[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"maternal-stress\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:maternal-stress":32},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,54,78,131],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":33,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100639394","skin-to-skin-contact-and-lavender-aromatherapy-after-elective-cesarean-effects-on-cortisol-and-early-breastfeeding-100639394",false,"NCT07612059","Skin-to-Skin Contact and Lavender Aromatherapy After Elective Cesarean: Effects on Cortisol and Early Breastfeeding","Elective Cesarean Section Postpartum Structured Mother-Infant Skin-to-Skin Contact With Maternal Lavender Aromatherapy: Effects on Maternal Salivary Cortisol, IgA Levels and Early Breastfeeding Outcomes - A Randomized Controlled Trial","LAVENDER-SSC","Inclusion Criteria:\n\n* Female participants aged 18 to 40 years\n* Term singleton pregnancy (≥37 weeks of gestation)\n* Scheduled for elective cesarean section\n* ASA physical status I-II\n* Planned spinal anesthesia\n* Clinically stable mother and newborn immediately after birth\n* Ability to initiate breastfeeding in the early postpartum period\n* Provision of written informed consent\n\nExclusion Criteria:\n\n* Emergency cesarean section\n* General anesthesia or conversion from spinal to general anesthesia\n* Need for neonatal resuscitation or severe neonatal compromise\n* Maternal hemodynamic instability or massive hemorrhage\n* Major fetal congenital anomalies\n* Known allergy or intolerance to lavender\n* Severe asthma or intolerance to strong odors\n* Major psychiatric disorders\n* Serious endocrine diseases affecting stress hormone regulation\n* Clinical conditions that preclude breastfeeding\n* Contraindications to spinal anesthesia\n* Refusal to participate in the study",true,"FEMALE","18 Years","40 Years",{"count":22,"type":23},150,"ESTIMATED","INTERVENTIONAL",[26],"NA","This single-center randomized controlled clinical trial will evaluate the effects of structured early postpartum mother-infant skin-to-skin contact, with or without maternal lavender aromatherapy, after elective cesarean section on maternal stress biomarkers and early breastfeeding outcomes. The study will enroll 150 term pregnant women scheduled for elective cesarean section under spinal anesthesia at Ataturk University Research Hospital. Participants will be randomized into three groups: routine postoperative care, structured skin-to-skin contact, and structured skin-to-skin contact combined with inhalational lavender aromatherapy. The primary outcome is the change in maternal salivary cortisol level from immediately after birth to 60 minutes postpartum. Secondary outcomes include maternal salivary IgA levels, state anxiety scores, postoperative pain and nausea, time to first analgesic requirement, early breastfeeding initiation and success, LATCH scores, neonatal axillary temperature, cumulative duration and continuity of skin-to-skin contact, maternal satisfaction, and the need for mother-infant separation within the first 2 hours postpartum.",[29,30,31,32],"Breastfeeding","Cesarean Section","Postpartum Period","Maternal Stress",[34,35,36,37,38,39,40],"Elective cesarean section","Skin-to-skin contact","Lavender aromatherapy","Salivary cortisol","Immunoglobulin A (IgA)","Early breastfeeding","Postoperative pain","NOT_YET_RECRUITING","2026-05-21",{"date":44,"type":45},"2026-05-28","ACTUAL",{"date":47,"type":23},"2026-06-01",{"date":49,"type":23},"2027-12-30",{"name":51,"class":52},"Ataturk University","OTHER",1,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":4,"eligibilityCriteria":60,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":61,"targetDuration":4,"studyType":24,"phases":63,"briefSummary":64,"conditions":65,"keywords":67,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":53},"100618470","the-effect-of-watching-cat-videos-on-non-stress-test-results-and-stress-parameters-in-pregnant-women-100618470","NCT07332039","The Effect of Watching Cat Videos on Non-Stress Test Results And Stress Parameters in Pregnant Women","The Effect of Watching Cat Videos on Maternal Stress and Fetal Well-being: A Single-Blind Randomized Controlled Trial","Inclusion Criteria:\n\n* Pregnant women who are primiparous,\n* Able to communicate in Turkish,\n* In their 34th-40th weeks of pregnancy,\n* Have no problems that would prevent them from viewing visual or auditory materials,\n* Have the cognitive ability to understand interactive video content,\n* Have not engaged in physical exercise for at least 2 hours prior to fetal heart rate monitoring will be included in the study.