[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"mechanical-ventilation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:mechanical-ventilation":26},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,103,0,25,[9,47,79,101,135,162,185,213,238,274,304,326,352,385,407,427,448,471,493,532,561,590,611,643,676],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100561856","intelligent-lung-support-in-the-intensive-care-unit-100561856",false,"NCT06595602","Intelligent Lung Support in the Intensive Care Unit","Intelligent Lung Support in the Intensive Care Unit (IntelliLung): An Observational, Prospective, Multicentre Study","IntelliLung","Inclusion Criteria:\n\n1. Male and female patients, age ⪰18 years\n2. Written informed consent\n3. Invasively mechanically ventilated patients expected to be intubated for more than 24 hours.\n\nExclusion Criteria:\n\n1. Expected to die within ≤48 hours\n2. Participation in an interventional mechanical ventilation trial\n3. Mechanical Ventilation with a closed-loop ventilation mode\n4. Persons dependent on the sponsor and\u002For investigator\n5. Subjects who are currently imprisoned or otherwise in confinement ordered by law or other official authorities","ALL","18 Years",{"count":21,"type":22},530,"ESTIMATED","OBSERVATIONAL","The aim of this observational study is to test the IntelliLung decision support system based on artificial intelligence. This system is intended to help to set the ventilator. The study includes patients with and without ARDS (acute respiratory distress syndrome) who are receiving invasive mechanical ventilation, as well as patients with additional extracorporeal lung support. The study will be conducted in several centers.\n\nThe main question of the study:\n\nHow well do the mechanical ventilation settings of healthcare staff match the recommendations of the IntelliLung system?",[26,27],"Mechanical Ventilation","Intensive Care Medicine",[29,30,31,32,33],"Invasive mechanical ventilation","Intensive care medicine","critical care medicine","artificial intelligence","decision support","RECRUITING","2026-06-30",{"date":37,"type":38},"2026-07-02","ACTUAL",{"date":40,"type":38},"2025-05-25",{"date":42,"type":22},"2027-12",{"name":44,"class":45},"Technische Universität Dresden","OTHER",5,{"id":48,"slug":49,"hasResults":12,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":57,"phases":58,"briefSummary":60,"conditions":61,"keywords":63,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":78},"100643157","flow-controlled-ventilation-to-improve-postoperative-pulmonary-outcome-after-thoracic-surgery-100643157","NCT07623395","Flow-Controlled Ventilation to Improve Postoperative Pulmonary Outcome After Thoracic Surgery","PROtective Ventilation With FLOW-Controlled Ventilation to Improve Postoperative Pulmonary Outcome After THORACic Surgery - an International Multicenter Pilot Randomized Clinical Trial","PROFLOW-THORAC","Inclusion Criteria:\n\n* aged ≥ 18 years; and\n* scheduled for elective open, video- or robot-assisted thoracic surgery with one-lung ventilation using a double-lumen tube (DLT); and\n* able to give written informed consent.\n\nExclusion Criteria:\n\n* body weight \\\u003C 40 kg;\n* ASA score IV - VI;\n* lung separation with other method than DLT (e.g. difficult airway, tracheostomy);\n* previous lung surgery;\n* COPD GOLD grades III and IV, lung fibrosis, documented bullae, severe emphysema, pneumothorax;\n* uncontrolled asthma;\n* Heart failure NYHA Grade 3 and 4, Coronary Heart Disease CCS Grade 3 and 4;\n* documented pulmonary arterial hypertension \\>25 mmHg mPAP at rest or \\>40mmHg syst. (estimated by ultrasound) or \\>20 mmHg mPAP measured by right heart catheterization, or pulmonary vascular resistance \\> 2.0 Wood units;\n* documented or suspected neuromuscular disease (thymoma, myasthenia, myopathies, muscular dystrophies, others);\n* planned mechanical ventilation after surgery;\n* bilateral procedures;\n* surgery in prone position;\n* persistent hemodynamic instability, intractable shock;\n* intracranial injury or tumor;\n* esophagectomy, pleural surgery only, sympathectomy surgery only, chest wall surgery only, mediastinal surgery only, lung transplantation;\n* presence before induction of anesthesia of one of the adverse events, listed as postoperative pulmonary complications (aspiration, moderate respiratory failure, infiltrates, pulmonary infection, atelectasis, cardiopulmonary oedema, pleural effusion, pneumothorax, pulmonary embolism, purulent pleuritis, lung hemorrhage);\n* documented preoperative hypercapnia \\> 45mmHg (6kPa)\n* previous enrolment in the current study;\n* being the study investigator of this study, his\u002Fher family members, employees and other dependent persons;\n* if female and of childbearing potential, known pregnancy or a positive urine pregnancy test (confirmed by a positive serum pregnancy test), or lactating; or\n* no written informed consent.",{"count":56,"type":22},140,"INTERVENTIONAL",[59],"NA","In an international multicenter randomized clinical pilot trial, intraoperative flow-controlled ventilation (FCV) will be compared with volume-controlled ventilation (VCV) in patients scheduled for (open, video- or robot-assisted) thoracic surgery with one-lung ventilation (OLV). This pilot trial is designed to test the feasibility and safety of FCV during all phases of intraoperative ventilation, and in particular during OLV, and to inform the design of a future trial testing the efficacy of FCV with regard to postoperative outcomes, including postoperative pulmonary complications (PPC).\n\nThe ventilation modes are conducted with CE-marked medical devices (anesthesia ventilators or medical ventilators), however these medical devices themselves are not under investigation. All CE-marked standard medical devices from varied manufacturers in use at the participating study centers will be used in full accordance with their instructions for use. FCV has shown safety and feasibility in various surgical settings, including thoracic surgery with OLV, however its feasibility in a multicenter trial has not been investigated yet.",[26,62],"Postoperative Pulmonary Complications (PPCs)",[64,65,66,67],"Flow-Controlled Ventilation","Thoracic Surgery","One-Lung Ventilation","Mechanical Power","NOT_YET_RECRUITING","2026-06-28",{"date":71,"type":38},"2026-07-01",{"date":73,"type":22},"2026-09-01",{"date":75,"type":22},"2027-12-01",{"name":77,"class":45},"Cantonal Hospital of St. Gallen",1,{"id":80,"slug":81,"hasResults":12,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":4,"eligibilityCriteria":85,"healthyVolunteers":86,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":87,"targetDuration":4,"studyType":57,"phases":89,"briefSummary":90,"conditions":91,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":96,"completionDateStruct":97,"leadSponsor":99,"locationsCount":4},"100644563","mechanical-power-during-different-ventilation-modes-in-laparoscopic-surgery-100644563","NCT07670494","Mechanical Power During Different Ventilation Modes in Laparoscopic Surgery","Comparison of Mechanical Power in Pressure-Regulated Volume Control and Volume-Controlled Ventilation Modes During Laparoscopic Cholecystectomy","Inclusion Criteria:\n\n* Patients undergoing elective laparoscopic cholecystectomy surgery.\n* Patients between 18 and 75 years of age.\n* American Society of Anesthesiologists (ASA) physical status I, II or III.\n* Body Mass Index (BMI) between 18.5 and 35 kg\u002Fm².\n* Voluntary written informed consent for participation.\n\nExclusion Criteria:\n\n* History of significant chronic obstructive pulmonary disease (COPD) or asthma.\n* Previous lung resection or major thoracic surgery.\n* Heavy smokers (more than 20 cigarettes per day).\n* Presence of spontaneous breathing effort during mechanical ventilation.\n* Conversion from laparoscopic surgery to open surgery during the procedure.\n* Emergency surgery cases.\n* Known pregnancy.",true,{"count":88,"type":22},80,[59],"This study investigates how different breathing machine (ventilator) settings affect the energy delivered to the lungs during surgery. Mechanical power is a measure of this energy, and high levels can sometimes lead to lung irritation. In clinical practice, a mode called Pressure-Regulated Volume Control (PRVC) is often used because it lowers the \"peak\" pressure in the airways, which is generally thought to be safer. However, doctors have noticed that even though the peak pressure goes down in PRVC mode, the total mechanical power displayed on the monitor might actually increase compared to the standard Volume-Controlled Ventilation (VCV) mode. In this study, patients undergoing gallbladder surgery will be monitored using both ventilation modes in a random order. The researchers will compare the machine-calculated mechanical power for both modes to see if the perceived benefit of lower peak pressure in PRVC actually results in lower overall energy transfer to the lungs.",[92,26,93],"Laparoscopic Cholecystectomy","Ventilator-Induced Lung Injury","2026-06-26",{"date":35,"type":38},{"date":71,"type":22},{"date":98,"type":22},"2026-08-12",{"name":100,"class":45},"Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital",{"id":102,"slug":103,"hasResults":12,"nctId":104,"briefTitle":105,"officialTitle":106,"acronym":107,"eligibilityCriteria":108,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":109,"enrollmentInfo":110,"targetDuration":4,"studyType":57,"phases":112,"briefSummary":113,"conditions":114,"keywords":122,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":4},"100644682","burn-asv-trial-adaptive-support-ventilation-in-severe-burn-injury-100644682","NCT07674563","BURN-ASV Trial: Adaptive Support Ventilation in Severe Burn Injury","Adaptive Support Ventilation Versus Conventional Lung-Protective Ventilation in Severe Burn Injury Including Thermobaric and Drone-Related Burns: The BURN-ASV Randomized Controlled Trial","BURN-ASV","Inclusion Criteria:\n\n* Age 18 years or older.