[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"mechanical-power\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:mechanical-power":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,10,0,[8,44,73,106,139,164,189,212,229,257],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":4},"100643194","a-study-of-the-determinants-of-neurological-outcomes-in-patients-with-acute-respiratory-distress-syndrome-100643194",false,"NCT07629973","A Study of the Determinants of Neurological Outcomes in Patients With Acute Respiratory Distress Syndrome","Etude Des déterminants de l'évolution NEUrologique Des Patients Ayant présenté un Syndrome de Détresse Respiratoire aiguë","NEURDS","Inclusion Criteria:\n\n* Adult patient\n* Patient admitted to the intensive care unit less than 48 hours ago\n* Patient diagnosed with mild, moderate or severe ARDS according to the Berlin classification based on the PaO₂\u002FFiO₂ ratio, with a minimum PEEP set at 5 cmH₂O (16), of pulmonary aetiology:\n\n  * Mild ARDS: 200 \\\u003C PaO₂\u002FFiO₂ \\\u003C 300 mmHg\n  * Moderate ARDS: 100 \\\u003C PaO₂\u002FFiO₂ \\\u003C 200 mmHg\n  * Severe ARDS: PaO₂\u002FFiO₂ \\\u003C 100 mmHg\n* Patients fitted with an oesophageal pressure measurement catheter (Nutrivent, Sidam, San Giacomo Roncole, Italy)\n* Patients registered with or covered by a social security scheme\n* Free and informed consent from the patient or a trusted relative (where the patient is unable to give consent).\n\nExclusion Criteria:\n\n* Patients with a history of central nervous system disorders resulting in cognitive impairment\n* Patients on ECMO\n* Patients admitted for symptomatic central nervous system disorders\n* Patients admitted for acute respiratory distress syndrome following cardiorespiratory arrest.\n* Patients being treated for a psychiatric condition, chronic heavy drinkers, or those undergoing long-term treatment with benzodiazepines, antidepressants or antipsychotics.\n* Pregnant, breastfeeding or labouring patients\n* Individuals subject to a legal protection order\n* Individuals receiving compulsory psychiatric care\n* Individuals deprived of their liberty by judicial or administrative decision","ALL","18 Years",{"count":20,"type":21},150,"ESTIMATED","INTERVENTIONAL",[24],"NA","Acute respiratory distress syndrome (ARDS) is characterized by pathological pulmonary edema caused by direct or indirect damage to the alveolar-capillary membrane.\n\nIts management relies on etiological treatment, invasive mechanical ventilation, and the use of sedatives and neuromuscular blockers, depending on the patient's condition.\n\nImprovements in patient care have led to an improved prognosis. However, in-hospital mortality remains high (between 35% and 45%). Notably, morbidity among surviving patients is very high and is largely dominated by neuropsychological sequelae. Attention and executive function disorders, confusion, disorientation, or memory impairment are thus found in 70 to 100% of patients following ARDS. These disorders are still present in 46 to 80% of surviving patients one year after ARDS and in 20% of them five years later.\n\nAlthough essential to treatment, mechanical ventilation carries a risk of significant complications. Beyond the risk of infection and complications related to sedation and neuromuscular blockade, the use of mechanical ventilation is associated with a risk of ventilator-induced lung injury (VILI).\n\nThe use of so-called protective ventilation reduces the risk of VILI and improves patient outcomes. However, analysis of relevant physiological parameters shows that the risk of VILI may still exist even when ventilator settings comply with recommendations and the concept of protective ventilation. Driving pressure (which represents Strain) is a good marker of VILI; it represents the distension of the lung with each breath relative to the initial lung volume. Values above 14 cmH₂O are associated with high mortality in patients with ARDS. Inspiratory transpulmonary pressure represents Stress-that is, the pressure that distends the alveoli at the end of inspiration-and is also associated with the risk of VILI. Finally, mechanical power represents the amount of energy delivered to the lung by the ventilator and has been validated as a marker of VILI. The advantage of mechanical power over the other indices described is that it incorporates all components that can lead to VILI.