[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"medication-adherence\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:medication-adherence":28},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,36,0,25,[9,46,72,95,124,150,191,218,241,270,301,326,361,383,409,436,460,483,515,541,564,592,619,646,675],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100610121","a-tailored-medication-adherence-promotion-intervention-for-adolescents-and-young-adults-with-cancer-100610121",false,"NCT07223463","A Tailored Medication Adherence-Promotion Intervention for Adolescents and Young Adults With Cancer","Inclusion Criteria:\n\n* Patient is 15.00 to 24.99 years of age\n* Patient is diagnosed with cancer\n* Patient is prescribed an oral anticancer\u002Fantitumor agent or prophylaxis\n\nExclusion Criteria:\n\n* Patient is not fluent in English\n* Patient evidences significant cognitive deficits\n* Patient's medical status or treatment precludes participation\n* Patient enrolled on a medical trial requiring medication storage in a trial-provided container\n* Patient demonstrates greater than or equal to 95% adherence during run-in period\n* Patient declines to use or has difficulty using electronic adherence monitoring device during run-in","ALL","15 Years","24 Years",{"count":20,"type":21},160,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to learn if a tailored intervention can help make it easier for adolescents and young adults with cancer to take their medications. The main questions the researchers are trying to answer are:\n\n* Does the tailored intervention increase adherence?\n* Does the tailored intervention improve quality of life?\n* Does the tailored intervention reduce health care utilization?\n\nThe researchers will compare the tailored intervention to a uniform standard of care intervention (an intervention designed to be similar to what is currently happening in clinical care) to see if the tailored intervention works to improve adherence.\n\nParticipants will:\n\n* Use an electronic pill bottle or box to store their medication\n* Participate in intervention sessions\n* Complete surveys before the intervention, after the intervention, and 6-months later",[27,28],"Cancer","Medication Adherence",[30,31,32],"adolescents and young adults","cancer","adherence","NOT_YET_RECRUITING","2026-06-23",{"date":36,"type":37},"2026-06-24","ACTUAL",{"date":39,"type":21},"2026-09-01",{"date":41,"type":21},"2030-08-31",{"name":43,"class":44},"Children's Hospital Medical Center, Cincinnati","OTHER",4,{"id":47,"slug":48,"hasResults":12,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":12,"sex":16,"minAge":52,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":55,"briefSummary":56,"conditions":57,"keywords":59,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":66,"completionDateStruct":67,"leadSponsor":69,"locationsCount":4},"100644299","the-id2-a-smart-eye-drop-cap-monitor-for-eye-drop-adherence-100644299","NCT07664943","The iD2: A Smart Eye Drop Cap Monitor for Eye Drop Adherence","Inclusion Criteria:\n\n* Age ≥ 18\n* Taking at least one glaucoma drop daily\n* A history of poor adherence when taking glaucoma eye drops. This is determined as an answer of 80% or less for the following question: \"Over the past month, what percentage of your drops do you think you took correctly?\"\n* Owns a functioning smart phone with Bluetooth and cellular connectivity\n\nExclusion Criteria:\n\n* Advanced cognitive impairment\n* Current or expected pregnancy during the study.","18 Years",{"count":54,"type":21},100,[24],"Most patients with glaucoma use eye drops to lower their intraocular pressure. However, poor adherence to prescribed eye drop regimens can lead to significant loss of vision-related quality of life. This study will test the iDrop Device (iD2), a device-on-cap electronic platform monitor designed to accurately track when a research participant removes an eye drop bottle cap, wirelessly communicate usage data to a database accessible to researchers, and send on-demand alerts when a medication is due. A device capable of tracking eye drop usage and sending dosage alerts will test the hypothesis that electronic reminders improve medication adherence and help research subjects improve their eye drop taking behavior. While our primary focus is on glaucoma adherence, this device could also benefit those with other chronic eye conditions requiring regular eye drop treatment, such as dry eye, corneal endothelial disease, eye infections, and uveitis.",[58,28],"Glaucoma",[60,61,62,58,63],"iD2","Adherence","Medication","Device","2026-06-17",{"date":36,"type":37},{"date":39,"type":21},{"date":68,"type":21},"2027-08-31",{"name":70,"class":71},"Universal Adherence LLC","INDUSTRY",{"id":73,"slug":74,"hasResults":12,"nctId":75,"briefTitle":76,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":12,"sex":16,"minAge":52,"maxAge":78,"enrollmentInfo":79,"targetDuration":4,"studyType":22,"phases":81,"briefSummary":83,"conditions":84,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":86,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":94},"100513292","phase-3-stroke-minimization-through-additive-anti-atherosclerotic-agents-in-routine-treatment-ii-study-smaart-ii-100513292","NCT05963568","Stroke Minimization Through Additive Anti-atherosclerotic Agents in Routine Treatment II Study (SMAART II)","Inclusion Criteria:\n\n* Above the age of 18 years; male or female\n* Ischemic stroke diagnosis no greater than two months before enrollment. Ischemic strokes including� lacunar, large-vessel atherosclerotic, cardio-embolic subtypes are eligible\n* Subjects with stroke may present with at least one of the following additional conditions:\n\nDocumented diabetes mellitus or previous treatment with oral hypoglycemic or insulin; documented hypertension \\>140\u002F90mmHg or previous treatment with antihypertensive medications; Mild to moderate renal dysfunction (eGFR 60-30ml\u002Fmin\u002F1.73m2); Prior myocardial infarction\n\n* Legally competent to sign informed consent.\n\nExclusion Criteria:\n\n* Unable to sign informed consent\n* Contraindications to any of the components of the polypill\n* Hemorrhagic stroke\n* Severe cognitive impairment\u002Fdementia or severe global disability limiting the capacity of self-care\n* Severe congestive cardiac failure (NYHA III-IV)\n* Severe renal disease, eGFR \\\u003C30ml\u002Fmin\u002F1.73m2), renal dialysis; awaiting renal transplant or transplant recipient\n* Cancer diagnosis or treatment in past 2 years\n* Need for oral anticoagulation at the time of randomization or planned in the future months;\n* Significant arrhythmias (including unresolved ventricular arrhythmias or atrial fibrillation)\n* Nursing\u002Fpregnant mothers\n* Do not agree to the filing, forwarding and use of his\u002Fher pseudonymized data.","100 Years",{"count":80,"type":21},1000,[82],"PHASE3","The overall objective of the Stroke Minimization through Additive Anti-atherosclerotic Agents in Routine Treatment II (SMAART-II) is to deploy a hybrid study design to firstly, demonstrate the efficacy of a polypill (Polycap ®) containing fixed doses of antihypertensives, a statin, and antiplatelet therapy taken as two capsules, once daily orally in reducing composite vascular risk over 24 months vs. usual care among 1000 recent stroke patients encountered at 12 hospitals in Ghana. Secondly, SMAART II seeks to develop an implementation strategy for routine integration and policy adoption of this polypill for post-stroke cardiovascular risk reduction in an under-resourced system burdened by suboptimal care and outcomes.",[85,28],"Stroke",{"date":87,"type":37},"2026-06-22",{"date":89,"type":21},"2026-08-01",{"date":91,"type":21},"2028-09-01",{"name":93,"class":44},"Northern California Institute of Research and Education",1,{"id":96,"slug":97,"hasResults":12,"nctId":98,"briefTitle":99,"officialTitle":99,"acronym":4,"eligibilityCriteria":100,"healthyVolunteers":101,"sex":102,"minAge":17,"maxAge":4,"enrollmentInfo":103,"targetDuration":4,"studyType":22,"phases":105,"briefSummary":106,"conditions":107,"keywords":111,"overallStatus":113,"whyStopped":4,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":123},"100487272","reducing-psychological-barriers-to-prep-persistence-among-pregnant-and-postpartum-women-in-cape-town-south-africa-100487272","NCT05624931","Reducing Psychological Barriers to PrEP Persistence Among Pregnant and Postpartum Women in Cape Town, South Africa","Inclusion Criteria:\n\n* For participants across all three aims are:\n\n  * Female sex\n  * Aged 15+\n  * Pregnant and presenting antenatal care at the Gugulethu MOU\n  * HIV-negative\n  * Recent PrEP initiation (\\\u003C1 month ago) or PrEP adherence challenges, either documented (\\>2 weeks late to pick up PrEP refill) or self-reported\n  * Moderate to severe symptoms of posttraumatic stress and\u002For depression (defined as a score of ≥31 on PTSD Checklist for DSM-5 (PCL-5) and\u002For a score of ≥13 on the Edinburgh Postnatal Depression Scale (EPDS). Cutoff scores may be adjusted by 3-5 points to facilitate recruitment.\n\nExclusion Criteria:\n\n* There are no exclusion criteria with respect to parity or gravidity.