[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"median-nerve-entrapment\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:median-nerve-entrapment":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,48,78,116],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100630163","efficacy-of-proximal-median-nerve-release-100630163",false,"NCT07484100","Efficacy of Proximal Median Nerve Release","Efficacy of Operative Versus Conservative Treatment in Proximal Median Nerve Compression","PROMER","Inclusion Criteria:\n\n1. Clinically diagnosed PMNC\n2. If the patient has clinically and electrodiagnostically confirmed carpal tunnel syndrome, at least 6 months must have passed since surgical treatment\n3. Age 18 or over\n4. Ability to understand Finnish\n5. Ability to complete electronic questionnaires independently\n6. Willingness to participate in research and follow research instructions\n7. Provision of informed consent from the participant\n\nExclusion Criteria:\n\n1. Nerve root disorder findings in ENMG\n2. Thoracic outlet syndrome, TOS\n3. Other neurological condition that causes upper limb symptoms such as MS, previous nerve injury\n4. Active rheumatoid arthritis or any other active inflammatory joint disease that affects hand function\n5. Significant compression symptoms of another peripheral nerve in association with PMNC\n6. Other upper extremity operation performed less than 6 months ago\n7. Another disease or condition that accounts for most of the patient's symptoms\n8. Other known reasons that may prevent participation or implementation of treatment during the study","ALL","18 Years",{"count":20,"type":21},160,"ESTIMATED","INTERVENTIONAL",[24],"NA","A multi-center randomized controlled clinical trial which determines the efficacy of proximal median nerve release in patients with persistent proximal median nerve compression. The primary outcome is patient reported improvement of symptoms on a 7-point Likert scale at 6 months after the randomization to treatment group.",[27,28,29],"Carpal Tunnel Surgery","Median Nerve Compression","Median Nerve Entrapment",[31,32,33,34],"proximal median nerve entrapment","proximal median nerve compression","proximal median nerve release","randomized controlled trial","NOT_YET_RECRUITING","2026-03-17",{"date":38,"type":39},"2026-03-19","ACTUAL",{"date":41,"type":21},"2026-03-01",{"date":43,"type":21},"2041-07",{"name":45,"class":46},"Tampere University Hospital","OTHER",2,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":58,"briefSummary":59,"conditions":60,"keywords":63,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":4},"100628170","comparison-of-wrist-splint-positions-in-carpal-tunnel-syndrome-100628170","NCT07458152","Comparison of Wrist Splint Positions in Carpal Tunnel Syndrome","Evaluation of the Effectiveness of Splint Use in Different Wrist Positions in the Treatment of Carpal Tunnel Syndrome: A Single-Blind, Randomized, Controlled Trial","Inclusion Criteria:\n\n* Diagnosis of mild to moderate carpal tunnel syndrome confirmed by electrophysiological studies performed within the last year.\n* Clinical findings consistent with carpal tunnel syndrome.\n* Age between 18 and 65 years.\n\nExclusion Criteria:\n\n* \\\u003C18 years or \\>65 years\n* Thenar atrophy\n* Surgery history for CTS\n* Steroid injection for CTS\n* Physical treatment for CTS in the last 6 months\n* Cervical radiculopathy\n* Tenosynovitis\n* Peripheral polyneuropathy\n* Another compressive neuropathy in the ipsilateral upper extremity\n* History of trauma\u002Ffracture to the hand-wrist region\n* Pregnancy\n* Metabolic disease\n* Rheumatic\u002Fautoimmune disease\n* Kidney failure","65 Years",{"count":57,"type":21},108,[24],"Carpal tunnel syndrome (CTS) is the most common nerve compression syndrome. It develops as a result of the compression of the median nerve while passing through the osteofibrous structure of the carpal tunnel located at the wrist. Sensory symptoms are