[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"meningioma-malignant\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:meningioma-malignant":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,43],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100558929","adjuvant-hypofractionated-stereotactic-radiosurgery-for-intermediate-risk-meningioma-100558929",false,"NCT06557512","Adjuvant Hypofractionated Stereotactic Radiosurgery for Intermediate-risk Meningioma","A Pilot Trial of Adjuvant Hypofractionated Stereotactic Radiosurgery for Intermediate-risk Meningioma (SRS-AIM)","SRS-AIM","Inclusion Criteria:\n\n* Age \\>+ 18 years at time of study entry\n* Ability to understand and the willingness to sign a written informed consent document.\n* Histologic diagnosis of newly diagnosed World Health Organization (WHO) grade 2 or recurrent WHO grade 1 meningioma. With regard to recurrent WHO grade 1 meningioma, participants must present with radiographic evidence of recurrence, and have a histologic diagnosis of WHO grade 1 meningioma at the most recent resection.\n\n  \\* Note: For participants diagnosed outside of University of California San Francisco (UCSF), re-review of pathology at UCSF is strongly encouraged. Hematoxylin and eosin (H\\&E) slides will be reviewed by UCSF pathologists.\n* Participants must have undergone a gross-total surgical resection as deemed by their neurosurgeon (Simpson grade I-III resection), using all available information which can include post-operative MRI, of a meningioma within 180 days of enrollment.\n* Participants must have a pre-operative MRI.\n* Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 (Karnofsky score of 70 or higher)\n* Participants must have post-operative MRI indicating anatomy suitable for hypofractionated radiosurgery, as reviewed by the Radiation Oncology co-principal investigators (PIs).\n\nExclusion Criteria:\n\n* Concurrent participation in another clinical study with an investigational product unless it is an observational (non-interventional) study or the follow-up period of an interventional study.\n* Extensive multifocal (3 or more meningiomas) or metastatic disease.\n* Participants with tumors within 2mm of the optic apparatus or brainstem will be excluded.\n* Participants with another active primary malignancy or history of previous malignancy (except non-melanoma skin cancers, low and favourable-intermediate risk prostate cancers, and in situ cancers such as bladder, gastric, colon, cervical\u002Fdysplasia, or breast) are excluded unless a complete remission was achieved at least 2 years prior to study entry and no additional therapy is required or anticipated to be required during the study period.\n* Female participants who are pregnant.\n* Any underlying medical or psychiatric condition that, in the opinion of the investigator, would interfere with evaluation of study treatment or interpretation of participant safety or study results.\n* Participants with uncontrolled seizures, defined as greater than 3 disabling seizures per day while on anti-epileptic drugs.\n* Participants who have had previous intracranial radiotherapy overlapping with the area that would be targeted for stereotactic radiosurgery by this study.","ALL","18 Years",{"count":20,"type":21},23,"ESTIMATED","INTERVENTIONAL",[24],"NA","This clinical trial tests the safety and effectiveness of hypofractionated stereotactic radiosurgery for treating patients who have undergone surgical resection for grade II meningiomas or grade I meningiomas that have come back after a period of improvement (recurrent). Radiation therapy uses high energy x-rays, particles, or radioactive seeds to kill tumor cells and shrink tumors. Stereotactic radiosurgery is a type of external radiation therapy that uses special equipment to position a patient and precisely deliver radiation to tumors in the body. Hypofractionated radiation therapy delivers higher doses of radiation therapy over a shorter period of time and may kill more tumor cells and have fewer side effects. Hypofractionated stereotactic radiosurgery may be safe, tolerable, and effective in treating patients with grade II or recurrent grade I meningiomas after surgical resection.",[27,28,29],"Meningioma","Meningioma, Malignant","Recurrent Meningioma","RECRUITING","2026-05-14",{"date":33,"type":34},"2026-05-18","ACTUAL",{"date":36,"type":34},"2024-12-13",{"date":38,"type":21},"2029-09-30",{"name":40,"class":41},"University of California, San Francisco","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":22,"phases":53,"briefSummary":55,"conditions":56,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":66},"100537291","phase-2-regorafenib-for-recurrent-meningioma-mirage-trial-100537291","NCT06275919","Regorafenib for Recurrent Meningioma (MIRAGE Trial)","Regorafenib for Recurrent Meningioma. A Multicenter, Randomized Phase II Study (MIRAGE Trial)","MIRAGE","Inclusion Criteria:\n\n* Subject must understand and voluntarily sign an ICF prior to any study-related assessments\u002Fprocedures being conducted\n* Patients capable of taking oral medication\n* Subject is willing and able to adhere to the study visit schedule and other protocol requirements.\n* Histological diagnosis of meningioma according to the WHO 2021 classification\n* Radiologically documented progression of any existing tumor with an estimated planar growth \\>25% (bidirectional) in the last 12 months or appearance of new lesions\n* Ineligible for further surgery and\u002For radiotherapy\n* at least 1 Measurable lesion (minimum 10 x 10mm) on baseline MRI\n* Eastern Cooperative Oncology Group performance status (ECOG PS) of 0 to 1 (or KPS ³70)\n* Male or female ≥ 18 years of age\n* Subjects must have life expectancy of at least 6 months\n* Paraffin-embedded tumor tissue available (mandatory)\n* Dosage of dexamethasone or equivalent steroid within 7 days prior the randomization ≤4mg\u002Fdie\n* Stable or decreasing dosage of steroids for 7 days prior to the randomization.