\n\n  * Participants who are unable to provide informed consent or assent in English or Xhosa\n  * Have a significant psychiatric illness (e.g., active psychotic disorder or untreated bipolar disorder) that could interfere with participation will be excluded. Positive symptoms of active psychosis or mania will be assessed by the research assistants. They will be trained to identify delusions, hallucinations, disorganized or pressured speech, flight of ideas, and grandiosity as they speak to potential participants.\n  * Potential participants will also be asked if they have any health conditions that make it difficult for them to travel to the clinic.",true,"FEMALE",{"count":104,"type":21},118,[24],"Pregnant women in South Africa (SA) are at high risk of HIV acquisition. Pre-exposure prophylaxis (PrEP) use during pregnancy is both safe and effective in preventing HIV. However, posttraumatic stress (associated with intimate partner violence and\u002For other traumas) and depression negatively impact PrEP adherence among women in SA. Addressing posttraumatic stress and depression will likely improve PrEP adherence and persistence (i.e., sustained PrEP adherence over time) during pregnancy and breastfeeding, which are periods of dramatically increased HIV risk. The overarching goal of this proposal is to develop and test the feasibility and acceptability of a cognitive behavioral intervention that targets common underlying factors of posttraumatic stress and depression to improve PrEP adherence and persistence during pregnancy and the postpartum transition. The specific aims of the project are to (1) explore the mechanisms by which posttraumatic stress and depression impact PrEP adherence and persistence during pregnancy via qualitative interviews; (2) develop a brief PrEP adherence and persistence intervention (\\~4 sessions) that reduces the negative impact of psychological mechanisms common to posttraumatic stress and depression on PrEP use, and builds behavioral skills to improve self-care; and (3) evaluate the feasibility, acceptability, and signals of preliminary efficacy of the intervention, which will be integrated into antenatal care, in a pilot randomized controlled trial. All data will be collected in the Midwife Obstetrics Unit (MOU) in Gugulethu, a peri-urban settlement and former township community outside of Cape Town, SA.",[108,109,110,28],"Depression","Posttraumatic Stress Disorder","Pregnancy Related",[112],"HIV, pregnancy, PrEP","RECRUITING","2026-06-15",{"date":116,"type":37},"2026-06-16",{"date":118,"type":37},"2025-04-17",{"date":120,"type":21},"2027-07-30",{"name":122,"class":44},"Boston University Charles River Campus",2,{"id":125,"slug":126,"hasResults":12,"nctId":127,"briefTitle":128,"officialTitle":129,"acronym":130,"eligibilityCriteria":131,"healthyVolunteers":12,"sex":16,"minAge":132,"maxAge":4,"enrollmentInfo":133,"targetDuration":4,"studyType":22,"phases":135,"briefSummary":136,"conditions":137,"keywords":4,"overallStatus":113,"whyStopped":4,"lastUpdateSubmitDate":140,"lastUpdatePostDateStruct":141,"startDateStruct":143,"completionDateStruct":145,"leadSponsor":147,"locationsCount":149},"100453378","medication-adherence-program-100453378","NCT05183763","Medication Adherence Program","Supporting Tailored Adaptive Change and Reinforcement for Medication Adherence Program: Randomized Trial of a Novel Approach to Improve Adherence in Older Hypertensive Women and Men","MAP","Inclusion Criteria:\n\n* fully insured by Blue Cross Blue Shield of Louisiana (BCBSLA)\n* continuously enrolled in BCBSLA for one year\n* planning to remain a member of BCBSLA for next year\n* English-speaking\n* telephone access\n* aged ≥40 years\n* diagnosis of essential hypertension (ICD-10-CM code I10)\n* currently filling antihypertensive medication\n* low antihypertensive medication refill (proportion of days covered (PDC) \\\u003C0.8)\n* low self-report adherence (4-item Krousel-Wood Medication Adherence Scale (K-Wood-MAS-4) score ≥1)\n* uncontrolled blood pressure (BP) (systolic BP ≥130 mm Hg or diastolic BP ≥80 mm Hg)\n* desire to improve BP\n\nExclusion Criteria:\n\n* living in a household with someone already enrolled in the study\n* enrollment in another clinical trial for drug adherence or BP control\n* moderate to severe cognitive impairment","40 Years",{"count":134,"type":21},402,[24],"Randomized controlled trial testing the efficacy of the Supporting Tailored Adaptive change and Reinforcement for Medication Adherence Program (STAR-MAP), a health coaching approach that aims to improve antihypertensive medication adherence, blood pressure control, and quality of life. Participants (n=402) \\>=40 years old with a diagnosis of hypertension, uncontrolled blood pressure, and low antihypertensive medication adherence will be recruited through a statewide health insurer, Blue Cross Blue Shield of Louisiana, and randomized to receive either interactive health coaching sessions with medication reminder tools (intervention) or medication reminder tools only (control) over one year. Data will be collected from participants at baseline, 6 months, 12 months, and 24 months using questionnaires, physical measurement (height, weight, blood pressure), a computer-based single-category implicit association test, and laboratory analysis of antihypertensive medication urinary metabolites.",[138,28,139],"Hypertension","Behavior and Behavior Mechanisms","2026-06-11",{"date":142,"type":37},"2026-06-12",{"date":144,"type":37},"2022-03-07",{"date":146,"type":21},"2027-04-30",{"name":148,"class":44},"Tulane University",5,{"id":151,"slug":152,"hasResults":12,"nctId":153,"briefTitle":154,"officialTitle":155,"acronym":156,"eligibilityCriteria":157,"healthyVolunteers":12,"sex":102,"minAge":52,"maxAge":4,"enrollmentInfo":158,"targetDuration":4,"studyType":22,"phases":160,"briefSummary":161,"conditions":162,"keywords":169,"overallStatus":113,"whyStopped":4,"lastUpdateSubmitDate":183,"lastUpdatePostDateStruct":184,"startDateStruct":185,"completionDateStruct":187,"leadSponsor":189,"locationsCount":94},"100613993","evaluating-an-ai-based-mobile-application-for-chemotherapy-support-in-breast-cancer-patients-100613993","NCT07273812","Evaluating an AI-Based Mobile Application for Chemotherapy Support in Breast Cancer Patients","Evaluating an AI-Based Mobile Application for Chemotherapy Support in Breast Cancer Patients: A Randomized Controlled Trial","AI-ChemoApp","Inclusion Criteria:\n\n* Confirmed diagnosis of breast cancer stages I, II, or III.\n* Patients must be currently scheduled to initiate their first-ever cycle of chemotherapy.\n* Age 18 years or older.\n* Ability to understand and provide informed consent.\n* Possession of a smartphone (Android or iOS) and functional digital literacy, defined as the ability to independently navigate mobile applications, read on-screen text in Arabic, and input daily health data. (for the intervention group).\n* Willingness to comply with study procedures and follow-up schedules.\n* Ability to communicate in Arabic, as the mobile application and chatbot will be developed in Arabic.\n\nExclusion Criteria:\n\n* Patients with Stage IV (Metastatic) breast cancer.\n* Patients receiving concurrent hormonal therapy during the chemotherapy phase, to isolate chemotherapy-induced adverse events.\n\nPatients with cognitive impairment or severe psychiatric disorders that would preclude effective interaction with the mobile application or questionnaire completion.\n\n* Patients receiving palliative care where symptom management is the sole focus and active chemotherapy is not being administered with curative or life prolonging intent.\n* Patients participating in other interventional clinical trials that might confound the outcomes of this study.\n* Patients with severe comorbidities that could significantly impact their ability to participate or bias outcome measures.",{"count":159,"type":21},130,[24],"The goal of this clinical trial is to learn if an Arabic-language mobile application that uses artificial intelligence (AI) can help women with breast cancer during chemotherapy. The app is designed to give personalized support by reminding participants about their medications, teaching them how to manage treatment side effects, and alerting their healthcare team about serious symptoms.\n\nThe main questions this study aims to answer are:\n\n1. Does the AI-based mobile app provide accurate and safe recommendations for the patients?\n2. Does using the AI-based mobile app help lower treatment-related symptoms and side effects compared to usual care?\n3. Does the app help participants take their medications more regularly?\n4. Does it increase participants' understanding and satisfaction with the information they receive about their treatment?\n\nResearchers will compare two groups:\n\nGroup 1: Participants who use the AI-based mobile app plus usual oncology care. Group 2: Participants who receive usual care only.\n\nParticipants will:\n\n1. Use the mobile app daily for 12 weeks while receiving chemotherapy.\n2. Complete short questionnaires about symptoms, medication use, and quality of life at the start and end of the study.