[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"memory-disorders-in-old-age\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:memory-disorders-in-old-age":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,41],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100405345","network-targeted-theta-burst-stimulation-for-episodic-memory-improvement-in-mild-cognitive-impairment-100405345",false,"NCT04558164","Network-targeted Theta-burst Stimulation for Episodic Memory Improvement in Mild Cognitive Impairment","Inclusion Criteria:\n\n* Agreement to participate in the study\n* 55-100 years of age\n* Right-handedness\n* In good general health\n* Living independently\n* Subjective memory complaints (self-report and positive score on MFQ)\n* Katz ADL scale and Lawton iADL scale: We will review scores on a case-by-case basis if they did not score 100%. We will exclude if the scores show impairment in ADLs that suggests problems with independent functioning due to cognitive impairment.\n* MMSE score \\> 24\n* PHQ Depression score =\\\u003C 7\n* Ability to read, write, and speak English fluently\n* Diagnosis of mild neurocognitive disorder according to DSM-5 (Diagnostic and Statistical Manual of Mental Disorders) criteria. Participants with subjective memory complaints without an aMCI diagnosis will be reviewed on a case-by-case basis based on neuropsychological scores. Participants scoring a raw score of 0 or 3 standard deviations below normative expectations on the long delay recall in two or more of the three tasks (BVMT-R, RCFT, and CVLT-III) will be excluded.\n* No change in use of psychotropic medication for treatment of depression, anxiety, ADHS or psychosis 1 month prior and during the study.\n\nScreening diagnostic criteria for aMCI will be subjective memory complaints, intact instrumental and basic activities of daily living (Smith et al., 1996), PHQ, MMSE, BVMT-R (25-minute delay), CVLT-II (20-minute delay), Rey-Osterrieth Complex Figure Task (30-minute delay). Baseline assessments will include neuropsychological testing of all study subjects.\n\nExclusion Criteria:\n\n* Unwilling or unable to provide informed consent\n* Diagnosis of dementia\n* Active major medical, psychiatric, or neurologic disorder associated with neurocognitive impairment\n* History of alcohol or substance abuse\n* Recent (\\\u003C 6 months) alcohol or substance abuse (excluding nicotine or caffeine)\n* History of stroke (if the stroke in our judgment is related to the memory problem), traumatic brain injury with loss of consciousness, or other neurologic disorder (e.g., epilepsy, Huntington's disease, Parkinson's disease)\n* Non-English speaking participants\n* Not right handed based on self-report or evaluation based on a standard report\n* Has received TMS before (not TMS naïve)\n* Poorly controlled hypertension or cardiovascular disease\n* Current enrollment in a memory-enhancement study or course\n* Contraindication to TMS or MRI including claustrophobia, metal in body, surgery within 60 days, certain implants, or previous abnormal MRI results.\n* scanning facial tattoos is okay if safe with MRI\n* is taking:\n\n  * anticholinergic medication (e.g., Detrol, Cogentin);\n  * sedating antihistamine (e.g., Benadryl);\n  * any drug that has significant anticholinergic or antihistaminic side effects (e.g., tricyclic antidepressant medications, Remeron).\n  * benzodiazepines. While not a strict rule out, this will be decided on a case-by-case basis depending on the dose.","ALL","55 Years","100 Years",{"count":19,"type":20},70,"ESTIMATED","INTERVENTIONAL",[23],"NA","The purpose of this study is to see if stimulation of the brain can improve memory. The investigators will use a device called transcranial magnetic stimulation that can stimulate and activate a specific part of the brain that is important for memory. The study will enroll MCI subjects and subjects with subjective memory complaints who will be randomly assigned to receive active or sham brain stimulation. 'Blinded' or 'sham-controlled' means that the subject will not know whether the treatment they receive is the active treatment or the non-active stimulation. In the 'sham' condition, the stimulator will turn on but will not actually be stimulating the target brain region.",[26,27],"Cognitive Dysfunction","Memory Disorders in Old Age","RECRUITING","2026-04-29",{"date":31,"type":32},"2026-05-05","ACTUAL",{"date":34,"type":32},"2021-01-26",{"date":36,"type":20},"2026-06-30",{"name":38,"class":39},"University of California, Los Angeles","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":48,"sex":15,"minAge":49,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":21,"phases":53,"briefSummary":54,"conditions":55,"keywords":66,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":40},"100525638","brain-health-virtual-reality-study-100525638","NCT06124339","Brain Health Virtual Reality Study","Interventions to Promote Brain Health Virtual Reality Study","Inclusion Criteria:\n\n1. 50-85 years of age\n2. Fluent in English\n3. Can safely ride a stationary bike\n\nExclusion Criteria:\n\n1. Dementia\n2. History of a neurological disorder\n3. Severe sensory deficits\n4. Inability to perform intervention (e.g., inability to cycle safely)\n5. Contraindications to MRI scan (e.g., pacemaker)\n6. Fear of needles\u002F blood\n7. Prior history of fainting due to sight of needles of blood",true,"50 Years","85 Years",{"count":52,"type":20},150,[23],"The Interventions for Brain Health Virtual Reality Study is a NIH-funded clinical research trial at the University of California San Diego (UCSD) Health under the supervision of the study principal investigator Dr. Judy Pa. The overarching goal of this trial is to use a novel virtual reality (VR) based intervention that simultaneously engages physical and cognitive activity aimed at improving brain health and cognition in older adults. The investigators will compare 3 types of interventions: physical activity, VR cognitive activity, and combined VR physical and cognitive activity over 16 weeks to evaluate physical and brain health changes.",[56,57,58,59,27,60,61,62,63,64,65],"Aging","Aging Problems","Memory Loss","Memory Impairment","Memory Disorder, Spatial","Memory Disorders","Mild Cognitive Impairment","Cognitive Decline","Cognitive Change","Cognition Disorders in Old Age",[67,68,69,70,71,72,73,74],"Virtual Reality","technology","intervention","exercise","cycling","memory","brain health","aging","2024-07-08",{"date":77,"type":32},"2024-07-10",{"date":79,"type":32},"2023-08-08",{"date":81,"type":20},"2029-02-01",{"name":83,"class":39},"University of California, San Diego"]