second premolar, first molar, or second molar\n* Unerupted maxillary second molars\n* Systemic diseases affecting oral health (e.g., diabetes mellitus)\n* Regular use of medications affecting pain perception (e.g., analgesics, corticosteroids)\n* Loss of separators before follow-up appointment\n* Failure to return within 72 hours for evaluation","12 Years","25 Years",{"count":263,"type":23},144,[91],"Orthodontic separators are small devices placed between teeth before fitting braces to create space for bands. This procedure may cause pain, discomfort, and changes in oral hygiene, which can affect plaque buildup and daily activities.\n\nThis study aims to compare three commonly used types of orthodontic separators-elastomeric, Kesling, and customized tie wire separators-in terms of the amount of tooth separation achieved, pain experienced by patients, and plaque accumulation.\n\nIn addition, the study will assess how these separators affect patients' quality of life, including eating, speaking, and daily comfort.\n\nParticipants will be assigned to one of the three separator types and will be evaluated after 48 to 72 hours. The findings of this study may help identify the most effective and comfortable separator, improving patient care and treatment experience in orthodontics.",[267,28,268],"Orthodontic Pain (D013850)","Orthodontic Treatment",[270,271,272,273,274],"Orthodontic separators","Pain perception","Plaque index","Quality of life","Tooth separation","2026-05-05",{"date":277,"type":47},"2026-05-08",{"date":279,"type":23},"2026-04-10",{"date":281,"type":23},"2028-04-10",{"name":283,"class":54},"Islamabad Medical and Dental College",{"id":285,"slug":286,"hasResults":12,"nctId":287,"briefTitle":288,"officialTitle":289,"acronym":4,"eligibilityCriteria":290,"healthyVolunteers":18,"sex":19,"minAge":291,"maxAge":292,"enrollmentInfo":293,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":295,"conditions":296,"keywords":4,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":298,"lastUpdatePostDateStruct":299,"startDateStruct":301,"completionDateStruct":303,"leadSponsor":305,"locationsCount":4},"100635356","research-on-deep-learning-based-intelligent-diagnosis-and-treatment-100635356","NCT07551622","Research on Deep Learning-Based Intelligent Diagnosis and Treatment","Research on Intelligent Diagnosis and Treatment Technologies for Craniomaxillofacial Multi-modal Imaging Based on Deep Learning","Inclusion Criteria:\n\n* Participants with available craniomaxillofacial imaging data obtained during routine dental, orthodontic, oral and maxillofacial, or related clinical care.\n* Participants with at least one eligible imaging modality, including two-dimensional facial photographs, cone-beam computed tomography images, or three-dimensional facial surface scans.\n* Participants with related clinical information available for model development or validation, such as demographic information, clinical diagnosis, skeletal or dental classification, cephalometric measurements, treatment-related records, or expert assessment results.\n* Imaging data of sufficient quality for artificial intelligence-based image analysis, annotation, segmentation, landmark detection, classification, or decision-support model development.\n\nExclusion Criteria:\n\n* Participants with incomplete or unavailable key imaging data or clinical information required for the planned analysis.\n* Images with severe artifacts, poor resolution, incorrect orientation, incomplete anatomical coverage, or other quality problems that prevent reliable analysis.\n* Duplicate records or repeated imaging records that cannot be reliably linked to a unique participant.\n* Participants whose data cannot be used according to institutional review board approval, consent requirements, or applicable privacy protection regulations.","6 Years","70 Years",{"count":294,"type":23},2000,"This study aims to develop and evaluate deep learning-based artificial intelligence models for craniomaxillofacial multi-modal imaging analysis and clinical decision support. Approximately 2,000 participants with craniomaxillofacial imaging data and related clinical information will be included. The imaging data may include two-dimensional facial photographs, cone-beam computed tomography images, and three-dimensional facial surface scans.\n\nThe study will use artificial intelligence methods to analyze craniofacial images and identify clinically meaningful features related to facial morphology, skeletal or dental classification, anatomical landmarks, regional structures, and craniomaxillofacial abnormalities. The models will be developed for tasks such as image classification, anatomical landmark detection, image segmentation, abnormality recognition, and treatment-related decision support.\n\nThe purpose of this study is to improve the accuracy, efficiency, and consistency of image-based assessment in dentistry, orthodontics, and oral and maxillofacial clinical practice. The artificial intelligence models developed in this study are intended to provide objective imaging analysis and decision-support information for health care providers. These models are designed to assist clinicians and will not replace professional diagnosis or individualized treatment planning by qualified clinicians.\n\nThis research may benefit patients and families by supporting earlier and more accurate recognition of craniomaxillofacial conditions, improving communication about diagnosis and treatment options, and promoting more personalized oral health care. All clinical images and related information will be handled according to approved research procedures and privacy protection requirements.",[28,297,150],"Craniofacial Morphology","2026-04-19",{"date":300,"type":47},"2026-04-27",{"date":302,"type":23},"2026-05-01",{"date":304,"type":23},"2029-12-31",{"name":306,"class":54},"Xi'an Jiaotong University",{"id":308,"slug":309,"hasResults":12,"nctId":310,"briefTitle":311,"officialTitle":312,"acronym":313,"eligibilityCriteria":314,"healthyVolunteers":18,"sex":19,"minAge":315,"maxAge":316,"enrollmentInfo":317,"targetDuration":4,"studyType":89,"phases":319,"briefSummary":320,"conditions":321,"keywords":323,"overallStatus":130,"whyStopped":4,"lastUpdateSubmitDate":329,"lastUpdatePostDateStruct":330,"startDateStruct":332,"completionDateStruct":334,"leadSponsor":336,"locationsCount":55},"100620787","clear-orthodontic-expander-versus-hyrax-100620787","NCT07362160","Clear Orthodontic Expander Versus Hyrax","Evaluating the Clinical Performance of a Novel Clear Orthodontic Expander Versus Hyrax: A Randomized Clinical Trial","COE-Hyarx","Inclusion Criteria:\n\n1. Patients' age at the start of treatment will range from 10-14 years.