\n3. Report any problems or feedback about using the app. The AI app is for support and education only. It does not make treatment decisions. All information from the app will be reviewed by oncologists and pharmacists to ensure participant safety.",[163,164,165,28,166,167,168],"Breast Cancer","Breast Neoplasm","Chemotherapy-Related Toxicities","Quality of Life in Cancer Patients","Accuracy of AI App","Symptom Management",[170,171,172,173,174,175,176,177,178,179,180,181,182],"Artificial Intelligence","Mobile Application","digital health","supportive care","chemotherapy","patient education","Symptom Monitoring","Human-in-the-Loop AI","Breast Cancer Chemotherapy","Oncology","Arabic Language App","Pharmacy Iraq","Randomized Controlled Trial","2026-06-10",{"date":142,"type":37},{"date":186,"type":37},"2026-06-01",{"date":188,"type":21},"2026-11-06",{"name":190,"class":44},"Dena h. Al-Tameemi",{"id":192,"slug":193,"hasResults":12,"nctId":194,"briefTitle":195,"officialTitle":196,"acronym":197,"eligibilityCriteria":198,"healthyVolunteers":101,"sex":16,"minAge":52,"maxAge":199,"enrollmentInfo":200,"targetDuration":4,"studyType":22,"phases":202,"briefSummary":203,"conditions":204,"keywords":207,"overallStatus":113,"whyStopped":4,"lastUpdateSubmitDate":210,"lastUpdatePostDateStruct":211,"startDateStruct":212,"completionDateStruct":214,"leadSponsor":216,"locationsCount":123},"100514489","effectiveness-and-adoption-of-the-teltex4bp-intervention-among-adults-with-hypertension-in-nepal-100514489","NCT05979168","Effectiveness and Adoption of the TelTex4BP Intervention Among Adults With Hypertension in Nepal","Effectiveness and Adoption of the Structured mHealth Intervention for Improving Blood Pressure Control (TelTex4BP) Among Adults With Hypertension in Nepal: A Randomized Controlled Trial","TelTex4BP","Inclusion Criteria:\n\n* Clinical diagnosis of hypertension\n* Currently receiving\u002Fprescribed blood pressure-lowering medication for more than three month\n* With uncontrolled blood pressure (\\>140\u002F90mm of Hg)\n* Should have access to a mobile phone\n* Able to read text messages ( by themselves\u002Fwith the help of family)\n\nExclusion Criteria:\n\n* Diagnosed with myocardial infarction, stroke, and kidney failure\n* Severe mental illness, cognitive impairment\n* Pregnant women or in the postpartum period","70 Years",{"count":201,"type":21},500,[24],"Despite evidence of preventing cardiovascular disease (CVD) risk through lifestyle changes, many patients with hypertension (HTN) do not comply with this and suffer from CVD and other complications. A previous study using a structured lifestyle intervention program has reported a 14% decrease in the 10-year risk of developing CVD at one year among hypertensive and diabetes patients. Low and Middle-Income countries (LMICs) struggle with a shortage of health workers to deliver such interventions. In this context, mobile phones can contribute to bridging this gap by incorporating them into the health system for health intervention delivery. There is a need to develop contextual mHealth intervention adapted to local needs and culture and test its effectiveness in LMIC settings like Nepal. Our previous small-scale pilot mHealth (text messages) study reported promising evidence in reducing blood pressure among hypertensive patients in the intervention arm \\[adjusted reduction in systolic blood pressure (BP) -6.50 (95% CI, -12.6; -0.33) and diastolic BP -4.60 (95% CI, -8.16; -1.04)\\], with a greater proportion achieving target BP (70% vs 48% in the control arm, p = 0.006)\\] and improving treatment compliance (p \\\u003C 0.001) in Nepal. This finding supports the expansion to a large-scale trial of a structured mHealth intervention to see its long-term effectiveness and sustainability for patients with HTN to improve BP control and reduce CVD risk. Hence, this study aims to assess the effectiveness of a behavioural intervention through mHealth (telephone\u002Fmobile phone calls and text messages) informed by the RE-AIM framework for improving blood pressure control among patients with hypertension in a hospital (Manamohan Cardiothoracic Vascular and Transplant Center) of Kathmandu, Nepal.",[138,28,205,206],"Blood Pressure","Cardiovascular Diseases",[208,209,138,182],"Mobile Intervention","Blood Pressure Control","2026-06-09",{"date":140,"type":37},{"date":213,"type":37},"2025-11-02",{"date":215,"type":21},"2027-12-31",{"name":217,"class":44},"Central Department of Public Health",{"id":219,"slug":220,"hasResults":12,"nctId":221,"briefTitle":222,"officialTitle":222,"acronym":4,"eligibilityCriteria":223,"healthyVolunteers":12,"sex":16,"minAge":52,"maxAge":4,"enrollmentInfo":224,"targetDuration":4,"studyType":22,"phases":226,"briefSummary":227,"conditions":228,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":233,"lastUpdatePostDateStruct":234,"startDateStruct":235,"completionDateStruct":237,"leadSponsor":239,"locationsCount":4},"100540313","examining-the-health-effects-of-npower365-among-black-same-gender-loving-men-100540313","NCT06315218","Examining the Health Effects of NPOWER365 Among Black Same Gender Loving Men","Inclusion Criteria:\n\n1. Identify as Black or African American, regardless of ethnicity\n2. Identify as male, regardless of sex assigned at birth\n3. Are living with HIV and prescribed a daily ART regimen\n4. Are age ≥ 18;\n5. Have sex with men\n6. Own an internet-connected device (e.g., smartphone, tablet)\n7. Reside in the Atlanta-area EHE jurisdictions.\n\nExclusion Criteria:\n\n1. Lack of English fluency\n2. Past participation in the pilot.",{"count":225,"type":21},350,[24],"This research study aims to test the effectiveness, reach, and maintenance over time of the NPOWER365 HIV care intervention for Black men who have sex with men (BMSM) living with HIV. NPOWER365 is a BMSM community-developed multicomponent intervention that aims to: 1) Support daily health promotion via HIV health education and health maintenance reminders; 2) Foster positive social connections among BMSM via online moderated forums, interpersonal chats, and community calendars; 3) Connect clients to BMSM-affirming healthcare, including HIV treatment and mental healthcare; 4) Provide resources for housing, transportation, and other economic empowerment.",[229,230,28,231,232],"Sexual and Gender Minorities","Social Stigma","Depressive Symptoms","Anxiety Symptoms","2026-06-08",{"date":183,"type":37},{"date":236,"type":21},"2026-08",{"date":238,"type":21},"2028-04",{"name":240,"class":44},"Rutgers, The State University of New Jersey",{"id":242,"slug":243,"hasResults":12,"nctId":244,"briefTitle":245,"officialTitle":246,"acronym":4,"eligibilityCriteria":247,"healthyVolunteers":12,"sex":16,"minAge":52,"maxAge":4,"enrollmentInfo":248,"targetDuration":4,"studyType":250,"phases":4,"briefSummary":251,"conditions":252,"keywords":258,"overallStatus":113,"whyStopped":4,"lastUpdateSubmitDate":261,"lastUpdatePostDateStruct":262,"startDateStruct":264,"completionDateStruct":266,"leadSponsor":268,"locationsCount":94},"100637379","impact-of-online-medical-misinformation-100637379","NCT07601308","Impact of Online Medical Misinformation","Impact of Online Medical Misinformation on Medication Adherence, Treatment Decisions, and Health-Seeking Behavior Among Patients With Chronic Diseases","Inclusion Criteria:\n\n* Adults ≥ 18 years\n* Disease duration ≥ 6 months\n* Social media use at least once weekly\n* Able to provide informed consent\n\nExclusion Criteria:\n\n* Severe cognitive or psychiatric disorders",{"count":249,"type":21},300,"OBSERVATIONAL","This mixed-methods study aims to examine the impact of exposure to online medical misinformation on medication adherence, treatment decision-making, and healthcare-seeking behavior among patients with chronic diseases. The study targets patients with hypertension, diabetes mellitus, and dyslipidemia and evaluates how misinformation influences real-world health behaviors. Quantitative and qualitative data will be collected concurrently to provide a comprehensive understanding of misinformation-related health risks.",[253,28,254,255,256,257],"Medical Misinformation","Health-Seeking Behavior","Chronic Diseases","Diabetes (DM)","Hypertension (HTN)",[259,260,28],"Online Misinformation","Chronic Disease","2026-06-04",{"date":263,"type":37},"2026-06-05",{"date":265,"type":21},"2026-05-15",{"date":267,"type":21},"2026-06-30",{"name":269,"class":44},"Alexandria University",{"id":271,"slug":272,"hasResults":12,"nctId":273,"briefTitle":274,"officialTitle":275,"acronym":276,"eligibilityCriteria":277,"healthyVolunteers":12,"sex":16,"minAge":52,"maxAge":4,"enrollmentInfo":278,"targetDuration":4,"studyType":22,"phases":280,"briefSummary":281,"conditions":282,"keywords":285,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":293,"lastUpdatePostDateStruct":294,"startDateStruct":295,"completionDateStruct":297,"leadSponsor":299,"locationsCount":94},"100643324","structured-nursing-intervention-for-adults-with-poorly-controlled-asthma-a-pilot-study-100643324","NCT07635537","Structured Nursing Intervention for Adults With Poorly Controlled Asthma: A Pilot Study","Design and Development of RESPiraIA-Asthma: A Structured Nursing Intervention for the Follow-up of Adults With Poorly Controlled Asthma. A Pilot Study","RESPiraIA-Asma","Inclusion Criteria:\n\n* Confirmed diagnosis of mild or moderate persistent, non-severe asthma.\n* Poorly controlled asthma, defined as an Asthma Control Test (ACT) score below 20.