\n* Thermal burn injury involving ≥20% total body surface area (TBSA).\n* Requirement for invasive mechanical ventilation expected to exceed 24 hours.\n* Admission to a participating intensive care unit within 48 hours of injury.\n* Burn injury resulting from conventional flame burns, explosion-related burns, drone-related burns, or thermobaric blast burns.\n* Written informed consent provided by the patient or a legally authorized representative.\n\nExclusion Criteria:\n\n* Age younger than 18 years.\n* Pregnancy or breastfeeding.\n* Pre-existing chronic respiratory failure requiring home oxygen therapy or long-term mechanical ventilation.\n* Severe chronic obstructive pulmonary disease (COPD GOLD IV) or other end-stage pulmonary disease.\n* Extracorporeal membrane oxygenation (ECMO) at the time of enrollment.\n* Severe traumatic brain injury requiring controlled hyperventilation.\n* Expected death within 24 hours of ICU admission.\n* Do-not-resuscitate (DNR) order or limitations of life-sustaining treatment.\n* Previous enrollment in the current study.\n* Participation in another interventional trial that may interfere with study outcomes.","50 Years",{"count":111,"type":22},100,[59],"Severe burn injury frequently requires prolonged mechanical ventilation because of inhalation injury, respiratory failure, systemic inflammation, and repeated surgical procedures. Patients with extensive burns are at high risk of ventilator-associated complications, prolonged intensive care unit (ICU) stay, and death.\n\nAdaptive Support Ventilation (ASV) is an automated mode of mechanical ventilation that continuously adjusts breathing support according to the patient's respiratory needs and lung mechanics. Although ASV has shown potential benefits in general ICU populations, its effectiveness in patients with severe burn injuries has not been adequately studied.\n\nThe purpose of this randomized controlled trial is to compare Adaptive Support Ventilation with conventional lung-protective mechanical ventilation in critically ill adult burn patients, including those with inhalation injury, drone-related burns, and thermobaric blast burns. Participants will be randomly assigned to receive either ASV or conventional ventilation. The study will evaluate whether ASV improves ventilator-free days, reduces duration of mechanical ventilation, decreases ventilator-associated complications, and improves clinical outcomes.\n\nThe results of this study may help identify optimal ventilation strategies for patients with severe burn injuries and improve critical care management in both civilian and military burn centers.",[115,26,116,117,118,119,120,121],"Burn","Mechanical Ventilation Complication","ICU","ICU Hospitalization","Critical Care, Intensive Care","Military Activity","Combat-Related Burn Injury",[123,121,124,125],"burn","adaptive support mechanical ventilation","mechanical ventilation","2026-06-24",{"date":128,"type":38},"2026-06-29",{"date":130,"type":22},"2026-09-23",{"date":132,"type":22},"2026-11-23",{"name":134,"class":45},"Ukrainian Society of Regional Anesthesia and Pain Therapy",{"id":136,"slug":137,"hasResults":12,"nctId":138,"briefTitle":139,"officialTitle":140,"acronym":141,"eligibilityCriteria":142,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":143,"targetDuration":4,"studyType":57,"phases":145,"briefSummary":146,"conditions":147,"keywords":149,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":153,"lastUpdatePostDateStruct":154,"startDateStruct":156,"completionDateStruct":158,"leadSponsor":160,"locationsCount":46},"100598875","effects-of-permissive-lung-protective-ventilation-on-outcome-in-critically-ill-invasively-ventilated-patients-100598875","NCT07077174","Effects of PERMISSive Lung-protective Ventilation on Outcome in Critically Ill Invasively Ventilated Patients","Effects of PERMISSive Lung-protective Ventilation on Outcome in Critically Ill Invasively Ventilated Patients (PERMISS) - a Feasibility and Safety Pilot Study for a Randomized Clinical Trial","PERMISS pilot","Inclusion Criteria:\n\n* admission to one of the participating ICUs;\n* intubated and receiving invasive ventilation with an expected duration of ventilation of at least 24 hours.\n\nExclusion Criteria:\n\n* age below 18 years;\n* receiving invasive ventilation \\> 1 hour in the ICU, or receiving invasive ventilation \\> 6 hours directly preceding the current ICU admission (i.e., in the operating room or in the emergency department);\n* receiving or planned to receive veno-venous, veno-arterial or arterio-venous extracorporeal membrane oxygenation (ECMO);\n* having COPD GOLD III and IV;\n* contra-indication for hypercapnia, such as ongoing cardiac ischemia (as defined in the guideline of the European Society of Cardiology), or having suspected or confirmed increased intracranial pressure due to brain injury, judged by the attending physician;\n* any neurologic diagnosis that can prolong duration of mechanical ventilation, e.g., Guillain-Barré syndrome, high spinal cord lesion or amyotrophic lateral sclerosis, multiple sclerosis, or myasthenia gravis;\n* suspected or confirmed pregnancy;\n* participation in another interventional trial using similar endpoints;\n* previously randomized in this study;\n* no informed consent; or\n* admitted for terminal care",{"count":144,"type":22},56,[59],"RATIONALE Lung-protective ventilation using a lower respiratory rate (RR) is an appealing strategy to reduce ventilation intensity, which may require permissive hypercapnia. However, the feasibility and safety of this so-called 'permissive lung-protective ventilation' must be investigated, before conducting a large randomized clinical trial to evaluate its effectiveness on patient-centered outcomes.\n\nOBJECTIVE To study the feasibility and safety of permissive lung-protective ventilation in adult critically ill patients receiving invasive ventilation for acute hypoxemic respiratory failure, and to inform the design of a future randomized clinical trial in this patient population.\n\nHYPOTHESIS Permissive lung-protective ventilation is a feasible and safe ventilation strategy.\n\nSTUDY DESIGN Multicenter, randomized clinical pilot trial. STUDY POPULATION Critically ill patients, aged \\> 18 years, intubated for acute hypoxemic respiratory failure, and expected to receive ventilation for \\> 24 hours.\n\nMETHODS Patients are randomized to permissive lung-protective ventilation wherein RR is stepwise reduced, or to conventional lung-protective ventilation.\n\nOUTCOME MEASURES The primary endpoint is feasibility, assessed by the difference in respiratory rate (RR) between the two groups, from the start of mechanical ventilation until first extubation. Secondary endpoints include protocol compliance and feasibility of collecting data, and safety, assessed by the occurrence of unacceptable hypercapnia and hypoxemia and the incidence of ventilator-associated complications SAMPLE SIZE To estimate the appropriate sample size for this pilot study, we considered the primary feasibility endpoint of detecting a difference in the respiratory rate (RR). Assuming an expected mean difference in RR of 7.5, based on previous studies \\[1, 2\\], with an SD of 10, a power of 90% and an alpha of 0.05, with a drop-out rate estimated at 10%, a two-tailed t-test was used. The required sample size is 84 patients (42 patients per group).\n\nNATURE AND EXTENT OF THE BURDEN AND RISKS ASSOCIATED WITH PARTICIPATION, BENEFIT AND GROUP RELATEDNESS Ventilation with a lower RR may require permissive hypercapnia, which, when kept within safe limits, is safe. In current daily practice, there is no guidance in setting RR; consequently, RR varies widely across patients and is often set high. This pilot study compares two forms of lung-protective ventilation, both considered standard care in current ICU practice. The control group receives conventional ventilation with low tidal volumes and high RR to maintain normal PaCO₂ and pH. The intervention group, permissive ventilation, uses a lower RR to reduce mechanical power, accepting mild hypercapnia and acidosis. Permissive ventilation is most often reserved for patients with severe lung conditions, where ventilator settings are more complex and ventilation intensity is high. In these patients, permissive ventilation is considered safe, and may even be beneficial. We aim to evaluate this strategy more broadly in critically ill patients. The collection of demographic, ventilation and outcome data causes no harm to patients. Blood is drawn for arterial blood gas analysis, but this is also part of standard care.",[26,148],"Intensive Care (ICU)",[125,150,151,152],"intensive care unit","mechanical power","respiratory rate","2026-06-19",{"date":155,"type":38},"2026-06-23",{"date":157,"type":38},"2025-08-31",{"date":159,"type":22},"2026-08-31",{"name":161,"class":45},"Reinier de Graaf Groep",{"id":163,"slug":164,"hasResults":12,"nctId":165,"briefTitle":166,"officialTitle":167,"acronym":168,"eligibilityCriteria":169,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":170,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":172,"conditions":173,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":176,"lastUpdatePostDateStruct":177,"startDateStruct":179,"completionDateStruct":181,"leadSponsor":183,"locationsCount":78},"100641424","swallowing-assessment-for-predicting-extubation-failure-in-critically-ill-patients-100641424","NCT07659275","Swallowing Assessment for Predicting Extubation Failure in Critically Ill Patients","Prospective Evaluation of the Prognostic Performance of an Orotracheal Tube-Adapted Swallowing Biomechanics Assessment for Predicting Extubation Failure in Critically Ill Patients","APEX","Inclusion Criteria:\n\n* Age ≥18 years.