\n2. Unstable unilateral or bilateral posterior crossbite due to maxillary constriction.\n3. The first molars are fully erupted.\n4. Good oral health free from caries and periodontal problems at the start of treatment.\n5. Good general health.\n\nExclusion Criteria:\n\n1. Patients with obvious facial asymmetry.\n2. Patients with orofacial cleft.\n3. Patients with previous orthodontic treatment.\n4. Patients with bad oral habits.\n5. Patients with active periodontal disease.","10 Years","14 Years",{"count":318,"type":23},40,[91],"This study will be conducted to evaluate the effectiveness of a clear expander fabricated from 2-mm biocompatible polyethylene terephthalate glycol (PETG) thermoforming material integrated with an expansion screw in achieving dental and skeletal expansion in adolescent patients, compared with the conventional Hyrax expander.",[28,322],"Narrow Maxilla",[324,325,326,327,328],"clear expander","hyrax","clinical trial","adolescent","thermoplastic material","2026-04-17",{"date":331,"type":47},"2026-04-22",{"date":333,"type":47},"2026-02-01",{"date":335,"type":23},"2027-02-01",{"name":337,"class":54},"University of Baghdad",{"id":339,"slug":340,"hasResults":12,"nctId":341,"briefTitle":342,"officialTitle":342,"acronym":343,"eligibilityCriteria":344,"healthyVolunteers":12,"sex":19,"minAge":4,"maxAge":4,"enrollmentInfo":345,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":346,"conditions":347,"keywords":357,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":363,"lastUpdatePostDateStruct":364,"startDateStruct":366,"completionDateStruct":368,"leadSponsor":370,"locationsCount":55},"100629572","oral-health-dento-facial-condition-and-ohrqol-in-subjects-with-mowat-wilson-syndrome-an-epidemiologic-study-100629572","NCT07476417","Oral Health, Dento-facial Condition and OHRQoL in Subjects With Mowat-Wilson Syndrome: an Epidemiologic Study.","ORALMOWAT26","Inclusion Criteria:\n\n* individuals affected by MWS with confirmed molecularly diagnosis of ZEB2 gene variation.\n* written informed consent statement signed by parents\u002Flegal guardians for participation in the study\n\nExclusion Criteria:\n\n* individuals not affected by MWS\n* refusal of parents\u002Flegal guardians to participate in the study",{"count":7,"type":23},"Mowat-Wilson Syndrome (MWS) is a rare syndrome characterized by the presence of facial gestalt and delayed psychomotor development, variably associated with intellectual disability, epilepsy, Hirschsprung's disease (HSCR) and multiple congenital malformations.\n\nAlthough there is evidence of the presence of dental and craniofacial anomalies in MWS, little epidemiological data is available to date.\n\nThe goal of this observational study is to assess oral health and dento-facial phenotype of people affected by Mowat-Wilson Syndrome (MWS). In addition, the Oral Health Related Quality of Life (OHRQoL) will be investigated.",[348,349,350,351,352,28,353,354,355,356],"Mowat-Wilson Syndrome","Dental Caries","Periodontal Diseases","Sleep Related Breathing Disorder","Tooth Diseases","Tooth Abnormalities","Oral Health Related Quality of Life (OHRQoL)","Craniofacial Abnormalities","Oral Mucosal Disease",[358,359,360,361,362,355],"Mowat-Wilson syndrome","dental caries","periodontal diseases","malocclusion","oral health","2026-03-19",{"date":365,"type":47},"2026-03-24",{"date":367,"type":23},"2026-04-01",{"date":369,"type":23},"2026-08-30",{"name":371,"class":54},"University of Milan",{"id":373,"slug":374,"hasResults":12,"nctId":375,"briefTitle":376,"officialTitle":377,"acronym":378,"eligibilityCriteria":379,"healthyVolunteers":18,"sex":19,"minAge":85,"maxAge":380,"enrollmentInfo":381,"targetDuration":4,"studyType":89,"phases":382,"briefSummary":383,"conditions":384,"keywords":385,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":390,"lastUpdatePostDateStruct":391,"startDateStruct":393,"completionDateStruct":394,"leadSponsor":396,"locationsCount":4},"100346744","comparison-of-orthodontic-molar-protraction-with-and-without-adjunctive-surgery-100346744","NCT03794726","Comparison of Orthodontic Molar Protraction With and Without Adjunctive Surgery","A Prospective, Randomized Clinical Trial to Compare Orthodontic Molar Protraction With and Without Adjunctive Periodontally Accelerated Osteogenic Orthodontic (PAOO) Surgery.","PAOO","Inclusion Criteria:\n\n* English speaking\n* At least 18 years old\n* Must be a patient of the University of Alabama at Birmingham (UAB) Dental School\n* Able to read and understand informed consent document\n* One or more nonadjacent 1st or 2nd molar teeth that require protraction of ≥ 5 mm in patients undergoing orthodontic tooth movement\n* Presence of periodontally healthy, non-carious neighboring teeth, healthy implants or edentulous ridges on either side of the involved site(s)\n* No anticipated need for restorative care at the teeth to be treated during the study period.\n\nExclusion Criteria:\n\n* Non-English speaking\n* Less than 18 years old\n* Smokers\u002Ftobacco users (\\>10 cigarettes\u002Fday)\n* Patients with systemic pathologies or conditions contraindicating oral surgical procedures or adversely affecting wound healing\n* Presence of active periodontal disease, caries, and\u002For periapical pathology at teeth to be moved orthodontically\n* Previous orthodontic therapy involving molar protraction of teeth to be treated\n* Previous periodontal surgery at site(s) to be treated","99 Years",{"count":318,"type":23},[91],"This study will compare orthodontic molar protraction with and without adjunctive periodontally accelerated osteogenic orthodontic (PAOO) surgery prior to orthodontic tooth movement.