\n\nExclusion Criteria:\n\n* Pregnant women with multiple pregnancies,\n* Uterine contractions detected during NST,\n* Diagnosed with a high-risk pregnancy (preeclampsia, gestational diabetes, placenta previa, etc.),\n* A phobia of cats (ailurophobia),\n* Pregnant women who became pregnant using assisted reproductive technologies (ART),\n* Have a history of a diagnosed endocrinological (e.g., hypothyroidism, hyperthyroidism, Cushing's syndrome) or psychiatric (e.g., anxiety disorder, depression) disease will be excluded from the study.",{"count":62,"type":23},50,[26],"Pregnancy is a period in which women are physiologically and psychologically vulnerable, and the stress experienced can affect both maternal mental health and fetal well-being. The non-stress test (NST), used to assess fetal health in the final weeks of pregnancy, can cause anxiety in some women because it requires the mother to remain supine and immobile for extended periods. Prolonged testing or non-reactive results can also increase this stress. Therefore, simple methods are needed to reduce stress during NST. Humorous and cute content, especially animal videos, is known to promote positive emotions and psychological relaxation. This study evaluated the effects of watching cat videos during NST on stress levels and fetal physiological parameters in primiparous pregnant women.",[32,66],"Fetal Well-Being",[66,32,68],"Cat Videos","2026-02-09",{"date":71,"type":45},"2026-02-11",{"date":73,"type":23},"2026-01-25",{"date":75,"type":23},"2026-02-05",{"name":77,"class":52},"Istanbul University - Cerrahpasa",{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":84,"eligibilityCriteria":85,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":86,"targetDuration":4,"studyType":88,"phases":4,"briefSummary":89,"conditions":90,"keywords":103,"overallStatus":121,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":53},"100607934","early-life-malnutrition-environmental-enteric-dysfunction-and-microbiome-trajectories-100607934","NCT07195006","Early Life Malnutrition, Environmental Enteric Dysfunction and Microbiome Trajectories","Early Life Diarrhoea Episode(s), Malnutrition, Environmental Enteric Dysfunction and Microbiome Trajectories From Birth Until 3 Years of Life ; The University of Zimbabwe Birth Cohort Study-2 (UZBCS-2)","UZBCS-2","Inclusion Criteria for Cases:\n\n* MUAC ≤23 cm in pregnancy\n* ≥18 years' old\n* At least 20 weeks' gestational age\n* Height ≥150 cm\n* Planning to be staying in the study area for the next 3 years\n* Willing to participate and comply with all study requirements and procedures.\n\nAny pregnant woman meeting the above eligible criteria regardless of HIV status who meet the above inclusion criteria will be invited to participate in the study\n\nInclusion criteria for Controls\n\n* Age, HIV status, gestational age at enrolment, and area residence matched normo-nourished peers with MUAC ≥25 - ≤35 cm\n* Haemoglobin level of ≥11g\u002FdL\n* ≥18 years' old\n* At least 20 weeks' gestational age\n* Height ≥150 cm\n* Planning to stay in the study area for the next 3 years\n\nExclusion Criteria\n\n* Acute or chronic conditions in mothers interfering with the study according to the judgment of the investigator (HIV infection is not an exclusion criterion)\n* Presence of severe mental health disorders interfering with study procedures according to the judgment of the investigator.",{"count":87,"type":23},368,"OBSERVATIONAL","Malnutrition in women of reproductive age remains a public health concern in Sub-Saharan Africa (SSA). Malnutrition during pregnancy affects foetal growth with a tendency of the exposed infants to also develop it. The interaction of the mother with the infant shapes the seeding and the trajectory of the infant intestinal microbiota which is crucial for development of a healthy immune system Malnutrition has been associated with intestinal inflammation, intestinal leakage and reduced calorie absorption. Early life malnutrition and environmental enteric dysfunction (EED) immunopathology remains poorly described in the context of mother-infant dyads. This is essential as malnutrition, poor water, sanitation and hygiene (WASH), including the presence of infectious diseases limit the developmental potential of the exposed infants in SSA, including Zimbabwe. In addition, maternal stress and poor mental health may also affect standard hygiene practices, including how a mother cares for her baby, potentially aggravating EED and the risk of the infant being malnourished.\n\nPrimary outcomes\n\n1. Infant malnutrition and recovery.\n2. Gut dysfunction (gut inflammation, leaky gut, malabsorption, dysbiosis)\n3. Diarrhea episodes, defined as any episode of acute diarrhoea (≥3 passages of loose stool within 24 hours as reported by the mother) occurring before the next study visit.\n\nDefinition of malnutrition outcomes to be assessed in babies born to malnourished women, is a mid- upper arm circumference (MUAC) \\\u003C23cm;\n\n* MUAC for age: Malnourished defined as those below -2 standard (SD) of the World Health Organisation (WHO) reference\n* Weight-for-age: Underweight defined as those below -2SD WHO reference\n* Weight-for-height: Wasted defined as those below -2SD WHO reference\n* Height-for-age: Stunted defined as those below -2SD WHO reference\n* Z-scores (as they are i.e. a continuous variable, taking age of infants into account)\n* A composite variable, any of malnourished, underweight, wasted or stunted.",[91,92,93,94,95,96,97,32,98,99,100,101,102],"Malnutrition Pregnancy","Malnutrition in Children","Malnutrition (Calorie)","Environmental Enteric Dysfunction","Gut Dysbiosis","Gut Permeability, Gut Inflammation","Diarrhea Infectious","Child Mental Health","Natural Killer Cell Mediated Immunity","Mycotoxin Biomonitoring","Environmental