[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"maternal-distress\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:maternal-distress":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,46,78],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100615707","in-vitro-fertilization-ivf-and-prenatal-effects-independent-of-genetics-100615707",false,"NCT07296107","In Vitro Fertilization (IVF) and Prenatal Effects Independent of Genetics","Leveraging IVF to Identify Prenatal Effects Independent of Shared Maternal-Child Genes","Inclusion Criteria:\n\n1. Individuals at 18-28 gestational weeks with donor and homologous IVF pregnancies, ages 18-50.\n2. Participants must be patients receiving their perinatal health care through Columbia University Irving Medical Center's Department of OB\u002FGYN and delivering at New York-Presbyterian Morgan Stanley Children's Hospital.\n3. Participants must be patients delivering at Columbia University Irving Medical Center's Department of OB\u002FGYN and delivering at New York-Presbyterian Morgan Stanley Children's Hospital.\n4. Participants will include the offspring of patients receiving care and delivering at the above institutions.\n5. Enrollment Location(s): Columbia University Irving Medical Center's Department of OB\u002FGYN, delivering at New York-Presbyterian Morgan Stanley Children's Hospital.\n\nExclusion Criteria:\n\n1. Identified addiction disorder\n2. Severe psychiatric condition (defined as symptoms that significantly impair daily functioning and are untreated or not effectively managed)\n3. Multiple fetal pregnancy\n4. Known chromosomal, genetic, or major fetal malformations (unlikely due to routine preimplantation genetic testing)\n5. Inflammatory conditions including rheumatoid arthritis, lupus, and multiple sclerosis\n6. Not planning to deliver at a CUIMC-affiliated hospital",true,"FEMALE","18 Years","50 Years",{"count":21,"type":22},360,"ESTIMATED","OBSERVATIONAL","This study examines how maternal stress during pregnancy affects infant brain and behavioral development, focusing on whether these effects are due to the prenatal environment or shared genes. By comparing IVF pregnancies using donor eggs\u002Fembryos (no shared genetics) with non-donor IVF pregnancies, the investigators aim to understand how stress influences the baby's development independent of genetic factors.\n\nParticipants will complete questionnaires, provide blood samples, and take part in placenta and cord blood collection, fetal monitoring, and newborn brain activity assessments.\n\nAim 1: The influence of maternal distress on perinatal neurobehavioral development.\n\nHypotheses: Independent of IVF group status, higher maternal AL will be associated with higher 3rd trimester FHR reactivity, lower FHR variability, AND lower FHR-movement coupling\n\nAim 2: Maternal distress affecting placenta gene methylation.\n\nHypotheses: Independent of IVF group status, maternal AL will be associated with placenta differential DNA methylation in glucocorticoid-regulating genes (FKBP5 and HSD11B2),\n\nAim 3: Maternal experiences associated with unique placenta transcriptomic profiles.\n\nHypotheses: Independent of IVF group status, maternal AL and well-being each will be associated with unique placenta gene expression in pro-inflammatory genes",[26,27],"Maternal Distress","Child Development",[29,30,31,32],"Developmental Origins of Health and Disease (DOHaD)","Maternal Health","Child development","IVF","RECRUITING","2026-05-11",{"date":36,"type":37},"2026-05-13","ACTUAL",{"date":39,"type":22},"2026-05",{"date":41,"type":22},"2030-07-31",{"name":43,"class":44},"Columbia University","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":17,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":58,"phases":59,"briefSummary":61,"conditions":62,"keywords":66,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":45},"100555283","providing-an-optimized-and-empowered-pregnancy-for-you-poppy-aim-3-randomized-controlled-trial-100555283","NCT06510075","Providing an Optimized and Empowered Pregnancy for You (POPPY) Aim 3: Randomized Controlled Trial","Providing an Optimized and emPowered Pregnancy for You (PᵌOPPY) Aim 3: Randomized Controlled Trial","P3OPPY","Inclusion Criteria:\n\n* Self Identifies as Non-Hispanic Black\n* Between 16-49 years old\n* Pregnant individuals between 8⁰ - 22⁶ weeks gestational age\n* Live singleton or dichorionic twin gestation\n* Dating sonogram at \\\u003C23 weeks gestation,\n* Area Deprivation Index (ADI) National 4th or 5th Quintile\n* Planning to deliver at UAB Hospital\n* Speaks and writes in English\n* No indication for delivery at the time of enrollment\n\nExclusion Criteria:\n\n* Declines randomization\n* Speaks or writes in languages other than English\n* Currently incarcerated\n* Fetal demise diagnosed prior to enrollment\n* Known major structural chromosomal abnormalities prior to enrollment\n* Participated in POPPY Pilot","16 Years","49 Years",{"count":57,"type":22},400,"INTERVENTIONAL",[60],"NA","The PᵌOPPY study is designed to support the American Heart Association's mission to improve maternal\u002Finfant health outcomes and address inequities in maternal\u002Finfant health care. The P3OPPY Project is one of five projects within the American Heart Association P3 EQUATE Network. The overarching goal of the P3 EQUATE American Heart Association Health Equity Research Network (HERN) is to promote equity in Maternal and Infant Health