\n\nTo the investigators' knowledge, this type of molar retraction in adult patients has not been compared with and without the adjunctive use of PAOO for differences in clinical linear tooth movement and patient centered outcomes (discomfort, change in daily activities, satisfaction with esthetic outcomes) in a controlled study.",[28],[386,387,388,389],"Orthodontic tooth movement","Molar protraction","Periodontally accelerated osteogenic orthodontics","Patient-centered outcomes","2026-03-17",{"date":392,"type":47},"2026-03-20",{"date":49,"type":23},{"date":395,"type":23},"2028-12-30",{"name":397,"class":54},"University of Alabama at Birmingham",{"id":399,"slug":400,"hasResults":12,"nctId":401,"briefTitle":402,"officialTitle":403,"acronym":4,"eligibilityCriteria":404,"healthyVolunteers":12,"sex":19,"minAge":85,"maxAge":4,"enrollmentInfo":405,"targetDuration":4,"studyType":89,"phases":407,"briefSummary":408,"conditions":409,"keywords":4,"overallStatus":130,"whyStopped":4,"lastUpdateSubmitDate":410,"lastUpdatePostDateStruct":411,"startDateStruct":412,"completionDateStruct":414,"leadSponsor":416,"locationsCount":419},"100615298","a-prospective-multicenter-clinical-investigation-evaluating-the-accuracy-of-the-trimline-design-when-treated-with-suresmile-aligners-100615298","NCT07290790","A Prospective Multicenter Clinical Investigation Evaluating the Accuracy of the Trimline Design When Treated With SureSmile® Aligners.","A Prospective, Multicenter, Randomized, Post-market Clinical Investigation to Assess the Accuracy of Different Tooth Movements for Patients Undergoing Clear Aligner Therapy (CAT) With SureSmile® Clear Aligners With Three Different Trimlines.","Inclusion Criteria:\n\n* Subject willing to participate in the clinical investigation, able to understand the intent risks and benefits of the clinical investigation as well as associated time commitment and follow-ups visits.\n* Subject has signed and dated the informed consent form (ICF) .\n* Subject aged 18 years or above at time of informed consent.\n* Subject has permanent dentition (i.e., all 2nd molars).\n* Subject with a dental malocclusion, consistent with Levels 1 and 2 case complexity and within the clinical references as defined in the SureSmile Case Selection Guide.\n\n  * Crowding or spacing must be ≤6mm present in one or both arches consistent with level 1 and 2 of case complexity.\n  * Midline deviation must be ≤3 mm consistent with level 1 and 2 of case complexity.\n  * Overjet must be ≤4 mm consistent with level 1 and 2 case complexity.\n  * Overbite must be ≤3 mm consistent with level 1 and 2 case complexity.\n  * Anterior open bite must be ≤1 mm, consistent with level 1 and 2 case complexity.\n* Intermaxillary elastics may be included within the treatment plan to support sagittal, vertical, or transverse correction within the limits defined under exclusion criteria.\n\nExclusion Criteria:\n\n* Subjects unlikely to comply with investigational procedures, or unlikely to come back for follow-up visits, as judged by the Investigator.\n* Subject that presents a dental malocclusion classified as level 3 case complexity, as defined in the SureSmile Case Selection Guide.\n* Subjects who have completed aligner therapy within the last 12 months or who are in active orthodontic treatment.\n* Subjects with active periodontal disease or other unresolved dental conditions such as active cavities, active periodontal disease.\n* Subjects with treatment plans requiring transverse correction requiring expansion greater than 4 mm per arch or 2 mm per quadrant, or any skeletal transverse correction.\n* Treatment plans requiring sagittal correction exceeding a half-cusp discrepancy (i.e., \\>½ unit) in molar or canine relationships.\n* Subjects with treatment plans require vertical correction beyond Level 1 and 2 thresholds (i.e., overbite \\>3 mm or anterior\u002Fposterior open bite \\>1 mm), or vertical elastics exceeding 3 mm.\n* TMJ (Temporo-Mandibular Join) disorders or history of headaches or migraines.\n* Participants with known history of plastic allergies.\n* Subjects with presence of skeletal discrepancies necessitating orthognathic surgery, rapid palatal expansion, other orthopedic intervention, unilateral or bilateral cross-bites, mandibular deviations in association with the diagnosed malocclusion\n* The use of TADs (Temporary Anchor Devices), plates, other fixed anchorage ancillaries or the use of functional appliances (distalizers, growth modification devices), any approach involving orthopedic or skeletal sagittal correction or the use of hybrid fixed appliances are not considered part of the scope of this clinical investigation and these subjects are not eligible.\n* Uncontrolled para-functional habits, e.g., bruxism.\n* Any other condition that would make the subject unsuitable for participation, including but not limited to:\n\n  * Unstable psychiatric illness.\n  * Recent myocardial infarction (\\\u003C 3 months\\*).\n  * Recent cerebrovascular accident (\\\u003C 3 months\\*).\n  * Recent cardiac-valvular prosthesis placement (\\\u003C 3 months\\*).\n  * Hemorrhagic diathesis.\n  * Severe liver dysfunction.\n  * Known or suspected current malignancy.\n* Known pregnancy at the time of enrolment.\n* Previous enrolment in the present clinical investigation.\n* Involvement in the planning and conduct of the clinical investigation (applies to both Dentsply Sirona personnel and the clinical investigation site).