[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"mechanical-ventilation-strategies\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:mechanical-ventilation-strategies":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":4},"100624414","prophylactic-use-of-aprv-before-extubation-in-morbidly-obese-patients-after-cardiac-surgery-100624414",false,"NCT07409324","Prophylactic Use of APRV Before Extubation in Morbidly Obese Patients After Cardiac Surgery.","Prophylactic Use of Airway Pressure Release Ventilation (APRV) Prior to Extubation in Morbidly Obese Patients Undergoing Elective Cardiac Surgery: Impact on Pulmonary Function, Oxygenation, and ICU Outcomes.","APRV-OBESE-CS","Inclusion Criteria:\n\nAdult patients aged 18-65 year of both sex.\n\nMorbidly obese patients (body mass index ≥ 40 kg\u002Fm² or ≥ 35 kg\u002Fm² with obesity-related comorbidities)\n\nScheduled for elective cardiac surgery (CABG, valve, or combined) requiring cardiopulmonary bypass\n\nPlanned postoperative admission to the cardiac surgical intensive care unit\n\nPatients eligible for mechanical ventilation with planned early extubation within 6-12 hours postoperatively\n\nAbility to provide written informed consent\n\nExclusion Criteria:\n\nSevere pulmonary disease (e.g., COPD GOLD III\u002FIV, home oxygen therapy, and pulmonary fibrosis).\n\nPatients with history of previous spontaneous pneumothorax or postoperative pneumothorax.\n\nIntracranial hypertension or contraindication to APRV. Hemodynamically unstable on admission (MAP less than 65 mmHg) Vasopressor\u002Finotropic score (VIS) more than 10 Requirement for postoperative extracorporeal membrane oxygenation (ECMO) or intra-aortic balloon pump (IABP).\n\nInability to obtain informed consent","ALL","18 Years","65 Years",{"count":21,"type":22},180,"ESTIMATED","INTERVENTIONAL",[25],"NA","Morbidly obese patients undergoing open heart surgery are at increased risk of breathing problems after removal of the breathing tube due to reduced lung function and chest wall restriction following surgery. These complications may result in poor oxygenation, respiratory failure, and prolonged ICU stay.\n\nAirway Pressure Release Ventilation (APRV) is a mechanical ventilation mode that improves lung recruitment and oxygenation. This study aims to evaluate whether the prophylactic use of APRV after ICU admission, compared with conventional lung-protective mechanical ventilation, improves oxygenation, lung function, and ICU outcomes in morbidly obese patients undergoing elective cardiac surgery.\n\nPatients will be randomly assigned to receive either APRV or conventional ventilation during postoperative mechanical ventilation, followed by standard weaning and extubation. Outcomes include oxygenation index, lung ultrasound findings, need for reintubation, and ICU clinical outcomes.",[28,29,30],"Morbid Obesity in Cardiac Surgery Patients","Postoperative Respiratory Dysfunction","Mechanical Ventilation Strategies",[32,33,34,35,36,37],"Airway Pressure Release Ventilation","Morbid Obesity","Cardiac Surgery","Postoperative Ventilation","Lung Ultrasound","Oxygenation","NOT_YET_RECRUITING","2026-02-08",{"date":41,"type":42},"2026-02-13","ACTUAL",{"date":44,"type":22},"2026-02-01",{"date":46,"type":22},"2026-11",{"name":48,"class":49},"Ain Shams University","OTHER"]