[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"mastectomy-lymphedema\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:mastectomy-lymphedema":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,45,79,104,134,155,177],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100636109","erector-spinae-block-versus-paravertebral-block-on-chronic-pain-after-mastectomy-100636109",false,"NCT07561411","Erector Spinae Block Versus Paravertebral Block on Chronic Pain After Mastectomy","The Effect of Erector Spinae Block Versus Paravertebral Block on the Incidence of Chronic Pain After Mastectomy: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Adult patients between 18 and 80 years old.\n* Scheduled to total mastectomy with or without axillary dissection\n* Willing to receive regional anesthesia in addition to GA\n* ASA classification 1-3\n\nExclusion Criteria:\n\n* Previous thoracic surgery with an incision of \\>2 cm\n* Patient's refusal\n* Allergy to local anesthetics\n* Pregnant women\n* Any contraindications to thoracic PVB, including intrathoracic infection, infection at the puncture site, cancer invasion of the puncture site, severe spinal deformity, history of spinal surgery, and severe coagulopathy; anticoagulants intake.\n* American Society of Anesthesiologists (ASA) classification of 4 or higher,\n* History of chronic pain or untreated clinical severe depression",true,"ALL","18 Years","80 Years",{"count":21,"type":22},132,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this clinical trial is to learn if the erector spinae block can reduce the incidence of chronic pain compared to the paravertebral block in adult patients undergoing total mastectomy. The study includes patients aged 18 to 80 years scheduled for mastectomy, with or without axillary dissection. The main questions it aims to answer are:\n\n* Does erector spinae block reduce the incidence of chronic pain at 3 months after mastectomy compared to paravertebral block?\n* Does erector spinae block affect postoperative outcomes such as opioid consumption at 48 hours, pain scores (in PACU, 24 and 48 hours), block performance time, and the incidence of complications, anxiety or depression, and pain intensity at 3 months?\n\nResearchers will compare patients receiving erector spinae block to those receiving paravertebral block to determine if erector spinae block provides equivalent or improved outcomes in terms of chronic pain and perioperative measures.\n\nParticipants will:\n\n* Be randomly assigned to receive either erector spinae block or paravertebral block prior to surgery\n* Undergo total mastectomy (with or without axillary dissection)\n* Have their pain assessed in the PACU and at 24 and 48 hours postoperatively\n* Have opioid consumption measured during the first 48 hours after surgery\n* Be followed up at 3 months to assess chronic pain, pain intensity, and psychological outcomes (anxiety or depression)",[28,29,30,31],"Mastectomy; Lymphedema","Chronic Pain","Regional Anesthesia Morbidity","Opioid Use","RECRUITING","2026-06-01",{"date":35,"type":36},"2026-06-02","ACTUAL",{"date":38,"type":36},"2026-05-19",{"date":40,"type":22},"2028-05-01",{"name":42,"class":43},"American University of Beirut Medical Center","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":52,"minAge":53,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":23,"phases":56,"briefSummary":58,"conditions":59,"keywords":65,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":78},"100523228","phase-2-iit2023-09-chung-upfronttad-upfront-tadsnb-in-patients-with-breast-cancer-with-nodal-metastases-100523228","NCT06092892","IIT2023-09-Chung-UpfrontTAD: Upfront TAD\u002FSNB in Patients With Breast Cancer With Nodal Metastases","IIT2023-09-Chung-UpfrontTAD: Upfront TAD\u002FSNB in Patients With Clinical T1-2N0 ER+ Her2- Breast Cancer With Ultrasound Detected Nodal Metastases","Inclusion Criteria:\n\n* Women age ≥ 45\n* Clinical T1-2N0 ER+ invasive breast cancer\n* US detected biopsy proven axillary nodal disease\n* Written informed consent obtained from subject and ability for subject to comply with the requirements of the study.