[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"mechanical-ventilation-weaning\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:mechanical-ventilation-weaning":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,50,79,108,131],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100635969","high-flow-tracheal-oxygen-for-weaning-of-tracheostomized-patients-100635969",false,"NCT07559591","High Flow Tracheal Oxygen for Weaning of Tracheostomized Patients","High Flow Tracheal Oxygen for Weaning of Tracheostomized Mechanically Ventilated Patients: A Pilot Randomised Controlled Trial (HFTO WEAN Trial)","HFTO-WEAN","Inclusion Criteria:\n\n1. Adults ≥ 18 years of age\n2. Intensive care unit (ICU) patients with tracheostomy inserted during the index ICU admission.\n3. Mechanically ventilated for ≤60 days.\n4. Successful spontaneous breathing trial for 1 hour.\n\nExclusion Criteria:\n\n1. Planned tracheostomy post head and neck surgery with ICU stay less than 48 hours\n2. Patient transferred from another hospital only if the intubation and tracheostomy dates are unavailable, otherwise would be eligible.\n3. Patient with an imminent plan for palliation and comfort care.\n4. Patient or substitute decision-maker declines consent to the study.\n5. The treating physician declines consent to the study.","ALL","18 Years",{"count":20,"type":21},88,"ESTIMATED","INTERVENTIONAL",[24],"NA","In this pilot randomized controlled trial (RCT), the investigators aim to explore the feasibility of conducting a powered RCT that examines the efficacy and safety of high flow tracheal oxygen (HFTO) in weaning critically ill tracheostomy patients from mechanical ventilation.\n\nObjective of the study\n\n1. To assess the feasibility of conducting a larger RCT as primary objective.\n2. To explore the effect of using HFTO in mechanically ventilated tracheostomized critically ill patients on ventilator-free days (VFD) compared to standard of care method using tracheal mask (TM) as secondary objective.",[27,28,29],"Tracheostomized Patients","Mechanical Ventilation Weaning","High Flow Oxygen Therapy",[31,32,33,34,35,36],"tracheostomized patients","tracheostomy","mechanical ventilation weaning","high flow tracheal oxygen","mechanical ventilation liberation","critically ill","RECRUITING","2026-05-29",{"date":40,"type":41},"2026-06-02","ACTUAL",{"date":43,"type":41},"2026-05-17",{"date":45,"type":21},"2027-05",{"name":47,"class":48},"King Faisal Specialist Hospital & Research Center","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":22,"phases":59,"briefSummary":60,"conditions":61,"keywords":63,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":4},"100637731","phenotype-guided-weaning-in-mechanically-ventilated-patients-with-chronic-comorbidities-100637731","NCT07594418","Phenotype-Guided Weaning in Mechanically Ventilated Patients With Chronic Comorbidities","Effect of a Phenotype-Guided Precision Intervention Strategy on 28-Day Ventilator-Free Days in Mechanically Ventilated Patients With Chronic Comorbidities: A Multicenter Open-Label Randomized Controlled Trial","Inclusion Criteria:\n\n1. Age 18 years or older.\n2. Presence of at least one chronic cardiovascular, cerebrovascular, or respiratory comorbidity. Cardiovascular and cerebrovascular comorbidities include stroke, hypertension, ischemic heart disease, valvular heart disease, heart failure, pulmonary heart disease, cardiomyopathy, and arrhythmia. Respiratory comorbidities include chronic obstructive pulmonary disease, asthma, bronchitis, emphysema, interstitial lung disease, and pneumoconiosis. These conditions will be identified according to the International Classification of Diseases 11th Revision diagnosis codes.\n3. Receiving invasive mechanical ventilation for at least 24 hours and expected to require mechanical ventilation for at least 72 hours.\n4. Not receiving neuromuscular blocking agents and having a Richmond Agitation-Sedation Scale score of -3 or higher.\n5. PaO2\u002FFiO2 of 150 mmHg or higher.\n\nExclusion Criteria:\n\n1. Severe neuromuscular disease, such as Guillain-Barre syndrome, myasthenia gravis, amyotrophic lateral sclerosis, multiple sclerosis, or high spinal cord injury.\n2. Severe dysfunction of other organs with expected death in the short term.\n3. Severe end-stage irreversible respiratory, cardiac, neurological, or malignant disease, or receiving palliative care.\n4. Pregnancy.\n5. Participation in another clinical study.\n6. Written informed consent not provided.",{"count":58,"type":21},1380,[24],"The goal of this clinical trial is to learn whether a phenotype-guided weaning strategy can help adults with chronic comorbidities be liberated from invasive mechanical ventilation earlier. It will also learn about the safety of this strategy.