[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"mechanical-ventilation-in-neonates\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:mechanical-ventilation-in-neonates":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100467831","pharmacokinetics-pharmacodynamics-of-morphine-with-or-without-midazolam-administered-by-continuous-infusion-in-neonatal-intensive-care-100467831",false,"NCT05371886","Pharmacokinetics-pharmacodynamics of Morphine With or Without Midazolam Administered by Continuous Infusion in Neonatal Intensive Care","Inclusion Criteria:\n\n* Neonates \\\u003C 45 weeks of corrected gestational age\n* Hospitalized in a Neonatal Intensive Care Unit\n* Undergoing mechanical ventilation\n* Patients that receive morphine alone or morphine and midazolam as continuous infusion\n* Affiliated to a social security system\n\nExclusion Criteria:\n\n* Current weight \\\u003C 600g\n* Neonates under palliative care\n* Therapeutic hypothermia for perinatal anoxia\n* Neonates who underwent a surgical procedure during the past 72 hours\n* Neonates receiving concomitantly a paralytic or another drug for sedation or analgesia other than morphine or midazolam (except for paracetamol\u002Facetaminophen)\n* Parents refusing that their child participate","ALL","20 Weeks","45 Weeks",{"count":19,"type":20},180,"ESTIMATED","INTERVENTIONAL",[23],"NA","This study aims to describe a dose-effect relationship of morphine alone and morphine and midazolam administered as continuous infusion in neonates hospitalized in Neonatal intensive care unit and undergoing mechanical ventilation, through PKPD modelling.",[26,27],"Sedation Complication","Mechanical Ventilation in Neonates",[29,30,31,32,33],"morphine, midazolam","pharmacokinetics","pharmacodynamics","analgesia","neonates","RECRUITING","2025-11-14",{"date":37,"type":38},"2025-11-17","ACTUAL",{"date":40,"type":38},"2023-04-01",{"date":42,"type":20},"2027-05-01",{"name":44,"class":45},"Centre Hospitalier Intercommunal Creteil","OTHER",5]