[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"mechanical-ventilation-complication\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:mechanical-ventilation-complication":27},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,37,0,25,[9,51,79,113,141,176,201,227,251,277,305,330,353,374,400,432,457,478,501,522,534,559,588,612,647],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100054228","volume-supportassist-control-mode-ventilation-and-diaphragmatic-atrophy-100054228",false,"NCT03901924","Volume Support\u002FAssist Control Mode Ventilation and Diaphragmatic Atrophy","A Phase III Randomized Trial Comparing the Effects of Volume Support and Assist Control Mode Ventilation on Ventilator-Free Days and Diaphragmatic Atrophy","Inclusion Criteria:\n\nsubjects \\> 18 years of age that have been intubated and mechanically ventilated for \\\u003C 36 hours at the time of screening will be eligible for enrollment\n\nExclusion Criteria:\n\n1. pregnancy\n2. cardiopulmonary arrest\n3. history of diaphragmatic paralysis or neuromuscular disease\n4. chronic obstructive pulmonary disease (COPD) or asthma exacerbation with evidence of auto-PEEPing requiring intubation\n5. neuromuscular blockade\n6. expectation to be liberated from ventilator in \\\u003C 24 hours\n7. history of mechanical ventilation in the last 6 months\n8. presence of tracheostomy\n9. high cervical spine injury","ALL","18 Years",{"count":20,"type":21},468,"ESTIMATED","INTERVENTIONAL",[24],"NA","The objective of the study is to determine how controlled mode ventilation and support mode ventilation impact ventilator-free days and diaphragmatic atrophy.",[27],"Mechanical Ventilation Complication",[29,30,31,32,33,34,35,36,37],"Diaphragm Atrophy","Ventilator Induced Diaphragm Dysfunction","Mechanical Ventilation","Volume Support Mode","Assist Control Mode","Diaphragm Thickening Fraction","Intubation","Delirium","Ventilator-Free Days","RECRUITING","2026-07-10",{"date":41,"type":42},"2026-07-13","ACTUAL",{"date":44,"type":42},"2019-03-04",{"date":46,"type":21},"2027-05",{"name":48,"class":49},"University of Chicago","OTHER",2,{"id":52,"slug":53,"hasResults":12,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":59,"targetDuration":4,"studyType":61,"phases":4,"briefSummary":62,"conditions":63,"keywords":65,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":78},"100611846","clustervap-multicentre-proteomic-endotyping-of-ventilator-associated-pneumonia-100611846","NCT07245888","ClusterVAP: Multicentre Proteomic Endotyping of Ventilator-associated Pneumonia","Endotyping of Ventilator-associated Pneumonia With Proteomics on Bronchoalveolar Lavage for Improved Diagnosis, the ClusterVAP Study","ClusterVAP","Inclusion Criteria:\n\nAdult patients (≥18 years) admitted to an intensive care unit (ICU). Receiving invasive mechanical ventilation. Undergoing bronchoalveolar lavage (BAL) or mini-BAL on clinical indication for suspected lower respiratory tract infection.\n\nNew or worsening clinical signs compatible with lower respiratory tract infection within the preceding 24 hours, defined as the treating clinician's suspicion plus at least one of:\n\nBody temperature \\>38 °C or \\\u003C36 °C. Visually purulent tracheal secretions. Signs of reduced oxygenation (e.g., increased FiO₂ and\u002For decreased arterial pO₂, increased positive end-expiratory pressure or driving pressure).\n\nRequest for chest radiograph to investigate infection or new infiltrate. Initiation of antibiotic therapy targeting lower respiratory tract infection.\n\nExclusion Criteria:\n\nBAL or mini-BAL performed solely for screening without suspicion of infection. Concurrent enrolment in the VAPmarkers study (reserved for external validation).\n\nAge \\\u003C18 years. Any condition that, in the opinion of the investigator, would preclude safe participation or confound study objectives.",{"count":60,"type":21},400,"OBSERVATIONAL","Ventilator-associated pneumonia (VAP) is a common and serious infection in patients receiving mechanical ventilation in intensive care units. Current diagnostic methods are imprecise, leading to unnecessary antibiotic use and delayed treatment. The ClusterVAP study aims to identify biologically and clinically distinct subgroups of patients with suspected VAP by analyzing proteins in bronchoalveolar lavage (BAL) fluid using advanced proteomic techniques. This multicentre observational study will enroll approximately 400 adult patients from intensive care units in Sweden, France, Portugal, Denmark, and the United Kingdom. BAL or mini-BAL samples collected for clinical reasons will be analyzed to define \"pneumoclusters\" and explore their association with patient outcomes. The study will also identify candidate biomarkers that could support future diagnostic tools. No experimental treatments are given; all patients receive standard care. Results may improve diagnostic accuracy and guide personalized treatment strategies for critically ill patients.",[64,27],"Ventilator Acquired Pneumonia",[66,67,68],"VAP","endotyping","mini-BAL","2026-06-25",{"date":71,"type":42},"2026-06-30",{"date":73,"type":42},"2026-05-01",{"date":75,"type":21},"2027-12",{"name":77,"class":49},"Region Skane",4,{"id":80,"slug":81,"hasResults":12,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":87,"enrollmentInfo":88,"targetDuration":4,"studyType":22,"phases":90,"briefSummary":91,"conditions":92,"keywords":99,"overallStatus":103,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":4},"100644682","burn-asv-trial-adaptive-support-ventilation-in-severe-burn-injury-100644682","NCT07674563","BURN-ASV Trial: Adaptive Support Ventilation in Severe Burn Injury","Adaptive Support Ventilation Versus Conventional Lung-Protective Ventilation in Severe Burn Injury Including Thermobaric and Drone-Related Burns: The BURN-ASV Randomized Controlled Trial","BURN-ASV","Inclusion Criteria:\n\n* Age 18 years or older.\n* Thermal burn injury involving ≥20% total body surface area (TBSA).\n* Requirement for invasive mechanical ventilation expected to exceed 24 hours.\n* Admission to a participating intensive care unit within 48 hours of injury.\n* Burn injury resulting from conventional flame burns, explosion-related burns, drone-related burns, or thermobaric blast burns.\n* Written informed consent provided by the patient or a legally authorized representative.\n\nExclusion Criteria:\n\n* Age younger than 18 years.\n* Pregnancy or breastfeeding.\n* Pre-existing chronic respiratory failure requiring home oxygen therapy or long-term mechanical ventilation.\n* Severe chronic obstructive pulmonary disease (COPD GOLD IV) or other end-stage pulmonary disease.\n* Extracorporeal membrane oxygenation (ECMO) at the time of enrollment.\n* Severe traumatic brain injury requiring controlled hyperventilation.\n* Expected death within 24 hours of ICU admission.\n* Do-not-resuscitate (DNR) order or limitations of life-sustaining treatment.\n* Previous enrollment in the current study.\n* Participation in another interventional trial that may interfere with study outcomes.","50 Years",{"count":89,"type":21},100,[24],"Severe burn injury frequently requires prolonged mechanical ventilation because of inhalation injury, respiratory failure, systemic inflammation, and repeated surgical procedures. Patients with extensive burns are at high risk of ventilator-associated complications, prolonged intensive care unit (ICU) stay, and death.\n\nAdaptive Support Ventilation (ASV) is an automated mode of mechanical ventilation that continuously adjusts breathing support according to the patient's respiratory needs and lung mechanics. Although ASV has shown potential benefits in general ICU populations, its effectiveness in patients with severe burn injuries has not been adequately studied.\n\nThe purpose of this randomized controlled trial is to compare Adaptive Support Ventilation with conventional lung-protective mechanical ventilation in critically ill adult burn patients, including those with inhalation injury, drone-related burns, and thermobaric blast burns. Participants will be randomly assigned to receive either ASV or conventional ventilation. The study will evaluate whether ASV improves ventilator-free days, reduces duration of mechanical ventilation, decreases ventilator-associated complications, and improves clinical outcomes.