\n* Admission to an intensive care unit.\n* Invasive mechanical ventilation for ≥48 hours.\n* Successful completion of a spontaneous breathing trial according to local practice.\n* Ability to undergo bedside swallowing biomechanics assessment using the APEX score before extubation.\n* Written informed consent from the patient or legally authorized representative, when required by local regulations.\n\nExclusion Criteria:\n\n* Presence of a tracheostomy.\n* Decision to withhold or withdraw life-sustaining treatments.\n* Structural abnormalities of the upper airway or face precluding APEX assessment.\n* Conditions preventing assessment of swallowing biomechanics (e.g., maxillofacial trauma, recent head and neck surgery, or other conditions judged by the investigator to interfere with the evaluation).",{"count":171,"type":22},800,"Extubation failure, defined as the need for reintubation after planned removal of the endotracheal tube, occurs in up to 20% of critically ill patients and is associated with prolonged mechanical ventilation, longer intensive care unit (ICU) stay, and increased mortality. Current assessments of extubation readiness focus primarily on respiratory performance and do not routinely evaluate upper airway protective function.\n\nThe Airway Protection for Extubation (APEX) score is a bedside assessment tool based on swallowing biomechanics designed to evaluate airway protection before extubation. In a pilot prospective cohort study, the APEX score demonstrated promising performance for identifying patients at increased risk of extubation failure.\n\nThis prospective multicenter cohort study will be conducted across ICUs in Brazil to externally validate the APEX score in critically ill adults undergoing planned extubation. The study will evaluate the discrimination, calibration, and clinical utility of the APEX score for predicting extubation failure and will assess its performance across different patient populations and hospital settings.\n\nThe results of this study may support the incorporation of a simple bedside assessment of swallowing biomechanics into extubation readiness evaluation and contribute to more individualized decision-making regarding extubation in critically ill patients.",[174,26,175],"Extubation Failure","Critical Illness","2026-06-15",{"date":178,"type":38},"2026-06-22",{"date":180,"type":22},"2027-03-30",{"date":182,"type":22},"2030-10-30",{"name":184,"class":45},"Universidade Federal de Pernambuco",{"id":186,"slug":187,"hasResults":12,"nctId":188,"briefTitle":189,"officialTitle":190,"acronym":191,"eligibilityCriteria":192,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":193,"targetDuration":4,"studyType":57,"phases":195,"briefSummary":196,"conditions":197,"keywords":198,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":176,"lastUpdatePostDateStruct":205,"startDateStruct":207,"completionDateStruct":209,"leadSponsor":211,"locationsCount":78},"100620470","effect-of-post-suction-recruitment-on-lung-volume-in-mechanically-ventilated-icu-patients-100620470","NCT07358039","Effect of Post-suction Recruitment on Lung Volume in Mechanically Ventilated ICU Patients","Impact of a Recruitment Maneuver After Closed Endotracheal Suctioning on End-expiratory Lung Volume in Mechanically Ventilated ICU Patients Assessed by Electrical Impedance Tomography","RESPIRE","Inclusion Criteria:\n\n* Adults aged ≥18 years\n* Covered by national health insurance\n* Admitted to the intensive care unit\n* Intubated and mechanically ventilated\n* Neuromuscular blockade at inclusion\n* Written informed consent obtained from a legally authorized representative or next of kin\n\nExclusion Criteria:\n\n* Contraindication to electrical impedance tomography (e.g. pacemaker, implantable cardioverter-defibrillator, or implanted electrical stimulation device)\n* Contraindication to recruitment maneuvers (e.g. emphysema, undrained pneumothorax, hemodynamic instability)\n* Refractory intracranial hypertension\n* Acute respiratory distress syndrome requiring prone positioning\n* Pregnant or breastfeeding women\n* Patients deprived of liberty or under legal protection\n* Any condition judged by the investigator to interfere with study evaluation",{"count":194,"type":22},32,[59],"Patients who are intubated and mechanically ventilated in the intensive care unit (ICU) require repeated endotracheal suctioning to remove airway secretions. Although this procedure is necessary, it can cause a temporary collapse of lung units (alveolar derecruitment), leading to a decrease in lung volume and impaired oxygenation.\n\nA recruitment maneuver consists of briefly applying a higher airway pressure after suctioning in order to reopen collapsed lung areas and restore lung volume. However, the clinical benefit of performing a recruitment maneuver systematically after suctioning remains uncertain.\n\nThis study aims to evaluate whether performing a recruitment maneuver immediately after closed-circuit endotracheal suctioning improves lung volume compared with suctioning alone. Lung volume will be assessed using electrical impedance tomography (EIT), a non-invasive bedside imaging technique that allows real-time monitoring of lung aeration.\n\nIn a randomized crossover design, each patient will undergo two suctioning procedures: one followed by a recruitment maneuver and one without, in a random order. The main outcome will be the change in end-expiratory lung volume 15 minutes after suctioning. The results may help optimize ventilatory care in mechanically ventilated ICU patients.",[26],[199,200,201,202,203,204],"Endotracheal suction","Alveolar recruitment","Electrical impedance tomography","End-expiratory lung volume","Intensive care","Mechanical ventilation",{"date":206,"type":38},"2026-06-16",{"date":208,"type":38},"2026-04-02",{"date":210,"type":22},"2027-04",{"name":212,"class":45},"Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer",{"id":214,"slug":215,"hasResults":12,"nctId":216,"briefTitle":217,"officialTitle":217,"acronym":218,"eligibilityCriteria":219,"healthyVolunteers":12,"sex":18,"minAge":4,"maxAge":19,"enrollmentInfo":220,"targetDuration":4,"studyType":57,"phases":222,"briefSummary":224,"conditions":225,"keywords":227,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":176,"lastUpdatePostDateStruct":231,"startDateStruct":233,"completionDateStruct":234,"leadSponsor":236,"locationsCount":78},"100609285","phase-2-biomarker-and-renal-angina-validation-to-assess-heart-kidney-outcomes-after-amino-acid-therapy-100609285","NCT07212595","Biomarker and Renal Angina Validation to Assess Heart-Kidney Outcomes After Amino Acid Therapy","BRAVE-HEART","Inclusion Criteria:\n\n* Expected to be at high risk of developing acute kidney injury after cardiac surgery based on Age, The Society of Thoracic Surgeons-European Association for Cardio-Thoracic Surgery (STAT) score, and anticipated cardiopulmonary bypass time\n* Age less than or equal to 18 years\n* Weight greater than or equal to 5 kilograms\n\nExclusion Criteria:\n\n* Preoperative extracorporeal organ support\n* History of chronic kidney disease\n* Known or suspected inborn errors of amino acid metabolism\n* Known hypersensitivity to amino acids\n* Aspartate Aminotransferase (AST) or Alanine Aminotransferase (ALT) \\> 3 times the upper limit of normal for age\u002Fgender\n* Preterm infants less than 6 months of age who were born at less than 36 weeks gestational age\n* Anuria at the time of randomization\n* Expected use of total parental nutrition (TPN) within the first 72 hours post-operatively",{"count":221,"type":22},30,[223],"PHASE2","The goal of the BRAVE-HEART study is to learn if an amino acid infusion can reduce the risk of developing acute kidney injury after cardiac surgery in children. The main questions it aims to answer are:\n\n1. Does an amino acid infusion decrease the number of participants with acute kidney injury?\n2. Does an amino acid infusion decrease the number of days that participants are on a ventilator after cardiac surgery?\n\nResearchers will compare amino acids to a placebo (a look-alike substance that contains no drug) to see if amino acids decrease the number of participants with acute kidney injury.\n\nParticipants will receive an amino acid or placebo infusion for up to 72 hours starting during cardiac surgery and only while in the operating room or the intensive care unit.",[226,26],"Acute Kidney Injury",[228,229,226,230],"Cardiac Bypass","Pediatric","Amino Acids",{"date":232,"type":38},"2026-06-17",{"date":71,"type":22},{"date":235,"type":22},"2027-12-31",{"name":237,"class":45},"Dana Fuhrman",{"id":239,"slug":240,"hasResults":12,"nctId":241,"briefTitle":242,"officialTitle":243,"acronym":4,"eligibilityCriteria":244,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":245,"targetDuration":4,"studyType":57,"phases":247,"briefSummary":248,"conditions":249,"keywords":255,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":266,"lastUpdatePostDateStruct":267,"startDateStruct":269,"completionDateStruct":270,"leadSponsor":272,"locationsCount":78},"100641181","compare-vent-feasibility-pilot-study-100641181","NCT07656259","COMPARE-VENT Feasibility Pilot Study","COMPARE-VENT Feasibility Pilot Study: A Pragmatic Cluster Randomized Crossover Trial for Ventilation Strategies and Hemodynamic Impact in Critically Ill Patients With Cardiovascular Disease","Inclusion Criteria:\n\nEligible adults ≥ 18 years of age admitted to the cardiac ICU with need for invasive mechanical ventilation of expected duration \\>12 hours.