\n\nAmong the various sources of neurological damage during ARDS, inflammatory processes appear to play a major role. Numerous inflammatory mediators (TNF-α, IL-6, IL-8, IL-1β) are secreted during ARDS, and animal studies have demonstrated a link between inflammation and hippocampal damage. Furthermore, cerebral ischemic lesions, exacerbated by systemic inflammation and endothelial activation leading to coagulation activation with thrombus formation, may also contribute to the development of cognitive impairments.\n\nIn addition to the inflammatory processes associated with ARDS, mechanical ventilation itself may have a significant impact on neuroinflammatory damage. Recently, the term \"ventilator-associated brain injury\" (VABI) has been proposed to describe these secondary neurological lesions induced by mechanical ventilation. Studies in mouse and pig models have demonstrated a relationship between the dose and duration of VILI, apoptosis, neuroinflammation, and neuronal damage. An animal study in mice also showed an association between the duration of mechanical ventilation and the onset of cognitive impairments.\n\nDuring brain injury, proteins and neurotransmitters are released and serve as biomarkers of brain damage. Elevated plasma levels of S100B protein indicate astrocyte damage caused by traumatic, anoxic-ischemic, or inflammatory mechanisms. It correlates with neurological prognosis following cardiac arrest, in ischemic or hemorrhagic strokes, in neurodegenerative diseases, and in patients with traumatic brain injury.\n\nClinical studies have shown a negative correlation between elevated S100B protein levels, the MoCA (Montreal Cognitive Assessment) score, and the MMSE (Mini-mental state evaluation ) in patients with OSA (Obstructive Sleep Apnea) or COPD (chronic obstructive pulmonary disease), respectively, indicating an association between this protein and cognitive impairment.\n\nThe investigators therefore hypothesize that mechanical ventilation associated with high mechanical power is linked to a significant risk of brain injury, reflected by elevated serum S100B protein levels and the presence of neurocognitive disorders long after ARDS.",[27,28,29,30,31],"Acute Respiratory Distress Syndrome (ARDS)","s100b","Mechanical Power","Ventilator Induced Lung Injury","Transpulmonary Pressure","NOT_YET_RECRUITING","2026-06-09",{"date":35,"type":36},"2026-06-10","ACTUAL",{"date":38,"type":21},"2026-10-17",{"date":40,"type":21},"2029-10-23",{"name":42,"class":43},"University Hospital, Angers","OTHER_GOV",{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":22,"phases":54,"briefSummary":55,"conditions":56,"keywords":59,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":72},"100637429","individualized-peep-and-pulmonary-complications-in-on-pump-cabg-100637429","NCT07623109","Individualized PEEP and Pulmonary Complications in On-Pump CABG","Effect of Individualized PEEP Guided by Driving Pressure and Mechanical Power on Postoperative Pulmonary Complications in On-Pump CABG: A Randomized Controlled Trial","Patients with ASA physical status II-III who are scheduled to undergo elective open-heart surgery via on-pump median sternotomy will be included in the study.\n\nPatients scheduled for emergency surgery, those planned to undergo off-pump cardiac surgery, patients with a history of myocardial infarction within the last 3 months, patients with advanced COPD, patients with an ARISCAT score of 44 or higher, patients with a BMI of 35 kg\u002Fm² or higher, patients with NYHA class IV status, patients receiving preoperative immunotherapy, and patients with severe hepatic or renal failure will be excluded from the study.","80 Years",{"count":53,"type":21},80,[24],"Postoperative pulmonary complications (PPCs) are an important cause of morbidity and mortality after major surgery and are frequently observed in cardiac surgery patients undergoing cardiopulmonary bypass (CPB). These complications are associated with prolonged mechanical ventilation, longer intensive care unit and hospital stays, increased healthcare costs, and higher mortality (1,2).