[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"maxillary-deficiency\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:maxillary-deficiency":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,48,77,103,128,156],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100540323","effect-on-periodontal-phenotype-of-flapless-piezoincission-during-orthodontic-treatment-100540323",false,"NCT06315348","Effect on Periodontal Phenotype of Flapless Piezoincission During Orthodontic Treatment","Effect on the Periodontal Phenotype of Flapless Alveolar Decortication and Augmentation During Orthodontic Treatment: A Randomized Clinical Trial","Piezo_Ortho","Inclusion Criteria:\n\nPatients will be consecutively selected among those attending the Faculty of Odontology, University Complutense (Madrid, Spain) looking for orthodontic therapy.\n\nThe inclusion criteria will be as follows:\n\n* patients requiring maxillary and\u002For mandible orthodontic treatment;\n* patients with permanent dentition in stage 5 or 6 of the cervical vertebral maturation method as described by Baccetti et al. (2002);\n* minimal to moderate maxillary and\u002For mandibular anterior crowding at baseline (arch length discrepancy from 3-8 mm); and\n* adequate oral health (i.e. periodontal health, absence of periapical infections and untreated caries).\n\nExclusion Criteria:\n\n* subjects with periodontitis stage III or IV (Papapanou et al., 2018);\n* subjects with poor oral hygiene (represented as full-mouth plaque scores (FMPS) \\>25%);\n* ongoing chronic drug therapy influencing bone metabolism (e.g. steroids, immunosuppressors or antiresorptive drugs);\n* subjects with uncontrolled systemic diseases (e.g. diabetes);\n* pregnancy and\n* subjects not willing to comply with the study visits","ALL","16 Years","70 Years",{"count":21,"type":22},40,"ESTIMATED","INTERVENTIONAL",[25],"NA","Research Question\n\nWhile the reduction in treatment times and the patient satisfaction after periodontally accelerated osteogenic orthodontics (PAOO) are well sustained in the scientific literature, there is still controversy regarding if grafting leads to i) change of the periodontal phenotype and ii) greater stability of post-orthodontic treatment outcomes, highlighting the need of controlled clinical trials.\n\nAims of the Project\n\nThe aim of this randomized clinical trial (RCT) is to compare piezocision-assisted orthodontics, concomitant to soft tissue grafting (volume-stable collagen matrix), with piezocision-assisted orthodontics, concomitant to bone grafting with a xenograft and a native collagen membrane, in orthodontic non-growing patients. The primary aim will be to determine the impact of this surgical protocol on the hard and soft tissue changes occurring on the buccal aspect of the dentition. Secondary objectives will include the assessment of the comparative impact on treatment duration, rate of tooth movements, presence of root resorption, periodontal parameters, bone level changes and patient-reported outcome measures (PROMs) between the two groups.",[28,29],"Dental Malocclusion","Maxillary Deficiency",[31,32,33,34],"Periodontal phenotype","Flapless piezoincision","Orthodontic tooth movement","Tissue augmentation","RECRUITING","2026-05-04",{"date":38,"type":39},"2026-05-08","ACTUAL",{"date":41,"type":39},"2024-04-20",{"date":43,"type":22},"2026-12",{"name":45,"class":46},"Universidad Complutense de Madrid","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":17,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":23,"phases":60,"briefSummary":61,"conditions":62,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":76},"100599712","trial-to-compare-the-effects-of-myo-munchee-therapy-and-oral-motor-therapy-omt-in-pediatric-patients-to-treat-maxillary-deficiency-and-orofacial-myofunctional-dysfunction-omd-100599712","NCT07088055","Trial to Compare the Effects of Myo Munchee Therapy and Oral Motor Therapy (OMT) in Pediatric Patients to Treat Maxillary Deficiency and Orofacial Myofunctional Dysfunction (OMD).","Multi-center, 6-month, Randomized, and Controlled Trial to Compare the Effects of Myo Munchee Therapy and Oral Motor Therapy (OMT) in Pediatric Patients (Aged 3-5 Years) to Treat