\n\nPre-Specified Subgroups for exploratory outcomes:\n\n1. SCAI Stages C-E Cardiogenic Shock\n2. Mechanical circulatory support use, including intra-aortic balloon pumps and microaxial flow pumps, including Impella CP, RP Impella Flex, and Impella 5.5 devices\n3. Heart failure with reduced ejection fraction: LVEF \\\u003C40% or;\n4. Moderate to severe RV systolic dysfunction or;\n5. Moderate to severe Pulmonary hypertension, as defined by ACC\u002FAHA\u002FESC guidelines\n\nExclusion Criteria:\n\n1. Expected duration of intubation \\\u003C12 hours.\n2. Severe COPD, bronchopleural fistulas, or severe ARDS (Berlin criteria P\u002FF \\\u003C100, in the absence of pulmonary edema)\n3. Home ventilator or chronic tracheostomy.\n4. Pregnant, incarcerated, patients or those receiving extracorporeal membrane oxygenation",{"count":246,"type":22},75,[59],"Cardiac disease complicated by respiratory insufficiency comprises the most frequent indication for cardiac intensive care unit (CICU) admission, with nearly one-third patients requiring advanced respiratory support and over 20% patients requiring invasive mechanical ventilation (IMV). IMV among patients with impaired cardiovascular reserve is further compounded by the adverse impact of positive pressure ventilation (PPV) and systemic sedation on intracardiac hemodynamics, pulmonary vascular mechanics and consequently end-organ perfusion. Despite widespread use, evidence guiding optimal ventilatory practices and mode selection in cardiovascular intensive care unit patients remains limited. Pressure-controlled and volume-controlled ventilation may differ in their effects on patient-ventilator synchrony, sedation requirements, and hemodynamic impact, but comparative data among patients with critical cardiac disease remains inconclusive. This pilot study will evaluate the feasibility of implementing a pragmatic cluster-randomized crossover trial comparing ventilatory modes in a contemporary cardiovascular intensive care unit.",[250,251,252,175,26,253,254],"Respiration Failure","Cardio Vascular Disease","Cardiogenic Pulmonary Oedema","Cardiogenic Shock","Cardiopulmonary",[256,257,258,259,260,261,262,263,264,204,265],"Cardiovascular disease","Cardiac arrest","Cardiogenic shock","Respiratory failure","Cardiopulmonary interactions","Critical illness","Intensive care unit","Critical care therapies","Outcomes","Positive pressure ventilation","2026-06-14",{"date":268,"type":38},"2026-06-18",{"date":71,"type":22},{"date":271,"type":22},"2027-06-30",{"name":273,"class":45},"Mayo Clinic",{"id":275,"slug":276,"hasResults":12,"nctId":277,"briefTitle":278,"officialTitle":279,"acronym":4,"eligibilityCriteria":280,"healthyVolunteers":12,"sex":281,"minAge":19,"maxAge":282,"enrollmentInfo":283,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":285,"conditions":286,"keywords":290,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":294,"lastUpdatePostDateStruct":295,"startDateStruct":297,"completionDateStruct":299,"leadSponsor":301,"locationsCount":78},"100643495","intraoperative-driving-pressure-and-postoperative-lung-ultrasound-score-in-robot-assisted-radical-prostatectomy-100643495","NCT07610824","Intraoperative Driving Pressure and Postoperative Lung Ultrasound Score in Robot-Assisted Radical Prostatectomy","Evaluation of the Relationship Between Intraoperative Driving Pressure and Postoperative Lung Ultrasound Score in Patients Undergoing Robot-Assisted Laparoscopic Radical Prostatectomy","Inclusion Criteria:\n\n* Male patients aged between 18 and 80 years.\n\nScheduled for elective robot-assisted laparoscopic radical prostatectomy.\n\nAmerican Society of Anesthesiologists (ASA) physical status I, II, or III.\n\nWillingness to provide written informed consent.\n\nExclusion Criteria:\n\n* Patient refusal to participate.\n\nSevere obstructive or restrictive pulmonary disease (e.g., severe COPD, uncontrolled asthma).\n\nBody Mass Index (BMI) \\> 35 kg\u002Fm\\^2.\n\nPre-existing severe lung pathology or active pulmonary infection.\n\nHemodynamic instability or severe cardiovascular disease (e.g., severe heart failure, recent myocardial infarction).\n\nRequirement for postoperative mechanical ventilation.\n\nEmergency surgery.","MALE","80 Years",{"count":284,"type":22},76,"The primary objective of this study is to evaluate the relationship between intraoperative driving pressure and postoperative lung ultrasound scores in patients undergoing robot-assisted laparoscopic radical prostatectomy. During this specific surgery, factors such as pneumoperitoneum and patient positioning can significantly affect respiratory mechanics. Postoperative lung condition will be objectively assessed using the lung ultrasound score (LUS). The findings may provide valuable insights for optimizing intraoperative mechanical ventilation strategies.",[26,62,287,288,289],"Prostatic Neoplams","Driving Pressure","Lung Ultrasonography Score",[291,292,293],"driving pressure","lung ultrasonography score","postoperative pulmonary comlications","2026-06-09",{"date":296,"type":38},"2026-06-11",{"date":298,"type":22},"2026-05-30",{"date":300,"type":22},"2026-09-15",{"name":302,"class":303},"Ankara Etlik City Hospital","OTHER_GOV",{"id":305,"slug":306,"hasResults":12,"nctId":307,"briefTitle":308,"officialTitle":308,"acronym":4,"eligibilityCriteria":309,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":310,"enrollmentInfo":311,"targetDuration":4,"studyType":57,"phases":313,"briefSummary":314,"conditions":315,"keywords":317,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":294,"lastUpdatePostDateStruct":319,"startDateStruct":320,"completionDateStruct":322,"leadSponsor":324,"locationsCount":78},"100642713","the-impact-of-ventilator-synchrony-on-muscle-relaxant-consumption-and-surgeon-satisfaction-during-laparoscopic-cholecystectomy-100642713","NCT07647770","The Impact of Ventilator Synchrony on Muscle Relaxant Consumption and Surgeon Satisfaction During Laparoscopic Cholecystectomy.","Inclusion Criteria:\n\n* Adults aged 18-60 years undergoing elective laparoscopic cholecystectomy.\n* ASA (American Society of Anesthesiologists) physical status I-II\n* BMI 18-35 kg\u002Fm²\n\nExclusion Criteria:\n\n* Severe COPD or restrictive lung disease\n* Neuromuscular disorders\n* Emergency surgery\n* Morbid obesity","60 Years",{"count":312,"type":22},60,[59],"The goal of this clinical trial is to investigate the Impact of adding SIMV Synchronization to our standard PCV-VG mode of ventilation on muscle relaxant consumption, the frequency of relaxant top-ups and surgeon satisfaction during Laparoscopic Cholecystectomy surgeries in ASA I\\&II. The main question it aims to answer is do Ventilator synchrony (PCV-VG+SIMV) reduces muscle relaxant consumption and improves surgeon satisfaction by minimizing the perception of inadequate paralysis?\n\nPrimary hypothesis: Ventilator synchrony (PCV-VG+SIMV) reduces muscle relaxant consumption and improves surgeon satisfaction by minimizing the perception of inadequate paralysis.\n\nPrimary outcome;\n\n1. Compare total intraoperative rocuronium consumption (mg\u002Fkg) between PCV-VG and PCV-VG + SIMV\n2. To determine the frequency of additional muscle relaxant requests",[316,26,92],"Muscle Relaxant Consumption",[318],"ventilator synchrony, muscle relaxant, laparoscopic cholecystectomy",{"date":176,"type":38},{"date":321,"type":22},"2026-08",{"date":323,"type":22},"2029-06",{"name":325,"class":45},"Hitham Mohammed Aly Elsayed",{"id":327,"slug":328,"hasResults":12,"nctId":329,"briefTitle":330,"officialTitle":331,"acronym":4,"eligibilityCriteria":332,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":333,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":335,"conditions":336,"keywords":339,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":345,"lastUpdatePostDateStruct":346,"startDateStruct":347,"completionDateStruct":349,"leadSponsor":350,"locationsCount":78},"100642406","flow-controlled-vs-volume-controlled-ventilation-in-morbidly-obese-patients-undergoing-laparoscopic-bariatric-surgery-100642406","NCT07641829","Flow-Controlled vs Volume-Controlled Ventilation in Morbidly Obese Patients Undergoing Laparoscopic Bariatric Surgery","Investigation of the Effects of Flow-Controlled Ventilation and Volume-Controlled Ventilation on Pulmonary Dynamics and Hemodynamics in Morbidly Obese Patients Undergoing Laparoscopic Bariatric Surgery","Inclusion Criteria:\n\n* Age between 18 and 65 years American Society of Anesthesiologists (ASA) physical status I, II, or III Body Mass Index (BMI) ≥ 40 kg\u002Fm² Scheduled for elective laparoscopic bariatric surgery Willing to participate in the study\n\nExclusion Criteria:\n\n* ASA physical status IV or V Emergency surgical procedures Pregnant patients Patients requiring vasopressor support to maintain mean arterial pressure above 65 mmHg intraoperatively Patients with advanced pulmonary disease Patients who decline to participate in the study",{"count":334,"type":22},34,"The goal of this clinical trial is to compare the effects of flow-controlled ventilation (FCV) and volume-controlled ventilation (VCV) on hemodynamic and respiratory parameters in obese patients undergoing elective laparoscopic bariatric surgery. The main questions it aims to answer are:\n\nDoes FCV provide better intraoperative hemodynamic and respiratory stability compared to VCV during laparoscopic bariatric surgery? Is FCV a safe and feasible ventilation strategy under high intraabdominal pressure and position changes required in bariatric surgery?\n\nResearchers will compare FCV group to VCV group to see if FCV improves intraoperative respiratory mechanics and hemodynamic parameters.