[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"marker-structural\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:marker-structural":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,42],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":25,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100601755","fatty-acid-binding-proteins-and-markers-of-cellular-senescence-in-cancer-survivors-100601755",false,"NCT07114614","Fatty Acid Binding Proteins and Markers of Cellular Senescence in Cancer Survivors","Inclusion Criteria:\n\n* Diagnosis of at least one malignancy for which chemotherapy, radiation, and\u002For stem cell transplantation was utilized as part of treatment\n* Completed all therapeutic interventions for their malignancy and are at least 2 years off therapy\n* At least 1-year post-stem cell transplant for malignant condition\n\nExclusion Criteria:\n\n1. Pregnancy at the time of the study\n2. Any autoimmune condition including but not limited to lupus, rheumatoid arthritis, Crohn's disease, ulcerative colitis, type 1 diabetes, EXCEPT well-controlled autoimmune hypothyroidism for at least 6 months\n3. Presence of active graft versus host disease\n4. Malignancy treated using surgery only\n5. Acute relapsed disease or second malignancy\n6. Transplant for non-malignant conditions (e.g. cell disease, Hurler syndrome)\n7. Currently taking systemic steroids and\u002For immunosuppressant medications\n8. Acute illness necessitating hospitalization in the 30 days prior to blood draw\n9. Presence of a chronic inflammatory disease EXCEPT obesity\n10. Fever, active infection or inflammation, or taking antibiotics at the time of blood draw\n11. A diagnosis of Type 2 diabetes or Hypertension treated with medication\n12. Currently lipid lowering medications\n13. Growth hormone deficiency or hypothalamic dysfunction","ALL","5 Years","50 Years",{"count":19,"type":20},120,"ESTIMATED","OBSERVATIONAL","The purpose of this research study is to investigate whether cancer survivors have higher levels of proteins called Fatty Acid Binding Proteins as well as 12 different markers of cellular senescence than people who have never had cancer. Investigators believe that these levels may be elevated in cancer survivors as a result of their cancer and the treatments they received and may put them at higher risk for chronic conditions such as high cholesterol, diabetes, high blood pressure, and obesity. This study will also compare the levels of these proteins and inflammatory markers in the blood with different aspects of cancer treatment the survivors received. Investigators are investigating if there is a correlation between levels of these proteins and markers, the type of treatment cancer survivors received, and development of metabolic conditions.",[24],"Marker; Structural",[26,27,28],"Fatty Acid Binding Proteins","Cancer Survivors","FABP4 and FABP5","RECRUITING","2026-06-29",{"date":32,"type":33},"2026-07-01","ACTUAL",{"date":35,"type":20},"2026-07",{"date":37,"type":20},"2026-12",{"name":39,"class":40},"Case Comprehensive Cancer Center","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":15,"minAge":49,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":53,"phases":54,"briefSummary":56,"conditions":57,"keywords":59,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":4},"100549947","effects-of-lifestyle-intervention-in-the-biological-aging-in-prediabetes-100549947","NCT06440681","Effects of Lifestyle Intervention in the Biological Aging in Prediabetes","Effects of a 6-month Lifestyle Intervention Program in the DNAm PhenoAge, SOST, and GDF15 Markers of Biological Aging in Adults With Prediabetes","Inclusion Criteria:\n\n1. Clinical diagnosis of pre-diabetes for all Saudis aged 30 years and above, males and females\n2. They must be able to exercise and be able to follow a diet\n\nExclusion Criteria\n\n1. Insulin-dependent diabetes and non-diabetic patients\n2. People with diseases that prevent them from participating and doing exercises","30 Years","80 Years",{"count":52,"type":20},500,"INTERVENTIONAL",[55],"NA","Lifestyle modifications, including dietary changes and increased physical activity, play a crucial role in controlling complications to reduce or eliminate them. As well as controlling disturbances in biochemical markers such as DNAm PhenoAge, and signs of aging such as circulating sclerostin (SOST) and growth differentiation factor 15 (GDF15). This study seeks to address this dilemma by focusing on specific groups of elderly Saudis with prediabetes . Lifestyle changes in elderly Saudis with prediabetes show promise in reducing or eliminating complications. The potential insights derived from this research extend beyond academia, offering tangible benefits for clinical practice and public health\n\nThe proposed study will be implemented to achieve the following objective:\n\n1. To determine changes in DNAm PhenoAge of elderly Saudis with prediabetes who underwent a 6-month lifestyle modification program.\n2. To determine changes in other candidate senescence markers such as circulating sclerostin (SOST) and growth differentiation factor 15 (GDF15) of elderly Saudis with prediabetes who underwent a 6-month lifestyle modification program.",[58,24],"PreDiabetes",[60,61,62,63],"DNAm PhenoAge","Lifestyle modification","SOST","DGF-15","NOT_YET_RECRUITING","2024-06-08",{"date":67,"type":33},"2024-06-11",{"date":69,"type":20},"2024-08-01",{"date":71,"type":20},"2025-11-01",{"name":73,"class":40},"King Saud University"]