Exposures","Cell-Mediated Immune Deficiency",[104,105,106,107,108,109,110,111,112,113,114,115,116,117,118,119,120],"diarrhoeal episodes","short chain fatty acids receptor agonists","intestinal inflammation, leakage and calory extraction","toxins in drinking water and food","macro- and micronutrient composition of breast milk","human anti-Gal antibodies","mitochondria health and nutrient uptake","endothelial dysfunction and oxidative stress","hormonal mediated molecular signalling mechanisms","interaction of epigenetics & socioeconomic factors","microbiota, pathobionts and oral microbiota","metagenomics","undernutrition and intestinal infections","infant mortality, morbidity within 1st 1000 days of life","low mid upper arm circumference","sleep adequacy in maternal mental health","chronic inflammation","RECRUITING","2025-09-18",{"date":124,"type":45},"2025-09-26",{"date":126,"type":45},"2025-01-27",{"date":128,"type":23},"2032-12-31",{"name":130,"class":52},"University of Zimbabwe",{"id":132,"slug":133,"hasResults":11,"nctId":134,"briefTitle":135,"officialTitle":136,"acronym":4,"eligibilityCriteria":137,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":138,"enrollmentInfo":139,"targetDuration":4,"studyType":24,"phases":141,"briefSummary":142,"conditions":143,"keywords":4,"overallStatus":121,"whyStopped":4,"lastUpdateSubmitDate":144,"lastUpdatePostDateStruct":145,"startDateStruct":147,"completionDateStruct":149,"leadSponsor":151,"locationsCount":153},"100586771","impact-of-vitamin-d-supplements-on-mental-health-and-milk-composition-in-mothers-living-in-idaho-100586771","NCT06919718","Impact of Vitamin D Supplements on Mental Health and Milk Composition in Mothers Living in Idaho","Effects of Maternal Stress on Human Milk Composition and Subsequent Infant Outcomes","Inclusion Criteria:\n\n* Mothers (\\>\u002F= 18 years of age) of newborn infants (within first 4 months postpartum) in Idaho\n\nExclusion Criteria:\n\n* Mothers (\\\u003C18 years of age) of newborn infants (within first 4 months postpartum)\n* Infants not anticipated to survive \\>72 hours","64 Years",{"count":140,"type":23},80,[26],"Mothers of preterm infants experience exaggerated emotional stressors compared to those typically associated with new motherhood, making these women particularly vulnerable to postpartum depression. As many as 70% of mothers of preterm infants experience postpartum depression compared to only 12.5% of those delivering full-term infants. Increased stress and depression during this critical period are detrimental because they hamper a mother's ability to care for her infant and are associated with increased neonatal sepsis and mortality, decreased neonatal growth, and delayed motor and cognitive development. Postpartum depression is also associated with excessive maternal weight gain and risk for metabolic diseases, anxiety, and sleep disturbances. Stress in breastfeeding mothers can also alter circulating concentrations of some bioactive components (e.g., immunoglobulins, cortisol) that can transfer into milk. As such, understanding factors predisposing these vulnerable women to extreme levels of stress and finding ways to lower this stress and lessen its negative health outcomes on mothers and infants are important public health challenges. The March of Dimes estimates that 8.5% of births in Idaho are preterm, making this topic particularly relevant for Idaho women. Risk factors for postpartum depression in mothers delivering term or preterm infants are complex, but maternal nutrient deficiencies may be involved. Vitamin D status, for instance, is inversely correlated with risk of postpartum depression in women delivering term infants. However, vitamin D interventions have yielded inconsistent results, perhaps due to confounding impacts of geographic location, skin color, and endogenous vitamin D synthesis. Endogenous vitamin D synthesis requires cutaneous sunlight exposure, placing Idaho women at even greater risk of vitamin D deficiency - particularly in the winter when days are extremely short (only 7 hr on the winter solstice). The impact of maternal vitamin D supplementation during lactation on infant variables (e.g., vitamin D status) has been examined. However, its effect on maternal mental health has not been rigorously studied - let alone in the 'frontier and remote' (FAR) rural West, including Idaho, with short periods of wintertime sunlight and poor access to healthcare. Our long term goal is to develop interventions to improve maternal and infant health in Idaho - particularly in the context of preterm births. The overall primary objective of this proposal is to determine if maternal vitamin D supplementation improves vitamin D status and mental health in Idahoan mothers of preterm infants. Our central hypothesis is that vitamin D supplementation improves vitamin D status and reduces stress and other indicators of poor postpartum maternal mental health in Idaho women delivering preterm infants. Secondarily, we will assess the effects of maternal vitamin D supplementation on human milk composition.",[32],"2025-07-31",{"date":146,"type":45},"2025-08-01",{"date":148,"type":45},"2024-12-04",{"date":150,"type":23},"2027-05-31",{"name":152,"class":52},"University of Idaho",2]