[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"marginal-bone-loss\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:marginal-bone-loss":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,47],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100634118",false,"NCT07535528","Implant Placement Depth and Peri-Implant Tissue Outcomes","Influence of Implant Placement Depth (-2 mm vs -4 mm Subcrestal) on Peri-implant Tissue Conditions: a Randomized Clinical Trial Protocol","Inclusion Criteria:\n\n* Patients ≥18 years old with partial edentulism.\n* Need for rehabilitation with fixed implant-supported prostheses in posterior regions.\n* Availability of minimum bone height for implants ≥6 mm in length.\n* Minimum bone width without the need for guided bone regeneration.\n* Supracrestal soft tissue thickness ≥2 mm.\n* Non-smokers or smokers of ≤10 cigarettes\u002Fday.\n* Plaque index and bleeding on probing \\\u003C20%.\n* Probing depth ≤3 mm.\n* Signed informed consent.\n\nExclusion Criteria:\n\n* Systemic diseases contraindicating implant surgery.\n* Treatment with intravenous bisphosphonates.\n* Head and neck radiotherapy.\n* Uncontrolled diabetes.\n* Pregnancy or breastfeeding.\n* Alcohol or drug use.\n* Psychiatric disorders.\n* Need for bone regeneration procedures.\n* Inability to complete follow-up.\n* Implant failure during the study period.",true,"ALL","18 Years",{"count":19,"type":20},80,"ESTIMATED","INTERVENTIONAL",[23],"NA","The primary aim of this randomized clinical trial is to evaluate the influence of subcrestal implant placement depth (-2 mm vs -4 mm) on peri-implant marginal bone level changes, including marginal bone loss and bone remodeling. Secondary outcomes include implant success, peri-implant probing depth (PPD), and bleeding on probing (BoP).\n\nPartially edentulous patients requiring fixed implant-supported prosthetic rehabilitation with two implants in posterior maxillary or mandibular regions will be included. Implants will be placed subcrestally at either -2 mm or -4 mm from the bone crest, following a submerged healing protocol. Allocation to insertion depth will be randomized. Marginal bone level changes will be assessed using standardized periapical radiographs at second-stage surgery, prosthesis placement, and at 1, 3, 6, and 12 months after functional loading. PPD and BoP will be recorded at the same time points.",[26,27,28],"Dental Implant Placement","Soft Tissue Management in Subcrestal Dental Implants","Marginal Bone Loss",[30,31,32,33],"Dental implant","Subcrestal placement","Marginal bone loss","Insertion depth","NOT_YET_RECRUITING","2026-04-14",{"date":37,"type":38},"2026-04-17","ACTUAL",{"date":40,"type":20},"2026-05-15",{"date":42,"type":20},"2027-07-20",{"name":44,"class":45},"University of Valencia","OTHER",1,{"id":48,"slug":49,"hasResults":10,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":10,"sex":16,"minAge":17,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":21,"phases":58,"briefSummary":59,"conditions":60,"keywords":62,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":46},"100576840","comparative-evaluation-between-one-piece-and-two-piece-implants-supporting-mandibular-screw-retained-all-on-four-full-arch-prosthesis-on-peri-implant-bone-changes-100576840","NCT06790524","Comparative Evaluation Between One-piece and Two-piece Implants Supporting Mandibular Screw-retained All-On-Four Full-arch Prosthesis on Peri-implant Bone Changes.","Evaluation of Peri-implant Bone Changes Around One-piece Implant and Two-piece Implants Supporting Mandibular Screw-retained All-On-Four Full Arch Prosthesis: a Randomized Controlled Clinical Trial","RCT","Inclusion Criteria:\n\n* Completely edentulous patients, who can sign an informed consent will be considered eligible for this trial.\n* Residual bone height should have sufficient volume and quality for implant placement with a minimum of 12-14 mm in height and 6 mm in width.\n* Patients who already have existing maxillary and mandibular complete dentures, and after examination of the mandibular dentures, technical problems concerning denture design and\u002For occlusion are found, or who are dissatisfied with the retention and stability of their technically satisfactory mandibular dentures.\n\nExclusion Criteria:\n\n* \\- Patients with conditions that may contraindicate implant placement (e.g., Immunosuppressed or immunocompromised patients, patients under treatment of intravenous amino bisphosphonates, patients undergoing radiotherapy to the head and neck region).\n* Inadequate mouth opening\n* Heavy smokers, more than 10 cigarettes\u002Fday\n* Patients with poor oral hygiene and motivation.\n* Pregnancy or nursing.\n* Drug abusers.\n* Psychiatric problems or unrealistic expectations.\n* Patients with infection and or inflammation in the area intended for implant placement.","70 Years",{"count":57,"type":20},22,[23],"Evaluating the bone changing after receiving one-piece implants supported full arch prosthesis compared to the conventional two-piece implants.",[28,61],"One-piece Implants Versus Two-piece Implants During the Osseointegration Phase",[63],"one-piece implants , All-On-Four, Marginal bone loss","2025-03-06",{"date":66,"type":38},"2025-03-07",{"date":68,"type":20},"2025-03",{"date":70,"type":20},"2025-10",{"name":72,"class":45},"Cairo University"]