\n* Participation in another clinical investigation that may interfere with the present clinical investigation.",{"count":406,"type":23},90,[91],"This is a three-armed, multicenter clinical study evaluating the SureSmile clear aligner medical device. The primary objective is to confirm the safety and assess the accuracy of different tooth movements. In addition, the study will investigate and compare three different trimline designs: Scalloped, Straight, and Straight Extended.",[28],"2026-03-06",{"date":247,"type":47},{"date":413,"type":47},"2026-01-29",{"date":415,"type":23},"2028-02-01",{"name":417,"class":418},"Dentsply Sirona Implants and Consumables","INDUSTRY",6,{"id":421,"slug":422,"hasResults":12,"nctId":423,"briefTitle":424,"officialTitle":425,"acronym":4,"eligibilityCriteria":426,"healthyVolunteers":12,"sex":19,"minAge":85,"maxAge":4,"enrollmentInfo":427,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":429,"conditions":430,"keywords":4,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":431,"lastUpdatePostDateStruct":432,"startDateStruct":434,"completionDateStruct":436,"leadSponsor":438,"locationsCount":55},"100621056","finite-element-modelling-of-le-fort-i-osteotomy-fixation--psi-vs-miniplates-100621056","NCT07365657","Finite Element Modelling of Le Fort I Osteotomy Fixation : PSI vs Miniplates","Subject-specific Finite Element Modelling of Le Fort I Osteotomy Fixation : Patient-specific Implants vs Miniplates","Inclusion Criteria:\n\n* Patient operated on By Pr SAVOLDELLI.\n* Patient undergoing patient-specific orthognathic surgery.\n* Access to numerical (digital) planning.\n\nExclusion Criteria:\n\n* Previous maxillo-facial trauma.\n* Facial cleft.",{"count":428,"type":23},2,"This study aimed to evaluate the biomechanical performance of patient-specific versus conventional fixation for Le Fort I osteotomy using subject-specific finite element models derived from real surgical plans. Two distinct clinical scenarios-a minor advancement without impaction and a moderate advancement with posterior impaction-were analyzed to determine how surgical movements influence implant stress, bone stress, and maxillary micromotion. By combining surgical planning with validated computational modeling, this work provides clinically relevant insight to optimize PSI design and guide fixation strategy selection in orthognathic surgery.",[28],"2026-01-16",{"date":433,"type":47},"2026-01-26",{"date":435,"type":23},"2026-01-20",{"date":437,"type":23},"2026-01-23",{"name":439,"class":54},"Centre Hospitalier Universitaire de Nice",{"id":441,"slug":442,"hasResults":12,"nctId":443,"briefTitle":444,"officialTitle":445,"acronym":446,"eligibilityCriteria":447,"healthyVolunteers":18,"sex":19,"minAge":260,"maxAge":448,"enrollmentInfo":449,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":451,"conditions":452,"keywords":453,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":455,"lastUpdatePostDateStruct":456,"startDateStruct":458,"completionDateStruct":460,"leadSponsor":462,"locationsCount":55},"100617171","validation-of-ai-based-cephalometric-analysis-in-orthodontics-100617171","NCT07315152","Validation of AI-Based Cephalometric Analysis in Orthodontics","Validation of Artificial Intelligence-Driven Cephalometric Analysis as a Reliable Tool for Orthodontic Diagnosis and Treatment Planning","AI-CEPH","Inclusion Criteria:\n\n* No systemic disease.\n* Not receiving medical treatment that could interfere with bone metabolism.\n* Good level of oral hygiene.\n* No periodontal disease or radiographic evidence of bone loss.\n\nExclusion Criteria:\n\n* Periodontally compromised patients.\n* Presence of systemic diseases.\n* Drug dependencies.\n* Uncooperative patients.","30 Years",{"count":450,"type":23},55,"This study is designed to evaluate whether artificial intelligence can analyze cephalometric images in orthodontics as a reliable tool for diagnosis and treatment planning. The study will include orthodontic patients who need cephalometric evaluation. Participants will have their X-ray images analyzed using both the AI system and traditional manual methods. The study will compare the results to see how closely the AI measurements match the standard measurements. This information may help patients, families, and health care providers understand how AI can support orthodontic diagnosis and treatment planning.",[28],[454],"Treatment planing Orthodontics cephalometric analysis","2026-01-03",{"date":457,"type":47},"2026-01-07",{"date":459,"type":23},"2026-05",{"date":461,"type":23},"2028-06",{"name":463,"class":54},"Al-Azhar University",{"id":465,"slug":466,"hasResults":12,"nctId":467,"briefTitle":468,"officialTitle":469,"acronym":4,"eligibilityCriteria":470,"healthyVolunteers":12,"sex":19,"minAge":471,"maxAge":472,"enrollmentInfo":473,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":475,"conditions":476,"keywords":4,"overallStatus":130,"whyStopped":4,"lastUpdateSubmitDate":477,"lastUpdatePostDateStruct":478,"startDateStruct":480,"completionDateStruct":482,"leadSponsor":484,"locationsCount":55},"100617085","facially-driven-digital-full-mouth-rehabilitation-100617085","NCT07314034","\"Facially Driven Digital Full-Mouth Rehabilitation\"","Facially Driven Digital Workflow for Esthetic and Functional Full-mouth Rehabilitation","Inclusion Criteria:\n\n* Adults aged 20-45 years with partial or complete edentulism requiring full-mouth rehabilitation.\n* Patients with bite dysfunction, malocclusion, or esthetic concerns suitable for digital workflow treatment.\n* Adequate bone volume for implant placement or candidates for TAD-assisted tooth movement.\n* Willingness to undergo treatment using a fully digital, facially guided workflow and comply with follow-up visits.\n* Ability to provide informed consent.\n\nExclusion Criteria:\n\n* Systemic conditions contraindicating implant or surgical procedures (e.g., uncontrolled diabetes, immunosuppression).\n* Active oral infections or untreated periodontal disease.\n* Heavy smokers (\\>10 cigarettes\u002Fday) or substance abuse.\n* History of head and neck radiation therapy or bisphosphonate use.\n* Pregnancy or breastfeeding.