\n\nParticipants will:\n\nUndergo elective laparoscopic bariatric surgery with BMI \\>40 kg\u002Fm² (ASA I-III) Receive either flow-controlled or volume-controlled ventilation with individualized PEEP and tidal volume of 6-8 ml\u002Fkg predicted body weight Have intraoperative hemodynamic and respiratory parameters monitored at regular intervals, including arterial blood gas analysis Be followed postoperatively for oxygen therapy requirement and intensive care need",[337,338,26],"Obesity, Morbid","Bariatric Surgery (Sleeve Gastrectomy )",[340,341,342,343,344],"Flow-controlled ventilation","Volume-controlled ventilation","Respiratory mechanics","Lung-protective ventilation","Bariatric surgery","2026-06-07",{"date":296,"type":38},{"date":348,"type":38},"2026-03-15",{"date":321,"type":22},{"name":351,"class":45},"Ankara Training and Research Hospital",{"id":353,"slug":354,"hasResults":12,"nctId":355,"briefTitle":356,"officialTitle":357,"acronym":358,"eligibilityCriteria":359,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":360,"targetDuration":362,"studyType":23,"phases":4,"briefSummary":363,"conditions":364,"keywords":366,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":375,"lastUpdatePostDateStruct":376,"startDateStruct":378,"completionDateStruct":380,"leadSponsor":382,"locationsCount":384},"100640429","patient-ventilator-asynchrony-occurence-and-clinical-impact-in-usual-care-100640429","NCT07624786","Patient-Ventilator Asynchrony: Occurence and Clinical Impact in Usual Care","Unraveling the Clinical Impact of Patient-Ventilator Asynchrony in Usual Care","PVA-detection","Inclusion Criteria:\n\n* Age \\> 18 years old.\n* Recordings available of ventilator waveforms synchronized with the patient's electronic health record during invasive mechanical ventilation.\n* Duration of mechanical ventilation of at least 24 hours.\n\nExclusion Criteria:\n\n* (Previous) registered objection of patient and\u002For relatives to re-use clinical data for research purposes\n* No consent for re-use of data for research",{"count":361,"type":22},110,"3 Months","The goal of this observational study is to unravel the occurence, impact and relations of Patient-Ventilator Aynchrony (PVA) in mechanically ventilated patients. The main questions it aims to answer are:\n\n* How often does PVA occur?\n* What are relations between clinical characteristics and PVA occurence?\n* What are relations between PVA occurence and patient outcomes?\n\nAll questions will be assessed using data collected during the whole course of mechanical ventilation. Mechanically ventilated patients' medical data will be re-used. PVAs will be automatically classified on ventilator waveform data, using validated Deep Breath software.",[26,365],"Patient-Ventilator Asynchrony",[367,368,369,370,125,371,372,373,117,374],"asynchrony","Patient-ventilator asynchrony","dyssynchrony","Patient-ventilator interaction","AI","algorithm","classification algorithm","Artificial intelligence","2026-05-29",{"date":377,"type":38},"2026-06-03",{"date":379,"type":22},"2026-06",{"date":381,"type":22},"2027-02",{"name":383,"class":45},"Erasmus Medical Center",3,{"id":386,"slug":387,"hasResults":12,"nctId":388,"briefTitle":389,"officialTitle":389,"acronym":4,"eligibilityCriteria":390,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":391,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":393,"conditions":394,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":398,"lastUpdatePostDateStruct":399,"startDateStruct":401,"completionDateStruct":403,"leadSponsor":405,"locationsCount":78},"100639949","right-ventricular-function-and-respiratory-acidosis-after-cardiac-surgery-100639949","NCT07619274","Right Ventricular Function and Respiratory Acidosis After Cardiac Surgery","Inclusion Criteria:\n\n* Previously included and complete study NCT05886413 or NCT06826794\n\nExclusion Criteria:\n\n* Absence of one or more of the following hemodynamic measurements: systolic or diastolic pulmonary artery pressure, central venous pressure, cardiac output\n* Absence of arterial blood gas on arrival to the intensive care unit",{"count":392,"type":22},220,"Right heart dysfunction remains a frequent cause of morbidity and mortality after cardiac surgery. Respiratory acidosis, particularly when accompanied by hypoxemia, plays a significant role in right heart failure, primarily by increasing right ventricular afterload through pulmonary vasoconstriction and elevated pulmonary arterial pressures. This phenomenon leads to increased right ventricular workload, causing dilation, decreased contractility, and ultimately right heart failure. The study aims to evaluate the effect of respiratory acidosis on right ventricular function after cardiac surgery.",[395,396,397,26],"Respiratory Acidosis in ICU Patients","Right Ventricular (RV) Dysfunction","Hemodynamic Changes","2026-05-28",{"date":400,"type":38},"2026-06-01",{"date":402,"type":22},"2026-05",{"date":404,"type":22},"2026-10",{"name":406,"class":45},"Laval University",{"id":408,"slug":409,"hasResults":12,"nctId":410,"briefTitle":411,"officialTitle":412,"acronym":4,"eligibilityCriteria":413,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":414,"enrollmentInfo":415,"targetDuration":4,"studyType":57,"phases":416,"briefSummary":417,"conditions":418,"keywords":420,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":398,"lastUpdatePostDateStruct":422,"startDateStruct":423,"completionDateStruct":424,"leadSponsor":426,"locationsCount":78},"100639262","flow-controlled-versus-volume-controlled-ventilation-in-lumbar-disc-herniation-surgery-100639262","NCT07614555","Flow-Controlled Versus Volume-Controlled Ventilation in Lumbar Disc Herniation Surgery","Comparison of Flow-Controlled and Volume-Controlled Ventilation During Lumbar Disc Herniation Surgery: A Prospective Randomized Trial","Inclusion Criteria:\n\n* Age between 18 and 65 years\n* ASA physical status I-III\n* Body Mass Index between 18 and 30 kg\u002Fm²\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years or \\> 65 years\n* Known or previously diagnosed pulmonary disease\n* Patients with severe preoperative pulmonary function impairment (e.g., FEV₁ \\\u003C 50% predicted, severe restrictive or obstructive pathology)\n* Patients with markedly altered lung anatomy or function due to prior major thoracic surgery\n* Patients who were dependent on supplemental oxygen therapy in the preoperative period\n* ASA physical status IV or higher\n* Refusal or inability to provide informed consent","65 Years",{"count":88,"type":22},[59],"This prospective randomized trial aims to compare the effects of flow-controlled ventilation (FCV) and volume-controlled ventilation (VCV) on intraoperative airway pressures and oxygenation in patients undergoing lumbar disc herniation surgery under general anesthesia.\n\nAdult patients aged 18-65 years, with ASA physical status I-III and a body mass index of 18-30 kg\u002Fm², will be allocated to receive either FCV or VCV during routine intraoperative mechanical ventilation. Ventilatory parameters, including peak airway pressure, plateau pressure, pulmonary compliance, EtCO₂, SpO₂, and arterial blood gas variables, will be recorded at predefined time points after intubation.\n\nThe primary endpoint is the PaO₂ value measured after 20 minutes in the prone position.\n\nBy comparing respiratory mechanics and oxygenation between the two ventilation modes, this study aims to contribute to the optimization of intraoperative ventilatory management in lumbar disc herniation surgery.",[419,26],"Lumbar Disc Herniation Surgery",[64,421,419],"Volume-Controlled Ventilation",{"date":400,"type":38},{"date":398,"type":38},{"date":425,"type":22},"2026-11-26",{"name":302,"class":303},{"id":428,"slug":429,"hasResults":12,"nctId":430,"briefTitle":431,"officialTitle":432,"acronym":4,"eligibilityCriteria":433,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":434,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":435,"conditions":436,"keywords":437,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":441,"lastUpdatePostDateStruct":442,"startDateStruct":443,"completionDateStruct":444,"leadSponsor":446,"locationsCount":78},"100640550","the-geniohyoid-muscle-in-critical-illness-100640550","NCT07606690","The Geniohyoid Muscle in Critical Illness","Assessing the Feasibility and Reliability of an Ultrasound-based Method of Measuring the Geniohyoid Muscle in Mechanically Ventilated Patients - an Observational Study","Inclusion Criteria:\n\n* · Mechanically ventilated patient on the intensive care unit\n\n  * Endotracheal tube via the mouth in-situ (size 7.0 and above)\n  * Can be recruited at any time during their admission\n\nExclusion Criteria:\n\n* · Ventilated via a nasal endotracheal tube\n\n  * Ventilated via a tracheostomy\n  * Ventilated via a micro-endotracheal tube\n  * Any previous or active history of head and neck cancer\n  * Any previous head and neck surgery (excluding tonsillectomy and adenoidectomy)\n  * Any cranio-facial deformity that would render access to the jaw difficult, including but not limited to short thymo-mental distance\n  * Any neuromuscular disorder, including previous stroke\n  * Any previous history of dysphagia or swallowing disorder\n  * Pregnant patients\n  * Patients under 18 years of age\n  * Agitation or movement that would make measurement difficult or inaccurate",{"count":221,"type":22},"Many patients lose muscle due to being unwell in an intensive care unit. This muscle loss can lead to weakness of the arms and legs when they leave the unit, and when they go home. For many years investigators have measured the size of these arm and leg muscles using an ultrasound machine, to take a picture of the muscles.\n\nIt is also known that patients who are on a ventilator (or \"breathing machine\") often have problems swallowing when the breathing tube is removed from their mouth. This may be because the muscles of swallowing may also shrink. One of these muscles sits under the jaw and can be measured with ultrasound - the method has been shown to be accurate and reliable in awake volunteers, but these volunteers are usually sat upright in a chair with their mouth closed.