[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"mechanical-ventilator-weaning\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:mechanical-ventilator-weaning":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,45,71,108],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":26,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100639546","d-rsbi-versus-rsbi-for-predicting-weaning-success-in-copd-patients-100639546",false,"NCT07590362","D-RSBI Versus RSBI for Predicting Weaning Success in COPD Patients","Diaphragmatic Rapid Shallow Breathing Index (D-RSBI) Versus Traditional Rapid Shallow Breathing Index (RSBI) for Prediction of Weaning Success From Mechanical Ventilation in COPD Patients","Inclusion Criteria:\n\n* Mechanically ventilated COPD patients fulfilling standard weaning readiness criteria.\n* Invasive mechanical ventilation for more than 24 hours before spontaneous breathing trial.\n* Hemodynamically stable without significant vasopressor support.\n* Adequate oxygenation with FiO2 ≤ 0.5 and PEEP ≤ 8 cmH2O .\n* Preserved mental status and ability to initiate spontaneous breathing.\n* Successful tolerance of spontaneous breathing trial conducted on CPAP mode with pressure support ≤ 8 cmH2O.\n\nExclusion Criteria:\n\n* Refusal of consent\n* Neuromuscular disease, phrenic nerve palsy, or diaphragmatic paralysis.\n* Large pneumothorax or pathology interfering with ultrasound assessment.\n* Terminal extubation.\n* Recent major thoracic surgery.\n* Poor sonographic window despite repeated attempts.","ALL","18 Years",{"count":19,"type":20},100,"ESTIMATED","OBSERVATIONAL","This prospective observational cohort study aims to compare the predictive accuracy of diaphragmatic rapid shallow breathing index (D-RSBI) versus traditional rapid shallow breathing index (RSBI) for predicting weaning success from invasive mechanical ventilation in COPD patients. Diaphragmatic ultrasound measurements will be performed during spontaneous breathing trials, and patients will be followed for 72 hours after extubation to assess weaning outcomes.",[24,25],"Chronic Obstructive Pulmonary Disease (COPD)","Mechanical Ventilator Weaning",[27,28,29,30,31],"D-RSBI","RSBI","COPD","Diaphragm Ultrasound","Mechanical Ventilation Weaning","RECRUITING","2026-05-14",{"date":35,"type":36},"2026-05-15","ACTUAL",{"date":38,"type":36},"2026-04-15",{"date":40,"type":20},"2027-06",{"name":42,"class":43},"Sohag University","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":54,"conditions":55,"keywords":57,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":44},"100550715","use-of-a-physiotherapy-assessment-to-predict-extubation-failure-in-mechanically-ventilated-patients-the-epic-assessment-100550715","NCT06450678","Use of a Physiotherapy Assessment to Predict Extubation Failure in Mechanically Ventilated Patients: the EPIC Assessment","PREDEXTUB","Inclusion Criteria:\n\n* Patient 18 years of age or older\n* Admitted to intensive care and placed on invasive mechanical ventilation for more than 48 hours\n* Having passed a T-Tube spontaneous ventilation test \\\u003C 24h\n\nExclusion Criteria:\n\n* Tracheostomized patient\n* Severe psychiatric pathology or cognitive disorders\n* Uncooperative patient\n* Patient under therapeutic restriction (terminal extubation)\n* Patient who has already participated in research\n* Patient or close relative (if patient not able) opposed to research\n* No relative if patient unable to receive information",{"count":53,"type":20},330,"\"Weaning from mechanical ventilation is a crucial step in the intensive care unit. Several factors complicate weaning and increase the risk of failure. To predict the success of extubation, the spontaneous ventilation test (T-Tube) remains essential. Despite this, the failure rate is around 10-20%.\n\nFailed extubation is not without consequences, since it increases the risk of pneumopathy and mortality. It therefore seems essential to identify potential extubation failures using effective predictive criteria. Several of these predictive criteria have been studied separately in the literature, but are still not widely used in practice. Many studies have sought to identify these predictive criteria, without actually linking them. However, when combined in a single assessment prior to extubation, they could represent a reliable prediction and decision-making aid.