\n\nExclusion Criteria:\n\n* Palpable nodes on physical exam\n* Her2+ or ER- invasive breast cancer\n* Extranodal extension \\> 3 mm on nodal biopsy\n* More than 2 suspicious nodes on preoperative imaging","FEMALE","45 Years",{"count":55,"type":22},45,[57],"PHASE2","The purpose of the study is to determine the recurrence rates and survival of patients with clinical T1-2N0 ER+\u002FHer2- invasive breast cancer who have biopsy proven image detected nodal disease treated with upfront lumpectomy or mastectomy with TAD followed by adjuvant therapy. This is a prospective, single arm phase II clinical trial. Patients will be screened and enrolled per eligibility criteria. Patient, tumor, and treatment data will be documented.",[60,61,62,63,28,64],"Breast Cancer","Axillary Nodal Disease","Female Breast Cancer","Axilla; Breast","Tumor, Breast",[66,67,68],"T1-2N0 ER+ invasive","biopsy","upfront lumpectomy","2026-05-06",{"date":71,"type":36},"2026-05-11",{"date":73,"type":36},"2024-04-07",{"date":75,"type":22},"2031-04",{"name":77,"class":43},"Alice Chung",3,{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":4,"eligibilityCriteria":85,"healthyVolunteers":11,"sex":52,"minAge":86,"maxAge":87,"enrollmentInfo":88,"targetDuration":4,"studyType":23,"phases":90,"briefSummary":91,"conditions":92,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":44},"100522406","pectoral-nerve-block-versus-paravertebral-block-in-the-incidence-of-chronic-pain-after-mastectomy-100522406","NCT06082206","Pectoral Nerve Block Versus Paravertebral Block In The Incidence of Chronic Pain After Mastectomy:","Pectoral Nerve Block Versus Paravertebral Block In The Incidence of Chronic Pain After Mastectomy: A Randomized Clinical Trial","Inclusion Criteria:\n\n* ASA grade I, II, or III female patients in the age group of 20-65 years\n* with body mass index (BMI) of 25-35 who were undergoing mastectomy with or without axillary lymph node or sentinel lymph node dissection or partial mastectomy (sparing the skin, areola, and nipple) with axillary lymph node dissection\n\nExclusion Criteria:\n\n* male sex; patient refusal,\n* a life expectancy less than 2 yr;\n* active malignant disease; pregnant or breastfeeding women;\n* bilateral surgery; ipsilateral breast surgery in the past 3 yr;","20 Years","65 Years",{"count":89,"type":22},90,[25],"Chronic pain after Mastectomy is frequent and an important healthcare priority because of its effect on quality of life. Although the association between the severity of acute pain after surgery and the likelihood of chronic pain is known, their causal relationship has not been clarified. Mastectomy, frequently done for the management of breast cancer, is associated with significant acute postoperative pain and limited shoulder movement.",[93,94,29,28],"Paravertebral Block","Pectoral Nerve Block","2026-03-06",{"date":97,"type":36},"2026-03-09",{"date":99,"type":36},"2023-11-15",{"date":101,"type":22},"2026-03",{"name":103,"class":43},"Assiut University",{"id":105,"slug":106,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":109,"acronym":4,"eligibilityCriteria":110,"healthyVolunteers":11,"sex":52,"minAge":18,"maxAge":4,"enrollmentInfo":111,"targetDuration":4,"studyType":23,"phases":113,"briefSummary":114,"conditions":115,"keywords":120,"overallStatus":124,"whyStopped":4,"lastUpdateSubmitDate":125,"lastUpdatePostDateStruct":126,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":4},"100620255","self-affirmation-intervention-after-mastectomy-100620255","NCT07355244","Self-Affirmation Intervention After Mastectomy","The Effect of Self-Affirmation Skills on Pain, Depression, Anxiety, and Stress in Patients Undergoing Mastectomy: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age 18 years or older\n* Female patients who have undergone mastectomy surgery\n* Able to speak and understand Turkish\n* Provides informed consent and agrees to participate voluntarily\n\nExclusion Criteria:\n\n* Diagnosed psychiatric disorder\n* Hearing impairment that prevents listening to the audio intervention",{"count":112,"type":22},42,[25],"This randomized controlled trial aims to evaluate the effect of a structured self-affirmation intervention on pain, depression, anxiety, and stress levels in patients undergoing mastectomy. The study will be conducted in two parallel groups, with the intervention group listening to an audio recording of positive self-affirmation statements. Primary outcomes will be assessed using the Visual Analog Scale and the Depression Anxiety Stress Scale (DASS-21). The goal is to provide evidence-based strategies to reduce psychosocial burden after mastectomy.",[116,28,117,118,119],"Breast