the most prominent feature of CTS. These symptoms are observed as pain, paresthesia, and decreased sensory sensitivity. As motor symptoms, thumb abduction and opposition are primarily affected. In advanced cases, atrophy develops in the thenar muscles. Patients may describe weakness as difficulty in writing, opening jars, buttoning, or grasping objects. The diagnosis is made by fulfilling both clinical and electrophysiological diagnostic criteria. CTS has both conservative and surgical treatment options. Conservative treatment includes splinting, physical therapy modalities, and injection options, and it is preferred in mild and moderate cases. Among non-surgical treatment options, splint use is a commonly applied intervention; however, there is no consensus regarding its effectiveness, the optimal wrist position during use, or the duration and frequency of splint application. A total of 108 hands from patients aged 18 to 55 years diagnosed with CTS will be included in this study and randomized into three groups. All groups will be given an education and exercise program. The first group will use a wrist splint fixed at 15° flexion; the second group at neutral position; and the third group at 20° extension, to be worn only at night for eight weeks. Patients will be evaluated before treatment, immediately after treatment, and two months after the end of treatment using measures of pain- numbness severity, functional status, motor and sensory examination findings, and nerve conduction studies. What makes this study unique is that it evaluates the effects of splints that stabilize the wrist at different angles together with electrophysiological findings. A review of the literature shows that while some studies have examined and compared the effects of splints fixed at different wrist angles on symptoms, functional status, and physical examination findings, there is no study that evaluates these effects along with electrophysiological findings. Therefore, this study, which will compare the effectiveness of splints at different angles, is expected to contribute to the literature. The expected outcomes of this research are that one or more types of splints used in the conservative treatment of CTS will provide improvements in symptom severity, functional status, sensory and motor physical examination findings, and electrophysiological evaluation findings at the end of treatment.",[61,62,29],"Carpal Tunnel Syndrome (CTS)","Peripheral Neuropathies",[64,65,66,67,68],"Splints","Electromyography","Wrist splinting","Rehabilitation","Wrist posture","2026-03-10",{"date":71,"type":39},"2026-03-12",{"date":73,"type":21},"2026-03",{"date":75,"type":21},"2029-01",{"name":77,"class":46},"Istanbul University",{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":82,"acronym":4,"eligibilityCriteria":83,"healthyVolunteers":84,"sex":17,"minAge":18,"maxAge":85,"enrollmentInfo":86,"targetDuration":4,"studyType":88,"phases":4,"briefSummary":89,"conditions":90,"keywords":97,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":111,"completionDateStruct":112,"leadSponsor":114,"locationsCount":115},"100625239","turkish-adaptation-of-the-cts-6-evaluation-tool-a-validation-and-reliability-study-100625239","NCT07420049","Turkish Adaptation of the CTS-6 Evaluation Tool: A Validation and Reliability Study","1\\) INCLUSION CRITERIA:\n\nParticipants aged 18-60 years will be categorized into three groups:\n\n1. Healthy Control Group\n2. Group Presenting with CTS-like Symptoms\n3. Group Diagnosed with CTS Based on Defined Criteria\n\na) Healthy Control Group: Participants in this group will have no clinical symptoms consistent with CTS based on specified clinical criteria and will be considered normal according to the defined electrophysiological criteria.\n\nb) Group Presenting with CTS-like Symptoms: Participants in this group may exhibit symptoms similar to clinically defined CTS; however, electrophysiological evaluations will show normal findings according to the defined criteria.