Maxillary Deficiency and Orofacial Myofunctional Dysfunction (OMD).","Inclusion Criteria:\n\n* Aged between 36 - 60 (3-5 yrs) months old and will not turn 6 years of age before the study completion\n* Diagnosed with having at least two maxillary skeletal-dental malocclusion traits as determined by the dentist\n* At least one of the identified Orofacial Myofunctional Dysfunction (OMD) traits determined by the Speech-Language Pathologist (CCC-SLP)\n\nExclusion Criteria:\n\n* A patient must be considered healthy to be included in this study. Definition of health: the patient does not have ongoing treatment, medication or specialized assessments (more than routine follow up exams) with health care providers regarding a condition. If they have had treatment for a condition (e.g. treated by respiratory physician for acute asthma hospitalization), it must have been 12 months or more since their last appointment with a health provider related to that condition.\n\nOf particular consideration:\n\nOngoing care from a sleep physician or respiratory physician Current use of Continuous Positive Airway Pressure (CPAP), nasal sprays, sleeping or behavioral medication to treat diagnosed sleep disorder or behavioral disorder Adenectomy or tonsillectomy within last 12 months\n\n* Any previous or current tumors or traumas in the head, neck and jaw region Patients with any known genetic or congenital conditions that impair oral motor muscle function, oral motor coordination, or speech articulation, such as but not limited to muscular dystrophy, cerebral palsy, will be excluded from the study.\n* Patients with any known syndromic conditions to affect oral motor function, including but not limited to syndromes that involve craniofacial anomalies, neuromuscular disorders, or developmental delays affecting oral motor muscle control, speech articulation, or swallowing, such as Down Syndrome, Pierre Robin sequence, or Moebius syndrome.\n* Children that do not have their 2nd molars by 36 months of age\n* Overweight, Z-scores Body Mass Index (BMI) above 85th percentile (z score of 1) Boys: https:\u002F\u002Fwww.cdc.gov\u002Fgrowthcharts\u002Fdata\u002Fextended-bmi\u002FBMI-Age-percentiles-BOYS-Z-Scores.pdf Girls: https:\u002F\u002Fwww.cdc.gov\u002Fgrowthcharts\u002Fdata\u002Fextended-bmi\u002FBMI-Age-percentiles-GIRLS-Z-Scores.pdf\n* History of prescription for therapeutic gum chewing and\u002For use of edibles in treatment program\n* Previous tongue tie releases (frenuloplasty and frenectomy)\n* Any therapeutic oral device treatment\n* Previous or current treatment from any other dental, Oral Motor Therapy (OMT) or orthodontic provider\n* Gross neglect of patient's oral health and presence of dental caries\n* Grade 4 tonsils on Brodsky scale",true,"3 Years","5 Years",{"count":59,"type":22},48,[25],"Multi-center, 6-month, randomized, and controlled trial to compare the effects of Myo Munchee therapy and Oral Motor Therapy (OMT) in pediatric patients (aged 3-5 years) to treat maxillary deficiency and orofacial myofunctional dysfunction (OMD).",[63,64,65,29],"Orofacial Myofunctional Disorders","Myo Munchee","Oral Motor Therapy","2025-07-19",{"date":68,"type":39},"2025-07-28",{"date":70,"type":22},"2025-08-20",{"date":72,"type":22},"2027-06",{"name":74,"class":75},"Myo Munchee (Operations) Pty Ltd","INDUSTRY",2,{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":17,"minAge":85,"maxAge":86,"enrollmentInfo":87,"targetDuration":4,"studyType":23,"phases":89,"briefSummary":90,"conditions":91,"keywords":93,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":101,"locationsCount":47},"100592540","evaluation-of-maxillary-expansion-using-clear-aligners-therapy-in-patients-with-cleft-lip-and-palate-at-the-mixed-dentition-stage-100592540","NCT06994754","Evaluation of Maxillary Expansion Using Clear Aligners' Therapy in Patients With Cleft Lip and Palate at the Mixed Dentition Stage","Evaluation of Maxillary Expansion Using Clear Aligners' Therapy in Patients With Cleft Lip and Palate at the Mixed Dentition Stage: A Pilot Study","Pilot","Inclusion Criteria:\n\n* Mixed dentition.\n* Both males and females.\n* Bilateral cleft lip and palate.\n* Lip repair performed between 3 and 6 months of age and palate repair performed between 12and 24 months of age.