\n\nIntraoperative lung-protective ventilation strategies have traditionally focused on individual parameters such as low tidal volume, positive end-expiratory pressure (PEEP), plateau pressure, and driving pressure. However, the effects of these parameters on postoperative pulmonary outcomes in cardiac surgery patients remain unclear. In particular, PEEP- and driving pressure-guided approaches are controversial in terms of feasibility and safety in patients undergoing CPB, who may be hemodynamically vulnerable.\n\nMechanical power is a comprehensive parameter that reflects the total energy delivered to the respiratory system per unit of time by integrating ventilatory variables such as tidal volume, airway pressures, respiratory rate, and flow. Therefore, mechanical power may provide a more comprehensive assessment of the mechanical load applied to the lungs compared with individual ventilatory parameters. Previous studies have reported that higher mechanical power values may be associated with lung injury, postoperative pulmonary complications, and mortality (3).\n\nThe aim of this study is to evaluate the effect of monitoring mechanical power during perioperative mechanical ventilation on postoperative pulmonary complications in patients undergoing cardiac surgery with cardiopulmonary bypass. The study hypothesis is that a mechanical power-based ventilation approach may reduce the incidence of PPCs compared with strategies based on conventional ventilation parameters.",[57,29,58],"Cardiac Surgery","Postoperative Pulmonary Complications (PPCs)",[60,61,62],"cardica surgery","mechanical power","postoperative pulmonary complications","2026-06-01",{"date":65,"type":36},"2026-06-03",{"date":67,"type":21},"2026-05-15",{"date":69,"type":21},"2026-07-15",{"name":71,"class":43},"Bursa City Hospital",1,{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":81,"minAge":18,"maxAge":4,"enrollmentInfo":82,"targetDuration":4,"studyType":22,"phases":84,"briefSummary":85,"conditions":86,"keywords":88,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":105},"100606051","eit-vs-dynamic-compliance-guided-peep-titration-during-laparoscopic-gynecological-surgery-100606051","NCT07170514","EIT vs Dynamic Compliance Guided PEEP Titration During Laparoscopic Gynecological Surgery","Electrical Impedance Tomography vs Dynamic Compliance Guided Positive End-expiratory Pressure Titration During Laparoscopic Gynecological Surgery: A Multi-center, Prospective Randomized Trial - TITRANT","TITRANT","Inclusion criteria:\n\n* Patient scheduled for elective laparoscopic gynaecological surgery\n* Age \\> 18 years\n* Signed consent to participate in the trial\n\nExclusion criteria:\n\n* Age \\\u003C 18 years\n* American Society of Anesthesiologists (ASA) physical status IV\n* History of severe restrictive or chronic obstructive pulmonary disease (COPD, Global Initiative for Chronic Obstructive Lung Disease grades III or IV)\n* Uncontrolled bronchial asthma\n* Pulmonary metastases\n* History of any thoracic surgery\n* Need for thoracic drainage before surgery\n* Congestive heart failure (NYHA grades III or IV)\n* Extreme obesity (BMI\\>35 kg m-2)\n* Lack of patient's consent","FEMALE",{"count":83,"type":21},200,[24],"The goal of this randomized controlled clinical trial is to compare the pulmonary protective effects of two different positive end-expiratory pressure (PEEP) titrating methods in patients with non-injured lungs undergoing laparoscopic gynecological surgery.\n\nDespite dynamic pulmonary compliance (Cdyn) guided lung protective ventilation has several proven advantages, the investigators hypothesize that optimizing intraoperative mechanical ventilation using electrical impedance tomography (EIT) may further improve patient outcomes, enhance postoperative recovery, shorten in-hospital stay and reduce healthcare related costs.\n\nThe main questions aim to answer are:\n\n* May EIT-guided PEEP titration reduce the mechanical power of ventilation and improve oxygenation more significantly than the Cdyn-guided method?