\n\nb.1) Clinical Findings \u002F Symptoms:\n\nb.1.1) Symptoms:\n\n(A) Sensory symptoms in any of the 1st, 2nd, 3rd, or the radial part of the 4th finger\n\n(B) Symptoms alleviated by shaking, squeezing, or other hand movements\n\n(C) Pain or paresthesia associated with gripping or hand use\n\n(D) Nocturnal paresthesia causing awakening from sleep\n\nb.1.2) Diagnostic Tests \u002F Signs:\n\n1. Tinel Sign\n2. Phalen Test\n3. Reverse Phalen Test\n4. Carpal Tunnel Compression Test\n5. Flick Sign\n\n   A clinical diagnosis of CTS will require symptoms persisting for at least three months, with at least one of the B, C, or D symptoms in addition to symptom A, plus at least one positive diagnostic test or sign.\n\n   b.2) Electrophysiological Evaluation:\n\n   b.2.1) Mild CTS:\n\n   Median-to-ulnar sensory distal latency difference ≥ 0.4 ms at the 4th finger\n\n   Median nerve sensory distal latency ≥ 2.8 ms at the 2nd finger\n\n   Median nerve conduction velocity \\\u003C 50 m\u002Fs\n\n   Sensory nerve action potential ≥ 12 µV\n\n   b.2.2) Moderate CTS:\n\n   Median nerve distal motor latency at Abductor Pollicis Brevis (APB) 4 ms ≤ x \\\u003C 6.5 ms\n\n   Median nerve conduction velocity \\\u003C 50 m\u002Fs\n\n   Compound Muscle Action Potential (CMAP) ≥ 5 mV\n\n   b.2.3) Severe CTS:\n\n   Median nerve distal motor latency at APB ≥ 6.5 ms\n\n   Median nerve conduction velocity \\\u003C 50 m\u002Fs and\u002For CMAP \\\u003C 5 mV\n\n   c) Group Diagnosed with CTS Based on Defined Criteria: Participants in this group meet the clinical diagnostic criteria for CTS and additionally fulfill electrophysiological evaluation criteria for mild, moderate, or severe CTS.\n\n2\\) EXCLUSION CRITERIA:\n\n2.a) Participants Diagnosed with CTS Based on Defined Criteria:\n\nHistory of cardiac pacemaker\n\nHistory of lymphedema in the affected extremity\n\nHistory of cervical radiculopathy\n\nPresence of ipsilateral upper extremity tenosynovitis\n\nPresence of another compressive neuropathy in the ipsilateral upper extremity\n\nHistory of peripheral polyneuropathy\n\nPresence of metabolic disease\n\nHistory of fracture in the hand, wrist, or forearm\n\nCurrent pregnancy\n\nOpen wound on the wrist\n\nUncontrolled medical conditions (including endocrinological, cardiovascular, pulmonary, hematological, hepatic, renal, active systemic inflammatory disease, and\u002For malignancy)\n\nHistory of inflammatory rheumatologic or autoimmune disease\n\nAge \\\u003C18 years or \\>60 years\n\nTrauma to the wrist or median nerve within the last 3 months\n\nReceived any injection in the wrist\n\nUndergone any surgical procedure on the wrist\n\nMental or cognitive incapacity preventing understanding or completion of questionnaires\n\n2.b) Participants Presenting with CTS-like Symptoms:\n\nMental or cognitive incapacity preventing understanding or completion of questionnaires\n\nAge \\\u003C18 years or \\>60 years\n\nCTS diagnosis confirmed based on clinical and electrophysiological criteria\n\n2.c) Healthy Control Group Participants:\n\nMental or cognitive incapacity preventing understanding or completion of questionnaires\n\nAge \\\u003C18 years or \\>60 years\n\nPresence of any clinical symptoms potentially related to CTS based on defined clinical criteria\n\nElectrophysiological findings consistent with CTS",true,"60 Years",{"count":87,"type":21},126,"OBSERVATIONAL","The purpose of this study is to develop the Turkish version of the CTS-6 Evaluation Tool and to comprehensively assess its validity and reliability in the Turkish population. The CTS-6 Evaluation Tool is a widely used and reliable instrument for the assessment of diagnosis and symptom severity in patients with carpal tunnel syndrome.