\n\nBefore it can be assed whether these muscles get smaller, it is needed to assess whether the chosen method is suitable in patients on a ventilator; these patients are lying in bed, and their mouths are open slightly due to the breathing tube.\n\nProposed Method\n\nThis investigation will measure the size of a muscle under the jaw (called the geniohyoid muscle) in patients who are sedated and have a breathing tube in their mouth connected to a ventilator.\n\nUsing a normal hospital ultrasound machine, one researcher will place the ultrasound probe under the patient's jaw. When the researcher is happy the probe is in the right place, they will take a picture of the muscle and measure its size and thickness. After a short break, the researcher will repeat this process. After a second short break, another researcher who did not watch the first researcher will also place the probe under the jaw and take a picture of the muscle.\n\nThese measurements can be used to to answer the following questions:\n\n1. How many patients scanned produced images that could be measured?\n2. How consistent are the measurements if one person measures the same muscle twice?\n3. If two people measure the same muscle, do their measurements agree with each other?\n\nThe patients will be under sedation when they take part in the study. Because of this, they cannot consent to take part in the study. The patient's next of kin or carer would advise on whether the patient would want to take part. When the patient is awake and has the breathing tube removed, the research team would ask them to sign a consent form to use their data.",[26],[125,438,439,440],"ultrasound","swallowing","geniohyoid","2026-05-22",{"date":398,"type":38},{"date":400,"type":22},{"date":445,"type":22},"2027-06-01",{"name":447,"class":45},"Warrington Hospital",{"id":449,"slug":450,"hasResults":12,"nctId":451,"briefTitle":452,"officialTitle":452,"acronym":4,"eligibilityCriteria":453,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":454,"enrollmentInfo":455,"targetDuration":4,"studyType":57,"phases":457,"briefSummary":458,"conditions":459,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":441,"lastUpdatePostDateStruct":462,"startDateStruct":464,"completionDateStruct":466,"leadSponsor":468,"locationsCount":470},"100477083","personalized-mechanical-ventilation-guided-by-ultrasound-in-patients-with-acute-respiratory-distress-syndrome-100477083","NCT05492344","Personalized Mechanical Ventilation Guided by UltraSound in Patients With Acute Respiratory Distress Syndrome","Inclusion Criteria:\n\n* Admitted to a participating ICU,\n* invasively ventilated and\n* fulfil the Berlin criteria for moderate or severe ARDS.\n\nExclusion Criteria:\n\n* Age under 18,\n* participation in other interventional studies with conflicting endpoints,\n* conditions in which LUS is not feasible or possible (e.g. subcutaneous emphysema, morbid obesity or wounds),\n* mechanical ventilation for longer than 7 consecutive days in the past 30 days,\n* history of ARDS in the previous month,\n* body-mass index higher than 40 kg\u002Fm²,\n* intracranial hypertension,\n* broncho-pleural fistula,\n* chronic respiratory diseases requiring long-term oxygen therapy or respiratory support,\n* pulmonary fibrosis with a vital capacity \\\u003C 50% (severe or very severe),\n* previously randomized in the PEGASUS study\n* ECMO\n* patients who receive invasive ventilation in home setting due to a neurological disease\n* pregnant patients\n* patients who are moribund or facing end of life and\n* no informed consent.","100 Years",{"count":456,"type":22},538,[59],"Rationale Acute respiratory distress syndrome (ARDS) is a frequent cause of hypoxemic respiratory failure with a mortality rate of approximately 30%. The identification of ARDS phenotypes, based on focal or non-focal lung morphology, can be helpful to better target mechanical ventilation strategies of individual patients. Lung ultrasound (LUS) is a non-invasive tool that can accurately distinguish 'focal' from 'non-focal' lung morphology. The investigators hypothesize that LUS-guided personalized mechanical ventilation in ARDS patients will lead to a reduction in 90-day mortality compared to conventional mechanical ventilation.",[460,461,26],"ARDS, Human","Lung Ultrasound",{"date":463,"type":38},"2026-05-27",{"date":465,"type":38},"2022-08-09",{"date":467,"type":22},"2027-11-01",{"name":469,"class":45},"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)",10,{"id":472,"slug":473,"hasResults":12,"nctId":474,"briefTitle":475,"officialTitle":476,"acronym":4,"eligibilityCriteria":477,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":478,"targetDuration":4,"studyType":57,"phases":480,"briefSummary":481,"conditions":482,"keywords":484,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":486,"lastUpdatePostDateStruct":487,"startDateStruct":488,"completionDateStruct":489,"leadSponsor":491,"locationsCount":4},"100640158","bronchoscopic-airway-clearance-for-improving-lung-aeration-in-mechanically-ventilated-patients-with-atelectasis-100640158","NCT07594379","Bronchoscopic Airway Clearance for Improving Lung Aeration in Mechanically Ventilated Patients With Atelectasis","Effect of Bedside Flexible Bronchoscopy-Guided Airway Clearance on Lung Aeration in Mechanically Ventilated Patients With Atelectasis: A Multicenter Randomized Controlled Trial","Inclusion Criteria:\n\n1. Age 18 years or older\n2. Receiving invasive mechanical ventilation for at least 48 hours\n3. Presence of atelectasis confirmed by chest computed tomography, chest X-ray, or lung ultrasound\n4. High airway secretion burden, defined as requiring airway suctioning at least twice per hour during the previous 8 hours\n5. Written informed consent obtained from the participant or legally authorized representative\n\nExclusion Criteria:\n\n1. Expected duration of artificial airway maintenance less than 5 days\n2. Untreated tension pneumothorax Known or suspected aspiration\n3. Active intrapulmonary hemorrhage\n4. Severe dysfunction of other organs with expected short-term mortality within 7 days or need for palliative care\n5. Any other condition judged by the medical team to make the participant unsuitable for the study\n6. Informed consent not obtained",{"count":479,"type":22},104,[59],"The goal of this clinical trial is to learn whether bedside flexible bronchoscopy-guided airway clearance can improve lung aeration in adult patients who are receiving invasive mechanical ventilation and have atelectasis with a high airway secretion burden.\n\nThe main questions it aims to answer are:\n\nDoes bedside flexible bronchoscopy-guided airway clearance reduce the proportion of nonaerated lung tissue from baseline to day 5? Does this treatment improve other lung aeration measures, respiratory mechanics, arterial blood gas parameters, pulmonary infection score, ventilator-free days, intensive care unit length of stay, and safety outcomes?\n\nResearchers will compare usual airway care plus bedside flexible bronchoscopy-guided airway clearance with usual airway care alone to see if bronchoscopy-guided airway clearance improves lung aeration and clinical outcomes.\n\nParticipants will be randomly assigned to one of two groups. Participants in the usual care group will receive standard airway management, which may include airway suctioning, postural drainage, humidification, chest physiotherapy, and other routine respiratory care. Participants in the bronchoscopy group will receive the same usual care, plus bedside flexible bronchoscopy-guided airway clearance when predefined criteria for high airway secretion burden are met.\n\nParticipants will have clinical assessments during the study, including chest imaging, respiratory mechanics measurements, arterial blood gas tests, pulmonary infection score assessment, and safety monitoring. The main assessment will compare quantitative chest computed tomography findings at baseline and day 5 to evaluate changes in nonaerated lung tissue.",[483,26],"Atelectasis",[483,26,485],"Airway Secretion Retention","2026-05-21",{"date":463,"type":38},{"date":400,"type":22},{"date":490,"type":22},"2028-06-01",{"name":492,"class":45},"Southeast University, China",{"id":494,"slug":495,"hasResults":12,"nctId":496,"briefTitle":497,"officialTitle":498,"acronym":499,"eligibilityCriteria":500,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":501,"targetDuration":4,"studyType":57,"phases":503,"briefSummary":504,"conditions":505,"keywords":518,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":524,"lastUpdatePostDateStruct":525,"startDateStruct":527,"completionDateStruct":528,"leadSponsor":530,"locationsCount":78},"100614048","amnioinfusions-protective-effects-on-respiratory-and-longitudinal-pediatric-outcomes-after-intrapartum-thick-meconium-exposure-100614048","NCT07274527","Amnioinfusion's Protective Effects on Respiratory and Longitudinal Pediatric Outcomes After Intrapartum Thick Meconium Exposure","The PEARL Trial: A Randomized Trial of Amnioinfusion's Protective Effects on Respiratory and Longitudinal Pediatric Outcomes After Intrapartum Thick Meconium Exposure","PEARL","Inclusion Criteria:\n\n* Maternal age greater than or equal to 18 years old\n* Singleton pregnancy\n* Gestational age of greater than or equal to 36 weeks 0 days gestation\n* Cephalic presentation\n* Cercial dilation between 2-10 centimeters\n* Meconium\n\nExclusion Criteria:\n\n* Major fetal anomaly\n* Multiple gestation\n* Eunice Kennedy Shrive National Institute of Child Health and Human Developmet (NICHD) Category III fetal heart tracing\n* Contraindication to internal monitors\n* Prelabor premature ruptuore of membranes before 36 weeks 0 days gestation, - Inability to consent",{"count":502,"type":22},320,[59],"Thick meconium in the amniotic fluid occurs in about one out of seven pregnancies and increases the chance that a newborn may have breathing problems after birth. These problems can include the need for oxygen, breathing support, admission to the neonatal intensive care unit (NICU), or, in severe cases, meconium aspiration syndrome or persistent pulmonary hypertension.