\n* What effect might a decrease in mechanical power of ventilation have on postoperative pulmonary complications?\n\nParticipants will:\n\n* Receive an EIT-guided or a Cdyn-guided PEEP titration procedure during laparoscopic gynecological surgery.\n* Be assessed for mechanical power of ventilation, oxygenation, atelectasis and postoperative pulmonary complications during and 2 days after surgery.\n* Be followed-up for mortality until the 28th postoperative day.",[29,58,87],"Oxygenation",[89,90,91,61,92,93,62],"electrical impedance tomography","dynamic pulmonary compliance","positive end-expiratory pressure","pulmonary protective ventilation","Pao\u002FFiO2","RECRUITING","2026-04-09",{"date":97,"type":36},"2026-04-14",{"date":99,"type":36},"2025-11-10",{"date":101,"type":21},"2027-10-30",{"name":103,"class":104},"Pest County Flór Ferenc Hospital","OTHER",3,{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":110,"acronym":4,"eligibilityCriteria":111,"healthyVolunteers":112,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":113,"targetDuration":4,"studyType":22,"phases":114,"briefSummary":115,"conditions":116,"keywords":126,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":133,"completionDateStruct":135,"leadSponsor":137,"locationsCount":72},"100607313","driving-pressure-during-surgeries-with-high-risk-for-postoperative-pulmonary-complications-100607313","NCT07186933","Driving Pressure During Surgeries With High Risk for Postoperative Pulmonary Complications","Inclusion Criteria\n\n* \\>17 years old\n* Surgery with general anesthesia \\& invasive mechanical ventilation\n* Preoperative ARISCAT score estimation \\>25\n\nExclusion Criteria:\n\n* \\\u003C18 years old\n* Preoperative ARISCAT score estimation \\\u003C26\n* Women during pregnancy or just given birth\n* Other type of anesthesia (Not general)\n* Contraindication of administration of neuromuscular blockade agents.\n* Contraindication of cease of spontaneous ventilation.\n* Mechanical ventilation without endotracheal intubation.\n* Severe heart failure \u002F Severe cardiac arrhythmia.\n* Severe emphysematous lung disease.\n* Patient denial of participation in the trial.",true,{"count":83,"type":21},[24],"The goal of this clinical trial is to compare two different types of perioperative mechanical ventilation (MV), specifically Protective Mechanical Ventilation (PMV) and MV with the lowest possible Driving Pressure (ΔP), in relation to the appearance of postoperative pulmonary complications (PPCs) in adult patients who are operated and have higher risk of PPCs.\n\nThe main questions it aims to answer are:\n\n* Is MV with lower ΔP better than conventional PMV in preventing PPCs in patients with higher risk for PPCs?\n* Does MV with lower ΔP decrease hospital stay, Intensive Care Unit (ICU) need and mortality?\n* Does MV with lower ΔP suit better than PMV to lung characteristics and needs intraoperatively?\n\nResearchers will compare MV with the lowest possible Driving Pressure (ΔP) to Protective Mechanical Ventilation (PMV) to see if any of this is more protective than the other concerning PPCs.\n\nAll participants will receive perioperative MV.\n\nHalf of them will receive conventional Protective Mechanical Ventilation (PMV). This will include well known generally protective settings for mechanical ventilation of patients, concerning volumes, pressures, respiratory rate, inspiratory gases and ventilation maneuvers.\n\nThe rest of participants will be ventilated with the lowest possible Driving Pressure (ΔP). This will be similar to PMV in the chosen volumes, respiratory rate, inspiratory gases and ventilation maneuvers. However, the pressure inside lung at the end of expiration, eg Positive End Expiratory Pressure (PEEP), will be not be preset for every patient. Initially, the investigators will perform a maneuver that will quantify each individual's lung characteristics and mechanics. According to this, the investigators will find the exact PEEP that seems to suit each patients lungs most, and use this perioperatively, trying to provide lungs the best conditions every time.