outcomes by identifying innovative and cost-effective strategies to enhance access to quality health information, care, and experiences during pregnancy, postnatal and postpartum\u002Fpreconception periods, particularly for Black and under-served populations. Collectively, the investigators will collaborate with pregnant and postpartum individuals and their families, hospitals, and communities to discover ways to reduce racism and social problems that contribute to poor health outcomes. In this trial, 400 non-Hispanic Black participants will be randomized to see if 2 promising interventions (digital health interventions and community health workers) reduce adverse pregnancy outcomes.",[63,26,64,65],"Pregnancy Complications","Adverse Birth Outcomes","Infant Conditions",[67,68],"Pregnancy outcomes","Health inequities","2025-08-13",{"date":71,"type":37},"2025-08-17",{"date":73,"type":37},"2024-08-01",{"date":75,"type":22},"2027-01-31",{"name":77,"class":44},"University of Alabama at Birmingham",{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":4,"eligibilityCriteria":84,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":85,"targetDuration":4,"studyType":58,"phases":87,"briefSummary":88,"conditions":89,"keywords":92,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":45},"100567070","laughter-yogas-impact-on-traumatic-childbirth-preparation-100567070","NCT06663397","Laughter Yoga's Impact on Traumatic Childbirth Preparation","The Effects Of Laughter Yoga-Supported Childbirth Preparation Training On Traumatic Birth Perception, Fear Of Birth, Prenatal Depression, And Attachment: A Randomized Controlled Study","Inclusion Criteria:\n\n* Women aged 18 years and older.\n* Pregnant individuals between 20-26 weeks of gestation (Childbirth preparation training should begin by the 20th week of pregnancy according to the recommendations of the Turkish Ministry of Health, and since the training is planned to last 4 weeks, participants will be recruited before entering the third trimester).\n* First-time pregnancies.\n* Individuals who understand, speak, and can read and write in Turkish.\n* Women who consent to participate in the study.\n\nExclusion Criteria:\n\n* Women with high-risk pregnancies (such as placenta previa, history of antepartum bleeding, ruptured membranes, preeclampsia, hypertension, diabetes, or other medical conditions, intrauterine growth restriction, multiple pregnancies, fetal anomalies, or any contraindications for normal vaginal delivery, substance or alcohol dependence, chronic illnesses, etc.).\n* Individuals diagnosed with psychiatric disorders.\n* Those who have received psychotherapy or medication within the last six months prior to the study.\n* Pregnant women with prior training or experience in cognitive awareness-based or mind-body methods.",{"count":86,"type":22},68,[60],"This study will be conducted as a single-center, parallel-group, randomized controlled intervention trial to determine the effects of birth preparation training supported by laughter yoga on the perception of traumatic birth, fear of birth, prenatal depression, and attachment in primiparous women. The research population will consist of pregnant women who attend the Pregnancy Clinic of the Department of Obstetrics and Gynecology at Cebeci Medical Faculty, Ankara University. The study will involve two groups: the first group will receive birth preparation training supported by laughter yoga, while the second group will receive standard birth preparation training. A total of 68 pregnant women, 34 in each group, are planned to participate in the study. Data will be collected using the Introductory Information Form, Traumatic Birth Perception Scale, Prenatal Self-Assessment Scale Fear of Birth Subscale, Edinburgh Depression Scale, and Prenatal Attachment Inventory. These instruments will be administered to the participants three times: before the training, immediately after the training, and one month later. The research data will be analyzed using the Statistical Package for Social Sciences (SPSS) version 24. Descriptive statistics (number, percentage, mean, standard deviation, minimum, and maximum values) will be used for data analysis. Independent samples t-test will be employed for comparisons between two independent groups, paired samples t-test will be used for repeated measures, one-way ANOVA will be used for comparisons among more than two groups, and Pearson correlation analysis will be applied for the relationship between two quantitative variables.\n\nWhen data do not follow a normal distribution, the Mann-Whitney U test will be used for comparisons between two independent groups, the Wilcoxon signed-rank test will be used for repeated measures, the Kruskal-Wallis test will be used for comparisons among more than two groups, and Spearman correlation analysis will be used for the relationship between two quantitative variables. The reliability of the scales used in the study will be determined using Cronbach's alpha coefficient. Statistical significance will be set at p \\< 0.05.",[26,90,91],"Prenatal Stress","Pregnancy Related",[93,94,95,96,97,98],"Perception of Traumatic Birth","Fear of Childbirth","Prenatal Depression","Prenatal Attachment","Laughter Yoga","Childbirth Preparation Training","NOT_YET_RECRUITING","2024-10-27",{"date":102,"type":37},"2024-10-29",{"date":104,"type":22},"2024-12-30",{"date":106,"type":22},"2026-03-31",{"name":108,"class":44},"Ankara University"]