\n\nIn the intensive care unit at Hôpital Bichat Claude Bernard, a team of physiotherapists dedicated solely to this unit carries out a routine EPIC Assessment, combining several criteria, some of which have individually demonstrated their reliability in predicting extubation outcome. Physiotherapists are health professionals working as part of the intensive care team, and are well versed in issues relating to bronchial congestion, respiratory function and muscle strength, whether for breathing or locomotion. Similarly, their involvement in issues relating to swallowing disorders acquired in intensive care gives them an overall view of the patient's ability to protect his or her airway post-extubation. The EPIC Assessment has been designed by them to address these issues. With the help of this assessment, and by following the cut-offs of the various criteria, they link the different criteria making up the EPIC Assessment and communicate a \"\"favorable\"\" or \"\"unfavorable\"\" opinion for extubation.\n\nOur hypothesis is that the EPIC Assessment is, in addition to its interpretation by physiotherapists, a reliable tool for predicting the outcome of extubation.\"",[25,56],"Mechanical Ventilation",[58,59,60,61],"ICU","extubation failure","predictive factors","physiotherapist","2026-03-26",{"date":64,"type":36},"2026-03-27",{"date":66,"type":36},"2024-04-15",{"date":68,"type":20},"2027-10",{"name":70,"class":43},"Assistance Publique - Hôpitaux de Paris",{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":79,"enrollmentInfo":80,"targetDuration":4,"studyType":82,"phases":83,"briefSummary":85,"conditions":86,"keywords":90,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":107},"100368678","brain-injured-patients-extubation-readiness-study-100368678","NCT04080440","Brain-injured Patients Extubation Readiness Study","Stepped Wedge Cluster Randomised Controlled Trial to Assess the Readiness of Extubation in Brain-injured Patients Using a Clinical Score","Biper","Inclusion Criteria:\n\n* Acute cerebral lesion with a Glasgow Coma Scale \\\u003C13 needing admission in ICU and mechanical ventilation with tracheal intubation for neurological cause : cerebrovascular stroke either ischemic or hemorrhagic including aneurysmal subarachnoid hemorrhage, traumatic brain injury, anoxo ischemic encephalopathy after cardiac arrest or brain tumour\n* Mechanical ventilation more than 48 hours\n* 18 to 75 years old\n* Neurological stability with no intracranial hypertension with minimal sedation\n* Glasgow Coma Scale motor response \\\u003C 6\n* Spontaneous breathing trial succeeded\n* First extubation attempt\n\nExclusion Criteria:\n\n* Posterior cranial fossa lesion\n* Admission for status epilepticus or central nervous system infection\n* Spinal cord injury (tetraplegia or paraplegia)\n* Uncontrolled status epilepticus or uncontrolled central nervous system infection\n* Care limitation plan\n* Chronic respiratory failure defined as ambulatory oxygen therapy or pressure support ventilation and\u002For proven COPD and\u002For ambulatory non-invasive CPAP therapy for sleep apnoea syndrome\n* More than 3 failed spontaneous breathing trials\n* Significant chest trauma (more than 2 broken ribs \u002F broken sternum \u002F with an indication of open thoracic surgery)\n* Surgery planned within 7 days\n* Tracheotomy or previous extubation outside of the protocol\n* Previous compromised upper airway permeability\n* Pregnant or breastfeeding woman\n* Adult under the protection of the law or without social assurance system\n* Inclusion in another clinical study about mechanical ventilation or weaning","75 Years",{"count":81,"type":20},660,"INTERVENTIONAL",[84],"NA","The BIPER study is a stepped wedge cluster randomised clinical trial aiming to decrease extubation failure in critically-ill brain-injured patients with residual impaired consciousness using a simple clinical score.",[25,87,88,56,89],"Acute Brain Injury","Altered Level of Consciousness","Airway Control",[91,92,93,94,95,96,97],"Coma","Intensive care units","Critical care","Stroke","Traumatic brain injury","Anoxic ischemic encephalopathy","Glasgow coma scale","2025-09-23",{"date":100,"type":36},"2025-09-24",{"date":102,"type":36},"2020-02-09",{"date":104,"type":20},"2027-10-13",{"name":106,"class":43},"University Hospital, Clermont-Ferrand",21,{"id":109,"slug":110,"hasResults":11,"nctId":111,"briefTitle":112,"officialTitle":113,"acronym":114,"eligibilityCriteria":115,"healthyVolunteers":11,"sex":16,"minAge":116,"maxAge":4,"enrollmentInfo":117,"targetDuration":4,"studyType":82,"phases":119,"briefSummary":120,"conditions":121,"keywords":123,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":44},"100493843","muscle-recruitment-during-neck-flexion-and-inspiratory-muscle-training-100493843","NCT05710432","Muscle Recruitment During Neck Flexion and Inspiratory Muscle Training","Muscle Recruitment During Neck Flexion and Inspiratory Muscle Training in Difficult and Prolonged Weaning Patients: a Physiological Study - The FLEX Study","FLEX","Inclusion Criteria:\n\n* Patients receiving invasive MV via endotracheal tube who had failed a planned extubation or failed at least three spontaneous breathing trials (SBTs) or receiving MV via tracheostomy (who required tracheostomy because of difficult or prolonged weaning, failed extubation and\u002For prolonged ventilation) and able to spontaneously trigger the ventilator.