[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"masseter-muscle\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:masseter-muscle":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,53,84],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100640110","efficacy-of-prp-injections-in-reducing-pain-for-myogenous-tmd-patients-100640110",false,"NCT07606378","Efficacy of PRP Injections in Reducing Pain for Myogenous TMD Patients","Platelet-Rich Plasma (PRP) Injections as Treatment for Myogenous Temporomandibular Disorders: A Randomized Clinical Trial","Inclusion Criteria:\n\n* for the experimental part of the project are: women 20 to 50 years with a confirmed diagnosis of myogenous TMD according to the DC\u002FTMD (21). Participants must have pain in the masticatory muscles. Pain duration must be at least 3 months. Participants must report current pain at the day of inclusion with a minimum score of 4 on the numeric rating scale (NRS 0 to 10).\n\nExclusion Criteria:\n\n* active infection or inflammation at the injection site, systemic infection, platelet or coagulation disorders, severe anemia, autoimmune or inflammatory rheumatic disease, chronic liver disease, uncontrolled diabetes, or active malignancy. Pregnancy or breastfeeding will also be exclusion criteria. Patients using anticoagulant or antiplatelet medication that cannot be temporarily discontinued, or receiving chronic corticosteroid or immunosuppressive therapy, will be excluded. Additional exclusion criteria include predominantly arthralgia temporomandibular disorders, previous temporomandibular joint surgery, or a history of significant trauma to the face, head, or neck, including orthognathic surgery. Patients will also be excluded if they present widespread pain conditions such as fibromyalgia, neuromuscular disorders such as craniomandibular dystonia or myasthenia gravis, diagnosed or severe psychiatric disease such as schizophrenia or bipolar disorder, neuropathic pain, or pain of dental origin. Patients unable to provide informed consent or complete study questionnaires will be excluded.","FEMALE","20 Years","50 Years",{"count":20,"type":21},50,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study aims to evaluate whether intramuscular injections of platelet-rich plasma (PRP) are more effective than isotonic saline in reducing pain and improving jaw function in individuals diagnosed with myogenous temporomandibular disorders (TMD). Myogenous TMD is a common source of orofacial muscle pain and functional limitation, and although conservative treatments help many patients, a significant proportion continue to experience persistent symptoms that affect daily life and quality of function.\n\nPRP is an autologous, minimally invasive biologic concentrate enriched with platelets and bioactive molecules that may promote tissue repair and modulate inflammation, making it a promising option for managing muscle-related pain conditions. However, evidence from well-controlled randomized clinical trials in myogenous TMD remains limited.\n\nIn this double-blind, randomized controlled clinical trial, participants will receive two intramuscular injections-either PRP or saline-administered one month apart. Follow-up assessments will occur at 1, 3, and 6 months using standardized and validated measures of pain intensity, pain sensitivity, mandibular function, and psychosocial factors.\n\nThe results of this study may help determine the clinical value of PRP for myogenous TMD and contribute to future standardization of regenerative treatment protocols in orofacial pain management.",[27,28,29],"Myogenic Temporomandibular Joint Disorders","Myofacial Pain","Masseter Muscle",[31,32,33,34,29,35,36,37,38,39],"Temporomandibuar disorders","Myogenous TMD","Myofascial Pain","Orofacial Pain","Platelet-Rich Plasma","PRP Injection","Regenerative Therapy","Intramuscular Injection","Pain Modulation","NOT_YET_RECRUITING","2026-05-19",{"date":43,"type":44},"2026-05-26","ACTUAL",{"date":46,"type":21},"2026-06-04",{"date":48,"type":21},"2026-12-20",{"name":50,"class":51},"Karolinska