\n\nAfter the completion of the operation, all the patients will be screened for PPCs, via arterial blood testing and chest X ray, and the results will be statistically analyzed trying to find if any of the forementioned strategies of mechanical ventilation surpasses the other concerning PPCs appearance. PPCs include atelectasis, respiratory failure, bronchospasm, pleural effusion, pneumonia, aspiration and pneumothorax.\n\nFurthermore hospital stay, ICU need and mortality will be noted. Finally, measurements of perioperative lung pressures, volumes and derived variables will be noted and compared statistically as well.",[117,118,119,120,121,122,123,124,29,125],"Postoperative Pulmonary Atelectasis","Postoperative Pulmonary Complications","Postoperative Respiratory Failure","Postoperative Bronchospasm","Postoperative Pleural Effusion","Postoperative Pneumothorax","Postoperative Pneumonia","Postoperative Aspiration Pneumonitis","Driving Pressure",[125,29,127,128,118,119,129],"Atelectasis","Pulmonary Complications","Elastic Power","2026-02-08",{"date":132,"type":36},"2026-02-11",{"date":134,"type":36},"2025-11-03",{"date":136,"type":21},"2027-11-30",{"name":138,"class":104},"University General Hospital of Patras",{"id":140,"slug":141,"hasResults":11,"nctId":142,"briefTitle":143,"officialTitle":144,"acronym":4,"eligibilityCriteria":145,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":146,"enrollmentInfo":147,"targetDuration":4,"studyType":149,"phases":4,"briefSummary":150,"conditions":151,"keywords":4,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":155,"lastUpdatePostDateStruct":156,"startDateStruct":158,"completionDateStruct":160,"leadSponsor":162,"locationsCount":72},"100520872","effect-of-transpulmonary-mp-on-prognosis-of-patients-with-severe-ards-treated-with-vv-ecmo-100520872","NCT06062212","Effect of Transpulmonary MP on Prognosis of Patients With Severe ARDS Treated With VV-ECMO","Effect of Transpulmonary Mechanical Power on the Prognosis of Patients With Severe Acute Respiratory Distress Syndrome Treated With Venovenous Extracorporeal Membrane Oxygenation","Inclusion Criteria:\n\n1. Meet the diagnostic criteria of Berlin's definition for ARDS;\n2. Receiving VV-ECMO support.\n\nExclusion Criteria:\n\n1. Patients had been on high pressure (Ppeak \\>35 cm H2O) and a high fraction of inspired oxygen (FiO2\\>0.8) ventilation for \\>7 days;\n2. Patients had a contraindication to heparinization;\n3. Patients had an irreversible neurological injury;\n4. Patients had severe chronic lung disease with life expectancy \\\u003C6 months.","75 Years",{"count":148,"type":21},100,"OBSERVATIONAL","Venovenous extracorporeal membrane oxygenation (VV-ECMO) is a salvage treatment for severe acute respiratory distress syndrome (ARDS). With the large-scale implementation of VV-ECMO in critical care medicine departments in China, significant progress has been made in treating severe ARDS. However, the patient mortality rate remains high. The pathophysiological essence of ARDS is an imbalance between the body's oxygen supply and demand, causing tissue and cell hypoxia, organ dysfunction, and even death. The VV-ECMO treatment process still requires mechanical ventilation assistance. However, inappropriate mechanical ventilation settings can lead to ventilator-related lung injury (VILI). In recent years, mechanical power has gradually attracted everyone's attention and is considered the cause of VILI. The transpulmonary mechanical power is more accurate to the energy directly performed to the lung tissue. Transpulmonary mechanical energy has a specific value in judging the prognosis of mechanically ventilated patients, but its clinical significance in treating patients with VV-ECMO is unclear. This study aimed to explore the value of transpulmonary mechanical power in predicting the prognosis of patients with severe ARDS patients treated with VV-ECMO.",[152,153,29,154],"Acute Respiratory Distress Syndrome","Extracorporeal Membrane Oxygenation","Transpulmonary Mechanical Power","2025-07-02",{"date":157,"type":36},"2025-07-03",{"date":159,"type":36},"2023-10-01",{"date":161,"type":21},"2025-12-31",{"name":163,"class":104},"Beijing Chao Yang