\n* Active inhaled maintenance therapy with inhaled corticosteroids (ICS), alone or combined with a long-acting beta-agonist (LABA).\n* Age 18 years or older.\n* Active follow-up in the Pulmonology outpatient clinic of Hospital Clínico San Carlos.\n* Sufficient cognitive capacity to participate and complete the questionnaires.\n* Access to a means of communication (in-person, telephone, digital, or mixed).\n* Signed informed consent.\n\nExclusion Criteria:\n\n* Significant respiratory comorbidity (chronic obstructive pulmonary disease ( COPD), bronchiectasis, pulmonary fibrosis, chronic pulmonary thromboembolism, or home oxygen therapy).\n* Acute asthma exacerbation within the 4 weeks before inclusion.\n* Participation in another clinical trial within the previous 12 months.\n* Cognitive impairment or language barriers preventing completion of the questionnaires.\n* Conditions limiting continuity of follow-up over the 12 months.\n* Mild comorbidities such as allergic rhinitis or mild sleep apnea are not exclusion criteria.",{"count":279,"type":21},30,[24],"Asthma affects a large number of adults, and many of them do not achieve good control of their symptoms. Poor inhaler technique, irregular medication use, and the lack of structured nursing follow-up are among the main reasons. RESPiraIA-Asma is a 12-month structured nursing intervention designed to address these gaps in adults with poorly controlled, non-severe asthma.\n\nThis is a quasi-experimental, single-group, before-and-after pilot study. Each participant is followed across six visits over one year, at baseline and at months 1, 3, 6, 9, and 12. The intervention combines therapeutic education, inhaler technique training, home peak-flow self-monitoring, biopsychosocial assessment, and a standardized nursing care plan based on internationally recognized nursing taxonomies for diagnoses, interventions, and outcomes: NANDA International (NANDA-I), Nursing Interventions Classification (NIC), and Nursing Outcomes Classification (NOC), activated by objective clinical thresholds.\n\nA central principle of the model is digital equity: the same standard of care is offered through three equivalent access routes (digital, mixed, or in-person), chosen according to each participant's digital skills, resources, and preferences, so that technology never becomes a barrier to access.\n\nThe study evaluates whether the model is feasible to deliver in routine clinical practice, measured through participant retention, data completeness, and acceptability, and it looks for preliminary signals of its effect on asthma control, treatment adherence, lung function, and biopsychosocial well-being. As an exploratory pilot, it is not designed to confirm efficacy; its purpose is to inform the design of a larger future trial.",[283,28,284],"Asthma","Self-management",[283,286,287,288,289,290,170,291,292],"Nursing Diagnosis","Treatment Adherence and Compliance","Nursing Care","Digital Divide","Digital Technology","Structured nursing intervention","NANDA-I, NIC, NOC","2026-06-03",{"date":210,"type":37},{"date":296,"type":21},"2026-10",{"date":298,"type":21},"2029-09",{"name":300,"class":44},"Hospital San Carlos, Madrid",{"id":302,"slug":303,"hasResults":12,"nctId":304,"briefTitle":305,"officialTitle":306,"acronym":4,"eligibilityCriteria":307,"healthyVolunteers":12,"sex":102,"minAge":52,"maxAge":4,"enrollmentInfo":308,"targetDuration":4,"studyType":22,"phases":310,"briefSummary":311,"conditions":312,"keywords":313,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":317,"lastUpdatePostDateStruct":318,"startDateStruct":320,"completionDateStruct":322,"leadSponsor":324,"locationsCount":45},"100636185","adjuvant-endocrine-therapy-adherence-intervention-pilot-in-rwanda-100636185","NCT07562399","Adjuvant Endocrine Therapy Adherence Intervention Pilot in Rwanda","Piloting an Intervention to Improve Adjuvant Endocrine Therapy Adherence in Patients With Breast Cancer in Rwanda","Inclusion Criteria:\n\n* Female patients\n* Age 18 or older\n* Pathologic confirmation of ER-positive breast cancer\n* Clinical or radiographic confirmation of disease localized to the breast and regional lymph nodes\n* Within 6-36 months of starting AET\n* Have a cellphone capable of receiving text messages.\n* Are currently receiving AET at Butaro or satellite clinics.\n\nExclusion Criteria:\n\n* Unwilling\u002FUnable to participate\n* Unable to comprehend study languages (English or Kinyarwanda)\n* Adults unable to consent\n* Individuals who are not yet adults (infants, children, teenagers)\n* Prisoners\n* Pregnant women",{"count":309,"type":21},224,[24],"This study aims to evaluate a multi-modal intervention designed to improve adherence to adjuvant endocrine therapy (AET) among patients with ER-positive breast cancer in Rwanda. The intervention includes educational, behavioral, and reminder components, and will be assessed for feasibility and impact on medication adherence.",[28,163],[314,315,316],"breast cancer","medication adherence","ER-positive breast cancer","2026-05-18",{"date":319,"type":37},"2026-05-20",{"date":321,"type":21},"2026-09-20",{"date":323,"type":21},"2028-12-31",{"name":325,"class":44},"Dana-Farber Cancer Institute",{"id":327,"slug":328,"hasResults":12,"nctId":329,"briefTitle":330,"officialTitle":331,"acronym":332,"eligibilityCriteria":333,"healthyVolunteers":12,"sex":16,"minAge":52,"maxAge":4,"enrollmentInfo":334,"targetDuration":4,"studyType":22,"phases":336,"briefSummary":337,"conditions":338,"keywords":342,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":353,"lastUpdatePostDateStruct":354,"startDateStruct":355,"completionDateStruct":357,"leadSponsor":359,"locationsCount":123},"100639134","medbridge-guided-ncmchw-post-discharge-support-for-high-risk-t2d-patients-100639134","NCT07599852","MEDBRIDGE-Guided NCM\u002FCHW Post-Discharge Support for High-Risk T2D Patients","MEDBRIDGE: AI-Driven Risk Stratification and Care Transition Intervention to Improve Diabetes Medication Management","MEDBRIDGE","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Diagnosis of type 2 diabetes (HbA1c of 6.5% or higher or relevant ICD-10 codes including E11, E13, E14, R73, L97.509, K31.84)\n* Discharged from UAB Hospital or its emergency departments\n* Receiving primary care at Cooper Green Mercy Health Services or UAB Post Discharge Clinic\n* Identified as high risk by the MEDBRIDGE prediction tool based on elevated risk of HbA1c elevation, diabetes-related emergency department visits, or diabetes-related hospitalizations within 3 months post-discharge\n\nExclusion Criteria:\n\n* Under age 18\n* No indication of type 2 diabetes\n* Not affiliated with Cooper Green Mercy Health Services or UAB Post Discharge Clinic for primary care\n* Unable to provide informed consent\n* Currently enrolled in another post-discharge intervention study",{"count":335,"type":21},45,[24],"This study tests whether a support program led by a nurse case manager and community health worker can help patients with type 2 diabetes manage their medications after leaving the hospital. Many patients with diabetes take multiple medications, and changes to these medications during hospital stays can cause confusion and lead to missed doses or incorrect use. This is especially common in communities with limited access to healthcare.\n\nThe study uses a computer-based tool called MEDBRIDGE (MEDication BRIDGE) to identify patients who may be at higher risk for problems after discharge, such as worsening blood sugar control or return visits to the emergency department. Patients identified as high-risk will receive 3 months of support from a nurse case manager and community health worker team, who will help with medication questions, coordinate with their doctor, and provide follow-up check-ins.\n\nThe main goal is to find out whether this type of support program is practical to deliver and acceptable to patients. The study will also track changes in blood sugar levels and emergency department visits. Forty-five patients will be enrolled over 6 months at the University of Alabama at Birmingham and Cooper Green Mercy Health Services in Jefferson County, Alabama.",[339,28,340,341],"Type 2 Diabetes","Care Transition","Medication Discrepancy",[339,343,344,345,346,347,348,170,349,350,351,352],"Medication Management","Care Transitions","Post-Discharge","Nurse Case Manager","Community Health Worker","Risk Stratification","HbA1c","Social Determinants of Health","Deep South","Underserved Populations","2026-05-14",{"date":319,"type":37},{"date":356,"type":21},"2029-05-01",{"date":358,"type":21},"2031-04-30",{"name":360,"class":44},"University of Alabama at Birmingham",{"id":362,"slug":363,"hasResults":12,"nctId":364,"briefTitle":365,"officialTitle":365,"acronym":366,"eligibilityCriteria":367,"healthyVolunteers":12,"sex":16,"minAge":52,"maxAge":4,"enrollmentInfo":368,"targetDuration":4,"studyType":22,"phases":370,"briefSummary":371,"conditions":372,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":376,"lastUpdatePostDateStruct":377,"startDateStruct":378,"completionDateStruct":380,"leadSponsor":381,"locationsCount":94},"100638079","evaluation-of-an-instructional-video-about-medication-management-during-admission-and-medication-adherence-for-kidney-transplantation-and-in-the-outpatient-clinic-in-a-dutch-university-hospital-100638079","NCT07592624","Evaluation of an Instructional Video About Medication Management During Admission and Medication Adherence for Kidney Transplantation and in the Outpatient Clinic in a Dutch University Hospital.","MediT","Inclusion Criteria:\n\n* The patient is able to take the medication independently or with the help of someone else (professionals not included).