Institutet","OTHER",1,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":4,"eligibilityCriteria":59,"healthyVolunteers":60,"sex":61,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":4,"studyType":66,"phases":4,"briefSummary":67,"conditions":68,"keywords":71,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":52},"100628987","masseter-muscle-thickness-in-individuals-with-chronic-neck-pain-100628987","NCT07468786","Masseter Muscle Thickness in Individuals With Chronic Neck Pain","Comparison of Masseter Muscle Thickness Measured by Ultrasonography in Individuals With Chronic Neck Pain Compared to Healthy Individuals","Inclusion Criteria:\n\n* Be between the ages of 18 and 45\n* Have neck pain that has persisted for at least 3 months\n* Agree to participate in the study voluntarily and provide written informed consent\n\nExclusion Criteria:\n\n* History of cervical spine surgery or severe trauma\n* Diagnosis of cervical radiculopathy, myelopathy, or neurological disease\n* Rheumatic, inflammatory, or systemic musculoskeletal diseases\n* Diagnosed temporomandibular joint disorder (TMD)\n* Diagnosis of bruxism or a pronounced habit of teeth clenching\u002Fgrinding\n* History of manual therapy, injection, or surgical intervention in the face, jaw, or neck region within the last 6 months\n* Currently undergoing orthodontic treatment or history of orthodontic treatment within the last 6 months\n* Cognitive impairment or conditions that prevent understanding and responding to questionnaires",true,"ALL","18 Years","45 Years",{"count":65,"type":21},90,"OBSERVATIONAL","The primary objective of our study is to compare the thickness of the masseter muscle, measured by ultrasound, in individuals with chronic neck pain to that of healthy individuals. The secondary objective of the study is to examine the relationships between masseter muscle thickness and pain intensity, neck disability level, pain catastrophizing level, and clinical diagnostic criteria in individuals with chronic neck pain.",[29,69,70],"Ultrasonographic","Chronic Neck Pain",[72,73,74],"chronic neck pain","Ultrasonographic measurement","Masseter muscle","2026-03-09",{"date":77,"type":44},"2026-03-13",{"date":79,"type":21},"2026-03-20",{"date":81,"type":21},"2026-05-20",{"name":83,"class":51},"Hasan Kalyoncu University",{"id":85,"slug":86,"hasResults":11,"nctId":87,"briefTitle":88,"officialTitle":88,"acronym":4,"eligibilityCriteria":89,"healthyVolunteers":60,"sex":61,"minAge":90,"maxAge":91,"enrollmentInfo":92,"targetDuration":4,"studyType":66,"phases":4,"briefSummary":94,"conditions":95,"keywords":98,"overallStatus":100,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":52},"100600214","evaluation-of-the-effect-of-adenoid-hypertrophy-on-the-masseter-muscle-in-children-a-comparative-ultrasonographic-study-100600214","NCT07094581","Evaluation of the Effect of Adenoid Hypertrophy on the Masseter Muscle in Children: A Comparative Ultrasonographic Study","Inclusion Criteria:\n\n* Children aged between 3 and 8 years\n* Children diagnosed with adenoid hypertrophy\n* Children without any systemic disease\n\nExclusion Criteria:\n\n* Children with a history of surgery for adenoid hypertrophy\n* Children who are uncooperative during clinical examination\n* Children with syndromes involving the maxillofacial region\n* Children with multiple missing teeth","3 Years","8 Years",{"count":93,"type":21},72,"The goal of this observational study is to evaluate the effect of adenoid hypertrophy on the masseter muscle in children aged 3 to 8 years. The primary objectives are:\n\n* To assess whether adenoid hypertrophy affects the thickness or structure of the masseter muscle.\n* To determine whether there is a measurable difference in masseter muscle characteristics between children with and without adenoid hypertrophy.\n\nResearchers will compare children diagnosed with adenoid hypertrophy and scheduled for adenoidectomy to healthy controls without adenoid hypertrophy.\n\nEach participant will:\n\n* Undergo ultrasonographic examination of the masseter muscle using a 9L linear probe (6-15 MHz), and\n* Have their occlusal relationship, dental findings, age, sex, and adenoid hypertrophy grade recorded.",[96,29,97],"Adenoid Hypertrophy","Malocclusion",[96,99,29],"Ultrasonography","RECRUITING","2025-12-25",{"date":103,"type":44},"2025-12-29",{"date":105,"type":44},"2024-07-20",{"date":107,"type":21},"2026-02-28",{"name":109,"class":51},"Melis AKYILDIZ"]