\n\nThe main questions it aims to answer are:\n\n* Does the phenotype-guided weaning strategy increase the number of ventilator-free days within 28 days after enrollment?\n* Does the strategy improve the process and success of ventilator liberation?\n* What safety events occur when this strategy is used?\n\nResearchers will compare the phenotype-guided weaning strategy with standard care in mechanically ventilated patients with chronic cardiovascular, cerebrovascular, or respiratory comorbidities.\n\nIn the intervention period, participants will receive a protocolized ventilator weaning pathway. This pathway includes assisted ventilation transition, daily weaning readiness screening, a 0 cmH2O continuous positive airway pressure test, spontaneous breathing trial, extubation assessment, and post-extubation respiratory support when appropriate.\n\nThe phenotype-guided part of the strategy is mainly used for participants who fail a spontaneous breathing trial or have difficult weaning. These participants will undergo structured ABCDE screening to identify the main phenotype or mechanism of weaning failure:\n\n* A: airway or lung dysfunction\n* B: brain dysfunction, including delirium, anxiety, agitation, or impaired consciousness\n* C: cardiac dysfunction\n* D: diaphragm or respiratory muscle dysfunction\n* E: endocrine, metabolic, or nutritional problems\n\nBased on the identified phenotype, clinicians will provide targeted assessment and treatment. Participants will be followed for ventilator-free days through day 28 and for clinical outcomes through day 90.",[28,62],"Chronic Disease",[64,65,66,67,68,69],"Phenotype-Guided Weaning","Ventilator Liberation","Ventilator-Free Days","Chronic Comorbidities","Spontaneous Breathing Trial","ABCDE Screening","NOT_YET_RECRUITING",{"date":72,"type":41},"2026-05-19",{"date":74,"type":21},"2026-09",{"date":76,"type":21},"2027-11",{"name":78,"class":48},"Southeast University, China",{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":4,"eligibilityCriteria":85,"healthyVolunteers":11,"sex":17,"minAge":86,"maxAge":87,"enrollmentInfo":88,"targetDuration":4,"studyType":22,"phases":90,"briefSummary":91,"conditions":92,"keywords":95,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":49},"100599274","the-use-of-diaphragmatic-ultrasonography-in-mechanical-ventilation-weaning-decision-in-copd-patient-100599274","NCT07082361","The Use of Diaphragmatic Ultrasonography in Mechanical Ventilation Weaning Decision in COPD Patient","The Use of Diaphragmatic Ultrasonography: Does It Change Mechanical Ventilation Weaning Decision and Predict Outcome in COPD Patient?","Inclusion Criteria:\n\n* Adult patient more than 21 years old of both sexes, coming to our intensive care unit with acute exacerbation of Chronic obstructive pulmonary disease \\& need mechanical ventilation at least 48 hr.\n\nExclusion Criteria:\n\n* Patient refusal.\n\n  * Morbid obesity with body mass index \\> 35 kg\u002Fm2.\n  * Patients with a history of recent thoracic surgery.\n  * Neuromuscular disorders affecting the diaphragm e.g.(myopathy).\n  * Congenital diaphragmatic disorders (Hiatal hernia).","21 Years","70 Years",{"count":89,"type":21},140,[24],"The aim of this study is to evaluate the use of diaphragmatic ultrasonography in taking mechanical ventilation weaning decision and predicting outcome in Chronic obstructive pulmonary disease patient.\n\nPrimary outcome:\n\n• Number of patients with failed weaning trial and need reintubation.\n\nSecondary outcomes:\n\n* Time till extubation trial.\n* Ventilation free days after extubation less or more than 48h .\n* Number of Intensive care unit discharges.\n* Sensitivity and specificity of diaphragmatic assessment as a predictor of weaning.",[93,28,94],"Ultrasonography","Chronic Obstructive Pulmonary Disease (COPD)",[93,96,97,98],"Diaphragmatic","Mechanical Ventilation","Weaning","2025-07-16",{"date":101,"type":41},"2025-07-24",{"date":103,"type":21},"2025-10-30",{"date":105,"type":21},"2025-12-30",{"name":107,"class":48},"Tanta University",{"id":109,"slug":110,"hasResults":11,"nctId":111,"briefTitle":112,"officialTitle":113,"acronym":114,"eligibilityCriteria":115,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":116,"targetDuration":4,"studyType":22,"phases":118,"briefSummary":119,"conditions":120,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":130},"100586248","feasibility-study-to-compare-two-ventilatory-modes-for-mechanical-ventilation-weaning-100586248","NCT06912906","Feasibility Study to Compare Two Ventilatory Modes for Mechanical Ventilation Weaning","Comparison of Two Strategies to Allow Mechanical Ventilation Separation Using Biphasic Airway Pressure Ventilation Without Any Synchronization (BIPAP) or Pressure Support Ventilation (PSV): a Randomized Feasibility Trial","BIWEAN","Inclusion Criteria:\n\n* Intubated ICU patient with acute respiratory failure;\n* PaO2-FiO2 ratio of less than 300 mmHg (40 kPa) at least one hour after intubation;\n* control or assist-control ventilation;\n* expected duration of mechanical ventilation of more than 24 hours;\n* clinician in charge considers that the patient can be switched to assisted ventilation (weaning phase start);\n* informed consent obtained by the patient himself \u002F legal representative or authorization received from independent physician\n\nExclusion Criteria:\n\n* less than 18 years old;\n* pregnant women (because of very different respiratory mechanics);\n* severe obesity (BMI \\> 40 kg\u002Fm2);\n* known obstructive pulmonary disease;\n* expected death within one week or very poor prognosis with end-of-life care decision expected\u002Ftreatment withdrawal;\n* neurological disorders heavily influencing breathing pattern, like suspected or proven hypoxic brain injury, spinal injury above C8, severe traumatic brain injury, polyneuropathies (ex. Guillain-Barré, myasthenia gravis);\n* home non-invasive ventilation prior to ICU admission, except CPAP for obstructive sleeping apnoea syndrome;\n* tracheostomised at ICU admission;\n* suspected or proven broncho-pleural fistulas;\n* extracorporeal membrane oxygenation (ECMO) treatment;\n* ICU admission for major burns;\n* enrolment in other trial with competitive outcomes or treatment strategies;\n* Known opposition to research participation if patient is not able to consent (eg patient with refused GC)",{"count":117,"type":21},84,[24],"We hypothesize that the ventilatory mode Bilevel Positive Airway Pressure without any synchronization (BIPAPasynchro) may facilitate the weaning process of patients intubated with acute hypoxiemic respiratory failure (AHRF) by obviating the problem of patient-ventilator asynchrony. In order to prove this hypothesis a large randomized controlled study should be perfromed comparing BIPAPasynchro versus pressure support ventilation (PSV), the most widely used ventilatory mode during the weaning process. In order to do so, a feasibility trial to demonstrate the ICU personnel can effectively use a non-standard ventilatory mode should be first performed. The objective of our study is, thus, to demonstrate the feasibility of using BIPAasynchro in the Lausanne Adult ICU.",[28],"2025-04-10",{"date":123,"type":41},"2025-04-15",{"date":125,"type":21},"2025-09-01",{"date":127,"type":21},"2027-04-15",{"name":129,"class":48},"University of Lausanne Hospitals",2,{"id":132,"slug":133,"hasResults":11,"nctId":134,"briefTitle":135,"officialTitle":135,"acronym":4,"eligibilityCriteria":136,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":137,"targetDuration":4,"studyType":139,"phases":4,"briefSummary":140,"conditions":141,"keywords":142,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":146,"lastUpdatePostDateStruct":147,"startDateStruct":149,"completionDateStruct":151,"leadSponsor":153,"locationsCount":49},"100561449","autonomic-modulation-in-patients-undergoing-assisted-mechanical-ventilation-comparison-between-pav-and-psv-100561449","NCT06590311","Autonomic Modulation in Patients Undergoing Assisted Mechanical Ventilation: Comparison Between PAV+ and PSV","Inclusion Criteria:\n\n* Patients admitted to the ICU, ≥18 years old, undergoing invasive controlled mechanical ventilation for at least 72 hours, eligible for assisted support but not yet ready for extubation or spontaneous breathing.\n\nExclusion Criteria:\n\n* Successful completion of a spontaneous breathing trial (SBT) and spontaneous breathing within 24 hours of enrollment\n* Acute ischemic heart disease, cardiac rhythm abnormalities, and\u002For patients with pacemakers and\u002For treated with anti-arrhythmic drugs\n* Hemodynamic instability\n* Chest drainage\n* Severe anemia (Hb \\<7g\u002FdL)\n* Pregnancy\n* Severe head trauma, dementia\n* High spinal cord injury\n* Neuromuscular disorders\n* Lack of consent",{"count":138,"type":21},48,"OBSERVATIONAL","The aim of the study is to investigate autonomic modulation in terms of heart rate variability (i.e., HRV) in patients undergoing assisted mechanical ventilation in PSV mode, compared to patients assisted in PAV+ mode. The hypothesis is that the greater patient-ventilator synchrony of the latter mode may represent an advantage in reducing the imbalance of autonomic modulation.",[28],[33,143,144,145],"heart rate variability","autonomic modulation","PAV+","2024-09-06",{"date":148,"type":41},"2024-09-19",{"date":150,"type":21},"2024-09-15",{"date":152,"type":21},"2025-12-15",{"name":154,"class":48},"University of Roma La Sapienza"]