\n* After admission, the patient is discharged to their own home or home of friend\u002Frelative.\n* The patient had a follow up at the outpatient clinic in the Erasmus Medical Center for at least one year after transplantation.\n* The patient is able to read the medication list or an illiteracy-friendly medication list.\n\nExclusion Criteria:\n\n* Patients under 18 years of age\n* Patients who got discharged with a medication dispenser\n* Refusal to participate in the study.\n* Cognitive impairments that hinder participation.\n* Patients and\u002For family who can not understand (language barrier) the instructional video.",{"count":369,"type":21},308,[24],"The goal of this RCT is to evaluate the effect of the instructional video on improving patient compliance and reducing medication errors. The study will include adult kidney transplant recipients (18 years or older) at Erasmus MC who have undergone a kidney transplantation starting January 2026.\n\nThe main questions it aims to answer:\n\nThe primary aim of this study is to assess whether our developed video instruction, compared with the traditional verbal instruction, both of which are given shortly before training during admission, reduces the number of medication errors in kidney transplant patients.\n\nThe study will also examine the correlation between patient characteristics (such as age, comorbidities, and language proficiency) and medication errors. Additionally, patient-reported medication errors will be measured through a questionnaire completed during follow-up visits at the outpatient clinic, which is part of standard care.\n\nThe instructional video will be evaluated by a short questionnaire.",[373,374,28,375],"Kidney Transplant","Adult","Instruction Videos","2026-05-11",{"date":317,"type":37},{"date":379,"type":21},"2026-07-01",{"date":215,"type":21},{"name":382,"class":44},"Erasmus Medical Center",{"id":384,"slug":385,"hasResults":12,"nctId":386,"briefTitle":387,"officialTitle":388,"acronym":389,"eligibilityCriteria":390,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":391,"enrollmentInfo":392,"targetDuration":4,"studyType":22,"phases":394,"briefSummary":395,"conditions":396,"keywords":397,"overallStatus":113,"whyStopped":4,"lastUpdateSubmitDate":400,"lastUpdatePostDateStruct":401,"startDateStruct":403,"completionDateStruct":405,"leadSponsor":407,"locationsCount":94},"100599412","final-prototype-refinement-of-adaptive-cell-phone-support-100599412","NCT07084155","Final Prototype Refinement of Adaptive Cell Phone Support","Adaptive Cell Phone Support to Promote Medication Adherence Among Adolescents and Young Adults With Chronic Health Conditions","ACPS","Inclusion Criteria:\n\n* Children's Hospital Los Angeles patient\n* between 15-20 years old at enrollment\n* taking at least one oral medication per day for a chronic health condition\n* English speaking\n* demonstrating sufficient cognitive capacity to engage in the assent\u002Fconsent process and study procedures\n\nThere is no exclusion criteria.","20 Years",{"count":393,"type":21},35,[24],"The goal of this feasibility pilot trial is to finalize the design of a mobile health intervention for promoting medication adherence in a population of adolescents and young adults with chronic health conditions. The main question\\[s\\] it aims to answer are:\n\n1. Is the final version of the intervention sufficiently feasible, usable, and acceptable for evaluation in a randomized clinical trial?\n2. Do participants show improvements in medication adherence during their field testing of the intervention?",[28],[398,399,32],"adolescents","mobile health","2026-05-08",{"date":402,"type":37},"2026-05-12",{"date":404,"type":37},"2026-03-25",{"date":406,"type":21},"2027-01-31",{"name":408,"class":44},"Children's Hospital Los Angeles",{"id":410,"slug":411,"hasResults":12,"nctId":412,"briefTitle":413,"officialTitle":414,"acronym":415,"eligibilityCriteria":416,"healthyVolunteers":101,"sex":16,"minAge":52,"maxAge":4,"enrollmentInfo":417,"targetDuration":4,"studyType":22,"phases":419,"briefSummary":420,"conditions":421,"keywords":423,"overallStatus":113,"whyStopped":4,"lastUpdateSubmitDate":428,"lastUpdatePostDateStruct":429,"startDateStruct":431,"completionDateStruct":433,"leadSponsor":434,"locationsCount":94},"100481393","improving-medication-adherence-using-family-focused-and-literacy-sensitive-strategies-100481393","NCT05548413","Improving Medication Adherence Using Family-focused and Literacy-sensitive Strategies","Improving Medication Adherence Using Family-focused and Literacy-sensitive Strategies in Patients With Heart Failure","FamLit_HF","Inclusion Criteria - Patient Participants:\n\n* confirmed diagnosis of heart failure (HF), either systolic or diastolic HF\n* ave suboptimal medication adherence\n* have a care partner (CP) (either spouse, daughter\u002Fson, partner, other relative, friend) who is identified by the patient as the person most involved in HF care\n* willingness to have a CP be involved in their medication taking\n* have undergone evaluation of HF and prescribed stable doses of HF medications for at least 3 months\n* live in a setting where the patient is responsible for their ow medication administration\n* willing to use the SimpleMed+ (i.e., an electronic pillbox to measure objective medication adherence)\n* availability by phone\n\nExclusion Criteria - Patient Participants:\n\n* cognitive impairment as indicated by having difficulties to understand and give informed consent\n* a recent hospitalization within 3 months of study enrollment\n* co-existing end-stage renal disease or terminal illness such as advanced malignancy, or any other condition with less than 1-year life expectancy\n* psychotic illness\n* current alcohol dependence or other substance abuse\n* inability to speak English or other communication barrier\n* currently or have received any similar self-care intervention recently in the past year\n\nInclusion Criteria - Care Partners:\n\n* unpaid family member, friend, partner, or other relation who is involved in the patients' care at least 3 times a week, designated by the patient\n* willing to receive interventions with the patient together\n* 18 years of age or older\n\nExclusion Criteria - Care Partners:\n\n* cognitive impairment as indicated by having difficulties to understand and give informed consent\n* coexisting terminal illness\n* non-English speaking or any other communication barrier",{"count":418,"type":21},328,[24],"People with heart failure who do not take their medications as prescribed are at high risk of complications leading to hospitalization, death and poor quality of life. In the proposed intervention, nurses will use easy-to-understand language to coach patients and their care partners to help them work together and build skills to overcome their individual barriers to adherence in order to 1) improve and sustain patient medication adherence; 2) reduce hospitalization; 3) improve quality of life. If effective, this intervention will support long-term medication adherence, thus reducing hospitalizations related to heart failure and quality of life.",[28,422],"Heart Failure",[424,425,426,427],"care partner","family","health literacy","teach back","2026-04-29",{"date":430,"type":37},"2026-05-05",{"date":432,"type":37},"2023-01-04",{"date":215,"type":21},{"name":435,"class":44},"Jia-Rong Wu",{"id":437,"slug":438,"hasResults":12,"nctId":439,"briefTitle":440,"officialTitle":440,"acronym":441,"eligibilityCriteria":442,"healthyVolunteers":12,"sex":16,"minAge":52,"maxAge":443,"enrollmentInfo":444,"targetDuration":4,"studyType":22,"phases":446,"briefSummary":447,"conditions":448,"keywords":453,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":454,"lastUpdatePostDateStruct":455,"startDateStruct":456,"completionDateStruct":457,"leadSponsor":458,"locationsCount":4},"100596312","impact-of-pharmate-trial-on-glycemic-control-diabetes-knowledge-medication-adherence-and-quality-of-life-in-type-2-diabetes-patients-a-mixed-method-study-protocol-100596312","NCT07043816","Impact of PharmaTE Trial on Glycemic Control, Diabetes Knowledge, Medication Adherence and Quality of Life in Type 2 Diabetes Patients: A Mixed-Method Study Protocol","PharmaTE","Inclusion Criteria\n\n* Patients diagnosed with uncontrolled type 2 diabetes (defined as glycated haemoglobin \\[HbA1c\\] \\>7%) within the previous 12 months\n* Adults (18 to 65 years) of either gender\n* Prescribed at least one antidiabetic medication\n* Have access to either a telephone or a mobile phone\n* Treated in an outpatient facility in IBOH, RAK\n* Arabic-speaking patients\n* Patients who understand study information and are given written informed consent.