\n* Inability to comply with treatment or follow-up protocol.","20 Years","45 Years",{"count":474,"type":23},10,"Participants with bite difficulties, smile dissatisfaction, and missing mandibular molars was rehabilitated using a fully digital, facially driven workflow. Integration of intraoral, facial, and CBCT data guided esthetic design, occlusion, and implant planning, resulting in precise alignment, functional occlusion, and esthetic restoration with veneers, zirconia crowns, TAD-assisted molar intrusion, and guided implants.",[28],"2025-12-30",{"date":479,"type":47},"2026-01-02",{"date":481,"type":47},"2024-06-01",{"date":483,"type":23},"2026-12-30",{"name":485,"class":54},"Menoufia University",{"id":487,"slug":488,"hasResults":12,"nctId":489,"briefTitle":490,"officialTitle":490,"acronym":4,"eligibilityCriteria":491,"healthyVolunteers":18,"sex":19,"minAge":492,"maxAge":493,"enrollmentInfo":494,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":496,"conditions":497,"keywords":500,"overallStatus":130,"whyStopped":4,"lastUpdateSubmitDate":502,"lastUpdatePostDateStruct":503,"startDateStruct":505,"completionDateStruct":507,"leadSponsor":509,"locationsCount":55},"100600214","evaluation-of-the-effect-of-adenoid-hypertrophy-on-the-masseter-muscle-in-children-a-comparative-ultrasonographic-study-100600214","NCT07094581","Evaluation of the Effect of Adenoid Hypertrophy on the Masseter Muscle in Children: A Comparative Ultrasonographic Study","Inclusion Criteria:\n\n* Children aged between 3 and 8 years\n* Children diagnosed with adenoid hypertrophy\n* Children without any systemic disease\n\nExclusion Criteria:\n\n* Children with a history of surgery for adenoid hypertrophy\n* Children who are uncooperative during clinical examination\n* Children with syndromes involving the maxillofacial region\n* Children with multiple missing teeth","3 Years","8 Years",{"count":495,"type":23},72,"The goal of this observational study is to evaluate the effect of adenoid hypertrophy on the masseter muscle in children aged 3 to 8 years. The primary objectives are:\n\n* To assess whether adenoid hypertrophy affects the thickness or structure of the masseter muscle.\n* To determine whether there is a measurable difference in masseter muscle characteristics between children with and without adenoid hypertrophy.\n\nResearchers will compare children diagnosed with adenoid hypertrophy and scheduled for adenoidectomy to healthy controls without adenoid hypertrophy.\n\nEach participant will:\n\n* Undergo ultrasonographic examination of the masseter muscle using a 9L linear probe (6-15 MHz), and\n* Have their occlusal relationship, dental findings, age, sex, and adenoid hypertrophy grade recorded.",[498,499,28],"Adenoid Hypertrophy","Masseter Muscle",[498,501,499],"Ultrasonography","2025-12-25",{"date":504,"type":47},"2025-12-29",{"date":506,"type":47},"2024-07-20",{"date":508,"type":23},"2026-02-28",{"name":510,"class":54},"Melis AKYILDIZ",{"id":512,"slug":513,"hasResults":12,"nctId":514,"briefTitle":515,"officialTitle":516,"acronym":361,"eligibilityCriteria":517,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":471,"enrollmentInfo":518,"targetDuration":4,"studyType":89,"phases":520,"briefSummary":521,"conditions":522,"keywords":4,"overallStatus":130,"whyStopped":4,"lastUpdateSubmitDate":524,"lastUpdatePostDateStruct":525,"startDateStruct":527,"completionDateStruct":529,"leadSponsor":531,"locationsCount":55},"100491851","treatment-of-mild-class-ii-malocclusion-in-adult-patients-with-clear-aligners-versus-fixed-multibracket-therapy-100491851","NCT05684510","Treatment of Mild Class II Malocclusion in Adult Patients With Clear Aligners Versus Fixed Multibracket Therapy","Evaluation of Efficacy of Clear Aligners in Correction of Class II Malocclusion Using Intermaxillary Elastics: A Randomized Controlled","Inclusion Criteria:\n\n* \\- Patients with permanent occlusion at age 15-20 years.\n* Patients with class II division I (half cusp or Less) with moderate overjet (2-4mm).\n* Patients with normal or horizontal growth pattern.\n* Mild crowding (\\_\\\u003C2 mm) in maxillary and mandibular arch.\n* Patient with satisfactory periodontal health and good oral hygiene\n* No previous orthodontic treatment\n* Comprehensive medical and dental history ruling out any systemic disease.\n\nExclusion Criteria:\n\n* Patients with periodontal disease.\n* Patients with vertical growth pattern.\n* Patients with missing or extracted teeth except third molar.\n* Patients with temporomandibular joint disorder.\n* Patients with Skeletal open bite.\n* Patients with poor oral and gingival health\n* Patients with neuromuscular disorder.\n* Patients with severe skeletal class II.",{"count":519,"type":23},24,[91],"Patient with class ii division 1 malocclusion who have mild increased overjet will be treated in this study. The efficacy of clear aligners in the treatment of Class II division 1 Malocclusion Using Intermaxillary Elastics will be assessed. The skeletal, dental and soft tissues changes resulted by this intervention will be studied and compared with the results of Traditional treatment with fixed appliances.\n\nThere are two group:\n\n1. a group of patients in which participants will be undergo to the clear aligners with class ii elastics.\n2. a group of patients in which participants will be undergo to the traditional fixed appliances with class ii elastics.",[28,523],"Class II Malocclusion","2025-09-09",{"date":526,"type":47},"2025-09-15",{"date":528,"type":23},"2026-08-25",{"date":530,"type":23},"2026-12-01",{"name":532,"class":54},"Hama University",{"id":534,"slug":535,"hasResults":12,"nctId":536,"briefTitle":537,"officialTitle":538,"acronym":539,"eligibilityCriteria":540,"healthyVolunteers":12,"sex":19,"minAge":85,"maxAge":86,"enrollmentInfo":541,"targetDuration":4,"studyType":89,"phases":542,"briefSummary":543,"conditions":544,"keywords":545,"overallStatus":130,"whyStopped":4,"lastUpdateSubmitDate":549,"lastUpdatePostDateStruct":550,"startDateStruct":552,"completionDateStruct":554,"leadSponsor":556,"locationsCount":55},"100557301","evaluation-of-the-perceived-experience-of-patients-treated-with-aligners-with-two-different-timings-100557301","NCT06536335","Evaluation of the Perceived Experience of Patients Treated With Aligners With Two Different Timings","Evaluation of the Perceived Experience of Patients Treated With Aligners With Two Different Attachment Placement Times: Randomised Controlled Clinical Trial","ALLIN-1","Inclusion Criteria:\n\n* Age between 18 and 40 years;\n* Class I malocclusion\n* Non-extractive treatment;\n* No missing teeth (third molars excluded);\n* Good oral and general health.