[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"mechanical-ventilator-care\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:mechanical-ventilator-care":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,41],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100632886","effect-of-early-transition-to-assisted-ventilation-on-28-day-successful-extubation-in-critically-ill-patients-100632886",false,"NCT07519512","Effect of Early Transition to Assisted Ventilation on 28-day Successful Extubation in Critically Ill Patients","Effect of Early Transition to Assisted Ventilation on 28-day Successful Extubation in Critically Ill Patients: A Multicenter Open-label Randomized Controlled Trial (EARLY-VENT)","EARLY-VENT","Inclusion Criteria:\n\n* Age ≥ 18 years.\n* Expected ICU stay and mechanical ventilation (MV) ≥ 48 hours.\n* Currently receiving controlled ventilation mode\n* No neuromuscular blocking agents in use, and sedation level RASS ≥ -3.\n* P\u002FF ≥ 150 mmHg.\n\nExclusion Criteria:\n\n* Severe end-stage irreversible respiratory, cardiac, or neurologic disease that may lead to long-term\u002Fchronic ventilator dependence or inability to wean from MV (e.g., interstitial lung disease\u002Fpulmonary fibrosis, cardiomyopathy, valvular disease, severe traumatic brain injury, Guillain-Barré syndrome, amyotrophic lateral sclerosis, multiple sclerosis, high cervical spinal cord injury, or other restrictive diseases).\n* Expected death or transfer out of the ICU within 48 hours.\n* Hemodynamic instability judged by the treating clinician.\n* Pregnancy.\n* Currently participating in other clinical studies related to mechanical ventilation.\n* Any other condition considered unsuitable for participation by the investigator.\n\nWritten informed consent not obtained.","ALL","18 Years",{"count":20,"type":21},1600,"ESTIMATED","INTERVENTIONAL",[24],"NA","EARLY-VENT is a multicenter, open-label, three-period cluster-randomized crossover trial designed to evaluate whether early transition from controlled to assisted ventilation improves outcomes in critically ill patients. The study will enroll approximately 1,600 adult patients across 10 ICUs who are expected to require mechanical ventilation for at least 48 hours and meet specific stability criteria (e.g., hemodynamically stable, light sedation). Participating centers will alternate between an experimental strategy, where patients transition to an assisted mode (preferably Pressure Support Ventilation) within 6 hours of eligibility, and a control strategy based on standard care practices. The primary endpoint is the rate of successful extubation at day 28, aiming to demonstrate that transition from controlled to assisted ventilation can reduce ventilation duration and improve prognosis compared to delayed transition.",[27],"Mechanical Ventilator Care","RECRUITING","2026-04-20",{"date":31,"type":32},"2026-04-23","ACTUAL",{"date":34,"type":21},"2026-08-01",{"date":36,"type":21},"2030-12-31",{"name":38,"class":39},"Southeast University, China","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":45,"acronym":4,"eligibilityCriteria":46,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":47,"targetDuration":4,"studyType":49,"phases":4,"briefSummary":50,"conditions":51,"keywords":52,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":56,"lastUpdatePostDateStruct":57,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":63,"locationsCount":40},"100625287","measurement-of-expiratory-gas-temperature-in-intubated-patients-to-estimate-expiratory-absolute-humidity-100625287","NCT07420673","Measurement of Expiratory Gas Temperature in Intubated Patients to Estimate Expiratory Absolute Humidity","Inclusion Criteria:\n\n* Adults (≥18 years)\n* Intubated and mechanically ventilated in the intensive care unite\n* Using passive humidification (Heat and Moisture exchanger)\n\nExclusion Criteria:\n\n* PEEP set \\\u003C 12 cmH₂O\n* Inhaled nitric oxide therapy\n* Tracheostomy",{"count":48,"type":21},70,"OBSERVATIONAL","Adequate humidification is essential for intubated patients because dry medical gases can cause thick secretions and dangerous endotracheal tube blockages. A clear correlation exists between exhaled and inhaled humidity delivered by heat and moisture exchanger. The objective of this study is to measure the temperature of exhaled gases in intubated patients in order to accurately calculate the absolute humidity during the expiratory phase. These data will allow for a more accurate reproduction of real clinical conditions during bench testing and will improve the assessment of heat and moisture exchanger performance device evaluation.",[27],[53,54],"humidification","Passive humidification","NOT_YET_RECRUITING","2026-02-12",{"date":58,"type":32},"2026-02-19",{"date":60,"type":21},"2026-04",{"date":62,"type":21},"2027-06",{"name":64,"class":39},"Laval University"]