Hospital",{"id":165,"slug":166,"hasResults":11,"nctId":167,"briefTitle":168,"officialTitle":169,"acronym":4,"eligibilityCriteria":170,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":171,"targetDuration":4,"studyType":22,"phases":173,"briefSummary":174,"conditions":175,"keywords":178,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":180,"lastUpdatePostDateStruct":181,"startDateStruct":183,"completionDateStruct":185,"leadSponsor":187,"locationsCount":72},"100588071","eit-guided-ventilator-settings-in-ahrf-100588071","NCT06936618","EIT-Guided Ventilator Settings in AHRF","Using Electrical Impedance Tomography-Guided Ventilator Settings to Reduce Mechanical Power in Acute Hypoxemic Respiratory Failure : An Exploratory Study","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Diagnosed with acute hypoxemic respiratory failure within 48 hours\n* Expected to require invasive mechanical ventilation ≥ 48 hours\n* On mechanical ventilation within 24 hours\n* Deep sedation and neuromuscular blockade\n\nExclusion Criteria:\n\n* Pregnancy\n* Body mass index (BMI) \\> 40 kg\u002Fm2\n* Contraindications to using electrical impedance tomography, including\n* Presence of a pacemaker or automatic implantable cardioverter-defibrillator (AICD)\n* Inability to place the belt due to presence of surgical wounds dressing, thoracic or spinal cord trauma, recent thoracic surgery, etc.\n* High risk for PEEP titration\n* Hemodynamic instability defined as mean arterial pressure \\\u003C 65 mmHg despite optimization of fluid status and\u002For use of vasopressors\n* Unstable cardiac arrhythmias\n* Presence of lung bullae greater than 2 cm in diameter, identified on chest X-ray\n* Presence of pneumothorax or pneumomediastinum\n* Right-sided heart failure or severe pulmonary hypertension\n* Neurologic conditions associated with a risk of intracranial hypertension\n* Use of extracorporeal membrane oxygenation (ECMO)\n* Severe chronic respiratory disease, defined as follows: requiring home oxygen therapy, or previous lung function showing (FEV1 less than 20 ml\u002Fkg PBW, or FEV1\u002FFVC less than 50% predicted value), or chronic hypercapnia (PaCO2 greater than 45 mmHg) and\u002For chronic hypoxemia (PaO2 less than 55 mmHg) on FIO2 = 0.21, or radiographic x-ray evidence of any chronic over-inflation or chronic interstitial infiltration, or chronic restrictive, obstructive, neuromuscular, chest wall or pulmonary vascular disease resulting in severe exercise restriction (unable to climb stairs or perform household duties, secondary polycythemia, severe pulmonary hypertension with mean pulmonary arterial pressure greater than 40 mmHg)\n* Decision to withhold life-sustaining treatment or palliative care.\n* Moribund status with an expected survival of less than 24 hours.\n* Refusal to provide informed consent",{"count":172,"type":21},17,[24],"This exploratory study aims to investigate the effect of Electrical Impedance Tomography (EIT)-guided ventilator settings on mechanical power in patients with acute hypoxemic respiratory failure (AHRF), including both ARDS and non-ARDS conditions. Mechanical power, a key factor associated with ventilator-induced lung injury (VILI), will be measured before and after EIT-guided PEEP titration. The study will evaluate feasibility and changes in lung mechanics, gas exchange, and EIT parameters. A total of 17 patients requiring invasive mechanical ventilation will be enrolled at Siriraj Hospital, Mahidol University.",[176,27,29,30,177],"Acute Hypoxemic Respiratory Failure","Electrical Impedance Tomography (EIT)",[179],"Acute Hypoxemic Respiratory Failure; Electrical Impedance Tomography; Mechanical Power, Ventilator-induced lung injury","2025-04-22",{"date":182,"type":36},"2025-04-27",{"date":184,"type":36},"2024-12-17",{"date":186,"type":21},"2026-12",{"name":188,"class":104},"Mahidol University",{"id":190,"slug":191,"hasResults":11,"nctId":192,"briefTitle":193,"officialTitle":193,"acronym":4,"eligibilityCriteria":194,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":195,"enrollmentInfo":196,"targetDuration":4,"studyType":149,"phases":4,"briefSummary":198,"conditions":199,"keywords":200,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":203,"lastUpdatePostDateStruct":204,"startDateStruct":206,"completionDateStruct":208,"leadSponsor":210,"locationsCount":72},"100554041","mechanical-power-as-a-predictor-for-weaning-in-chronic-obstructive-pulmonary-disease-patients-prospective-cohort-study-100554041","NCT06493929","Mechanical Power As a Predictor for Weaning in Chronic Obstructive Pulmonary Disease Patients :Prospective Cohort Study.","Inclusion Criteria:\n\n* All COPD mechanically ventilated patients admitted to respiratory intensive care unit and eligible for weaning according to European respiratory society 2016 (5).