[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"maxillomandibular-advancement-surgery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:maxillomandibular-advancement-surgery":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":28,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100637904","natural-history-of-central-and-mixed-sleep-apneas-followed-by-maxillomandibular-advancement-for-obstructive-sleep-apnea-100637904",false,"NCT07596719","Natural History of Central and Mixed Sleep Apneas Followed by Maxillomandibular Advancement for Obstructive Sleep Apnea","CMAI","Inclusion Criteria:\n\n* Adults aged 18 years or older;\n* Mild to severe OSA as determined by a polysomnography (PSG) preoperatively;\n* Completion of MMA for OSA treatment;\n* Subjects with preoperative and postoperative PSG;\n* Patients who are present with MMA treatment-related central apneas postoperatively\n\nExclusion Criteria:\n\n* Patients who underwent other adjunctive procedures at the time of MMA (e.g., multi-piece Le Fort osteotomy, TMJ reconstruction);\n* Previous history of orthognathic surgery;\n* Cleft palate and syndromic patients.","ALL","18 Years",{"count":19,"type":20},60,"ESTIMATED","OBSERVATIONAL","The goal of this observational prospective cohort study is to learn about the natural course of central and mixed sleep apneas that develop after maxillomandibular advancement (MMA) surgery for obstructive sleep apnea (OSA) in adult patients.\n\nThe main question it aims to answer is:\n\nDo central and mixed apneas resolve, partially resolve, or persist in the long term after MMA?\n\nParticipants will:\n\nUndergo a first postoperative polysomnography (PSG) at 3-6 months after MMA (part of standard care).\n\nBe invited into the study if central\u002Fmixed apneas are detected (CMAI% \\>25%). Undergo a second PSG at least 12 months after MMA (extra study procedure)",[24,25,26,27],"Sleep Apnea Syndrome (OSAS)","Central Sleep Apnea","Maxillomandibular Advancement Surgery","Orthognathic Surgical Procedures",[29,30,25],"OSA","MMA","NOT_YET_RECRUITING","2026-05-13",{"date":34,"type":35},"2026-05-19","ACTUAL",{"date":37,"type":20},"2026-12-01",{"date":39,"type":20},"2027-12-31",{"name":41,"class":42},"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":16,"minAge":51,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":55,"phases":56,"briefSummary":58,"conditions":59,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":43},"100357094","preliminary-evaluation-of-a-rcmp-to-predict-failure-of-maxillomandibular-advancement-surgery-for-osa-100357094","NCT03929549","Preliminary Evaluation of a RCMP to Predict Failure of Maxillomandibular Advancement Surgery for OSA","Preliminary Evaluation of a Remotely Controlled Mandibular Positioner to Predict Failure of Maxillomandibular Advancement Surgery for Obstructive Sleep Apnea","Inclusion Criteria:\n\nAHI ≥ 15\u002Fhour\n\n30-65 years of age\n\nBMI 25-34.9\n\nIdeal operative candidate\n\nUnable or unwilling to use PAP\n\nExclusion Criteria:\n\nBMI ≥ 35\n\nyounger than 30 or older than 65 years of age\n\npregnancy\n\nCentral sleep apnea (CSA) on baseline polysomnogram\n\nChronic opioid use\n\nActive TMJ Disorders\n\nInability to protrude the mandible beyond 5 mm\n\nInability to follow-up after surgery\n\nDental disorders including loose teeth or advanced periodontal disease","30 Years","65 Years",{"count":54,"type":20},20,"INTERVENTIONAL",[57],"NA","Maxillomandibular advancement (MMA) surgery, one of the most successful surgical procedures for the treatment of obstructive sleep apnea (OSA), is predominantly used to manage patients with moderate to severe OSA. However, limiting factors include incomplete response in some cases, unfavorable facial changes as a result of large advancements, and risk of malocclusion or malunion.\n\nThis study will be done to determine predictors of success with MMA surgery in patients with moderate to severe OSA. Studies have already shown the value of a remote controlled mandibular positioner (RCMP) device to identify the correct level of therapeutic protrusion needed with oral appliance therapy. Moreover, some patients experience a dose dependent improvement in sleep parameters based on the degree of protrusion during the titration study. Use of RCMP as a means to identify potential candidates for MMA, may help customize treatment options for patients with OSA by providing predictive value.",[60,26],"Obstructive Sleep Apnea","RECRUITING","2024-12-04",{"date":64,"type":35},"2024-12-09",{"date":66,"type":35},"2019-08-12",{"date":68,"type":20},"2026-07",{"name":70,"class":42},"University of Michigan"]