\n\nExclusion Criteria:\n\n* Under 18 years old\n* Pregnant ladies\n* Patients admitted to the emergency department\n* Patients with severe hepatic or renal dysfunction\n* Diagnosed with type 1 DM or diagnosed with gestational diabetes\n* Having vision or hearing impairments and psychological problems\n* Immunocompromised patients, e.g., organ transplants, AIDS, cancer patients, and patients on immunosuppressant therapy\n* Patients with no or limited access to either a telephone or mobile phone, as well as those without reliable internet access","65 Years",{"count":445,"type":21},154,[24],"The goal of this clinical trial is to find out whether a pharmacist-led tele-educational program (PharmaTE trial) can help people with type 2 diabetes manage their condition better.\n\nThe main questions this study aims to answer are:\n\n1. Does the PharmaTE trial improve blood sugar control (HbA1c levels)?\n2. Does it help patients better understand their condition?\n3. Does it increase how well patients follow their medication schedule?\n4. Does it improve the quality of life for patients with type 2 diabetes?\n5. Is this type of tele-education program feasible and acceptable for patients?\n\nParticipants will:\n\nBe randomly placed into one of two groups:\n\nIntervention group: Receive five virtual education sessions with a clinical pharmacist over the phone or via Zoom (each lasting 20-30 minutes), in addition to their usual diabetes care.\n\nControl group: Continue receiving standard diabetes care from their healthcare team without the additional pharmacist-led sessions.\n\nComplete assessments at the beginning and end of the study. These include:\n\nA blood test for HbA1c\n\n, Questionnaires on diabetes knowledge, medication adherence, and quality of life\n\nSome participants in the intervention group will be invited for interviews after the sessions to share their experiences and opinions about the program.\n\nWho can join? Adults aged 18-65 with uncontrolled type 2 diabetes (HbA1c \\> 7%), receiving care at Ibrahim Bin Hamad Obaidullah Hospital in Ras Al-Khaimah, who speak Arabic and can provide consent.",[449,450,451,28,452],"Type 2 Diabetes (T2DM)","Glycemic Control","Diabetes Knowledge","Quality of Life",[441],"2026-04-28",{"date":428,"type":37},{"date":39,"type":21},{"date":215,"type":21},{"name":459,"class":44},"Rabia Hussain",{"id":461,"slug":462,"hasResults":12,"nctId":463,"briefTitle":464,"officialTitle":464,"acronym":465,"eligibilityCriteria":466,"healthyVolunteers":101,"sex":102,"minAge":52,"maxAge":4,"enrollmentInfo":467,"targetDuration":4,"studyType":22,"phases":468,"briefSummary":469,"conditions":470,"keywords":4,"overallStatus":113,"whyStopped":4,"lastUpdateSubmitDate":474,"lastUpdatePostDateStruct":475,"startDateStruct":477,"completionDateStruct":479,"leadSponsor":481,"locationsCount":94},"100532729","women-focused-encounters-for-resilience-independence-strength-and-eudaimonia-100532729","NCT06216600","Women Focused Encounters for Resilience Independence Strength and Eudaimonia","WE RISE","Inclusion Criteria:\n\n1. Is a woman\n2. Able to read and understand English\n3. Able to participate in a low intensity exercise program\n4. HIV-seropositive\n5. At risk substance use (any illegal or unprescribed drug), tobacco, marijuana or alcohol use (four or more drinks in one day or 8 or more in one week).\n6. Reports missing more ART doses than previous months, or \\> 5 in a month, or has a detectable HIV viral load\n7. Experienced interpersonal violence\n8. Able and willing to provide informed consent\n\nExclusion Criteria:\n\n1. Unwilling to participate in video record sessions (used to evaluate the quality of the intervention)\n2. Enrolled in hospice\n3. Not willing or not able to comply with study advisory board group participation agreement.",{"count":249,"type":21},[24],"The goal of this combination Type 1 hybrid and observational study is to evaluate the impact of a peer delivered intervention of acceptance and commitment therapy (ACT) + exercise + social support to address the substance (ab)use, violence, and AIDS\u002FHIV (SAVA) to improve medication adherence for women living with HIV (WLWH). This intervention will be implemented by community based organizations that focus on WLWH across four counties. The main question it aims to answer are:\n\n* Will peer provision of ACT, exercise, and social support improve medication adherence for WLWH?\n* Will community based organizations be able to sustain the intervention after research is completed, and what changes will need to be made to sustain the intervention.",[471,472,473,28],"HIV Infections","Substance Use","Trauma","2026-04-27",{"date":476,"type":37},"2026-05-01",{"date":478,"type":37},"2024-09-19",{"date":480,"type":21},"2028-05-31",{"name":482,"class":44},"University of California, San Diego",{"id":484,"slug":485,"hasResults":12,"nctId":486,"briefTitle":487,"officialTitle":488,"acronym":489,"eligibilityCriteria":490,"healthyVolunteers":12,"sex":491,"minAge":52,"maxAge":18,"enrollmentInfo":492,"targetDuration":4,"studyType":250,"phases":4,"briefSummary":493,"conditions":494,"keywords":496,"overallStatus":113,"whyStopped":4,"lastUpdateSubmitDate":507,"lastUpdatePostDateStruct":508,"startDateStruct":510,"completionDateStruct":512,"leadSponsor":513,"locationsCount":94},"100635944","beyond-study-improving-hiv-treatment-and-well-being-among-young-msm-in-vietnam-100635944","NCT07559266","BEYOND Study: Improving HIV Treatment and Well-Being Among Young MSM in Vietnam","BEYOND Study: Bridging Equity, Youth, And Optimal Nurture for HIV Dynamics - Enhancing Treatment and Well-Being Among Young MSM Living With HIV in Vietnam","BEYOND","Inclusion Criteria:\n\n* Aged 18 to 24 years\n* Self-identified as male and reporting sex with men in the past 12 months\n* Confirmed HIV diagnosis according to Vietnam Ministry of Health (MOH) national HIV testing guidelines\n* Currently receiving antiretroviral therapy (ART) at one of the participating study clinics\n* Residing in Ho Chi Minh City or nearby areas and able to attend study visits at participating clinics\n* Able to understand and communicate in Vietnamese\n* Willing and able to provide informed consent and participate in study procedures\n\nExclusion Criteria:\n\n* Younger than 18 years or older than 24 years\n* Not currently receiving ART or receiving ART from a non-participating clinic\n* Severe cognitive impairment or mental health condition that, in the judgment of the research team, would interfere with the ability to provide informed consent or participation\n* Currently enrolled in another clinical or behavioral study that may interfere with this study\n* Unwilling or unable to provide informed consent or comply with study procedures","MALE",{"count":249,"type":21},"The BEYOND Study aims to evaluate HIV treatment outcomes and well-being among young men who have sex with men (YMSM) living with HIV in Ho Chi Minh City, Vietnam. Despite progress in HIV services, YMSM continue to experience disparities in engagement in care, antiretroviral therapy (ART) adherence, and viral suppression, influenced by individual, social, and structural factors including stigma and limited access to person-centered care.\n\nThis prospective cohort study will enroll 300 YMSM living with HIV from four clinical sites, including public, private, and community-based clinics. Participants will be followed for 12 months, with data collection at baseline, 6 months, and 12 months. The study will assess key outcomes including viral suppression, ART adherence, retention in care, mental health, and quality of life. In addition, in-depth interviews will be conducted with a subset of 20-30 participants to explore experiences with HIV care and barriers and facilitators to engagement.\n\nThe study will also examine the implementation and perceived impact of person-centered care and one-stop-shop service models across different healthcare settings. Findings from this study will inform strategies to improve HIV treatment outcomes and support the development of integrated, patient-centered approaches to care for YMSM living with HIV in Vietnam and similar settings.",[471,495,28],"Mental Health",[497,498,499,500,501,502,495,503,504,505,506],"HIV","YMSM","Antiretroviral Therapy Adherence","Viral Suppression","HIV Care Continuum","Retention in Care","Person-Centered Care","One-Stop-Shop Services","Integrated HIV Care","Ho Chi Minh City","2026-04-23",{"date":509,"type":37},"2026-04-30",{"date":511,"type":37},"2026-03-10",{"date":215,"type":21},{"name":514,"class":44},"Center for Applied Research on Men and Community Health, Vietnam",{"id":516,"slug":517,"hasResults":12,"nctId":518,"briefTitle":519,"officialTitle":520,"acronym":4,"eligibilityCriteria":521,"healthyVolunteers":12,"sex":102,"minAge":52,"maxAge":4,"enrollmentInfo":522,"targetDuration":4,"studyType":22,"phases":523,"briefSummary":524,"conditions":525,"keywords":529,"overallStatus":113,"whyStopped":4,"lastUpdateSubmitDate":507,"lastUpdatePostDateStruct":534,"startDateStruct":535,"completionDateStruct":537,"leadSponsor":539,"locationsCount":94},"100486003","1morestep-an-intervention-to-increase-hiv-care-engagement-and-reduce-intimate-partner-violence-among-black-women-living-with-hiv-100486003","NCT05608421","1MoreStep: An Intervention to Increase HIV Care Engagement and Reduce Intimate Partner Violence Among Black Women Living With HIV","1MoreStep: Pilot Trial of an Intervention to Increase HIV Care Engagement and Reduce Intimate Partner Violence Among Black Women Living With