[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"melanocytic-nevi\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:melanocytic-nevi":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,40],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100614309","reflectance-confocal-microscopy-and-molecular-correlation-in-atypical-melanocytic-lesions-100614309",false,"NCT07277920","Reflectance Confocal Microscopy and Molecular Correlation in Atypical Melanocytic Lesions","Evaluation of Reflectance Confocal Microscopy (RCM) Features in Surgically Excised Atypical Melanocytic Lesions and Their Correlation With Next-Generation Sequencing (NGS) Patterns","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Presence of cutaneous lesions with dermoscopic and reflectance confocal microscopy suspicion of melanocytic neoplasia, already scheduled for surgical excision\n* Written informed consent obtained\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years\n* Lesions not scheduled for excision or with uncertain dermoscopic diagnosis\n* Lack of informed consent","ALL","18 Years",{"count":19,"type":20},200,"ESTIMATED","OBSERVATIONAL","This observational, prospective cohort study aims to evaluate the diagnostic relevance of Reflectance Confocal Microscopy (RCM) features in atypical melanocytic lesions scheduled for surgical excision, and to correlate these imaging features with molecular profiles obtained through Next-Generation Sequencing (NGS). Approximately 200 consecutive lesions, including atypical nevi and early-stage melanomas, will be analyzed from patients attending the Videomicroscopy and Confocal Clinic at the Dermatology Department of the University Hospital of Modena.\n\nThe primary objective is to assess the diagnostic significance of RCM features-specifically atypical cells and disarrangement of the dermoepidermal junction (DEJ)-for early detection of melanoma. Secondary objectives include correlating RCM morphological patterns with NGS-derived genetic alterations and identifying molecular signatures that differentiate early-stage melanomas from benign nevi.\n\nAll procedures are performed as part of routine clinical care, including dermoscopic and confocal evaluation, surgical excision, histopathology, and molecular analysis on formalin-fixed, paraffin-embedded blocks. Data will be anonymized, securely stored, and analyzed to determine associations between imaging and genetic variables. This study integrates morphological and molecular data to refine diagnostic workflows and improve early melanoma detection.",[24,25,26],"Melanocytic Nevi","Melanoma (Skin Cancer)","Next Generation Sequencing (NGS)","RECRUITING","2025-11-29",{"date":30,"type":31},"2025-12-11","ACTUAL",{"date":33,"type":31},"2023-11-01",{"date":35,"type":20},"2026-12-31",{"name":37,"class":38},"University of Modena and Reggio Emilia","OTHER",1,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":44,"acronym":4,"eligibilityCriteria":45,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":46,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":48,"conditions":49,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":50,"lastUpdatePostDateStruct":51,"startDateStruct":53,"completionDateStruct":55,"leadSponsor":57,"locationsCount":39},"100289963","genetic-basis-of-melanocytic-nevi-100289963","NCT03054584","Genetic Basis of Melanocytic Nevi","Inclusion criteria:\n\n* Male or female subjects that are 18 years or older\n* Subjects with melanocytic nevi\\\\\n\nExclusion criteria:\n\n* Patients less than 18 years of age\n* Patients without melanocytic nevi\n* Patients with a bleeding disorder or are taking anticoagulation medication",{"count":47,"type":20},50,"The objective of this protocol is to further elucidate the genetic mutations that drive melanocytic nevi (benign melanocytic neoplasms, moles). This will be performed by whole genome, whole exome, or targeted sequencing of de-identified specimens.\n\nHerein, the investigators plan to isolate DNA from de-identified skin biopsy specimens and blood samples:\n\n1. From melanocytic nevi collected by skin biopsy (a shave or punch biopsy). A part of the tissue will be submitted for routine diagnostic dermatopathology and investigational histomorphologic and immunohistochemical analysis.\n2. From corresponding normal tissue (blood). DNA isolated from blood will be used as a normal control when analyzing sequencing data to identify somatic mutations in lesional tissue.",[24],"2025-09-12",{"date":52,"type":31},"2025-09-18",{"date":54,"type":31},"2017-06-26",{"date":56,"type":20},"2028-06",{"name":58,"class":38},"University of California, Davis"]