\n* Signature of written informed consent to participate in the study\n\nExclusion Criteria:\n\n* Patients with tooth-related pain (presence of dental and\u002For periodontal abscesses and presence of gingivitis)\n* Presence of semi-included elements;\n* Patients taking bisphosphonates or other anti-resorptive drugs;\n* Patients with conditions involving chronic pain and\u002For on chronic therapy with antifiammatories\u002Fopiods or other drugs that may act on pain perception;\n* Patients with temporomandibular disorders;\n* Patients with conditions that may impair the ability to objectively report any sensations of discomfort or pain (e.g., mental retardation, dementia);\n* Refusal to sign the written informed consent to participate in the study",{"count":519,"type":23},[91],"The primary aim of the study is to compare the perception of pain and discomfort with two different protocols of attachments' placement during clear aligner therapy: the conventional protocol (CP), when attachments' placement is performed are placed at the delivery of the first aligner; the delayed protocol (DP), when the attachments' placement is performed at the delivery of the third aligner. The rationale of this study is to evaluate whether dividing the two phases most associated with the onset of pain and discomfort, namely the initiation of aligner therapy and the placement of attachments, can improve patients' quality of life during clear aligner treatment. Patients' discomfort will be evaluated with a questionnaire adapted by OHIP-14 (Oral Health Impact Profile 14)",[28],[546,547,28,548],"Attachment","Discomfort","Questionnaires","2025-08-26",{"date":551,"type":47},"2025-08-27",{"date":553,"type":47},"2024-09-01",{"date":555,"type":23},"2025-11-30",{"name":557,"class":54},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS",{"id":559,"slug":560,"hasResults":12,"nctId":561,"briefTitle":562,"officialTitle":563,"acronym":4,"eligibilityCriteria":564,"healthyVolunteers":12,"sex":19,"minAge":260,"maxAge":85,"enrollmentInfo":565,"targetDuration":566,"studyType":24,"phases":4,"briefSummary":567,"conditions":568,"keywords":569,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":574,"lastUpdatePostDateStruct":575,"startDateStruct":577,"completionDateStruct":578,"leadSponsor":580,"locationsCount":55},"100602763","relationship-between-malocclusion-severity-and-periodontitis-risk-100602763","NCT07127744","Relationship Between Malocclusion Severity and Periodontitis Risk","Determination of the Relationship Between Orthodontic Malocclusion Severity and Periodontitis Risk Using RANKL, OPG and Oxidative Stress Markers","Inclusion Criteria:\n\n* Patients between the ages of 12 and 18,\n* Patients with all permanent teeth,\n* Not having taken antibiotics, steroids, and\u002For nonsteroidal anti-inflammatory drugs in the last 3 weeks,\n* Not having an active infectious disease,\n* Not having chronic medication use that affects periodontal tissues (cyclosporine A, Phenytoin),\n* Not having taken antioxidant supplements in the last 6 months.\n\nExclusion Criteria:\n\n* Presence of any congenital craniofacial deformity (cleft lip and palate or any other craniofacial syndrome or deformity),\n* Patients who have previously started or completed orthodontic treatment,\n* Patients who have received periodontal treatment in the last 6 months,\n* Acute illness,\n* Systemic illness, mental illness, immunosuppressive medications, or immunodeficiency.",{"count":22,"type":23},"1 Day","The goal of this observational study is to examine the potential relationship between the severity of orthodontic malocclusion and the risk of developing periodontitis in individuals by evaluating salivary and gingival crevicular levels of RANKL, osteoprotegerin (OPG), and oxidative stress biomarkers.\n\nThe main question it aims to answer is:\n\nDoes increasing severity of orthodontic malocclusion contribute to a higher risk of periodontitis through changes in RANKL\u002FOPG balance and oxidative stress levels?\n\nParticipants with different levels of tooth misalignment (malocclusion) will be examined to assess the condition of their teeth and gums. During this examination, information such as dental plaque, gum bleeding, and the depth of gum pockets will be recorded. In addition, fluid samples collected from the gums will be tested in the laboratory to measure certain biological substances and chemical markers related to the body's balance between harmful and protective effects. These measurements will be done using special laboratory tests.",[28],[361,570,571,572,573],"periodontitis","RANKL","Osteoprotegerin","oxidative stress","2025-08-16",{"date":576,"type":47},"2025-08-22",{"date":526,"type":23},{"date":579,"type":23},"2026-01-19",{"name":581,"class":54},"Recep Tayyip Erdogan University Training and Research Hospital",{"id":583,"slug":584,"hasResults":12,"nctId":585,"briefTitle":586,"officialTitle":587,"acronym":4,"eligibilityCriteria":588,"healthyVolunteers":12,"sex":19,"minAge":260,"maxAge":85,"enrollmentInfo":589,"targetDuration":566,"studyType":24,"phases":4,"briefSummary":591,"conditions":592,"keywords":593,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":598,"lastUpdatePostDateStruct":599,"startDateStruct":601,"completionDateStruct":602,"leadSponsor":604,"locationsCount":55},"100601885","salivary-stress-markers-associated-with-malocclusion-severity-100601885","NCT07116317","Salivary Stress Markers Associated With Malocclusion Severity","Determination of the Relationship Between Orthodontic Malocclusion Severity and Salivary Cortisol, Dehydroepiandrosterone and Chromogranin A Levels","Inclusion Criteria:\n\n* Patients between the ages of 12 and 18,\n* Patients with all permanent teeth,\n* Patients with the ability to read and understand,\n* Patients with a cephalometric evaluation file and maxillary and mandibular impression dental models before diagnostic orthodontic treatment.