\n\nThe results of this study may help identify optimal ventilation strategies for patients with severe burn injuries and improve critical care management in both civilian and military burn centers.",[93,31,27,94,95,96,97,98],"Burn","ICU","ICU Hospitalization","Critical Care, Intensive Care","Military Activity","Combat-Related Burn Injury",[100,98,101,102],"burn","adaptive support mechanical ventilation","mechanical ventilation","NOT_YET_RECRUITING","2026-06-24",{"date":106,"type":42},"2026-06-29",{"date":108,"type":21},"2026-09-23",{"date":110,"type":21},"2026-11-23",{"name":112,"class":49},"Ukrainian Society of Regional Anesthesia and Pain Therapy",{"id":114,"slug":115,"hasResults":12,"nctId":116,"briefTitle":117,"officialTitle":118,"acronym":4,"eligibilityCriteria":119,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":120,"enrollmentInfo":121,"targetDuration":4,"studyType":22,"phases":123,"briefSummary":125,"conditions":126,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":132,"lastUpdatePostDateStruct":133,"startDateStruct":135,"completionDateStruct":137,"leadSponsor":138,"locationsCount":140},"100560314","phase-4-efficacy-and-safety-of-remimazolam-besylate-for-sedation-in-post-non-cardiac-surgery-patients-requiring-mechanical-ventilation-100560314","NCT06575530","Efficacy and Safety of Remimazolam Besylate for Sedation in Post-Non-Cardiac Surgery Patients Requiring Mechanical Ventilation","Efficacy and Safety of Remimazolam Besylate for Sedation in Post-Non-Cardiac Surgery Patients Requiring Mechanical Ventilation: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Aged between 18 and 64 years\n* Scheduled to undergo elective non-cardiac surgery\n* Planned for general anesthesia\n* With or without combined regional nerve blockade\n* Admitted to the ICU with endotracheal intubation post-surgery\n* With an anticipated duration of postoperative mechanical ventilation greater than 24 hours\n* Clinically requiring light sedation( target RASS score 0 to -2)\n\nExclusion Criteria:\n\n* Undergoing intracranial surgery, or having a history of severe neurological or spinal cord diseases\n* Pre-existing history of schizophrenia, epilepsy, or Parkinson's disease\n* Inability to communicate preoperatively due to coma, severe dementia, or language barriers\n* Preoperative .cardiac insufficiency or severe cardiac arrhythmias\n* Severe hepatic impariment( Child-Pugh class C)\n* Severe renal impariment\n* Preoperative( within 24 hours prior to surgery) or intraoperative administration of dexmedetomidine or remimazolam\n* Pregnancy or lactation\n* Participation in any clinical trial involving investigational drugs within 30 days prior to enrollment\n* Any other conditions deemed by the investigators to render the patient unsuitable for study participation\n* Refusal to provide written informed consent","64 Years",{"count":122,"type":21},306,[124],"PHASE4","A multi-center, prospective, randomized, double-blind, active-controlled, no-inferiority clinical trial conducted across 5 tertiary medical centers in China. The objective of this RCT is to evaluate the sedative efficacy and safety profile of remimazolam besylate compared with dexmedetomidine in patients requiring mechanical ventilation following non-cardiac surgery. The study hypothesized that remimazolam besylate is non-inferior to dexmedetomidine regarding the primary efficacy outcome.",[127,128,27,129,130,131],"Effect of Drug","Adverse Drug Event","Critical Illness","Surgery","Sedation","2026-06-13",{"date":134,"type":42},"2026-06-16",{"date":136,"type":42},"2025-01-20",{"date":71,"type":21},{"name":139,"class":49},"Beijing Shijitan Hospital, Capital Medical University",1,{"id":142,"slug":143,"hasResults":12,"nctId":144,"briefTitle":145,"officialTitle":146,"acronym":147,"eligibilityCriteria":148,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":149,"targetDuration":4,"studyType":61,"phases":4,"briefSummary":151,"conditions":152,"keywords":156,"overallStatus":103,"whyStopped":4,"lastUpdateSubmitDate":167,"lastUpdatePostDateStruct":168,"startDateStruct":170,"completionDateStruct":172,"leadSponsor":174,"locationsCount":140},"100643211","silent-aspiration-following-extubation-in-the-icu-100643211","NCT07635888","Silent Aspiration Following Extubation in the ICU","Incidence, Risk Factors, and Outcomes of Silent Aspiration Post Extubation in the ICU","SAFE-ICU","Inclusion Criteria:\n\n* Adult ICU patients requiring invasive mechanical ventilation for 5 days or longer\n* Successful extubation after invasive mechanical ventilation\n* Undergoing bedside nursing swallow screening after extubation\n* Ability to undergo Fiberoptic Endoscopic Evaluation of Swallowing (FEES) within 72 hours after extubation\n* Provision of informed consent by the patient or legally authorized representative\n\nExclusion Criteria:\n\n* Presence of tracheostomy\n* Do-not-reintubate orders\u002FAllow natural death\n* Pregnancy\n* Absence of informed consent\n* Contraindication to FEES as determined by the treating physician (e.g., high bleeding risk or severe oxygen requirements)",{"count":150,"type":21},274,"Post-extubation dysphagia is common in critically ill patients and may lead to silent aspiration, which often remains undetected because patients do not exhibit overt clinical signs such as coughing or choking. Current bedside nursing swallow screening may fail to identify silent aspiration in patients recovering from prolonged mechanical ventilation.\n\nThe goal of this observational study is to learn about the incidence, risk factors, and clinical outcomes of silent aspiration in critically ill adult patients who require prolonged mechanical ventilation and are extubated in the ICU. The main questions it aims to answer are:\n\n* How often does silent aspiration occur in ICU patients intubated for 5 days or longer after extubation?\n* Can silent aspiration be present despite passing the routine bedside nursing swallow screen?\n* What clinical factors are associated with silent aspiration?\n* Is silent aspiration associated with worse clinical outcomes such as aspiration pneumonia, reintubation, prolonged ICU stay, ventilator-free days, or mortality? Participants who have been mechanically ventilated for 5 days or more will undergo routine bedside swallow screening followed by Fiberoptic Endoscopic Evaluation of Swallowing (FEES), considered the gold-standard diagnostic tool for detecting silent aspiration, within 72 hours after extubation. Researchers will compare bedside nursing swallow screening results with FEES findings to evaluate the diagnostic accuracy of bedside screening in detecting silent aspiration. Clinical data, swallowing assessment findings, and patient outcomes will also be collected and analyzed.",[153,154,155,129,27],"Silent Aspiration","Post-Extubation Dysphagia","Deglutition Disorders",[157,158,159,160,161,162,163,164,165,166],"Silent aspiration","ICU extubation","Post-extubation dysphagia","FEES","Fiberoptic Endoscopic Evaluation of Swallowing","Mechanical ventilation","Swallow screening","Aspiration pneumonia","Critical care","Dysphagia screening","2026-06-03",{"date":169,"type":42},"2026-06-09",{"date":171,"type":21},"2026-06",{"date":173,"type":21},"2028-06",{"name":175,"class":49},"Cleveland Clinic Abu Dhabi",{"id":177,"slug":178,"hasResults":12,"nctId":179,"briefTitle":180,"officialTitle":181,"acronym":182,"eligibilityCriteria":183,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":184,"targetDuration":4,"studyType":22,"phases":186,"briefSummary":187,"conditions":188,"keywords":190,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":167,"lastUpdatePostDateStruct":193,"startDateStruct":195,"completionDateStruct":197,"leadSponsor":199,"locationsCount":140},"100586920","targeting-pressure-muscle-index-to-avoid-ventilatory-over-assistance-during-pressure-support-ventilation-100586920","NCT06921655","Targeting prEssure-Muscle-index to Avoid Ventilatory Over-Assistance During Pressure Support Ventilation","Targeting