Neoplasms","Pain","Depression","Stress, Psychological",[121,60,122,123,118],"Mastectomy","Stress","Anxiety","NOT_YET_RECRUITING","2026-01-12",{"date":127,"type":36},"2026-01-21",{"date":129,"type":22},"2026-01-01",{"date":131,"type":22},"2026-12-01",{"name":133,"class":43},"Muş Alparslan University",{"id":135,"slug":136,"hasResults":11,"nctId":137,"briefTitle":138,"officialTitle":139,"acronym":4,"eligibilityCriteria":140,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":141,"targetDuration":4,"studyType":23,"phases":143,"briefSummary":145,"conditions":146,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":147,"lastUpdatePostDateStruct":148,"startDateStruct":150,"completionDateStruct":152,"leadSponsor":153,"locationsCount":44},"100560198","phase-4-post-mastectomy-recovery-comparing-preoperative-pecs-ii-blocks-with-intraoperative-pectoral-blocks-100560198","NCT06574022","Post-mastectomy Recovery: Comparing Preoperative PECS-II Blocks With Intraoperative Pectoral Blocks","Post-mastectomy Recovery: A Randomized Clinical Trial Comparing Preoperative PECS-II Blocks With Intraoperative Pectoral Blocks","Inclusion Criteria:\n\n* Patients who are 18 years of age or older\n* Patients undergoing mastectomy with or without axillary surgery, with or without reconstruction surgery at UCMC for breast cancer or high-risk of breast cancer. Patients with high-risk of breast cancer are those who have atypical\u002Fprecancerous breast lesion(s), genetic mutation with increased risk of cancer (e.g., BRCA1, BRCA2 etc..) and\u002For a strong family history of breast cancer in the opinion of the investigator.\n\nExclusion Criteria:\n\n* Patients undergoing only a partial mastectomy or tissue-based reconstruction.\n* Non-English speaking.\n* Patients who are pregnant.\n* Patients with an allergy to local anesthetics\n* Except: patients with allergies only to topical anesthetics may be included.\n* Patients with a preoperative acute or chronic pain disorder with an opioid prescription that has been prescribed within 30 days of surgery. Patients who have not filled such a prescription or who state they have not taken the medications prescribed, may be eligible on a case-by-case basis per investigator judgement.\n* Patients with a history of opioid use disorder.\n* Inability to provide informed consent.\n* Patients who otherwise in the opinion of the Investigator are not good candidates for participation (e.g., deemed unreliable for follow-up).",{"count":142,"type":22},100,[144],"PHASE4","The purpose this research is to compare two different standards of care for pain management and two different standards of care for local numbing medicine for breast cancer patients who will have a total mastectomy.",[28,60],"2025-11-03",{"date":149,"type":36},"2025-11-04",{"date":151,"type":36},"2024-09-25",{"date":131,"type":22},{"name":154,"class":43},"University of Cincinnati",{"id":156,"slug":157,"hasResults":11,"nctId":158,"briefTitle":159,"officialTitle":160,"acronym":4,"eligibilityCriteria":161,"healthyVolunteers":16,"sex":52,"minAge":18,"maxAge":87,"enrollmentInfo":162,"targetDuration":4,"studyType":164,"phases":4,"briefSummary":165,"conditions":166,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":168,"lastUpdatePostDateStruct":169,"startDateStruct":171,"completionDateStruct":173,"leadSponsor":175,"locationsCount":44},"100389849","examining-and-comparing-the-temporal-changes-and-results-of-cosmetic-quality-of-life-and-patient-satisfaction-achieved-with-immediate-and-delayed-immediate-implant-based-breast-reconstruction-procedures-and-contralateral-symmetrization-techniques-100389849","NCT04356235","Examining and Comparing the Temporal Changes and Results of Cosmetic, Quality of Life and Patient Satisfaction Achieved With Immediate and Delayed-immediate Implant-based Breast Reconstruction Procedures and Contralateral Symmetrization Techniques","Examining and Comparing Patient Satisfaction and Long-term Cosmetic Results Achieved With Implant-based Breast Reconstruction Surgery With Submuscular Silicone Implant After Skin Sparing \u002F Areola Sparing \u002F Nipple Sparing Mastectomy and Contralateral Symmetrization (With Mastopexy and\u002For Silicone Implant and\u002For Ultrapro Mesh) With Unilateral Simple Mastectomies and With Bilateral Skin-sparing Mastectomies and Implant-based Immediate Breast Reconstructions. Response-adaptive Prospective Randomized, Comparative Clinical Trial","Inclusion Criteria:\n\n* Under