HIV","Inclusion Criteria:\n\n* Cis-gender female\n* Black or African American\n* ≥ Age 18\n* Living with HIV\n* ≤ 1 HIV care visit in previous 12 months OR virally unsuppressed (\\>50 copies\u002FmL) OR at high risk for poor HIV care adherence (PHQ ≥ 3, Generalized Anxiety Disorder (GAD) ≥ 3, active substance use)\n* IPV within the previous 2 years\n* Ability to attend in-person for up to 8 sessions\n* Do not report immediate severe danger from their partner\n* English fluency\n\nExclusion Criteria:\n\n* Not a Cis-gender female\n* Not Black or African American\n* ≤ Age17 or younger\n* Not living with HIV\n* ≥ 2 HIV care visits in previous 12 months\n* No IPV within the previous 2 years\n* Inability to attend in-person for up to 8 sessions\n* Reports immediate severe danger from their partner\n* Not fluent in English",{"count":54,"type":21},[24],"This study tests a 5-session cognitive behavioral approach program (herein referred to as the 1MoreStep intervention) to train Black women living with HIV (BWLWHI) and exposed to intimate partner violence (IPV) in the past 2 years (hereafter, BWLWHI) in: 1) cognitive and behavioral skills to access internal and external sources of strength (e.g. self-reliance, safety net); safety strategies, knowledge about Undetectable = Untransmissible (U=U) and HIV care; and reduce internalized and anticipated stigma; 2) communication skills to respond to enacted HIV and IPV stigma and enlist social support; and 3) addressing structural barriers to HIV care engagement with an HIV navigator component. The intervention is informed by the HIV-Stigma Framework and a resilient-reintegration model which views women as active participants in responding to IPV and managing life with HIV.\n\nAim 1: Examine preliminary efficacy of the 1MoreStep intervention on: (a) IPV safety strategies (informal and formal resources, safety planning, and placating strategies at baseline, 3-month and 6-month follow-up visits); and (b) HIV care engagement (medical record confirmed visit with an HIV care provider, antiretroviral therapy (ART) prescription, medication adherence, and viral load status during 3-month and 6-month follow-up visits).\n\nAim 2: Examine the acceptability and feasibility of the 1MoreStep intervention operationalized by (a) quantitative measures: session attendance and fidelity to key intervention components and (b) qualitative interviews to assess: program fit, facilitators and barriers to participation, and using 1MoreStep intervention skills.",[526,497,527,528,28],"Violence, Domestic","Stigma, Social","Engagement, Patient",[497,530,531,532,533],"Intimate Partner Violence (IPV)","Black women","Cognitive behavioral approach","Randomized Control Trial (RCT)",{"date":428,"type":37},{"date":536,"type":37},"2023-06-26",{"date":538,"type":21},"2026-12",{"name":540,"class":44},"Johns Hopkins University",{"id":542,"slug":543,"hasResults":12,"nctId":544,"briefTitle":545,"officialTitle":545,"acronym":4,"eligibilityCriteria":546,"healthyVolunteers":12,"sex":16,"minAge":52,"maxAge":4,"enrollmentInfo":547,"targetDuration":4,"studyType":22,"phases":549,"briefSummary":550,"conditions":551,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":556,"lastUpdatePostDateStruct":557,"startDateStruct":558,"completionDateStruct":560,"leadSponsor":562,"locationsCount":94},"100635491","a-digital-pill-system-to-measure-and-support-acamprosate-adherence-in-individuals-with-alcohol-associated-liver-disease-100635491","NCT07553377","A Digital Pill System to Measure and Support Acamprosate Adherence in Individuals With Alcohol Associated Liver Disease","Inclusion Criteria:\n\n* Being treated for AUD\n* Diagnosed with DSM-5 moderate to severe AUD\n* Screens positive ALD utilizing non-invasive blood tests\n* Planned initiation of acamprosate\n\nExclusion Criteria:\n\n* History of hypersensitivity to acamprosate\n* Allergy to magnesium or silver\n* Severe renal impairment (creatinine clearance of 30mL\u002Fmin or less)",{"count":548,"type":21},50,[24],"This study seeks to develop and test a novel digital pill system (DPS) that measures real-time medication ingestion and pairs it with a cognitive behavioral therapy (CBT)-based intervention to provide personalized, data-driven adherence support, with the long-term goal of providing new and improved personalized support and increase medication adherence for people with AUD and ALD.",[552,553,554,555,28],"Alcohol Use Disorder","Alcohol Associated Liver Disease","Medications for Alcohol Use Disorder","Behavioral Medicine","2026-04-21",{"date":454,"type":37},{"date":559,"type":21},"2027-10",{"date":561,"type":21},"2030-10",{"name":563,"class":44},"Yale University",{"id":565,"slug":566,"hasResults":12,"nctId":567,"briefTitle":568,"officialTitle":569,"acronym":570,"eligibilityCriteria":571,"healthyVolunteers":12,"sex":16,"minAge":52,"maxAge":4,"enrollmentInfo":572,"targetDuration":4,"studyType":22,"phases":574,"briefSummary":575,"conditions":576,"keywords":578,"overallStatus":113,"whyStopped":4,"lastUpdateSubmitDate":583,"lastUpdatePostDateStruct":584,"startDateStruct":586,"completionDateStruct":588,"leadSponsor":590,"locationsCount":94},"100583431","mobile-cued-adherence-therapy-mcat-for-blood-pressure-medication-100583431","NCT06876233","Mobile Cued Adherence Therapy (mCAT) for Blood Pressure Medication","Mobile Cued Adherence Therapy (mCAT): A Scalable Habit Formation Intervention to Improve Blood Pressure Medication Adherence Based on a Widely Used Smartphone App","mCAT","Eligibility Criteria:\n\n* Aged 18 years or older\n* Currently diagnosed with hypertension (either stage I or stage II hypertension)\n* Able to read\u002Fwrite\u002Funderstand English\n* Have daily access to a smartphone\n* Engaged in hypertension care: Already been prescribed hypertension medication for a minimum of 6 months at the time of study enrollment\n* Demonstrated AH medication nonadherence by having over 73 days without documented AH medication prescription coverage (observable in Arizona Health Care Cost Containment System (AHCCCS) prescription drugs claims) in the past 12 months (i.e. \\\u003C80% mean adherence)",{"count":573,"type":21},600,[24],"The goal of this clinical trial is to determine the effectiveness of a novel mobile health-based habit formation intervention for increasing and maintaining adherence to anti-hypertensive (AH) medication among people living with hypertension and indicate medication nonadherence. The main questions it aims to answer are:\n\n* Can daily incentives for AH pill taking increase and maintain AH medication adherence, control blood pressure, and reduce healthcare utilization and costs?\n* Can daily incentives for AH pill taking, combined with action planning (e.g., \"After I drink my morning coffee, I will take my medication.\") increase and maintain medication adherence, control blood pressure, and reduce healthcare utilization and costs?\n* What aspects of daily incentives and\u002For action planning do participants find most helpful or effective for AH medication adherence?\n* What barriers exist for participants who receive daily incentives and\u002For action planning?\n\nResearchers will compare three study groups: those who only receive daily incentives for the AH pill taking, those who receive daily incentives for AH pill taking combined with action planning, and a control group (who do not receive daily incentives for AH pill taking or action planning). By comparing these three groups, the researchers will be able to determine the effectiveness of the daily incentives with or without action planning for promoting long-term AH medication adherence, reduce healthcare costs, and improve blood pressure.\n\nParticipants will:\n\n* Complete 5 online surveys over the course of 2 years (baseline, month 4, month 8, month 12, month 24).\n* Submit blood pressure reading for 7 consecutive days after each survey timepoint.\n* Submit photo evidence of their AH pill taking for 4 months (intervention groups only).\n\nThe highest- and lowest-performing participants in each intervention group will also be invited to complete a 30-minute interview to identify additional factors that contributed to either successful or unsuccessful completion of the intervention.",[28,138,577],"Habits",[579,315,580,581,582],"habits","hypertension","blood pressure","mobile app","2026-03-12",{"date":585,"type":37},"2026-03-16",{"date":587,"type":37},"2025-09-01",{"date":589,"type":21},"2029-03-30",{"name":591,"class":44},"Chad Stecher@asu.edu",{"id":593,"slug":594,"hasResults":12,"nctId":595,"briefTitle":596,"officialTitle":597,"acronym":598,"eligibilityCriteria":599,"healthyVolunteers":12,"sex":16,"minAge":600,"maxAge":132,"enrollmentInfo":601,"targetDuration":4,"studyType":22,"phases":603,"briefSummary":604,"conditions":605,"keywords":608,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":611,"lastUpdatePostDateStruct":612,"startDateStruct":614,"completionDateStruct":615,"leadSponsor":617,"locationsCount":94},"100628036","development-and-validation-of-psycho-social-program-psp-100628036","NCT07456410","Development and Validation of Psycho-Social Program (PSP)","Development and Validation of Psycho-Social Program (PSP) for Mental Health Problems Among Patients With Type 2 Diabetes Mellitus (T2DM): A Randomised Controlled Trial","PSP-T2DM","Inclusion Criteria: Participants must be adults aged 30-40 years with Type 2 diabetes, experiencing mild-to-moderate mental health problems related to diabetes will be eligible.