prEssure-Muscle-index to Avoid Ventilatory Over-Assistance During Pressure","TEMA","Inclusion Criteria:\n\n1. Age ≥ 18 years\n2. Mechanically ventilated in the ICU\n3. Diagnosis of Acute Hypoxemic Respiratory Failure (AHRF)\n4. Normocapnia or non-severe hypercapnia\n5. Receiving Pressure Support Ventilation (PSV) for at least 24-72 hours\n6. Presence of an arterial line for blood gas sampling\n\nExclusion Criteria:\n\n1. Age \\\u003C 18 years\n2. Known neurological or neuromuscular disorders affecting diaphragm function\n3. Chronic Obstructive Pulmonary Disease (COPD) or hypercapnic respiratory failure\n4. Psychomotor agitation or inadequate sedation",{"count":185,"type":21},36,[24],"The TEMA study (Targeting prEssure-Muscle-index to avoid ventilatory over-Assistance during pressure support ventilation) is a prospective, interventional crossover trial investigating the relationship between pressure support (PS) and tidal volume (Vt) in ICU patients with acute hypoxemic respiratory failure (AHRF) receiving pressure support ventilation (PSV). The study aims to assess whether the Pressure-Muscle Index (PMI)-a marker derived from the difference between plateau and peak inspiratory pressure-can help identify the optimal level of ventilatory assistance, preventing over-assistance and its associated complications such as diaphragm atrophy and patient self-inflicted lung injury (P-SILI). By exploring the sigmoidal relationship between PS and Vt, the study seeks to define a physiological threshold (PMI=0) that may serve as a personalized target for PSV titration.",[189,27],"Acute Hypoxemic Respiratory Failure",[191,192,189],"Pressure Support","Tidal Volume",{"date":194,"type":42},"2026-06-05",{"date":196,"type":42},"2025-10-08",{"date":198,"type":21},"2028-12-15",{"name":200,"class":49},"Centre for Medical Sciences",{"id":202,"slug":203,"hasResults":12,"nctId":204,"briefTitle":205,"officialTitle":206,"acronym":207,"eligibilityCriteria":208,"healthyVolunteers":12,"sex":17,"minAge":209,"maxAge":4,"enrollmentInfo":210,"targetDuration":4,"studyType":22,"phases":212,"briefSummary":215,"conditions":216,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":167,"lastUpdatePostDateStruct":219,"startDateStruct":221,"completionDateStruct":223,"leadSponsor":225,"locationsCount":140},"100517176","phase-2-volatile-sedation-for-patients-with-the-acute-respiratory-distress-syndrome-100517176","NCT06014138","Volatile Sedation for Patients With the Acute Respiratory Distress Syndrome","Effect of Volatile Sedation on Spontaneous Breathing During Mechanical Ventilation for Patients With the Acute Respiratory Distress Syndrome","ISO-DRIVE","Inclusion Criteria:\n\n* Adult patients admitted to the Intensive Care Unit (ICU)\n* ARDS\n* Invasive mechanical ventilation (IMV)\n* Spontaneous breathing in pressures support mode (PSV) for less than or equal to 48 hours\n* Sedated with intravenous sedation (ie. propofol and \u002F or midazolam and fentanyl or alternate short acting opioid)\n* Anticipated to remain on IMV and PSV and with a stable sedation score for a further 24 hours without planned sedation interruption \u002F spontaneous breathing trial or other significant change in the level of ventilator support\n* Not receiving \u002F anticipated to receive paralysis\n* In supine position\n\nExclusion Criteria:\n\n* Personal or family history of malignant hyperpyrexia\n* Known or suspected elevated intracranial pressure\n* High dose vasopressors (ie. Noradrenaline \\> 0.3mcg\u002Fkg\u002Fmin or equivalent)\n* Contra-indication to oesophageal balloon (i.e. oesophageal \u002F upper gastro-intestinal pathology)\n* Pregnancy\n* High dose oral sedatives (e.g. benzodiazepines) or opioids (e.g. oxycodone \u002F oral morphine) which may affect respiratory drive","17 Years",{"count":211,"type":21},20,[213,214],"PHASE2","PHASE3","This study will investigate how different types of routine sedation may affect patient's breathing whilst on a ventilator in the Intensive Care Unit (ICU). There are different approaches to sedation which may have advantages and disadvantages. During the study patients will receive both intravenous and inhaled volatile sedation (similar to anaesthetic 'gases' used for general anaesthesia) and the drive to breath, breathing efforts and function of the lung will be assessed.",[217,27,218],"Acute Respiratory Distress Syndrome","Sedation Complication",{"date":220,"type":42},"2026-06-04",{"date":222,"type":42},"2023-11-01",{"date":224,"type":21},"2027-07-31",{"name":226,"class":49},"Guy's and St Thomas' NHS Foundation Trust",{"id":228,"slug":229,"hasResults":12,"nctId":230,"briefTitle":231,"officialTitle":232,"acronym":233,"eligibilityCriteria":234,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":235,"targetDuration":4,"studyType":22,"phases":237,"briefSummary":238,"conditions":239,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":241,"lastUpdatePostDateStruct":242,"startDateStruct":244,"completionDateStruct":246,"leadSponsor":248,"locationsCount":250},"100456642","systolic-function-and-weaning-induced-pulmonary-edema-systowean-study-100456642","NCT05226247","Systolic Function and Weaning-induced Pulmonary Edema (SystoWean Study)","Evaluation of the Role of Systolic Dysfunction in Weaning Failure Related to Weaning-induced Pulmonary Edema: the SystoWean Study","SystoWean","Inclusion Criteria:\n\n1. Invasive mechanical ventilation for more than 48 hours\n2. Patients indicated, according to intensivists, for carrying out a spontaneous breathing trial weaning test, based on the presence of all of the following criteria:\n\n   1. SpO2\\> 90% with FiO2 ≤40% and PEEP ≤5 cmH2O\n   2. Cough effectiveness on tracheal aspirations\n   3. Lack of hemodynamic instability and of disorders of consciousness\n3. Patients at high risk of weaning-induced pulmonary edema (WIPO), defined by one or more of the following criteria:\n\n   1. Obesity, defined by a body mass index\\> 30 kg\u002Fm²\n   2. Chronic obstructive pulmonary disease\n   3. Chronic heart disease\n\nExclusion Criteria:\n\n1. Age \\\u003C18 years and pregnant women\n2. Patients with a decision of not to resuscitate\n3. Poor echogenicity\n4. Severe mitral valve disease (leakage and\u002For stenosis, bioprosthesis)\n5. Patients with pacemaker\n6. Tracheostomy\n7. Chronic neuromuscular or neurodegenerative diseases",{"count":236,"type":21},250,[24],"The purpose of this study is to determine if the left and right ventricular systolic function is involved in the development of weaning failure related to weaning-induced pulmonary edema.",[27,240],"Pulmonary Edema","2026-05-21",{"date":243,"type":42},"2026-05-22",{"date":245,"type":42},"2022-08-08",{"date":247,"type":21},"2026-09",{"name":249,"class":49},"Centre Hospitalier Universitaire de Nice",3,{"id":252,"slug":253,"hasResults":12,"nctId":254,"briefTitle":255,"officialTitle":256,"acronym":4,"eligibilityCriteria":257,"healthyVolunteers":258,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":259,"targetDuration":4,"studyType":22,"phases":261,"briefSummary":262,"conditions":263,"keywords":265,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":269,"lastUpdatePostDateStruct":270,"startDateStruct":272,"completionDateStruct":273,"leadSponsor":275,"locationsCount":140},"100553817","effects-of-mechanical-insufflation-exsufflation-with-optimized-settings-on-wet-mucus-volume-during-invasive-ventilation-100553817","NCT06491017","Effects of Mechanical Insufflation-Exsufflation With Optimized Settings on Wet Mucus Volume During Invasive Ventilation","Effects of Mechanical Insufflation-Exsufflation With Optimized Settings on Suctioned Wet Mucus Volume During Invasive Ventilation","Inclusion Criteria:\n\n* Adults (\\> 18yo).\n* Endotracheal intubation and invasive mechanical ventilation for \\> 48h and active humidification for \\> 24h.\n* Richmond Agitation-Sedation Scale -3 to -5.\n* Signed informed consent.\n\nExclusion Criteria:\n\n* Patients with hemodynamic instability (MAP \\\u003C 60 or \\> 110, Heart Rate \\\u003C 50 or \\> 130, new onset arrhythmias), respiratory instability (PEEP \\> 12cmH2O, SpO2 \\\u003C 90% or fraction of inspired oxygen (FiO2) \\> 60%).