\n* Presence of maxillary constriction that needs maxillary expansion.\n* Good periodontal health.\n* No previous orthodontic treatment.\n\nExclusion Criteria:\n\n* Syndromic cleft lip and palate patients.\n* Taking medications that influence growth.","6 Years","12 Years",{"count":88,"type":22},10,[25],"The goal of this clinical trial is to learn if the aligners can expand upper dental arch in patients with cleft lip and palate at age of 6-8 years old to correct their collapsid archs. The main questions it aims to answer are:\n\nDoes aligners can achieve transverse dento-skeletal changes? Does aligners can achieve anteroposterior and vertical dento-skeletal changes?\n\nParticipants will:\n\nWear sequence of aligners (each for 10 days). Visit the clinic every month for checkups. 3D x-ray and intraoral scan will be taken after completion of the aligners set to evaluate the intervention.",[29,92],"Cleft Lip and Palate",[94],"Maxillary Expansion by Aligners","2025-06-09",{"date":97,"type":39},"2025-06-12",{"date":99,"type":39},"2025-04-06",{"date":43,"type":22},{"name":102,"class":46},"Cairo University",{"id":104,"slug":105,"hasResults":11,"nctId":106,"briefTitle":107,"officialTitle":107,"acronym":108,"eligibilityCriteria":109,"healthyVolunteers":55,"sex":17,"minAge":110,"maxAge":111,"enrollmentInfo":112,"targetDuration":4,"studyType":23,"phases":114,"briefSummary":115,"conditions":116,"keywords":4,"overallStatus":119,"whyStopped":4,"lastUpdateSubmitDate":120,"lastUpdatePostDateStruct":121,"startDateStruct":123,"completionDateStruct":125,"leadSponsor":127,"locationsCount":4},"100578157","evaluating-the-impact-of-prefabricated-acrylic-splints-on-premaxillary-stability-in-alveolar-cleft-bone-graft-repairs-a-randomized-controlled-trial-100578157","NCT06807645","Evaluating the Impact of Prefabricated Acrylic Splints on Premaxillary Stability in Alveolar Cleft Bone Graft Repairs: a Randomized Controlled Trial","RCT","Eligibility criteria:\n\nA suitable and representative sample will be selected by setting trial participant eligibility criteria. Mesa et al (2016) claimed that, the inclusion and exclusion criteria will consider demographics, disease severity, prior treatment, diagnostics, and other factors. This trial must balance accurately representing the target population with avoiding overly restrictive selection criteria.\n\nInclusion Criteria\n\n1. Patients diagnosed with bilateral alveolar clefts.\n2. Age 8- 12 within the specified range.\n3. Willingness to comply with trial requirements.\n\nExclusion Criteria\n\n1. Patients with allergy use acrylic splints.\n2. Severe medical conditions such as mental retardation.\n3. Inability to provide informed consent or assent.\n\nOperator-dependent interventions will have clear eligibility criteria for care providers and centers to ensure consistency in administration. To improve external validity and clinical applicability, the trial will avoid overly restrictive participant selection (Sessler \\& Imrey 2015; Aggarwal \\& Ranganathan 2019). To ensure generalizability, trial participants must reflect the diversity of the target population.","9 Years","13 Years",{"count":113,"type":22},36,[25],"Rationale for conducting the research:\n\nBilateral alveolar clefts pose significant management challenges, with current treatments like autogenous bone grafting showing instability in up to 40% of cases within a year, risking graft failure and aesthetic issues . Prefabricated acrylic splints may offer a minimally invasive alternative, potentially improving bone graft outcomes and premaxillary stability, crucial for speech, feeding, and respiration. This study evaluates the efficacy of acrylic splinting versus traditional open healing, aiming to enhance patient outcomes and reduce healthcare costs associated with this congenital condition . This research underscores the need for evidence-based, minimally invasive treatments that can improve quality of life and guide clinical practices for managing bilateral alveolar clefts.