\n\nIn this study, the CTS-6 will undergo translation and cultural adaptation to ensure linguistic and cultural appropriateness for the Turkish population. The goal is to produce a valid, reliable, and practical tool that can be used efficiently in clinical settings. The adapted version is intended to be applicable across multiple medical specialties involved in the diagnosis and management of carpal tunnel syndrome in Turkey. The results are expected to provide a trustworthy Turkish version of the CTS-6 suitable for both clinical practice and research purposes.",[61,29,91,92,93,94,95,96],"Peripheral Nerve Disease","Peripheral Nerve Disorder","Reliability and Validity","Cross-cultural Adaptation","TURKISH VALIDITY AND RELIABILITY STUDY OF CTS-6 EVALUATİON TOOL","Diagnostic Tool",[98,99,100,101,102,103,96,104,105,106,107],"CTS-6 Evaluation Tool","CTS-6","Cross-cultural adaptation","Carpal Tunnel Syndrome","median nerve entrapment","reliability and validity","Peripheral nerve disease","Peripheral nerve disorders","Turkish version","Turkish Validity and Reliability Study of CTS-6 Evaluation Tool","2026-02-12",{"date":110,"type":39},"2026-02-19",{"date":41,"type":21},{"date":113,"type":21},"2026-07-01",{"name":77,"class":46},1,{"id":117,"slug":118,"hasResults":11,"nctId":119,"briefTitle":120,"officialTitle":120,"acronym":121,"eligibilityCriteria":122,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":123,"enrollmentInfo":124,"targetDuration":4,"studyType":22,"phases":126,"briefSummary":127,"conditions":128,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":115},"100568240","ultrasound-guided-release-of-the-median-nerve-at-the-elbow-in-patients-with-lacertus-syndrome-100568240","NCT06678646","Ultrasound-guided Release of the Median Nerve at the Elbow in Patients With Lacertus Syndrome","LACECHOCHIR","Inclusion Criteria:\n\n* Patient, male or female, aged ≥ 18 years and \\\u003C 70 years\n* Patient with isolated or bilateral Lacertus syndrome (no associated procedure on the day of surgery).\n* Patient with a normal EMG\n\nExclusion Criteria:\n\n* Patient with previous elbow surgery\n* Patient with a history of elbow fracture\n* Patient taking part in another study","70 Years",{"count":125,"type":21},107,[24],"Lacertus syndrome is an orthopaedic condition that occurs when the median nerve is compressed where it passes under the lacertus fibrosus.\n\nTreatment for lacertus syndrome is generally aimed at relieving compression of the median nerve and reducing associated symptoms. Treatment options vary according to the severity of the condition and the patient's individual needs.\n\nSectioning the Lacertus fibrosus frees the median nerve. It is performed as an outpatient procedure under local anaesthetic, and the patient can resume his or her activities immediately. Lacertus fibrosus section has been described as an open procedure, i.e. with a horizontal scar in the elbow crease.\n\nUltrasound guided surgery is an innovative technique that has proved its effectiveness for nerve releases such as the median nerve in the carpal tunnel or the ulnar nerve in the elbow. This technique was tested on a series of 18 cadavers and then on a series of 15 patients with a lacertus syndrome. The patients underwent the operation without any immediate surgical or anaesthetic complications. Muscle strength returned immediately and persisted. Pain was reduced and all patients who were working were able to carry out their professional activities from the very first week. The millimetric skin incision healed without hypertrophic scar tissue. A small haematoma appeared at week 1 and resolved spontaneously. No other late complications were observed.\n\nIn this context, this study would consolidate the preliminary results observed and confirm the hypothesis that minimally invasive percutaneous surgery under ultrasound is appropriate for sectioning Lacertus fibrosus safely, rapidly and effectively in Lacertus syndrome.",[29],"2025-11-18",{"date":131,"type":39},"2025-11-24",{"date":133,"type":21},"2025-12-01",{"date":135,"type":21},"2026-12-31",{"name":137,"class":46},"GCS Ramsay Santé pour l'Enseignement et la Recherche"]