\n* Undrained pneumothorax\u002Fpneumomediastinum.\n* Unstable intracranial pressure (ICP \\> 20mmHg or MAP \\\u003C 60).\n* Severe bronchospasm.\n* Post cardiothoracic surgical patients.\n* Active pulmonary tuberculosis.\n* Bronchoesophageal or bronchopleural fistulas.\n* Prone position.\n* Pregnancy.",true,{"count":260,"type":21},26,[24],"Retention of airway secretions is a frequent complication in critically ill patients requiring invasive mechanical ventilation (MV).This complication is often due to excessive secretion production and ineffective secretion clearance.\n\nMechanical insufflator-exsufflator (MI-E) is a respiratory physiotherapy technique that aims to assist or simulate a normal cough by using an electro-mechanical dedicated device. A positive airway pressure is delivered to the airways, in order to hyperinflate the lungs, followed by a rapid change to negative pressure that promotes a rapid exhalation and enhances peak expiratory flows.\n\nHowever, there is no consensus on the best MI-E settings to facilitate secretion clearance in these patients. Inspiratory and expiratory pressures of ±40 cmH2O and inspiratory-expiratory time of 3 and 2 seconds, respectively, are often used as a standard for MI-E programming in the daily routine practice, but recent laboratory studies have shown significant benefits when MI-E setting is optimized to promote an expiratory flow bias.\n\nThe investigators designed this study to compare the effects of MI-E with an optimized setting versus a standard setting on the wet volume of suctioned sputum in intubated critically ill patients on invasive MV for more than 48 hours.",[264,27],"Mucus Retention",[266,267,268,102],"Mechanical insufflation-exsufflation","Physiotherapy","Mucus retention","2026-05-07",{"date":271,"type":42},"2026-05-08",{"date":271,"type":42},{"date":274,"type":21},"2028-12",{"name":276,"class":49},"Hospital Clinic of Barcelona",{"id":278,"slug":279,"hasResults":12,"nctId":280,"briefTitle":281,"officialTitle":282,"acronym":283,"eligibilityCriteria":284,"healthyVolunteers":12,"sex":17,"minAge":285,"maxAge":4,"enrollmentInfo":286,"targetDuration":4,"studyType":22,"phases":288,"briefSummary":289,"conditions":290,"keywords":294,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":296,"lastUpdatePostDateStruct":297,"startDateStruct":299,"completionDateStruct":301,"leadSponsor":303,"locationsCount":250},"100530297","behavioral-economic--staffing-strategies-in-the-icu-100530297","NCT06184945","Behavioral Economic & Staffing Strategies in the ICU","Behavioral Economic and Staffing Strategies To Increase Adoption of an Evidence Based Bundle in the Intensive Care Unit (BEST ICU): A Stepped Wedge Cluster Randomized Controlled Trial","BEST-ICU","Inclusion Criteria:\n\n* Age \\>19 years at time of ICU admission\n* Received invasive mechanical ventilation while in the ICU\n* Admitted to participating cluster ICU\n* ICU length of stay of at least 24 hours\n\nExclusion Criteria:\n\n* Patient who is admitted to the hospital who is already receiving chronic long-term mechanical ventilation from the home, assisted living, or long-term care setting\n* Prisoners","19 Years",{"count":287,"type":21},8100,[24],"The overarching goal of this study is to support the \"real world\" assessment of strategies used to foster adoption of several highly efficacious evidence-based practices in healthcare systems that provide care to critically ill adults with known health disparities. Investigators will specifically evaluate two discrete strategies grounded in behavioral economic and implementation science theory (i.e., real-time audit and feedback and registered nurse implementation facilitation) to increase adoption of the ABCDEF bundle in critically ill adults.",[291,36,129,27,292,293],"Implementation Science","ICU Acquired Weakness","Pain",[295],"ABCDEF bundle, delirium, intensive care, critical care, mechanical ventilation","2026-02-16",{"date":298,"type":42},"2026-02-19",{"date":300,"type":42},"2024-07-01",{"date":302,"type":21},"2028-04",{"name":304,"class":49},"University of Nebraska",{"id":306,"slug":307,"hasResults":12,"nctId":308,"briefTitle":309,"officialTitle":310,"acronym":311,"eligibilityCriteria":312,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":313,"enrollmentInfo":314,"targetDuration":4,"studyType":61,"phases":4,"briefSummary":316,"conditions":317,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":321,"lastUpdatePostDateStruct":322,"startDateStruct":324,"completionDateStruct":326,"leadSponsor":328,"locationsCount":140},"100455523","diaphragm-atrophy-and-dysfunction-in-mechanical-ventilation-100455523","NCT05211661","Diaphragm Atrophy and Dysfunction in Mechanical Ventilation","Development of Diaphragm Atrophy, Dysfunction and Inhibited Cortical Control in Mechanical Ventilation","DAM","Inclusion Criteria:\n\n* Initiation of invasive mechanical ventilation in the Intensive Care Unit within 48 hours.\n* Expected duration of invasive mechanical ventilation of at least 5 days.\n\nExclusion Criteria:\n\n* Body-mass-index (BMI) \\>40\n* Expected absence of active participation of the patient in study-related measurements after extubation\n* Alcohol or drug abuse\n* Non MRI compatible implant in the body\n* Slipped disc\n* Epilepsy\n* Patients in an interdependence or with an employment contract with the principal investigator, Co-PI or his deputy.","75 Years",{"count":315,"type":21},15,"The gold standard of twitch transdiaphragmatic pressure recordings would ultimately clear the fog around the rate of development of Ventilator induced Diaphragm Dysfunction (VIDD) in mechanically ventilated patients over time.\n\nThrough measurements made even after mechanical ventilation (MV) it could be clarified to what extent patients recover from VIDD.\n\nPaired with cortical stimulation and electromyographic recordings of diaphragm muscle potentials, it could be explored to what extent decreased diaphragm excitability due to long term MV contributes to VIDD on the level of motor cortex.\n\nAgainst that background the present project aims at determining the rate of decline in diaphragm function, strength and control in patients undergoing MV (including measurements after extubation).",[318,27,319,320],"Diaphragm Issues","Respiratory Failure","Intensive Care (ICU) Myopathy","2026-02-04",{"date":323,"type":42},"2026-02-09",{"date":325,"type":42},"2022-10-10",{"date":327,"type":21},"2028-06-01",{"name":329,"class":49},"RWTH Aachen University",{"id":331,"slug":332,"hasResults":12,"nctId":333,"briefTitle":334,"officialTitle":335,"acronym":4,"eligibilityCriteria":336,"healthyVolunteers":12,"sex":17,"minAge":337,"maxAge":338,"enrollmentInfo":339,"targetDuration":4,"studyType":22,"phases":341,"briefSummary":342,"conditions":343,"keywords":4,"overallStatus":103,"whyStopped":4,"lastUpdateSubmitDate":344,"lastUpdatePostDateStruct":345,"startDateStruct":347,"completionDateStruct":349,"leadSponsor":351,"locationsCount":140},"100620145","ventilator-based-inspiratory-muscle-training-for-patients-with-respiratory-failure-100620145","NCT07353814","Ventilator-based Inspiratory Muscle Training for Patients With Respiratory Failure","Ventilator-based Inspiratory Muscle Training: Trigger Sensitivity Adjustment Versus Stepwise Pressure Support Reduction for Patients With Respiratory Failure","Inclusion Criteria:\n\n* Acute respiratory failure patients in the ICU are receiving MV for 48 h or more in a controlled mode.\n* Their ages will range from 40 to 55 years old, and both sexes will be included.\n* Conscious and oriented patients with a Glasgow coma score ≥13 (≥9T).\n* Alertness score with a Richmond Agitation-Sedation Scale (RASS) will be from 0 to -1.\n* All patients in this study must be hemodynamically and medically stable.\n* Patients must be able to trigger spontaneous breaths on the ventilator but couldn't generate maximum inspiratory pressure more than -15 mbar.\n\nExclusion Criteria:\n\n* Persistent hemodynamic instability as life-threatening conditions or comorbidities interfere with and compromise weaning, like cardiac arrhythmia, pericardial effusion, congestive heart failure, or acute coronary syndrome.