the age of 65 with uni- or bilateral primary breast cancer ( clinical Stage 0-III), needing modern skin sparing mastectomy, nipple sparing mastectomy or areola sparing mastectomy independently of the axillary surgery, having immediate or delayed-immediate implant based reconstrucion on the ipsilateral side and symmetrisation on the contralateral side ( mastopexy and\u002For implant based reconstruction and\u002For breast sling with ultrapro mesh)\n* Control group: patients under 65 years with unilateral simplex mastectomy without breast reconstruction\n\nExclusion Criteria:\n\n* In case the patient does not volunteer for the examination or the follow-ups\n* Age above 65 years or poor general health condition, where the estimated life expectancies would be less than 2 years even without the tumorous disease\n* Malignant invasive tumor in the past history (except for non-melanoma skin tumors)\n* Mastectomyand reconstruction performed due pregnancy associated breast cancer\n* Prior breast surgery (e.g. aesthetic surgery, mastopexy) and\u002For radiotherapy on the breast or in the axilla\n* Malignant tumor is not removed completely with pathological examination\n* Severe non-surgical (e.g. radiotherapy) complication, which could influence the aesthetic and functional results\n* Autoimmune diseases\n* Mastitis carcinomatosa\n* Lymphangitis carcinomatosa\n* Open wound therapy due SSI\n* Long-term steroid usage, which changed the skin's quality and structure\n* Patient under foster care, or psychically non-cooperative patient\n* If breast correction performed during the 5 years follow up",{"count":163,"type":22},528,"OBSERVATIONAL","This is a response-adaptive (RAR) prospective randomized study with a long-term follow-up and the aim of this clinical study is to measure with qualitative and quantitative indicators the changes in cosmetic results, quality of life and patient satisfaction after breast reconstructive surgery with silicone implant (following SSM, ASM or NSM mastectomy) and symmetrization (mastopexy and\u002For silicone implant and\u002For Ultrapro mesh sling technique) over time.\n\nAccording to the hypothesis of the study, the results of implant-based breast reconstruction and symmetrization following advanced postmastectomy techniques significantly decrease over time and later results limited patient satisfaction rate.\n\nThis is mainly due to the fact that over time, the natural breast differs from the reconstructed breast with silicone implant. Because of the different biological properties (gravity results ptosis on breast with mastopexy, significant volume increasement of the breast with mastopexy due to endocrine therapy, gradually progressive capsular contracture on the tumorous side, nipple flattening, nipple tattoo fading etc.) the two sides change differently resulting in significant asymmetry and consequently could lead to decreased patient satisfaction.\n\nThe high degree of asymmetry over time (which can be similar to the difference between the result of a simple mastectomy and natural breast (control group)), may indicates additional surgeries or usage of medical devices, putting a financial burden on the patient and the health system. On the other hand, the symmetry can be achieved with bilateral skin-sparing mastectomies and implant-based immediate or delayed-immediate reconstructions is clearly better and change less with time. The mastectomy of the contralateral disease-free side is considered as an unreasonable burden for moderate risk patients.\n\nThe information such as the need for multiple surgeries, change in symmetry over time etc., should be an important part of the professional decision-making mechanism and the surgeon should inform the patient during the primer surgery. Nowadays due to the lack of evidence-based knowledge, it is not part of the patient's information and surgical planning internationally. Planning breast units, attention, capacity and financial resources must also be provided to meet the long-term needs of patients who underwent postmastectomy breast reconstruction. Simple mastectomy with an external prosthesis can be an alternative for patients with intolerable degree of asymmetry or on the contrary, the results may justify the need for bilateral mastectomy and reconstruction even in the absence of high oncological risk and for purely symmetrical and cosmetic reasons.",[28,60,167],"Quality of