\n\nExclusion Criteria:\n\n* Presence of any congenital craniofacial deformity (cleft lip and palate or any other craniofacial syndrome or deformity),\n* Patients who have previously initiated or completed orthodontic treatment,\n* Patients with a history of psychiatric illness, the presence of caries, facial asymmetry, and any skin deformity affecting facial aesthetics.",{"count":590,"type":23},120,"The aim of this observational study is to evaluate the relationship between the severity of orthodontic malocclusion and psychophysiological stress levels in individuals aged 12 to 18 years. The study will investigate the association between malocclusion severity and both stress-related salivary biomarkers and psychosocial factors.\n\nThe primary research question is as follows:\n\nAs the severity of orthodontic malocclusion increases, do levels of salivary stress biomarkers (cortisol, DHEA, and chromogranin A), self-esteem, and social appearance anxiety significantly change in adolescent individuals?\n\nMethod:\n\nThe study will include participants between the ages of 12 and 18. The severity of malocclusion will be assessed through clinical examination. Psychological assessments will be conducted using structured questionnaires to measure self-esteem and social appearance anxiety. In addition, saliva samples collected in the morning will be analyzed using the ELISA method to determine levels of cortisol, DHEA, and chromogranin A (CgA). The data will be statistically analyzed to identify the potential relationship between orthodontic malocclusion and biological and psychosocial indicators of stress.",[28],[361,594,595,596,597],"stress","cortisol","Dehydroepiandrosterone","Chromogranin A","2025-08-08",{"date":600,"type":47},"2025-08-11",{"date":600,"type":23},{"date":603,"type":23},"2026-02-09",{"name":581,"class":54},{"id":606,"slug":607,"hasResults":12,"nctId":608,"briefTitle":609,"officialTitle":609,"acronym":4,"eligibilityCriteria":610,"healthyVolunteers":18,"sex":19,"minAge":85,"maxAge":86,"enrollmentInfo":611,"targetDuration":4,"studyType":89,"phases":613,"briefSummary":614,"conditions":615,"keywords":4,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":616,"lastUpdatePostDateStruct":617,"startDateStruct":619,"completionDateStruct":621,"leadSponsor":623,"locationsCount":55},"100602154","comparison-of-outcome-of-safe-t-separators-and-conventional-elastomeric-separators-100602154","NCT07119814","Comparison of Outcome of Safe T Separators and Conventional Elastomeric Separators","Inclusion Criteria:\n\n* Age range (18-40) Years Male\u002FFemale Patients undergoing fixed orthodontic treatment as mentioned in operational\n\nExclusion Criteria:\n\n* Patients with poor oral hygiene Patients with periodontal conditions Patients failed to provide consent form",{"count":612,"type":23},66,[91],"All participants in this study will be provided with information concerning the study's objectives, and benefits associated with participation. Participants will be informed that their involvement in this study presents no potential risks associated with their participation. Written consent will be obtained with appropriate information provided. Demographic data like age, BMI, gender, residence, socio economic status, occupation status, and literacy status will be documented. Patients undergoing fixed orthodontic treatment will be allocated in two groups equally by using the blocked randomization technique. Patients in Group A will undergo safe-T separators i.e initial thickness of Safe-T separators will be 1mm, Patients in Group B will undergo conventional elastomeric separators i.e thickness of elastomeric separators will be 1.2 mm. Separators will be positioned on either side of lower arch, each type of separator will be in sites, resulting in a sites within the lower arch. A separator placement tool will be utilised to position the separators. The comprehensive assessment will be carried out under the supervision of a consultant possessing at least five years of post-fellowship experience. Patient data will be recorded using a predefined structured proforma.",[28],"2025-08-06",{"date":618,"type":47},"2025-08-13",{"date":620,"type":23},"2025-12-01",{"date":622,"type":23},"2026-04-15",{"name":624,"class":54},"Khyber College of dentistry",{"id":626,"slug":627,"hasResults":12,"nctId":628,"briefTitle":629,"officialTitle":630,"acronym":4,"eligibilityCriteria":631,"healthyVolunteers":12,"sex":19,"minAge":632,"maxAge":4,"enrollmentInfo":633,"targetDuration":4,"studyType":89,"phases":635,"briefSummary":636,"conditions":637,"keywords":639,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":650,"lastUpdatePostDateStruct":651,"startDateStruct":653,"completionDateStruct":655,"leadSponsor":657,"locationsCount":55},"100597799","comparing-ligation-methods-during-canine-retraction-stage-using-conventional-brackets-100597799","NCT07063186","Comparing Ligation Methods During Canine Retraction Stage Using Conventional Brackets","Comparing Ligation Methods During Canine Retraction Stage Using Conventional Brackets: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients aged 16 years and above.\n* Patients who require extraction of one or both maxillary first premolars as part of their orthodontic treatment.\n* Patient who are planned for maximum anchorage using Nance appliance.\n* Patients who require at least 4mm of maxillary canine retraction as part of their orthodontic treatment.\n* Patients with good oral hygiene.