\n* Severe breathlessness when spontaneously breathing.\n* Any progressive neuromuscular disease, such as myopathy or neuropathy, that would interfere with responding to inspiratory muscle training due to inadequate training performance of the inspiratory muscle.\n* Spinal cord injury.\n* Skeletal pathology (scoliosis, flail chest, spinal instrumentation) that would seriously impair the movement of the chest wall and ribs.\n* Patients in a coma or under heavy sedation (RASS ≤ -2) and with respiratory muscle paralysis.\n* High peak airway pressure (barotrauma), high PEEP \\>10, or active pneumothorax.","40 Years","55 Years",{"count":340,"type":21},60,[24],"This study will be conducted to compare the effectiveness of progressive inspiratory flow trigger sensitivity rising versus stepwise pressure support reduction as ventilator-based inspiratory muscle training methods on weaning and extubation success in mechanically ventilated patients with respiratory failure.",[319,27],"2026-01-17",{"date":346,"type":42},"2026-01-20",{"date":348,"type":21},"2026-01",{"date":350,"type":21},"2027-03",{"name":352,"class":49},"Cairo University",{"id":354,"slug":355,"hasResults":12,"nctId":356,"briefTitle":357,"officialTitle":358,"acronym":4,"eligibilityCriteria":359,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":360,"targetDuration":4,"studyType":22,"phases":362,"briefSummary":363,"conditions":364,"keywords":4,"overallStatus":103,"whyStopped":4,"lastUpdateSubmitDate":366,"lastUpdatePostDateStruct":367,"startDateStruct":369,"completionDateStruct":370,"leadSponsor":372,"locationsCount":140},"100614962","nebulized-furosemide-heparin-hypertonic-saline-in-mechanically-ventilated-acute-respiratory-distress-syndrome-adult-patients-100614962","NCT07286409","Nebulized Furosemide, Heparin, Hypertonic Saline in Mechanically Ventilated Acute Respiratory Distress Syndrome Adult Patients","Nebulized Furosemide, Heparin, Hypertonic Saline in Mechanically Ventilated Acute Respiratory Distress Syndrome Adult Patients: A Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Adult patients (≥18 years)\n* ICU admission, mechanical ventilation for \\\u003C 7 days\n* ARDS diagnosed within 24 hours per the Berlin Definition, which includes Chest x-ray showing bilateral opacities, not fully explained by effusions, lung collapse; Respiratory failure not fully explained by cardiac failure or fluid overload, and exclusion of hydrostatic edema (by echocardiography);\n* Oxygenation and ventilator settings matching one of the three categories of ARDS: Mild: 200 mmHg \\\u003C PaO2\u002FFIO2 ≤ 300 mmHg with positive end-expiratory pressure (PEEP) or continuous positive airway pressure (CPAP) ≥ 5 cm H2O. Moderate: 100 mm Hg \\\u003C PaO2\u002FFIO2 ≤ 200 mm Hg with PEEP ≥ 5 cm H2O. Severe: PaO2\u002FFIO2 ≤ 100 mm Hg with PEEP ≥ 5 cm H2O.\n\nExclusion Criteria:\n\n* 1- Pregnant Patient. 2- Refusal to participate in the trial by the patient's guardian. 3- Known allergy to furosemide or heparin. 4- Active major bleeding, recent intracranial hemorrhage 5- End-stage renal disease 6- Severe chronic liver disease. 7- Uncontrolled shock (e.g., high vasopressor doses). 8- Advanced directives limiting care (e.g., do-not-resuscitate orders), which could affect mortality outcomes.\n\n  9- Body Mass Index (BMI) \\> 40 or severe obesity, which can severely impact lung mechanics and confound results.\n\n  10- Electrolyte imbalance",{"count":361,"type":21},344,[24],"There are no specific drugs or therapies available to directly treat\u002Fprevent ARDS. Mechanical ventilation with an aim to minimize Ventilator Induced Lung Injury (VILI) and management of refractory hypoxemia are the keystones in supportive management of ARDS.",[365,27],"Respiratory Distress Syndrome","2025-12-02",{"date":368,"type":42},"2025-12-16",{"date":348,"type":21},{"date":371,"type":21},"2027-01",{"name":373,"class":49},"Tanta University",{"id":375,"slug":376,"hasResults":12,"nctId":377,"briefTitle":378,"officialTitle":379,"acronym":4,"eligibilityCriteria":380,"healthyVolunteers":12,"sex":381,"minAge":18,"maxAge":382,"enrollmentInfo":383,"targetDuration":4,"studyType":22,"phases":385,"briefSummary":386,"conditions":387,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":390,"lastUpdatePostDateStruct":391,"startDateStruct":393,"completionDateStruct":395,"leadSponsor":397,"locationsCount":140},"100553199","the-effects-of-vc-versus-pc-ventilation-on-cerebral-and-respiratory-parameters-in-patients-undergoing-laparoscopic-gynecologic-surgery-100553199","NCT06482983","The Effects of VC Versus PC Ventilation on Cerebral and Respiratory Parameters in Patients Undergoing Laparoscopic Gynecologic Surgery","The Effects of Volume-controlled Ventilation Versus Pressure-controlled Ventilation on Cerebral and Respiratory Parameters in Patients Undergoing Laparoscopic Gynecologic Surgery","Inclusion Criteria:\n\n* 18-70 age\n* ASA 1-3\n\nExclusion Criteria:\n\n* Under 18 years of age, over 70 years of age,\n* ASA IV,\n* history of severe chronic obstructive pulmonary disease (COPD, GOLD III or IV)\n\n  ,-history of severe or uncontrolled bronchial asthma, presence of restrictive lung disease,\n* history of any thoracic surgery operation, need for thoracic drainage before surgery\n* patients receiving preoperative renal replacement therapy,\n* congestive heart failure (NYHA grade III or IV),\n* extremely obese (body Mass Index, BMI \\> 35 Kg\u002Fm2)\n* patients without patient consent","FEMALE","70 Years",{"count":384,"type":21},120,[24],"The aim of the study was to determine whether the use of different mechanical ventilation modes in patients with Trendelenburg position and CO2 insufflation affects respiration and cerebral oxygenation due to postoperative atelectasis, and was to determine whether there was any hemodynamic effect.",[388,389,27],"Anesthesia","Gynecologic Cancer","2025-11-16",{"date":392,"type":42},"2025-11-19",{"date":394,"type":42},"2023-05-01",{"date":396,"type":21},"2026-07-31",{"name":398,"class":399},"Umraniye Education and Research Hospital","OTHER_GOV",{"id":401,"slug":402,"hasResults":12,"nctId":403,"briefTitle":404,"officialTitle":405,"acronym":406,"eligibilityCriteria":407,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":408,"enrollmentInfo":409,"targetDuration":4,"studyType":22,"phases":411,"briefSummary":412,"conditions":413,"keywords":418,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":423,"lastUpdatePostDateStruct":424,"startDateStruct":426,"completionDateStruct":428,"leadSponsor":430,"locationsCount":140},"100608916","eit-guided-peep-titration-versus-standard-ventilation-in-bariatric-surgery-100608916","NCT07207772","EIT-guided PEEP Titration Versus Standard Ventilation in Bariatric Surgery","Prevention of Postoperative Pulmonary Complications in Patients Undergoing Laparoscopic Gastric Sleeve Resection by PEEP Titration Based on EIT: A Randomized Controlled Study","EIT","Inclusion Criteria:\n\n1. Age between 18 and 65 years;\n2. Plan to receive laparoscopic bariatric surgery under general anesthesia;\n3. American Society of Anaesthesiologists (ASA) physical status I-III;\n4. BMI between 30 and 55 kg\u002Fm2;\n5. Voluntary participation in this study and signing of an informed consent form.