\n\nExclusion Criteria:\n\n\\- 1. Patients with associated lung pathology that may alter lung mechanics (Bronchiectasis, interstitial lung diseases, lung scarring) will be excluded from the study.\n\n2\\. Tracheostomized patients.","100 Years",{"count":197,"type":21},84,"The primary objective is to evaluate the mechanical power as a predictor of weaning of mechanical ventilation in COPD patients hospitalized in the respiratory intensive care unit of Assiut University Hospital The secondary objective is to compare between mechanical power and diaphragmatic excursion (DE) assessed by ultrasound as a predictor of weaning in these patients. Also, to investigate the association between MP and DE and mortality in these patients",[29],[201,202],"Mechanical power","Weaning","2024-11-29",{"date":205,"type":36},"2024-12-03",{"date":207,"type":21},"2024-12-01",{"date":209,"type":21},"2026-08-01",{"name":211,"class":104},"Assiut University",{"id":213,"slug":214,"hasResults":11,"nctId":215,"briefTitle":216,"officialTitle":217,"acronym":218,"eligibilityCriteria":219,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":195,"enrollmentInfo":220,"targetDuration":221,"studyType":149,"phases":4,"briefSummary":222,"conditions":223,"keywords":224,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":203,"lastUpdatePostDateStruct":225,"startDateStruct":226,"completionDateStruct":227,"leadSponsor":228,"locationsCount":4},"100555317","mechanical-power-versus-diaphragmatic-excursion-as-a-predictor-for-weaning-in-chronic-obstructive-pulmonary-disease-patients-100555317","NCT06510517","Mechanical Power Versus Diaphragmatic Excursion As a Predictor for Weaning in Chronic Obstructive Pulmonary Disease Patients","Mechanical Power Versus Diaphragmatic Excursion As a Predictor for Weaning in Chronic Obstructive Pulmonary Disease Patients: Prospective Cohort Study","weaning","Inclusion Criteria:\n\nAll COPD patients who are mechanically ventilated patients. Must be eligible for weaning according to European respiratory society 2016.\n\nExclusion Criteria:\n\n1. Patients with Bronchiectasis, interstitial lung diseases, lung scarring.\n2. Tracheostomized patients.",{"count":197,"type":21},"8 Weeks","The primary objective is to evaluate the mechanical power as a predictor of weaning of mechanical ventilation in COPD patients hospitalized in the respiratory intensive care unit of Assiut University Hospital.\n\nThe secondary objective is to compare between mechanical power and diaphragmatic excursion (DE) assessed by ultrasound as a predictor of weaning in these patients. Also, to investigate the association between MP and DE and mortality in these patients",[29],[201,202],{"date":205,"type":36},{"date":207,"type":21},{"date":209,"type":21},{"name":211,"class":104},{"id":230,"slug":231,"hasResults":11,"nctId":232,"briefTitle":233,"officialTitle":234,"acronym":235,"eligibilityCriteria":236,"healthyVolunteers":11,"sex":17,"minAge":237,"maxAge":51,"enrollmentInfo":238,"targetDuration":4,"studyType":149,"phases":4,"briefSummary":240,"conditions":241,"keywords":243,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":248,"lastUpdatePostDateStruct":249,"startDateStruct":251,"completionDateStruct":253,"leadSponsor":255,"locationsCount":72},"100546832","ventilatory-parameters-in-predicting-outcomes-in-ards-patients-100546832","NCT06400095","Ventilatory Parameters in Predicting Outcomes in ARDS Patients","Occlusion Pressure at 100 Msec, TCe ( Expiratory Time Constant ), Stress Energy Density, Mechanical Power, Ventilatory Ratio and C20\u002FCdyn in Predicting Outcomes in Patients With Moderately Severe ARDS, Who Are on Mechanical Ventilation","OCTANE","Inclusion Criteria:\n\n* Patients with Acute respiratory failure needing mechanical