\n\nExclusion Criteria: Participants will be excluded if they have severe psychiatric disorders, serious medical comorbidities, are taking psychiatric medications that may affect outcomes, or are unable to participate in the intervention sessions.\n\n\\-","30 Years",{"count":602,"type":21},80,[24],"The study aims to determine the effectiveness of a structured psycho-social program (PSP) in improving mental health outcomes among patients with Type 2 diabetes mellitus (T2DM). The intervention is designed to reduce symptoms of depression, anxiety, and diabetes-related distress (DD) by addressing maladaptive thoughts, emotional responses, and coping behaviors associated with chronic illness management. Through structured sessions incorporating cognitive restructuring, stress management techniques, behavioral activation, and adaptive coping strategies, participants will learn to manage emotional distress more effectively while improving treatment adherence and daily functioning. The intervention is expected to enhance psychological well-being, promote healthier coping mechanisms, and support better overall adjustment to living with T2DM.",[606,108,607,452,28],"Mental Health Issue","Diabetes Distress",[609,610],"Type 2 Diabetes Mellitus","mental health problems","2026-03-04",{"date":613,"type":37},"2026-03-06",{"date":404,"type":21},{"date":616,"type":21},"2026-08-28",{"name":618,"class":44},"Government College University Faisalabad",{"id":620,"slug":621,"hasResults":12,"nctId":622,"briefTitle":623,"officialTitle":624,"acronym":4,"eligibilityCriteria":625,"healthyVolunteers":12,"sex":16,"minAge":52,"maxAge":443,"enrollmentInfo":626,"targetDuration":627,"studyType":250,"phases":4,"briefSummary":628,"conditions":629,"keywords":633,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":637,"lastUpdatePostDateStruct":638,"startDateStruct":640,"completionDateStruct":642,"leadSponsor":644,"locationsCount":4},"100618312","fear-of-hypoglycemia-in-patients-with-diabetes-100618312","NCT07329985","FEAR of HYPOGLYCEMIA in PATIENTS WITH DIABETES","THE EFFECT OF FEAR OF HYPOGLYCEMIA ON DIET AND MEDICATION ADHERENCE IN PATIENTS WITH DIABETES","Inclusion Criteria:\n\nDiagnosed with diabetes Aged 18-65 Having experienced at least one hypoglycemic attack previously, Using antidiabetic medication (oral pills and\u002For insulin), Volunteered to participate in the study\n\nExclusion Criteria:\n\nunable to communicate in the same language having cognitive impairment wanting to leave the study at any stage",{"count":54,"type":21},"1 Day","Fear of hypoglycemia has a significant impact on both medication and dietary adherence in individuals with diabetes. Through avoidance behaviors, it can disrupt metabolic control, prevent the achievement of glycemic targets, and increase the risk of long-term complications. Therefore, monitoring only biochemical parameters is insufficient in diabetes management. It is crucial for healthcare professionals to systematically assess the fear of hypoglycemia.",[630,631,28,632],"Diabetes Mellitus","Diet, Healthy","Hypoglycemia",[634,28,635,636],"Diabetes","Nursing","Diet","2026-02-19",{"date":639,"type":37},"2026-02-20",{"date":641,"type":21},"2026-04-15",{"date":643,"type":21},"2026-12-15",{"name":645,"class":44},"Bilecik Seyh Edebali Universitesi",{"id":647,"slug":648,"hasResults":12,"nctId":649,"briefTitle":650,"officialTitle":651,"acronym":4,"eligibilityCriteria":652,"healthyVolunteers":12,"sex":16,"minAge":52,"maxAge":4,"enrollmentInfo":653,"targetDuration":4,"studyType":22,"phases":655,"briefSummary":656,"conditions":657,"keywords":660,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":666,"lastUpdatePostDateStruct":667,"startDateStruct":669,"completionDateStruct":671,"leadSponsor":673,"locationsCount":4},"100624628","telemedicine-based-behavioral-intervention-to-improve-self-care-among-hypertensive-patients-100624628","NCT07412106","Telemedicine-Based Behavioral Intervention to Improve Self-Care Among Hypertensive Patients","Effectiveness of a Telemedicine-Based Behavioral Intervention for Improving Self-Care Practice and Management Outcomes Among Hypertensive Patients Attending Tertiary Hospitals in Northwest Amhara: A Quasi-Experimental Study Intervention Protocol","Inclusion Criteria:\n\n* Adult patients ≥18 with hypertension who have follow-up for ≥6 months at the study settings\n* Have access to mobile or fixed telephones\n* Will stay for the study follow-up period\n\nExclusion Criteria:\n\n* Participants who have coexisting severe mental health illnesses\n* Severe hearing impairments\n* Pregnant will be excluded",{"count":654,"type":21},320,[24],"The goal of this quasi-experimental clinical study is to learn whether a telemedicine-based behavioral intervention can improve self-care practices among adult patients with hypertension receiving care at teaching hospitals in Northwest Amhara.\n\nThe main questions it aims to answer are:\n\n* Does a telemedicine-based intervention improve self-care practices among hypertensive patients?\n* Does the intervention improve medication adherence among hypertensive patients?\n* Does the intervention increase patients' knowledge about hypertension?\n* Does the intervention reduce emergency hospital admissions among hypertensive patients? We will compare patients who receive telemedicine-based counseling with patients who receive usual care to see if the intervention improves self-care, medication adherence, knowledge, and reduces emergency admissions.\n\nParticipants will:\n\n* Receive 10-15-minute telephone counseling sessions every two weeks for three months (intervention group only)\n* Receive education on blood pressure monitoring, medication adherence, diet, physical activity, and stress management (intervention group only)\n* Continue routine hypertension care at the hospital (both groups)",[138,658,28,659],"Self-Care Practices","Hospital Admission",[661,662,663,664,665,138],"Self-care practice","Medication adherence","Knowledge about hypertension","Emergency admission","Quasi experimental study","2026-02-12",{"date":668,"type":37},"2026-02-17",{"date":670,"type":21},"2026-02-10",{"date":672,"type":21},"2026-07-10",{"name":674,"class":44},"Bahir Dar University",{"id":676,"slug":677,"hasResults":12,"nctId":678,"briefTitle":679,"officialTitle":680,"acronym":681,"eligibilityCriteria":682,"healthyVolunteers":12,"sex":16,"minAge":52,"maxAge":199,"enrollmentInfo":683,"targetDuration":627,"studyType":250,"phases":4,"briefSummary":685,"conditions":686,"keywords":688,"overallStatus":113,"whyStopped":4,"lastUpdateSubmitDate":666,"lastUpdatePostDateStruct":694,"startDateStruct":695,"completionDateStruct":697,"leadSponsor":699,"locationsCount":94},"100625284","multilevel-ecological-and-com-b-determinants-of-medication-adherence-in-adults-with-diabetes-100625284","NCT07420634","Multilevel Ecological and COM-B Determinants of Medication Adherence in Adults With Diabetes","Multilevel Ecological Determinants of Medication Adherence Among Diabetes Patients: A Health Ecology-COM-B Framework Analysis","ADHECOM","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Diagnosed with at least one chronic disease (e.g., diabetes mellitus, hypertension, cardiovascular disease, chronic respiratory disease, chronic kidney disease) for a minimum duration of six months\n* Prescribed long-term medication therapy\n* Able to understand and respond to the study questionnaire\n* Willing to provide written informed consent\n\nExclusion Criteria:\n\n* Patients with acute medical conditions requiring immediate care\n* Individuals with severe cognitive impairment or psychiatric illness that would preclude reliable participation\n* Patients who are terminally ill\n* Patients unwilling to participate or provide consent",{"count":684,"type":21},220,"This observational study aims to understand why some adults with diabetes find it difficult to take their medicines as prescribed. Medication adherence is essential for controlling blood sugar levels and preventing complications, yet many patients face challenges that go beyond personal motivation.\n\nThe study will examine multiple factors that may influence medication-taking behavior, including patients' understanding of their medicines, beliefs about treatment, family and social support, communication with healthcare providers, and practical issues such as medicine cost, availability, and distance to care. These factors will be analyzed using a structured behavioral framework to better understand how capability, opportunity, and motivation contribute to adherence.\n\nBy identifying the most important barriers and supports across different levels, this research aims to provide evidence that can guide patient-centered care strategies and improve medication adherence in diabetes management.",[630,687,28],"Diabetes Mellitus Type 2",[689,690,28,630,691,692,693],"Health Ecology Model","COM-B Model","Capability Opportunity Motivation","Behavioral Determinants","Medication Literacy",{"date":637,"type":37},{"date":696,"type":37},"2025-12-15",{"date":698,"type":21},"2026-08-30",{"name":700,"class":44},"University of Malaya"]