\n\nExclusion Criteria:\n\n1. History of smoking or previous thoracic surgery;\n2. Invasive mechanical ventilation within 30 days;\n3. Pregnancy;\n4. Allergy to EIT electrodes;\n5. Persistent hemodynamic instability or refractory shock;\n6. Severe cardiopulmonary disease (e.g., severe COPD (Chronic obstructive pulmonary disease), NYHA (New York Heart Association) Class III or IV, acute coronary syndrome, or sustained ventricular tachycardia);\n7. Severe pulmonary hypertension (systolic pulmonary artery pressure \\>40 mmHg);\n8. Increased intracranial pressure, intracranial injury\u002Ftumor, or neuromuscular disorders;\n9. Conversion to laparotomy;\n10. Planned transfer to intensive care unit after surgery.","65 Years",{"count":410,"type":21},118,[24],"This study is a prospective, single-center, single-blind, randomized controlled clinical trial. Patients scheduled for laparoscopic bariatric surgery will be selected and randomly assigned to either the EIT-guided individualized PEEP group (Group P-eit) or the control group (Group P-8). Group P will be ventilated using the PEEP value determined by EIT, while Group C will be ventilated with a fixed PEEP value of 8 cmH2O.The primary outcome is the incidence of postoperative pulmonary complications (PPCs) within 72 hours after surgery.",[414,415,416,27,417],"Electrical Impedance Tomography (EIT)","Postoperative Pulmonary Complications (PPCs)","Recruitment","Obesity",[414,415,419,420,421,422],"Lung protective ventilation strategy","Recruitment manoeuvre(RM)","Conventional lung-protective ventilation","bariatric","2025-09-27",{"date":425,"type":42},"2025-10-06",{"date":427,"type":42},"2025-07-28",{"date":429,"type":21},"2027-12-31",{"name":431,"class":49},"Jianbo Wu",{"id":433,"slug":434,"hasResults":12,"nctId":435,"briefTitle":436,"officialTitle":436,"acronym":437,"eligibilityCriteria":438,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":439,"targetDuration":4,"studyType":61,"phases":4,"briefSummary":441,"conditions":442,"keywords":445,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":448,"lastUpdatePostDateStruct":449,"startDateStruct":451,"completionDateStruct":453,"leadSponsor":455,"locationsCount":78},"100606999","prevalence-of-pain-in-mechanically-ventilated-patients-in-intensive-care-units-100606999","NCT07182851","Prevalence of Pain in Mechanically Ventilated Patients in Intensive Care Units","PainICU","Inclusion Criteria\n\nParticipants of both sexes, aged 18 or over;\n\nParticipants who are using invasive mechanical ventilation,\n\nExclusion Criteria:\n\nParticipants undergoing treatment with neuromuscular blockers,;\n\nParticipants with any condition associated with altered pain perception (e.g., Guillain-Barré Syndrome, SCI, etc.);\n\nParticipants with any condition that would likely interfere with behavioral assessments of pain (e.g., decortication or decerebration posture)\n\nAs the assessments will be carried out before and after the tracheal aspiration procedure, if the patient does not have objective criteria for tracheal aspiration, he\u002Fshe will be excluded from the study, irrefutably preventing the procedure from being carried out without express need.",{"count":440,"type":21},370,"Introduction: Pain is a subjective symptom, a physiological response that is difficult to assess, which affects the body physically and\u002For emotionally. It is a common phenomenon among clinical and surgical patients in Intensive Care Units (ICU). And its effects are the combined results of physiological and behavioral aggressions caused by clinical conditions, immobility and the execution of common procedures in ICU's. The presence of pain appears to be independently associated with worse clinical outcomes, including higher infection rates, patient-ventilator asynchronies, delirium, prolonged mechanical ventilation (MV), length of hospital stay and higher healthcare costs. Objectives: To evaluate the prevalence of pain and its associated factors in mechanically ventilated surgical patients in ICU's. Methods: This is a cohort, prospective, multicenter study designed to estimate the prevalence of pain, its intensity, its associated factors, correlating them to outcomes such as patient-ventilator asynchrony rate, time to weaning, and 28-day mortality in mechanically ventilated patients. All research participants who meet the inclusion criteria and who are not using neuromuscular blockers, or have any other condition associated with altered pain perception, will be evaluated using the Behavioral Pain Scale (BPS) and the Critical Care Pain Observation Tool (CPOT) on the 2nd day of mechanical ventilation and on the first day of awakening, when the RASS scale is between 4 and -2. At the same time, data will be collected on the ongoing sedoanalegesia strategy, and the asynchrony index will be calculated \\[(Nº of asynchronous ventilatory cycles\u002FNº of ventilatory cycles studied) \\*100\\]. The end point of the research will be 28 days, where the time until weaning, time until discharge or death will be established using the Kaplan-Meier estimators. Expected results: The prevalence of pain and its intensity is associated with the presence of patient-ventilator asynchronies and thus with harsh outcomes related to the length of stay in the ICU, time until weaning and thirty-day mortality in the ICU. It is estimated that there is agreement between the BPS and CPOT scales in mechanically ventilated patients.",[443,444,27],"Sedation and Analgesia","Pain Intensity Assessment",[102,446,447],"intensive care unit","Pain Assessment","2025-09-17",{"date":450,"type":42},"2025-09-19",{"date":452,"type":42},"2025-06-01",{"date":454,"type":21},"2026-03-31",{"name":456,"class":49},"Centro Universitário Augusto Motta",{"id":458,"slug":459,"hasResults":12,"nctId":460,"briefTitle":461,"officialTitle":462,"acronym":4,"eligibilityCriteria":463,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":464,"targetDuration":4,"studyType":61,"phases":4,"briefSummary":466,"conditions":467,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":469,"lastUpdatePostDateStruct":470,"startDateStruct":472,"completionDateStruct":474,"leadSponsor":476,"locationsCount":140},"100316913","a-new-ultrasonographic-tool-to-assess-pulmonary-strain-in-the-icu-100316913","NCT03405779","A New Ultrasonographic Tool to Assess Pulmonary Strain in the ICU","A Pilot Study of a New Ultrasonographic Tool to Assess Regional Pulmonary Strain in Mechanically Ventilated Patients Suffering From Pulmonary Diseases in an Intensive Care Setting.","Inclusion Criteria:\n\n* Adult intensive care patients under mechanical ventilation suffering from a pulmonary disease with a static lung compliance of less than 40 mL\u002Fcm H2O.\n\nExclusion Criteria:\n\n* Obesity (Body Mass Index superior to 30 kg\u002Fm2)\n* Previous thoracic procedure (chest tube, thoracotomy, thoracoscopy)\n* Intra-abdominal pressure inferior to 15 mm Hg (if available)\n* Previous participation to the study",{"count":465,"type":21},10,"The primary objective of the study is to create a small dataset of regional pulmonary strain values in patients suffering from pulmonary diseases under mechanical ventilation in an intensive care setting.\n\nHypothesis: The analysis of lung ultrasonographic sequences using speckle-tracking allows the determination of local pleural strain in 4 predetermined pulmonary areas in mechanically ventilated patients suffering from pulmonary diseases.",[27,468],"Ventilator-Induced Lung Injury","2025-09-12",{"date":471,"type":42},"2025-09-18",{"date":473,"type":42},"2018-03-12",{"date":475,"type":21},"2026-02-01",{"name":477,"class":49},"Centre hospitalier de l'Université de Montréal (CHUM)",{"id":479,"slug":480,"hasResults":12,"nctId":481,"briefTitle":482,"officialTitle":483,"acronym":484,"eligibilityCriteria":485,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":486,"targetDuration":4,"studyType":22,"phases":488,"briefSummary":489,"conditions":490,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":492,"lastUpdatePostDateStruct":493,"startDateStruct":495,"completionDateStruct":497,"leadSponsor":499,"locationsCount":140},"100579630","ventilo-prospective-study-100579630","NCT06826794","VentilO Prospective Study","Frequency of Respiratory Acidosis in the Intensive Care Unit After Postoperative Cardiac Surgery. Impact of Using VentilO Application","VentilO","Inclusion Criteria:\n\n* Adults (\\> 18 years old)\n* Intubated patients admitted to intensive care immediately post-operatively after cardiac surgery (all cardiac surgery combined)\n* Ventilation in controlled mode (Assist Control or SIMV)\n\nExclusion Criteria:\n\n* Absence of anthropometric data (height and weight) of patients available in the patient file\n* Respiratory cycles mainly spontaneous on arrival\n* Patient extubated on arrival in intensive care",{"count":487,"type":21},76,[24],"This is a randomized, open-label study comparing intial settings made by clinicians with settings recommandation made by the VentilO application immediately after intensive care unit admission.The study will allow direct comparison of the frequency of acidosis when