ventilation\n* Diagnosis of Severe ARDS with severity: PF ratio \\\u003C 150, with PEEP\u002FCPAP \\> 5\n\nExclusion Criteria:\n\n* r2 \\\u003C 0.95, monitored on the ventilator\n* Expiratory flow that is not first-order or non-exponential decay\n* Patients with Nor-epinephrine requirements \\> 0.1 mcg\u002Fkg\u002Fmin within 2 hours of intubation\n* Patients requiring ECMO ( Extracorporeal membrane oxygenation)\n* Patients with COPD or pulmonary fibrosis with a premorbid FEV1 \\\u003C 1.5 L\n* Severe atherosclerotic vascular disease\n* Patients with a chest tube, intra-abdominal hypertension or with its risk factors\n* Patients with structural heart disease including pulmonary hypertension (RVSP \\> 45) and heart failure\n* All comfort care orders in the ICU\n* Patients who underwent tracheostomy","19 Years",{"count":239,"type":21},50,"This is a single-centre prospective observational study aimed to determine if Pocc (occlusion pressure at 100 msec), TCe ( Expiratory time constant ), Mechanical Stress power, Ventilatory ratio and C20\u002FCdyn would predict outcomes in patients with moderately severe ARDS (Acute respiratory distress syndrome), who are on mechanical ventilation",[242,29],"ARDS",[244,245,246,247],"Expiratory time constant","Ventilator ratio","Cdyn\u002FC20","Occlusion pressure at 100 msec","2024-08-20",{"date":250,"type":36},"2024-08-22",{"date":252,"type":36},"2023-06-01",{"date":254,"type":21},"2025-07",{"name":256,"class":104},"CentraCare",{"id":258,"slug":259,"hasResults":11,"nctId":260,"briefTitle":261,"officialTitle":261,"acronym":4,"eligibilityCriteria":262,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":263,"targetDuration":4,"studyType":149,"phases":4,"briefSummary":264,"conditions":265,"keywords":4,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":266,"lastUpdatePostDateStruct":267,"startDateStruct":269,"completionDateStruct":271,"leadSponsor":273,"locationsCount":72},"100548773","use-of-mechanical-power-as-a-predictor-of-increased-serum-and-pulmonary-proinflammatory-cytokine-concentrations-in-patients-with-acute-hypoxemic-respiratory-failure-a-prospective-observational-study-100548773","NCT06425354","Use of 'Mechanical Power' as a Predictor of Increased Serum and Pulmonary Proinflammatory Cytokine Concentrations in Patients With Acute Hypoxemic Respiratory Failure: A Prospective Observational Study","Inclusion Criteria:\n\n* Patients with AHRF (P\u002FF \\\u003C300 mmHg) undergoing invasive mechanical ventilation within 7 days from the onset of symptoms\n* Invasive mechanical ventilation for less than 6 hours\n* Evidence of newly developed lung consolidation on chest imaging (X-ray, CT)\n* Age ≥18 years\n\nExclusion Criteria:\n\n* Prior invasive mechanical ventilation during the same hospitalization\n* Tracheostomy\n* Severe anemia (Hb\\\u003C7g\u002FdL)\n* Severe neutropenia\n* Renal insufficiency or RRT (Renal Replacement Therapy)\n* Noradrenaline \\>0.5 mcg\u002Fkg\u002Fmin\n* Pregnancy\n* Extracorporeal circulation (ECCO2R, ECMO)\n* Life expectancy \\\u003C24 hours as clinically judged\n* Lack of consent",{"count":20,"type":21},"The aim of this study is to report the proportion of patients with acute hypoxemic respiratory failyre (AHRF) undergoing mechanical ventilation who exceed 17 J\u002Fmin of mechanical power (MP) and the difference in terms of proinflammatory cytokine concentration in blood samples and bronchoalveolar lavage.\n\nThe main questions it aims to answer are:\n\n1. Which is the proportion of patients who exceed 17 J\u002Fmin of mechanical power (MP) during the first 72 hours of mechanical ventilation?\n2. Is there a difference in terms of cytokine concentration in patients undergoing mechanical power \\>17 J\u002Fmin compared to \\\u003C17 J\u002Fmin?\n\nPatients will be divided into two groups based on respiratory mechanics measurements: low MP group (average MP \\\u003C17 J\u002Fmin) and high MP group (average MP ≥17 J\u002Fmin). The researchers will collect blood and BAL samples and perform cytokine assays.",[29],"2024-05-17",{"date":268,"type":36},"2024-05-22",{"date":270,"type":36},"2023-04-15",{"date":272,"type":21},"2027-06-15",{"name":274,"class":104},"University of Roma La Sapienza"]