[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"malocclusions\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:malocclusions":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,47,71,104],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100627978","assessment-of-the-locally-administrated-vitamin-d3-and-corticision-efficacy-on-orthodontic-canine-retraction-100627978",false,"NCT07455656","Assessment of the Locally Administrated Vitamin D3 and Corticision Efficacy on Orthodontic Canine Retraction","Assessment of the Locally Administrated Vitamin D3 and Corticision Efficacy on Orthodontic Canine Retraction: A Prospective Clinical Study","Inclusion criteria:\n\n1. Orthodontic patients referred for therapeutic extraction of bilateral maxillary first premolars (Angle Class II division 1 cases, with crowding and bimaxillary protrusion).\n2. Fully erupted permanent teeth (except third molar).\n3. Age 13-20 patients.\n4. No previous orthodontic treatment.\n5. Good oral and general health.\n6. No systemic disease or regular medication that could interfere with and\u002For affect orthodontic teeth movement.\n\nExclusion criteria:\n\n1. Patients with impacted canines.\n2. Patients with severe crowding.\n3. Patients with untreated decay or any endodontic lesions.\n4. Patients with thyroid, parathyroid, or renal and liver disease.",true,"ALL","13 Years","20 Years",{"count":21,"type":22},16,"ESTIMATED","INTERVENTIONAL",[25],"NA","To study the effect vitamin D effect on orthodontic tooth movement when used in combination with coticision technique, independent t test or an equivalent non-parametric test will be used for comparison. According to a previous study by (S. T. Varughese, et al. (2019) , \"Effect of vitamin D on canine distalization and alveolar bone density using multi-slice spiral CT: a randomized controlled trial",[28,29],"Malocclusions","Canine Retraction",[31,32,33],"Orhodontic tooth movement","Canine retraction","Extraction first premolars","RECRUITING","2026-03-03",{"date":37,"type":38},"2026-03-06","ACTUAL",{"date":40,"type":38},"2025-08-01",{"date":42,"type":22},"2027-08-01",{"name":44,"class":45},"Al-Azhar University","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":17,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":23,"phases":58,"briefSummary":59,"conditions":60,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":46},"100615972","effects-of-vitamin-d-in-patients-undergoing-fixed-orthodontic-mechanotherapy-100615972","NCT07299552","Effects of Vitamin D in Patients Undergoing Fixed Orthodontic Mechanotherapy","Effects of Vitamin D on Salivary Opiorphin Level, Pain Perception and Tooth Movement in Patients Undergoing Fixed Orthodontic Mechanotherapy","Inclusion Criteria:\n\n1. Age Range: 18 to 35 years old. This age group is common and suitable for orthodontic treatment. During this period, skeletal remodeling is active, which is conducive to observing tooth movement and related physiological changes. It is also a stage where the regulatory effects of vitamin D on growth, development, and physiological functions are more pronounced.\n2. Orthodontic Requirement: Patients diagnosed with Class I malocclusion with extraction of all first premolars in both upper and lower arches, using MBT orthodontic brackets，and recruited from multiple operators.\n3. Health Status: Patients should be in good general health, without endocrine system diseases that affect calcium and phosphorus metabolism and bone metabolism (such as hyperthyroidism or hypothyroidism, parathyroid diseases, etc.). They should also have no severe liver or kidney diseases (since abnormal liver and kidney functions can interfere with the activation and metabolism of vitamin D), and no autoimmune diseases (as autoimmune abnormalities may affect the inflammatory response and tissue repair mechanisms, thus interfering with the experimental results).\n4. Medication History: Patients who have not taken any medications affecting calcium and phosphorus metabolism (such as bisphosphonates), bone metabolism (such as recombinant human growth hormone or other drugs that promote or inhibit bone growth), and pain perception (such as long-term use of opioid analgesics, antidepressants that affect neurotransmitters) within the past three months are eligible. This ensures that the experiment is not interfered with by external drug factors.\n\nExclusion Criteria:\n\n1. Oral Local Problems: Patients with uncontrolled acute or chronic oral inflammations are excluded, such as the acute stage of pericoronitis of wisdom teeth, severe gingivitis, or periodontitis in the progressive and destructive stage. Such inflammations can interfere with the reaction of orthodontic teeth to force and pain assessment. Those with oral mucosal lesions that affect the comfort of wearing orthodontic appliances and the stability of the oral microenvironment are also excluded.\n2. Systemic Diseases: Besides the aforementioned endocrine, liver and kidney, and autoimmune diseases, patients with severe cardiovascular diseases (who may have difficulty tolerating the stimulation of orthodontic force application and the regular follow-up process), hematological diseases (which affect blood coagulation and tissue repair and increase the risks of orthodontic treatment), malignant tumors (undergoing radiotherapy or chemotherapy that affects systemic metabolism and immunity) are also excluded. These systemic diseases will introduce too many complex variables and affect the observation of the single factor effect of vitamin D.\n3. Special Physiological Periods or Conditions: Pregnant or lactating women are excluded because of the significant fluctuations in hormones and the special nutritional requirements of the fetus or infant, which change the pattern of calcium and phosphorus metabolism. Patients with a recent history of major traumas such as fractures, whose bodies are in a critical period of trauma repair and bone metabolism is in a special stress state, are also not suitable for this experiment as it may interfere with the study of normal orthodontic bone remodeling.