patients are ventilated using the parameters of the VentilO application versus parameters chosen by the clinician. The variables determined by the clinician or VentilO will be respiratory rate, tidal volume and resulting minute ventilation.",[27,491],"Respiratory Acidosis","2025-08-27",{"date":494,"type":42},"2025-09-04",{"date":496,"type":42},"2025-04-24",{"date":498,"type":21},"2027-06",{"name":500,"class":49},"Laval University",{"id":502,"slug":503,"hasResults":12,"nctId":504,"briefTitle":505,"officialTitle":506,"acronym":4,"eligibilityCriteria":507,"healthyVolunteers":12,"sex":17,"minAge":508,"maxAge":509,"enrollmentInfo":510,"targetDuration":4,"studyType":61,"phases":4,"briefSummary":511,"conditions":512,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":514,"lastUpdatePostDateStruct":515,"startDateStruct":517,"completionDateStruct":519,"leadSponsor":521,"locationsCount":140},"100590716","early-diagnosis-of-ards-in-mechanically-ventilated-patient-using-lus-score-in-comparison-with-ct-100590716","NCT06971042","Early Diagnosis of ARDS in Mechanically Ventilated Patient Using LUS Score in Comparison With CT","Early Diagnosis of Acute Respiratory Distress Syndrome (ARDS) in Mechanically Ventilated Patient Using Lung Ultrasound Score in Comparison With CT Chest","Inclusion Criteria:\n\n* Patients aged more than 21 years old of both sexes .\n* Patients who are expected to be mechanically ventilated more than 24 h .\n* Patients who are suspected to be Acute Respiratory Distress Syndrome according to Berlin definition which consists of clinical criteria and with precipitating factors which starts within 1 week of known insult as in trauma patients with lung contusions.\n\nExclusion Criteria:\n\n* Patient's first guardian who refuse the inclusion in the study .\n* History of pre-existing lung disease ( tumors, interstitial lung diseases)\n* In cases of volume overload.\n* Patients with acute kidney injuiry or renal failure","22 Years","80 Years",{"count":211,"type":21},"The aim of this study is to assess accuracy of Lung ultrasound score for early diagnosis of acute respiratory distress syndrome in patients who expected to be mechanically ventilated more than 24 hour in comparison with computed tomography chest .",[217,27,513],"Computed Tomography","2025-06-25",{"date":516,"type":42},"2025-06-29",{"date":518,"type":42},"2024-08-10",{"date":520,"type":21},"2025-08-20",{"name":373,"class":49},{"id":523,"slug":4,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":524,"targetDuration":4,"studyType":22,"phases":525,"briefSummary":25,"conditions":526,"keywords":527,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":528,"lastUpdatePostDateStruct":529,"startDateStruct":531,"completionDateStruct":532,"leadSponsor":533,"locationsCount":50},"100354976",{"count":20,"type":21},[24],[27],[29,30,31,32,33,34,35,36,37],"2025-06-03",{"date":530,"type":42},"2025-06-06",{"date":44,"type":42},{"date":46,"type":21},{"name":48,"class":49},{"id":535,"slug":536,"hasResults":12,"nctId":537,"briefTitle":538,"officialTitle":538,"acronym":4,"eligibilityCriteria":539,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":540,"targetDuration":4,"studyType":22,"phases":542,"briefSummary":543,"conditions":544,"keywords":547,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":551,"lastUpdatePostDateStruct":552,"startDateStruct":554,"completionDateStruct":556,"leadSponsor":557,"locationsCount":140},"100531715","the-efficacy-of-p01-guided-sedation-protocol-in-critically-ill-patients-receiving-invasive-mechanical-ventilation-a-randomized-controlled-trial-100531715","NCT06203405","The Efficacy of P0.1-guided Sedation Protocol in Critically Ill Patients Receiving Invasive Mechanical Ventilation: A Randomized Controlled Trial","Inclusion Criteria:\n\n1. Patients admitted to the medical intensive care unit at Department of Medicine, Siriraj Hospital\n2. Age ≥18 years old\n3. Receiving mechanical ventilation due to acute respiratory failure within 72 hours before enrollment (including patients receiving mechanical ventilation before ICU admission)\n\nExclusion Criteria:\n\n1. Patients receiving mechanical ventilation due to indications other than acute respiratory failure, such as postoperative procedures or airway protection in comatose patients\n2. Patients receiving mechanical ventilation for \\>72 hours before enrollment\n3. Patients receiving neuromuscular blocking agents prior to randomization\n4. Patients with impaired secretion clearance or upper airway obstruction anticipating a tracheostomy\n5. Patients with severe metabolic acidosis (arterial pH \\\u003C7.2) who do not have a plan for renal replacement therapy\n6. Patients intubated for neurological conditions, including intracranial hypertension, intracranial hemorrhage, large cerebral infarction, status epilepticus, or neuromuscular diseases\n7. Post-cardiac arrest patients\n8. Patients with severe liver dysfunction, including acute fulminant liver failure or cirrhosis with the Child-Pugh score B or C\n9. Patients who have a previous allergy to any of the opioid, sedation, or neuromuscular blocking drugs\n10. Pregnancy\n11. Patients with do-not-resuscitate (DNR) orders or decisions to withhold life-sustaining treatments\n12. Patients who refuse to participate in the study or cannot identify legally authorized representatives (LAR) within 24 hours after enrollment",{"count":541,"type":21},214,[24],"This clinical trial aims to assess the efficacy of sedation protocol targeting optimal respiratory drive using P0.1 and arousal level compared with conventional sedation strategy (targeting arousal level alone) in patients requiring mechanical ventilation in the medical intensive care unit.",[319,129,545,546,27],"Respiratory Distress Syndrome, Adult","Lung Injury",[548,549,550,102,446],"acute respiratory failure","sedation","respiratory drive monitoring","2025-05-19",{"date":553,"type":42},"2025-05-22",{"date":555,"type":42},"2023-12-22",{"date":71,"type":21},{"name":558,"class":49},"Siriraj Hospital",{"id":560,"slug":561,"hasResults":12,"nctId":562,"briefTitle":563,"officialTitle":564,"acronym":565,"eligibilityCriteria":566,"healthyVolunteers":12,"sex":17,"minAge":4,"maxAge":567,"enrollmentInfo":568,"targetDuration":570,"studyType":61,"phases":4,"briefSummary":571,"conditions":572,"keywords":576,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":579,"lastUpdatePostDateStruct":580,"startDateStruct":582,"completionDateStruct":584,"leadSponsor":586,"locationsCount":78},"100528894","current-practice-of-ventilation-strategies-in-children-undergoing-general-anesthesia-100528894","NCT06166706","Current Practice of Ventilation Strategies in Children Undergoing General Anesthesia","Current Practice of Ventilation Strategies in Children Undergoing General Anesthesia and Associations With Postoperative Pulmonary Complications - a Multicenter Prospective Cohort Study","BIG APPLE","Inclusion Criteria:\n\n* aged ≤ 16 years;\n* undergoing general anesthesia\n* airway management with tube or LMA; and\n* connected to mechanical ventilator . minimum duration of procedure: 15 minutes\n\nExclusion Criteria:\n\n* patients undergoing surgical procedures involving extra-corporal circulation;\n* patients receiving ventilation with high frequency jet ventilation or high frequency oscillatory ventilation;\n* sedation without airway management in the form of a endotracheal tube or a supraglottic airway device; and\n* (rigid) bronchoscopic procedures with maintenance of spontaneous ventilation.","16 Years",{"count":569,"type":21},10000,"5 Days","Postoperative pulmonary complications (PPCs) are common in children undergoing general anesthesia and are associated with prolonged stay in the hospital and high costs. Development of PPCs is associated with ventilator settings in adult patients undergoing general anesthesia. Data on perioperative ventilator settings in children are lacking, leaving the anaesthetist without guidance. Consequently, the current standard of care in perioperative mechanical ventilation in children is expected to be extremely heterogeneous, leading to ventilation with higher levels of energy than necessary. Therefore, it is