Life","2020-04-21",{"date":170,"type":36},"2020-04-22",{"date":172,"type":22},"2020-04-27",{"date":174,"type":22},"2027-04-10",{"name":176,"class":43},"National Institute of Oncology, Hungary",{"id":178,"slug":179,"hasResults":11,"nctId":180,"briefTitle":181,"officialTitle":182,"acronym":4,"eligibilityCriteria":183,"healthyVolunteers":11,"sex":52,"minAge":18,"maxAge":87,"enrollmentInfo":184,"targetDuration":4,"studyType":164,"phases":4,"briefSummary":186,"conditions":187,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":189,"lastUpdatePostDateStruct":190,"startDateStruct":191,"completionDateStruct":192,"leadSponsor":194,"locationsCount":44},"100388993","examining-the-cosmetic-results-quality-of-life-and-patient-satisfaction-achieved-with-skin-reducing-nipple-sparing-mastectomy-and-implant-based-breast-reconstruction-and-comparing-it-to-classic-skin--sparing-mastectomy-and-implant--based-breast-reconstructive-surgeries-100388993","NCT04345081","Examining the Cosmetic Results, Quality of Life and Patient Satisfaction Achieved With Skin Reducing Nipple Sparing Mastectomy and Implant Based Breast Reconstruction, and Comparing it to Classic Skin- Sparing Mastectomy and Implant- Based Breast Reconstructive Surgeries","Examining the Cosmetic Results and Patient Satisfaction Achieved With Skin Reducing Nipple Sparing Mastectomy of Ptotic Breast Followed by Delayed-immediate Submuscular Implant Based- Breast Reconstruction Surgery, and Comparing it to Submuscular Delayed- Immediate Implant- Based Breast Reconstruction Procedures After Skin- Sparing Mastectomy. Response-adaptive, Prospective Randomized Clinical Trial","Inclusion Criteria:\n\n* Under the age of 65 with uni- or bilateral primary breast cancer ( clinical Stage 0-III), needing skin sparing mastectomy, nipple sparing mastectomy or patients require risk reducing mastectomy independently of the axillary surgery, having immediate or delayed-immediate implant based reconstruction.\n\nExclusion Criteria:\n\n* In case the patient does not volunteer for the examination or the follow-ups\n* Age above 65 years or poor general health condition, where the estimated life expectancies would be less than 2 years even without the tumorous disease\n* Malignant invasive tumor in the past history (except for non-melanoma skin tumors)\n* Mastectomy and reconstruction performed due pregnancy associated breast cancer\n* Prior breast surgery (e.g. aesthetic surgery, mastopexy) and\u002For radiotherapy on the breast or in the axilla\n* Malignant tumor is not removed completely with pathological examination\n* Severe non-surgical (e.g. radiotherapy) complication, which could influence the aesthetic and functional results\n* Autoimmune diseases\n* Mastitis carcinomatosa\n* Lymphangitis carcinomatosa\n* Open wound therapy due SSI\n* Long-term steroid usage, which changed the skin's quality and structure\n* Patient under foster care, or psychically non-cooperative patient",{"count":185,"type":22},110,"This is a response-adaptive (RAR) prospective randomized study with a long-term follow-up and the aim of this clinical study is to measure with qualitative and quantitative indicators the changes in cosmetic results, quality of life and patient satisfaction after delayed- immediate breast reconstruction with standardized technique Skin Reducing Nipple sparing mastectomy, SRNSM and SSM with standardized horizontal skin incision.\n\nAccording to our hypothesis, SRNSM with standardized technique on pendulous\u002F ptotic breasts is a safe procedure compared to SSM. It also promotes the cosmetic efficacy of SRNSM with the removal of the entire glandular tissue through avoidance of the reduction of projection, the need later nipple reconstruction surgery and of areola tattoo.\n\nIn our study we propose that compared to one of the well-known and widely investigated studied SSM, our current standardized SRNSM technique is able to perform similar oncologically safe entire gland tissue removal, with low complication rate, accommodating for adjuvant treatments. Furthermore, it may provide superior cosmetic results than SSM (NAC is not removed, projection is maintained, and there is no need for further nipple reconstruction or tattoo) with high patient satisfaction which is maintained long term.",[60,28,167,188],"Patient Satisfaction","2020-04-18",{"date":168,"type":36},{"date":189,"type":36},{"date":193,"type":22},"2027-04-05",{"name":176,"class":43}]