\n\nExclusion Criteria:\n\n* Patients with craniofacial anomalies.\n* Patients with systemic or bone diseases that could affect tooth movement (e.g., osteopetrosis, osteogenesis imperfecta, Paget's disease).\n* Patients on medications that may affect tooth movement.\n* Patients with hypodontia.\n* Patients with poor dental health where orthodontic treatment is not feasible.","16 Years",{"count":634,"type":23},60,[91],"The goal of this Randomized Controlled Trial (RCT) is to determine the most effective way to tie the main wire to the regular orthodontic brackets during the stage of orthodontic treatment where the canines are retracted. This study is for orthodontic patients aged 16 years and older who need to have their canines retracted into spaces where other teeth have been removed.\n\nThe main questions it aims to answer are:\n\n1. What is the effect of different ways of tying the wire to the braces on how much the maxillary canine moves back using conventional brackets?\n2. How do various ways of tying the wire influence unwanted movements of the maxillary canines-specifically rotation, tipping, and extrusion?\n3. What is the effect of these different tying methods on how much the back molar teeth shift forward (this is called \"anchorage loss\") while the maxillary canine is being pulled back?\n\nResearchers will compare three different ways of tying the wire to the braces to see if they differ in the amount of maxillary canine retraction, three-dimensional positional changes (rotation, tipping, and extrusion), and anchorage loss of maxillary first molars:\n\n* Group A: Uses an elastic power chain that wraps around all four parts (wings) of the brace.\n* Group B: Uses thin stainless-steel wires (ligatures) to tie the brace first, then an elastic power chain is placed over these wires, also wrapping around all four parts of the brace.\n* Group C: Uses small elastic rings on the two front parts (mesial wings) of the brace, and an elastic power chain on the two back parts (distal wings) of the brace.\n\nParticipants will consist of orthodontic patients aged 16 years and above from the Postgraduate Orthodontic Clinic, Kulliyyah of Dentistry, IIUM, Kuantan, who require extraction of one or both maxillary first premolars, are planned for maximum anchorage using a Nance appliance, need at least 4mm of maxillary canine retraction, and have good oral hygiene.\n\nParticipants will:\n\n* Undergo screening and provide written informed consent for participation.\n* Receive a comprehensive orthodontic examination, including photographic records, impressions, and radiographs.\n* Have molar bands fitted and a Nance button fabricated and cemented, followed by dental extractions of maxillary first premolars.\n* Undergo bond-up with conventional stainless-steel brackets and initial archwire placement.\n* Progress through an alignment and levelling phase using progressively larger archwires, culminating in a 0.019 x 0.025-inch stainless steel archwire.\n* At baseline (T0) and subsequent 4-week follow-up intervals (T1, T2, T3), have intraoral three-dimensional scans taken after archwire removal.\n* Receive canine retraction using elastomeric power chains delivering a standardized 150g force. This is done as a two-step retraction, where the canine is retracted in isolation.\n* Continue to receive full orthodontic treatment to completion even after the data collection period ends at T3.",[28,638],"Canine Retraction",[640,638,641,642,643,644,645,646,647,648,649],"Ligation Methods","Conventional Brackets","3D Superimposition","Two-step Retraction","Anchorage Loss","Three-dimensional Positional Change","Canine Rotation","Canine Tipping","Canine Extrusion","Intraoral Scanners","2025-07-12",{"date":652,"type":47},"2025-07-16",{"date":654,"type":23},"2025-11-01",{"date":656,"type":23},"2027-12-31",{"name":251,"class":54},{"id":659,"slug":660,"hasResults":12,"nctId":661,"briefTitle":662,"officialTitle":663,"acronym":4,"eligibilityCriteria":664,"healthyVolunteers":12,"sex":19,"minAge":665,"maxAge":471,"enrollmentInfo":666,"targetDuration":566,"studyType":24,"phases":4,"briefSummary":668,"conditions":669,"keywords":4,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":671,"lastUpdatePostDateStruct":672,"startDateStruct":674,"completionDateStruct":676,"leadSponsor":678,"locationsCount":4},"100543170","epidemiological-investigation-of-malocclusion-in-china-100543170","NCT06352385","Epidemiological Investigation of Malocclusion in China","A Comprehensive Epidemiological Investigation of Malocclusion in China","Inclusion Criteria:\n\n1. Individuals with all genders;\n2. Individuals with good general health;\n3. Individuals with no history of orthodontic treatment or other maxillofacial surgical interventions;\n4. Individuals who agree to and are willing to sign the informed consent form.\n\nExclusion Criteria:\n\n1. Individuals diagnosed with genetic or systemic disorders;\n2. Individuals with a recent (within the past 3 months) history of maxillofacial trauma;\n3. Individuals who are incapable of undergoing oral examinations or completing the necessary questionnaires.","4 Years",{"count":667,"type":23},19847,"Malocclusion is a kind of craniomaxillofacial complex deformity caused by heredity, environment, bad habits, trauma, inflammation, tumor and aging. Notably, the last comprehensive national prevalence data on malocclusion in China, which encompassed a significant sample size, dates back over two decades. Given the evolving nature of these epidemiological metrics, such as prevalence rates, it is imperative to update our understanding. Consequently, there is an urgent need for China to undertake a unified, standardized epidemiological survey of malocclusion with a substantial sample size to ensure accurate and timely data collection.",[670,28],"Epidemiological Investigation","2025-05-11",{"date":673,"type":47},"2025-05-14",{"date":675,"type":23},"2025-05",{"date":677,"type":23},"2026-12",{"name":679,"class":54},"Shanghai Jiao Tong University School of Medicine"]