highly necessary to evaluate the current practice in perioperative ventilation in children and to determine associations with PPCs.",[27,573,574,575],"Pediatric ALL","Pulmonary Complication","Perioperative\u002FPostoperative Complications",[577,578,102],"pediatric anesthesia","postoperative pulmonary complications","2025-04-07",{"date":581,"type":42},"2025-04-09",{"date":583,"type":42},"2024-01-29",{"date":585,"type":21},"2026-01-07",{"name":587,"class":49},"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)",{"id":589,"slug":590,"hasResults":12,"nctId":591,"briefTitle":592,"officialTitle":593,"acronym":4,"eligibilityCriteria":594,"healthyVolunteers":12,"sex":17,"minAge":4,"maxAge":595,"enrollmentInfo":596,"targetDuration":4,"studyType":22,"phases":598,"briefSummary":599,"conditions":600,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":603,"lastUpdatePostDateStruct":604,"startDateStruct":606,"completionDateStruct":608,"leadSponsor":610,"locationsCount":140},"100474164","phase-4-the-caffeine-therapy-in-the-fetal-to-neonatal-transition-100474164","NCT05454332","The Caffeine Therapy in the Fetal to Neonatal Transition","The Caffeine Therapy in the Fetal to Neonatal Transition in Preterms","Inclusion Criteria:\n\n* Premature newborns with birth weight less than 1250 grams\n* Who are not intubated in the delivery room\n\nExclusion Criteria:\n\n* Premature newborns from other hospitals\n* Presence of a major congenital malformation or genetic syndrome","2 Hours",{"count":597,"type":21},50,[124],"Introduction: The caffeine is used in the treatment for apnea of prematurity and it has several positive effects in the neurodevelopment of preterm babies. There are innumerable observational studies suggesting that initiating caffeine in the first hours of life may offer more benefits in the reduction of the necessity of intubation and in ventilation time. It is necessary to expand further research on the best time to start caffeine, which may improve the quality of care for premature infants.\n\nObjective: To evaluate the benefits of caffeine administration in the first two hours of life compared to administration at 24 hours of life in premature patients on noninvasive mechanical ventilation with birth weights less than 1250 grams.\n\nMethodology: Preterm newborn patients with birth weight \\\u003C 1250 grams born at Hospital de Clínicas de Porto Alegre who are not intubated in the delivery room will be included. Patients will be randomized into two groups. One arm of the study will receive caffeine at 2 hours of age and the other arm will receive caffeine at 24 hours of age (control). Patients in the control group will receive 0.9% SF at 2 hours of life in order to keep the study blinded. The following outcomes will be evaluated: need for intubation, time on invasive and non-invasive mechanical ventilation, BPD, necrotizing enterocolitis, need for ROP treatment, PDA with hemodynamic repercussions, peri-intraventricular hemorrhage, leukomalacia and death. The sample size calculation is 50 patients, 25 in each arm.\n\nExpected Results: It is expected to find a 43% reduction in the need for intubation in preterm infants who receive caffeine in the first two hours of life compared to administration at 24 hours of life. It is also expected to find a reduction in mechanical ventilation time, in addition to a possible reduction in negative outcomes associated with prematurity.",[27,601,602],"Caffeine","Ventilator Lung; Newborn","2025-03-27",{"date":605,"type":42},"2025-04-02",{"date":607,"type":42},"2022-04-27",{"date":609,"type":21},"2026-08-30",{"name":611,"class":49},"Hospital de Clinicas de Porto Alegre",{"id":613,"slug":614,"hasResults":12,"nctId":615,"briefTitle":616,"officialTitle":617,"acronym":618,"eligibilityCriteria":619,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":620,"targetDuration":4,"studyType":22,"phases":621,"briefSummary":622,"conditions":623,"keywords":628,"overallStatus":103,"whyStopped":4,"lastUpdateSubmitDate":637,"lastUpdatePostDateStruct":638,"startDateStruct":640,"completionDateStruct":642,"leadSponsor":644,"locationsCount":646},"100539984","mechanical-insufflation-exsufflation-and-hypertonic-saline-in-nosocomial-bacterial-respiratory-tract-infection-100539984","NCT06310941","Mechanical Insufflation-exsufflation and Hypertonic Saline in Nosocomial Bacterial Respiratory Tract Infection","Aspiration of Bronchial Secretions With Mechanical Insufflation-Exsufflation and Hypertonic Saline in Bacterial Nosocomial Tracheobronchitis and Pneumonia in Intubated Patients.","ABSENTA","Inclusion Criteria:\n\n* Signed informed consent\n* Nosocomial pneumonia (vHAP or VAP) or nosocomial tracheobronchitis\n* Intubated with a cuffed endotracheal tube or tracheostomy cannula.\n\nExclusion Criteria:\n\n* Ominous prognosis\n* Frank hemoptisis\n* Barotrauma (pneumothorax or pneumomediastinum)\n* Bronchospasm (patients on bronchodilators for previous bronchospasm may be included\n* Unstable thoracic cage\n* Suspected unmonitored intracraneal hypertension",{"count":89,"type":21},[24],"Multicenter, randomized open label clinical trial to evaluate IEM and HS as concomitant therapy for respiratory tract infection in patients under artificial ventilation in the ICU.\n\nLung infection is a serious complication that may occur during hospital stay and may need artificial respiration or even develop during artificial ventilation for other causes.\n\nCurrent specific treatment consists of intravenous antibiotics. The current study evaluated whether aspiration and drainage of infected sputum helps curing this severe complication and whether nebulized HS has additional benefits, like loosening of secretions, eradicating bacteria or reducing inflammation.",[624,625,626,27,627],"Nosocomial Infection","Nosocomial Pneumonia","Tracheobronchitis","Endotracheal Intubation",[629,630,631,632,633,634,635,636],"mechanical insufflation-exsufflation","cough assist device","hypertonic saline","nosocomial respiratory tract infection","hospital-acquired pneumonia","tracheobronchitis","ventilator-associated pneumonia","nebulization","2025-03-21",{"date":639,"type":42},"2025-03-26",{"date":641,"type":21},"2026-01-01",{"date":643,"type":21},"2027-12-30",{"name":645,"class":49},"Hospital San Carlos, Madrid",8,{"id":648,"slug":649,"hasResults":12,"nctId":650,"briefTitle":651,"officialTitle":652,"acronym":4,"eligibilityCriteria":653,"healthyVolunteers":12,"sex":17,"minAge":654,"maxAge":655,"enrollmentInfo":656,"targetDuration":4,"studyType":22,"phases":658,"briefSummary":659,"conditions":660,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":662,"lastUpdatePostDateStruct":663,"startDateStruct":665,"completionDateStruct":667,"leadSponsor":669,"locationsCount":140},"100403514","how-early-mobilization-impacts-on-diaphragm-thickness-in-critically-ill-children-100403514","NCT04534296","How Early Mobilization Impacts on Diaphragm Thickness in Critically Ill Children","A Randomized Control Trial Comparing the Effects of Early Mobilization and Routine Care on Diaphragmatic Thickness","Inclusion Criteria:\n\n* subjects \\> 6 months and \\\u003C 12 years of age；\n* subjects been intubated and mechanically ventilated for \\\u003C 24 hours at the time of screening;\n* the Glasgow Coma Scale (GCS) on admission of Pediatric Intensive Care Unit (PICU) is greater than 3\n\nExclusion Criteria:\n\n* cardiopulmonary arrest;\n* history of diaphragmatic paralysis or neuromuscular disease;\n* neuromuscular blockade;\n* expectation to be liberated from ventilator in \\\u003C 24 hours\n* history of mechanical ventilation in the last 6 months\n* presence of tracheostomy\n* high cervical spine injury\n* status convulsion\n* thoracic trauma when ultrasonic examination cannot be performed","6 Months","12 Years",{"count":657,"type":21},160,[24],"The objective is to compare the impact of early mobilization and routine care on diaphragm thickness in critically ill children",[27,661],"Ventilator-induced Diaphragm Dysfunction","2025-02-11",{"date":664,"type":42},"2025-02-12",{"date":666,"type":42},"2021-04-26",{"date":668,"type":21},"2025-12",{"name":670,"class":49},"Children's Hospital of Fudan University"]