\n\nReview of literature:\n\nThe existing body of literature on bilateral alveolar clefts and their management reflects several inadequacies and gaps in the evidence base. Bilateral alveolar clefts present unique challenges that have not been fully addressed in the literature on cleft lip and palate management. Limited evidence suggests more focused research in this area. The prevailing treatment options for bilateral alveolar clefts predominantly involve surgical bone grafting procedures. These grafting techniques have shown varying success rates, with factors such as graft quality, surgical technique, and premaxillary stability influencing outcomes. However, the specific challenges posed by bilateral alveolar clefts have not been addressed comprehensively in the existing literature. While grafting procedures have undoubtedly improved the lives of countless patients, there remains a need for more targeted interventions that can enhance premaxillary stability and graft success, particularly in the context of bilateral alveolar clefts. The proposed use of prefabricated acrylic splints represents a novel and innovative approach to address these inadequacies. These splints are designed to provide consistent and reliable support to the premaxilla during the critical early phases of healing following grafting procedures. By minimizing premaxillary mobility, they have the potential to enhance graft success rates, improve premaxillary stability, and enhance the overall outcomes of bilateral alveolar cleft repairs.\n\nExplanation for choice of comparators:\n\nstandard bone grafting without acrylic splints is considered the 'gold standard' for treating alveolar clefts. Using normal repair as the comparator allows for a clear assessment of the possible advantages and challenges of incorporating acrylic splints into existing best practices.\n\n7\\. Objectives:\n\nAim of the Study The primary aim of this study is to assess the impact of prefabricated acrylic splints on premaxillary stability, soft tissue healing, and graft stability in patients with bilateral alveolar clefts.\n\nHypothesis:\n\nNull Hypothesis (H0): Bilateral alveolar cleft patients who receive prefabricated acrylic splints have similar premaxillary stability, soft tissue healing, and graft stability.\n\nAlternative Hypothesis (H1): Prefabricated acrylic splints improve premaxillary stability, soft tissue healing, and graft stability in bilateral alveolar cleft patients.\n\nThe above hypotheses are neutral and not biased. The study tests these hypotheses to obtain objective and evidence-based conclusions about prefabricated acrylic splints for bilateral alveolar cleft repairs.\n\nThis randomized controlled trial will be conducted in Cairo hospital (Abu El-Reesh El-Mounira Children University Hospital). To ensure clinical facilities, medical expertise, and target patient access, this study will be conducted in a hospital. The population density of Cairo and prevalence of bilateral alveolar clefts make it ideal for this research . Cairo study sites will be available upon request and documented in the trial.\n\nInterventions All surgical procedures will be conducted under general anesthesia with nasotracheal intubation, and a first-generation cephalosporin will be administered as antibiotic prophylaxis prior to incision. Autogenous bone grafts will be harvested from the anterior iliac crest using a pediatric minimally invasive technique, involving a 2 cm skin incision made 1 cm lateral to the iliac crest, meticulously dissected to preserve soft tissue. pain management strategies will be employed postoperatively to ensure comprehensive pain control and enhance patient comfort throughout the recovery period.\n\nFor the alveolar cleft repair, a sulcular incision will be made to develop full thickness mucoperiosteal advancement flaps extending into the cleft, with careful elevation of buccal flaps above the piriform rim. The bone graft will be contoured to fill the defect, ensuring cortical bone contacts the nasal lining and cancellous bone chips fill remaining spaces. Closure will be performed using interrupted sutures, starting with the nasal floor",[117,29,118],"Bilateral Complete Cleft Lip And\u002For Alveolus and Acrylic