\n* Over or equal to 16 years of age\n* Tolerating levels of pressure support of 10 cmH2O or lower (or equivalent support in NAVA or PAV+) for at least 15 minutes\n* In stable clinical and hemodynamic conditions and adequate level of oxygenation (cardiac frequency ≤ 140 beats\u002Fminute, systolic blood pressure 90-160 mmHg, no or minimal vasopressors, PaO2\u002FFiO2 over or equal to 150 mmHg)\n* Able to understand and follow simple verbal instructions\n\nExclusion Criteria:\n\n* Patients with a previously diagnosed severe neuromuscular disorder (such as amyotrophic lateral sclerosis, muscular dystrophy, multiple sclerosis, myasthenia gravis or spinal cord injury)\n* Patients with chronic respiratory failure already ventilated before ICU admission\n* Patients unable to collaborate or understand instructions","16 Years",{"count":118,"type":20},10,[84],"Respiratory muscle dysfunction is highly prevalent in patients with prolonged weaning from mechanical ventilation and is strongly associated with weaning failure. Efforts to strengthen the respiratory muscles, aimed at reversing or minimizing the impact of respiratory muscle weakness on clinical outcomes, have generally focused on the diaphragm with specific inspiratory muscle training (IMT) exercises. However, the effectiveness of these exercises and impact on clinical outcomes are not current practice in the majority of ICUs, as they are hardly feasible in ICU patients who often cannot be disconnected from the ventilator and cannot fully cooperate.\n\nPromising results have been published concerning non-respiratory training techniques, which can also target the accessory muscles, particularly important in the presence of increased load to the respiratory system, as in the case of the weaning phase. These non-respiratory training techniques would have the advantage of not entailing disconnection of the patient from the ventilator. In particular, in healthy subjects, a quasi-isometric neck contraction, called neck flexion, appeared to generate greater or comparable recruitment of some principal and accessory muscles of respiration, when compared to conventional IMT. However, this has not been studied in patients requiring prolonged mechanical ventilation, for whom IMT with threshold loading devices remains the primary recommended rehabilitation strategy.\n\nTherefore, the primary aim of the investigators is to assess the feasibility, tolerability, and safety of neck flexion and to compare them with IMT technique in patients with difficult and prolonged weaning from mechanical ventilation. Secondary aims are: i) to characterize which respiratory muscles are recruited and their level of activation at different levels of ventilatory assistance and ii) to assess which respiratory muscles are recruited and their level of activation during the two techniques and to compare these findings.\n\nThe hypothesis of the investigators is that neck flexion will be feasible (more than conventional IMT), well tolerated, and safe in patients with difficult and prolonged weaning. The investigators also hypothesize that, reducing the level of assistance and during unassisted breathing, a progressively increasing activation of the diaphragm, neck and trunk respiratory muscles, reflecting increased ventilatory load, will be fund. Finally, the hypothesis of the investigators is that the level of muscle activation\u002Frecruitment during neck flexion will be comparable or even greater to that occurring during IMT, as found in healthy subjects.\n\nFinding a new and highly feasible rehabilitative technique, able to recruit and train the respiratory muscles (including accessory muscles), will have the potential to promote patients' weaning and improve all related clinical outcomes, and therefore to dramatically shift the paradigm about the role of rehabilitation in ICU.",[25,122],"Respiratory Muscle Training",[56,124,125,25],"Inspiratory Muscle Training","Neck Flexion","2025-05-15",{"date":128,"type":36},"2025-05-20",{"date":130,"type":36},"2023-02-09",{"date":132,"type":20},"2025-11-15",{"name":134,"class":43},"Unity Health Toronto"]