\n\nAlthough amnioinfusion or placing sterile fluid into the uterus during labor was previously studied as a way to reduce these complications, earlier research had major limitations. Past studies included all types of meconium, used different fluid types and temperatures, had inconsistent protocols, and did not measure biomarkers of inflammation or look at long-term outcomes. As a result, it is still unclear whether a modern, standardized approach to amnioinfusion can meaningfully improve newborn health when the meconium is truly thick.\n\nThe PEARL Trial is a randomized clinical trial designed to answer this question. The study will enroll pregnant individuals at or beyond 36 weeks of gestation who develop thick meconium-stained amniotic fluid, confirmed using a simple, objective measurement (\"meconium-crit\"). Participants will be randomly assigned to receive either:\n\nWarm lactated Ringer's (LR) amnioinfusion through an intrauterine pressure catheter (IUPC), following a standardized protocol, or standard care without amnioinfusion.\n\nThe main goal is to determine whether warm LR amnioinfusion reduces short-term breathing problems in newborns. The study also collects umbilical cord blood at birth to evaluate markers of inflammation and potential brain injury, which may help explain why some infants develop complications. Families will also be contacted when their child is 12 months old to complete a developmental questionnaire that is widely used in pediatric practice.\n\nBy using a clear definition of thick meconium, a warm LR infusion protocol, fidelity checklists, and long-term follow-up, this trial aims to provide high-quality evidence to guide care in labor and delivery units nationwide.",[506,507,508,509,510,511,512,26,513,514,515,516,517],"Neonatal Respiratory Distress Related Conditions","Meconium","Perinatal Morbidity","Neonatal Acidosis","Cord Blood","Neonatal Brain Injury","Maternal Morbidity","CPAP","Surfactant","Perinatal Death","Amnioinfusion","NICU Admission",[516,507,519,520,512,521,522,523],"Neonatal morbidity","Developmental Screening","Neonatal respiratory morbidity","Umbilical cord gas and biomarkers","Healthcare Utilization","2026-05-15",{"date":526,"type":38},"2026-05-19",{"date":524,"type":38},{"date":529,"type":22},"2030-04-15",{"name":531,"class":45},"Medical College of Wisconsin",{"id":533,"slug":534,"hasResults":12,"nctId":535,"briefTitle":536,"officialTitle":537,"acronym":538,"eligibilityCriteria":539,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":540,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":541,"conditions":542,"keywords":548,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":553,"lastUpdatePostDateStruct":554,"startDateStruct":555,"completionDateStruct":557,"leadSponsor":559,"locationsCount":78},"100516838","diaphragmatic-speckle-tracking-during-spontaneous-breathing-trial-100516838","NCT06009731","Diaphragmatic Speckle Tracking During Spontaneous Breathing Trial","DIAPHRAGMATIC SPECKLE TRACKING DURING SPONTANEOUS BREATHING TRIAL","DIAST","Inclusion Criteria:\n\n* Consecutive adult patients (≥18 years old) undergoing mechanical ventilation for at least 24h (regardless of the reason of intubation)\n* patients fulfilling criteria for an SBT\n* patients will have to be able to trigger ventilator breaths with a reasonable level of assistance,\n* patients with lack of severe impairment in gas exchange,\n* patients that not require significant hemodynamic support.\n* Patients will be recruited by the study coordinator following completion of informed consent from the patient or legally authorized substitute decision maker.\n\nExclusion Criteria:\n\n* Use of pressure support during the SBT.\n* Severe hemodynamic instability (\\>30% increase in vasopressors in the last 6 hours or norepinephrine \\> 0.5 µg\u002Fkg\u002Fmin).\n* Severe or very severe chronic obstructive pulmonary disease (COPD) according to the GOLD criteria (stage III: FEV1 30-50% predicted; stage IV: FEV1 \\\u003C 30% predicted).\n* Known or suspected severe or progressive neuromuscular disorder likely to result in prolonged or chronic ventilator dependence\n* Clinical judgement of the attending physician.",{"count":312,"type":22},"Currently, measurement of transdiaphragmatic pressure (Pdi) using oesophageal and gastric balloons is the gold standard for the assessment of diaphragmatic effort. This technique is relatively invasive and its interpretation may be complex. The diaphragmatic longitudinal strain (LSdi) and strain rate (LSRdi) might provide additional information in the assessment of diaphragmatic effort and movement during SBT, allowing early detection of diaphragmatic dysfunction. Patients will be monitored during a 30-120 minutes SBT consisting of no assistance on the ventilator using CPAP with a pressure level of 0 cmH2O. Parameters to evaluate diaphragm function will include diaphragmatic strain (LSdi and LSRdi), diaphragmatic thickening fraction (TFdi), and airway occlusion pressure (ΔP0.1 and ΔPocc). These parameters will be measured immediately before ('baseline') the SBT, as well as 2 minutes ('early' assessment), 15 ('intermediate' assessment) and 30 minutes ('late' assessment) after the beginning of the SBT.",[543,544,26,545,546,547],"Weaning","Spontaneous Breathing Trial","Speckle Tracking","Strains","Diaphragm",[549,550,125,551,546,552],"weaning","spontaneous breathing trial","speckle tracking","diaphragm","2026-05-12",{"date":524,"type":38},{"date":556,"type":38},"2023-06-12",{"date":558,"type":22},"2027-07",{"name":560,"class":45},"Centre Hospitalier Universitaire, Amiens",{"id":562,"slug":563,"hasResults":12,"nctId":564,"briefTitle":565,"officialTitle":566,"acronym":567,"eligibilityCriteria":568,"healthyVolunteers":12,"sex":18,"minAge":569,"maxAge":4,"enrollmentInfo":570,"targetDuration":4,"studyType":57,"phases":572,"briefSummary":573,"conditions":574,"keywords":578,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":581,"lastUpdatePostDateStruct":582,"startDateStruct":584,"completionDateStruct":586,"leadSponsor":588,"locationsCount":78},"100636648","skin-conductance-in-ventilated-preterms-100636648","NCT07568418","Skin Conductance in Ventilated Preterms","Pain Assessment Using Skin Conductance Measurement During Different Types of Invasive Ventilation in Newborn Infants","SCiP","Inclusion Criteria:\n\n* Need for mechanical ventilation\n\nExclusion Criteria:\n\n* Other distracting painful conditions\n* Facial malformation or neuromuscular disease, not allowing regular visual pain assessment","22 Weeks",{"count":571,"type":22},50,[59],"The goal of this observational study is to learn more about the pain and stress experienced by newborn infants receiving mechanical ventilation (breathing through a machine).\n\nThe main questions it aims to answer are:\n\n* Do different ventilator settings (modi) cause different degrees of pain and stress?\n* Can skin conductance measurement be used to evaluate the pain and stress caused by mechanical ventilation in newborns?\n* Can skin-to-skin care alleviate the stress caused by mechanical ventilation?\n\nParticipants will be monitored according to clinical protocol with the addition of electrodes placed on the infant's foot, measuring changes in skin conductance.",[26,575,576,577],"Pain","Skin to Skin Care","Kangaroo Mother Care",[579,575,580],"Skin Conductance Measurement","Newborn","2026-04-30",{"date":583,"type":38},"2026-05-05",{"date":585,"type":38},"2025-08-08",{"date":587,"type":22},"2028-12-31",{"name":589,"class":45},"Uppsala University Hospital",{"id":591,"slug":592,"hasResults":12,"nctId":593,"briefTitle":594,"officialTitle":595,"acronym":596,"eligibilityCriteria":597,"healthyVolunteers":86,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":598,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":600,"conditions":601,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":604,"lastUpdatePostDateStruct":605,"startDateStruct":607,"completionDateStruct":608,"leadSponsor":609,"locationsCount":78},"100635584","clinical-practices-of-extubation-after-invasive-mechanical-ventilation-100635584","NCT07554586","Clinical Practices of Extubation After Invasive Mechanical Ventilation","Clinical Practices of Extubation After Invasive Mechanical Ventilation in Anesthesia and Intensive Care","EPP\u002FEPP = 1","Inclusion Criteria:\n\n* Physicians and students in anesthesiology and critical care,\n* Critical care physicians,\n* State-certified nurse anesthetists (IADE),\n* State-certified nurses (IDE) working in an anesthesia or intensive care team\n* Students (medical or nurse anesthetist) with at least 1 year of extubation experience.\n\nExclusion Criteria:\n\n* Healthcare professionals with no experience in extubation (less than one year of practice) Refusal to participate",{"count":599,"type":22},200,"Extubation is a delicate and complex phase of airway management in anesthesia and critical care. A variety of complications are of concern, ranging from transient hypoxemia to the need for reintubation, which can then become life-threatening for the patient.\n\nFor this procedure, it may be recommended to use the positive end-expiratory pressure (PEEP) extubation technique to reduce the risks of hypoxemia, atelectasis, and aspiration. However, no specific technique is preferred given the diversity of described procedures (spontaneous ventilation on an auxiliary circuit, PEEP-assisted spontaneous ventilation, adjustment of the APL valve). However, results may vary depending on the patient population (children, adults) and the setting (operating room, intensive care unit).