\n4. Poor Compliance: Patients who cannot be guaranteed regular follow-ups, take medications as prescribed, and cooperate with various examinations are excluded. For example, those with mental or psychological disorders that make it difficult to follow the medical plan, or those who are highly mobile and unable to maintain stable and continuous treatment and observation. Excluding such patients ensures the integrity and reliability of experimental data and the smooth progress of the experimental process.","18 Years","35 Years",{"count":57,"type":22},48,[25],"The goal of this interventional research is to determine the impact of vitamin D intake on substances in saliva, pain, tooth movement, and the density of the bone around teeth in patients during orthodontic treatment. It will compare the effects of vitamin D supplementation with a placebo to clarify its role in the aforementioned aspects of orthodontic care. The main questions it aims to answer are:\n\nHow does vitamin D supplementation affect salivary opiorphin levels in patients undergoing fixed orthodontic mechanotherapy at Specialist Hospital Universiti Sains Malaysia? What is the impact of vitamin D supplementation on pain perception during fixed orthodontic mechanotherapy? How does vitamin D supplementation influence the rate and quality of tooth movement in patients undergoing fixed orthodontic mechanotherapy? What is the relationship between salivary opiorphin levels and pain perception in patients supplemented with vitamin D during fixed orthodontic mechanotherapy? How does vitamin D supplementation affect changes in alveolar bone density during fixed orthodontic mechanotherapy? Researchers will provide vitamin D to the experimental group while the control group receives a placebo to see if vitamin D intake has an impact on substances in saliva, pain, tooth movement, and the density of the bone around teeth during orthodontic treatment.\n\nParticipants will:\n\nTake vitamin D or a placebo every day for 4 months Visit the clinic once every 4 weeks for checkups and tests Participate in the study for a duration of up to 4 months",[28],"NOT_YET_RECRUITING","2025-12-09",{"date":64,"type":38},"2025-12-23",{"date":66,"type":22},"2025-12-30",{"date":68,"type":22},"2027-01-01",{"name":70,"class":45},"Hospital Universiti Sains Malaysia",{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":75,"acronym":76,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":17,"minAge":54,"maxAge":4,"enrollmentInfo":78,"targetDuration":4,"studyType":23,"phases":80,"briefSummary":81,"conditions":82,"keywords":86,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":46},"100582081","effectiveness-of-auxiliary-segmental-lingual-appliances-in-leveling-the-curve-of-wilson-at-second-molars-100582081","NCT06858670","Effectiveness of Auxiliary Segmental Lingual Appliances in Leveling the Curve of Wilson at Second Molars","EASLALCW","Inclusion Criteria:\n\n* Patients undergoing labial fixed orthodontic treatment.\n* Patients exhibiting an excessive (deep) Curve of Wilson at the second molar bilaterally (meaning lingually inclined mandibular second molar).\n* Patients willing to participate and provide informed consent.\n\nExclusion Criteria:\n\n* Patients with limited mouth opening and gagging reflex preventing placement of auxiliary segmental lingual appliances.",{"count":79,"type":22},20,[25],"This study aims to evaluate the effectiveness of auxiliary segmental lingual appliances in leveling the Curve of Wilson at the second molars in patients undergoing labial fixed orthodontic treatment. Patients exhibiting an excessive (deep) Curve of Wilson at the second molar bilaterally (meaning lingually inclined mandibular second molar) will be recruited.. Using a split-mouth design, one side will receive the intervention (auxiliary segmental lingual appliances), while the other side will serve as the control. The variables measured include the Curve of Wilson at the second and first molars, and the distance from the mesiolingual and distolingual cusps of the second molar to the occlusal plane of the first molar. Measurements will be taken on digital impressions at baseline (T0), after leveling with a stainless steel labial archwire (T1), and three months after applying the auxiliary segmental lingual appliances. The effectiveness will be assessed by comparing the two groups.",[83,84,28,85],"Malocclusion","Malocclusion; Displaced or Missing Teeth","Orthodontic Treatment",[87,88,89,90,91,92,83,93,94],"Auxiliary Segmental Lingual Appliances","Curve of Wilson","Second Molars","Labial Fixed Orthodontic Treatment","Split-Mouth Design","Digital Impressions","Dental Occlusion","Orthodontic Treatment Outcomes","2025-02-27",{"date":97,"type":38},"2025-03-05",{"date":99,"type":22},"2025-03-01",{"date":101,"type":22},"2029-03-01",{"name":103,"class":45},"Hanoi Medical University",{"id":105,"slug":106,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":108,"acronym":4,"eligibilityCriteria":109,"healthyVolunteers":11,"sex":17,"minAge":110,"maxAge":111,"enrollmentInfo":112,"targetDuration":4,"studyType":23,"phases":114,"briefSummary":115,"conditions":116,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":120,"lastUpdatePostDateStruct":121,"startDateStruct":123,"completionDateStruct":125,"leadSponsor":127,"locationsCount":5},"100566984","hyrax-vs-invisalign-palatal-expander-clinical-study-100566984","NCT06662279","Hyrax Vs. Invisalign Palatal Expander Clinical Study","Inclusion Criteria:\n\n* Subject ages 6-11 years old\n* Subject must need maxillary expansion\n* Subjects must have erupted dentition in the area of the primary molars or permanent premolars and the first permanent molar\n\nExclusion Criteria:\n\n* Subjects with palatal exostosis\u002Fsurface aberration\u002F cleft palate\n* Subject's dentition not compatible with device or allergy to device materials\n* Subject with active caries, periodontal disease, TMD","6 Years","11 Years",{"count":113,"type":22},36,[25],"The purpose of this study is to compare expansion result and the overall experience between the Invisalign Palatal Expander and the Hyrax expander.",[28,117,118,119],"Narrow Maxilla","Narrow Maxillary Arch","Crowding","2024-12-02",{"date":122,"type":38},"2024-12-04",{"date":124,"type":38},"2024-10-25",{"date":126,"type":22},"2026-01",{"name":128,"class":129},"Align Technology, Inc.","INDUSTRY"]