Splint, and","Stability","NOT_YET_RECRUITING","2025-02-06",{"date":122,"type":39},"2025-02-10",{"date":124,"type":22},"2025-02-20",{"date":126,"type":22},"2026-12-30",{"name":102,"class":46},{"id":129,"slug":130,"hasResults":11,"nctId":131,"briefTitle":132,"officialTitle":133,"acronym":134,"eligibilityCriteria":135,"healthyVolunteers":11,"sex":17,"minAge":136,"maxAge":4,"enrollmentInfo":137,"targetDuration":4,"studyType":23,"phases":139,"briefSummary":140,"conditions":141,"keywords":143,"overallStatus":119,"whyStopped":4,"lastUpdateSubmitDate":147,"lastUpdatePostDateStruct":148,"startDateStruct":150,"completionDateStruct":152,"leadSponsor":154,"locationsCount":4},"100572049","osseodensification-versus-alveolar-ridge-splitting-100572049","NCT06728202","Osseodensification Versus Alveolar Ridge Splitting","A Horizontal Ridge Augmentation in Atrophic Maxillary Ridge: Evaluating Alveolar Ridge Splitting and Osseodensification","OD Vs ARS","Inclusion Criteria:\n\nI. Patients with atrophic maxillary alveolar ridges in horizontal dimension \\\u003C18 years old. II. the bucco-palatal alveolar ridge dimension 2-4 mm III. a minimal vertical bone height of 10 mm\n\nExclusion Criteria:\n\nI. Bad oral hygiene. II. Patients with non healthy habits as (Smokers, Alcoholics, or drug abusers). III. Patients with any active periapical pathosis. IV. Patients treated with chemo or radiotherapy during the past 5 years. V. Acute and progressive periodontal disease. VI. Medically compromised patient not indicated for surgical procedures. VII. Patient with history of bleeding disorders. VIII. Patient with osteo-porotic disease.","18 Years",{"count":138,"type":22},46,[25],"Evaluation of clinical and radiological outcomes of the alveolar ridge splitting technique versus Osseodensification burs in atrophic maxillary alveolar ridges in horizontal dimension.",[29,142],"Horizontal Alveolar Bone Defect",[144,145,146],"Osseodensification","Alveolar Ridge Splitting","Dental implant","2024-12-06",{"date":149,"type":39},"2024-12-11",{"date":151,"type":22},"2024-12",{"date":153,"type":22},"2025-09",{"name":155,"class":46},"Fayoum University",{"id":157,"slug":158,"hasResults":11,"nctId":159,"briefTitle":160,"officialTitle":160,"acronym":4,"eligibilityCriteria":161,"healthyVolunteers":55,"sex":17,"minAge":136,"maxAge":162,"enrollmentInfo":163,"targetDuration":4,"studyType":23,"phases":164,"briefSummary":165,"conditions":166,"keywords":168,"overallStatus":119,"whyStopped":4,"lastUpdateSubmitDate":171,"lastUpdatePostDateStruct":172,"startDateStruct":174,"completionDateStruct":175,"leadSponsor":177,"locationsCount":4},"100550408","radiographic-assessment-of-bone-gain-following-sinus-lifting-with-simultaneous-implant-placement-using-crestal-approach-with-membrane-control-technique-for-bone-augmentation-of-atrophied-maxillary-posterior-ridge-100550408","NCT06446687","Radiographic Assessment of Bone Gain Following Sinus Lifting With Simultaneous Implant Placement Using Crestal Approach With Membrane Control Technique for Bone Augmentation of Atrophied Maxillary Posterior Ridge","Inclusion Criteria:\n\n1. Patients required dental implant treatment in the posterior maxilla, in the premolar and molar regions ( both sexes).\n2. Residual bone height 4-8mm in the estimated implant positions.\n3. The bone width of the alveolar ridge is at least 5mm in estimated implant positions.\n4. The edentulous ridges are covered with optimal thickness of mucoperiosteum.\n\nExclusion Criteria:\n\n1. Patients with a systemically diseases or inflammation whether local or generalized.\n2. Patients with bleeding disorders.\n3. Subjected to irradiation in the head and neck area less than 1 year before implantation.\n4. Poor oral hygiene and motivation.\n5. Pregnant or nursing.\n6. Severe bruxism or clenching.\n7. Active infection or severe inflammation in the area intended for implant placement.\n8. Unable to open mouth sufficiently to accommodate the surgical tooling.","90 Years",{"count":88,"type":22},[25],"This study aims to evaluate the quantity and quality of the native and the newly bone around dental implants that's simultaneously installed with sinus lifting",[167,29],"Implant Site Reaction",[169,170],"Closed Sinus lifting","Bone Gain","2024-06-01",{"date":173,"type":39},"2024-06-06",{"date":171,"type":22},{"date":176,"type":22},"2025-02-01",{"name":102,"class":46}]