\n\nGiven the lack of a preferred technique for performing extubation under positive end-expiratory pressure, the aim of this study is to describe the techniques used by healthcare professionals (physicians, nurse anesthetists, nurses) during the extubation of a surgical or intensive care patient.",[26,602,603,119],"Extubation","Anesthesia","2026-04-28",{"date":606,"type":38},"2026-05-04",{"date":604,"type":22},{"date":404,"type":22},{"name":610,"class":45},"Centre Hospitalier Universitaire de Nīmes",{"id":612,"slug":613,"hasResults":12,"nctId":614,"briefTitle":615,"officialTitle":616,"acronym":617,"eligibilityCriteria":618,"healthyVolunteers":12,"sex":18,"minAge":619,"maxAge":454,"enrollmentInfo":620,"targetDuration":622,"studyType":23,"phases":4,"briefSummary":623,"conditions":624,"keywords":631,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":635,"lastUpdatePostDateStruct":636,"startDateStruct":637,"completionDateStruct":639,"leadSponsor":641,"locationsCount":78},"100600102","rehabilitation-practices-in-critically-ill-patients-receiving-invasive-mechanical-ventilation-in-the-intensive-care-unit-100600102","NCT07093125","Rehabilitation Practices in Critically Ill Patients Receiving Invasive Mechanical Ventilation in the Intensive Care Unit.","An Observational Study on Rehabilitation Practices in the ICU for Critically Ill Patients Undergoing Invasive Mechanical Ventilation - Report (REPOrt)","REPOrt","Inclusion Criteria:\n\n* Patients admitted to a participating ICU\n* Adult patients (aged 16 years or older, depending on local regulations for the definition of \"adults\")\n* Patients who have received invasive ventilation for at least 48 hours\n* Patients who have obtained written informed consent from the patient or next of kin (if local legislation demands so)\n\nExclusion Criteria:\n\n• Patients admitted for withdrawn of life sustain therapy","16 Years",{"count":621,"type":22},2400,"28 Days","This international, multicenter, observational study aims to describe rehabilitation practices in Intensive Care Units (ICUs) worldwide.\n\nThe primary objective is to provide an overview of current rehabilitation strategies used in ICUs globally.\n\nSecondary objectives include assessing the relationship between rehabilitation and key ICU outcomes such as ICU and hospital mortality, length of stay, duration of invasive ventilation, extubation failures, and long-term outcomes including quality of life and functional performance 28 days post-ICU discharge.\n\nThe study will also compare rehabilitation practices across different geographic and economic regions to identify potential disparities. The study is structured into three modules, with participation contingent on local resources and feasibility.\n\nThe BASIC Module (mandatory for all centers) gathers fundamental data on rehabilitation practices and their association with patient outcomes.\n\nThe EXTENDED Module (optional) collects more detailed information on the type, timing, duration, and safety of rehabilitation interventions, including passive exercises, active mobilization, respiratory therapies, dysphagia training, occupational therapy, and cognitive support.\n\nThe EXTENDED FOLLOW-UP Module (optional) evaluates the patient's quality of life and functional recovery 28 days after ICU discharge. By examining global rehabilitation practices and their impact on patient outcomes, this study aims to improve rehabilitation strategies in ICUs, contributing to better patient care, recovery, and long-term health outcomes.",[26,625,626,627,628,174,629,630],"Pulmonary Rehabilitation","Intensive Care Units (ICUs)","Quality of Life (QOL)","Outcome Assessment","Mortality","Critical Care",[632,26,633,634],"Pulmonary rehabilitation","Intensive Care Unit (ICU)","Rehabilitation Outcomes","2026-04-27",{"date":606,"type":38},{"date":638,"type":38},"2025-10-01",{"date":640,"type":22},"2029-10-01",{"name":642,"class":45},"Universita degli Studi di Genova",{"id":644,"slug":645,"hasResults":12,"nctId":646,"briefTitle":647,"officialTitle":648,"acronym":649,"eligibilityCriteria":650,"healthyVolunteers":12,"sex":18,"minAge":651,"maxAge":19,"enrollmentInfo":652,"targetDuration":4,"studyType":57,"phases":653,"briefSummary":655,"conditions":656,"keywords":665,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":670,"lastUpdatePostDateStruct":671,"startDateStruct":672,"completionDateStruct":673,"leadSponsor":674,"locationsCount":78},"100630322","phase-1-influence-of-lung-volume-optimization-maneuver-on-cardiac-output-and-lung-compliance-in-ventilated-children-with-congenital-heart-disease-undergoing-surgical-repair-100630322","NCT07486167","Influence of Lung Volume Optimization Maneuver on Cardiac Output and Lung Compliance in Ventilated Children With Congenital Heart Disease Undergoing Surgical Repair","Influence of Lung Volume Optimization Maneuver on Cardiac Output and Lung Mechanics in Children With Congenital Heart Disease","ILOCO-CHD","Inclusion Criteria:\n\n* Inclusion Criteria\n* congenital heart disease\n* surgery with cardiopulmonary bypass\n\nExclusion Criteria:\n\n* single ventricle physiology\n* ECMO\u002FVAD\n* \\\u003C36weeks of gestational age\n* chronic lung disease\n* Endotracheal tube leak \\> 15%\n* lack of informed consent from parents.","0 Days",{"count":88,"type":22},[654,223],"PHASE1","The aim of this randomized interventional multi-center clinical trial is to determine whether a standardized lung volume optimization maneuver (LVOM), including PEEP titration, improves outcomes in children undergoing biventricular repair for congenital heart disease (CHD) with cardiopulmonary bypass.\n\nThe primary hypothesis is that optimizing end-expiratory lung volume through a standardized PEEP titration maneuver improves cardiac performance and lung function.\n\nSecondary objectives are to evaluate whether this strategy reduces duration of mechanical ventilation, improves hemodynamics and ventilation-perfusion matching, and decreases the need for vasopressor support.",[657,658,26,659,660,661,662,663,397,664],"Congenital Heart Disease","Cardiopulmonary Bypass","Peep Titration in Lung Protective Ventilation","Positive End-expiratory Pressure (PEEP)","Lung Volume","Lung Mechanics","Children","Cardiac Surgery",[666,667,668,669],"cardiopulmonary interactions","end-expiratory lung volume","electrical impedance tomography","PEEP titration","2026-04-26",{"date":581,"type":38},{"date":73,"type":22},{"date":587,"type":22},{"name":675,"class":45},"Charite University, Berlin, Germany",{"id":677,"slug":678,"hasResults":12,"nctId":679,"briefTitle":680,"officialTitle":681,"acronym":682,"eligibilityCriteria":683,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":684,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":686,"conditions":687,"keywords":689,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":692,"lastUpdatePostDateStruct":693,"startDateStruct":695,"completionDateStruct":697,"leadSponsor":698,"locationsCount":78},"100604828","effects-of-abclo-fascial-approximation-device-in-patients-with-open-abdomen-on-respiratory-mechanics-100604828","NCT07154589","Effects of AbClo Fascial Approximation Device in Patients With Open Abdomen on Respiratory Mechanics","Effects of AbClo Fascial Approximation Device in Patients With Open Abdomen on Respiratory Mechanics (AbClo-Resp)","AbClo-Resp","Inclusion Criteria:\n\n* Adult patients aged 18 years or older\n* Patients admitted to an ICU\n* Patients with postoperative abdominal surgery with open abdomen\n* Patients treated with AbClo device\n* Patients intubated and mechanically ventilated\n* Patients treated with intravenous sedation with a sedation-agitation scale score of 1-3\n\nExclusion Criteria:\n\n* Transient criteria: Patients with severe hemodynamic instability, defined systolic blood pressure less than 75 mmHg or mean arterial pressure less than 60 mmHg despite vasopressor use\n* Transient criteria: Patients with severe bleeding diathesis, defined as the latest platelet count less than 20 · 109\u002FL, or the latest INR higher than 2.0\n* Patients with concurrent injuries to upper gastrointestinal tract that would preclude esophageal balloon insertion\n* Patients with bronchopleural fistula\n* Patients with measured and uncontrolled increased intracranial pressure",{"count":685,"type":22},18,"Patients who underwent an abdominal surgery and had the abdomen remain open are called to have an \"open abdomen\". To limit the risk of further widening of their wounds, surgeons can use AbClo, which is a non-invasive abdominal binding device, to keep the abdominal wall together (i.e., approximate the fascia). However, as the device also compresses on the abdomen and adjacent lungs, this study aims:\n\n* To assess whether the abdominal binding device causes changes in the pressure compressing the lungs, the lung volume, and the function of the lungs.\n* To assess whether adjusting the breathing machine can mitigate such negative changes.\n\nParticipants will already be on the abdominal binding device when joining the study. Measurements on various aspects of the lung function (including its physical properties and capability to oxygenate the blood) will be done before and after adjustment of the abdominal binding device to the pressure (measured in the device itself) recommended by the manufacturer, as well as after the surgery to close the abdomen.",[688,26],"Open Abdomen",[690,125,691],"open abdomen","transpulmonary pressure","2026-04-16",{"date":694,"type":38},"2026-04-22",{"date":696,"type":38},"2025-06-10",{"date":379,"type":22},{"name":699,"class":45},"Unity Health Toronto"]