\n* Adequate cardiac function and adequate liver, renal and hematological function\n* Subject must have the following laboratory values at screening within 14 days before starting Regorafenib:\n* Absolute neutrophil count (ANC) ≥ 1.5 x 109\u002FL without growth factor support for 7 days (14 days if subject received pegfilgrastim).\n* Hemoglobin (Hgb) ≥10 g\u002FdL\n* Platelet count (plt) ≥100x 109\u002FL\n* Serum potassium concentration within normal range, or correctable with supplements\n* Serum glutamic oxaloacetic transaminase (SGOT)\u002Faspartate aminotransferase (AST) and serum glutamate pyruvic transaminase (SGPT)\u002Falanine aminotransferase (ALT) ≤ 3.0 x Upper Limit of Normal (ULN).\n* Serum total bilirubin ≤ 1.5 x ULN\n* Serum creatinine ≤ 1.5 x ULN or measured glomerular filtration rate (GFR) ≥ 50 mL\u002Fmin\u002F1.73 m2 using an exogenous filtration marker such as iohexol, inulin, 51Cr EDTA or 1125 iothalamate, or creatinine clearance of ≥ 50 mL\u002Fmin using Cockroft-Gault equation.\n* Serum albumin \\> 3.5 g\u002FdL\n* PT (or INR) and APTT within normal range\n* For women who are not postmenopausal (i.e., \\\u003C 2 years after last menstruation) or surgically sterile (absence of ovaries and\u002For uterus) and who are sexually active: agreement to use an adequate method of contraception (oral contraceptives, intrauterine contraceptive device, or barrier method of contraception in conjunction with spermicidal jelly) during the Treatment period and for at least 6 months after the last dose of study drug.\n* For male patients who are partners of premenopausal women: agreement to use a barrier method of contraception during the Treatment period and for at least 6 months after the last dose of study drug.\n* Participants with type I diabetes mellitus, hypothyroidism only requiring hormone replacement, skin disorders (such as vitiligo, psoriasis, or alopecia) not requiring systemic treatment, or conditions not expected to recur in the absence of an external trigger are permitted to participate.\n* 19\\. Patients with measurable, progressive meningioma who received radiation therapy are potentially eligible but need to show evidence of progression at least 24 weeks from completion of radiation therapy.\n* 20\\. Possible prior use of bevacizumab in the treatment of radionecrosis (3-24 months after radiosurgery or radiotherapy; 5mg\u002Fkg q14w, 4-6 cycles)\n\nExclusion Criteria:\n\n* Prior antineoplastic therapy for meningioma\n* Subject incapacitated to understand and voluntarily sign an ICF prior to any study-related assessments\u002Fprocedures being conducted\n* Are taking strong cytochrome P (CYP) CYP3A4 inhibitors (eg, clarithromycin, indinavir, itraconazole, ketoconazole, nefazodone, nelfinavir, posaconazole, ritonavir, saquinavir, telithromycin, voriconazole) or strong CYP3A4 inducers (eg, carbamazepine, phenobarbital, phenytoin, rifampin, St. John's Wort)\n* Are taking strong UGT1A9 inhibitors (e.g. mefenamic acid, diflunisal and niflumic acid)\n* Receiving additional, concurrent, active therapy for Meningioma outside of the trial.\n* Disease outside the brain (ie. spinal cord or bone or metastasis to a distant organ)\n* Candidate for urgent palliative intervention for primary disease (e.g., impending herniation) as judged by the Investigator\n* History of allergy or hypersensitivity to any of the study treatments or any of their excipients.\n* In the presence of therapeutic intent to anticoagulate the patient:,INR or PT and aPTT not within therapeutic limits (according to the medical standard in the institution)\n* Unable or unwilling to undergo brain MRI scans with intravenous (IV) gadolinium\n* History of another malignancy in the previous 3 years, with a disease-free interval of\\\u003C 3 years. Patients with prior history of in situ cancer or basal or squamous cell skin cancer are eligible.\n* Serious, non-healing wound, ulcer, bone fracture, or abscess.\n* Any cerebrovascular accident (including transient ischemic attacks) within the last 6 months prior to initiation of study treatment.\n* Have an ongoing infection with severity of Grade 2 or above (CTCAE 5.0)\n* Any hemorrhage or bleeding event that is ≥ Grade 3 based on the National Cancer Institute (NCI) Common Terminology Criteria for Adverse Event (CTCAE), Grade 2 intracranial hemorrhage, or persistent thrombotic\u002Fembolic event within 4 weeks prior to the start of study medication.\n* Uncontrolled or severe cardiac disease (e.g., history of unstable angina, myocardial infarction, coronary stenting, or bypass surgery within the last 6 months prior to initiation of study treatment), symptomatic congestive heart failure, serious uncontrolled cardiac arrhythmia (including atrial flutter\u002Ffibrillation), requirement for inotropic support or use of devices for cardiac conditions (e.g.,pacemakers\u002Fdefibrillators), or hypertension (participants with systolic blood pressure\\[BP\\] of \\> 160 mmHg or diastolic BP of \\> 100 mmHg despite optimal medical management are to be excluded).\n* History of interstitial lung disease, history of slowly progressive dyspnea and unproductive cough, sarcoidosis, silicosis, idiopathic pulmonary fibrosis, pulmonary hypersensitivity pneumonitis, or symptomatic pleural effusion.\n* Active, known, or suspected auto-immune disease, including systemic lupus erythematosus, Hashimotos thyroiditis, scleroderma, polyarteritis nodosa, or auto-immune hepatitis.\n* Known history of hepatitis B, human immunodeficiency virus (HIV), or active hepatitis C infection requiring treatment with antiviral therapy. Note: HIV testing is not required in the absence of clinical suspicion.\n* History of bleeding diathesis (irrespective of severity).\n* Uncontrolled intercurrent illness including (e.g., symptomatic ascites), but not limited to ongoing or active infection.\n* Persistent ≥ Grade 3 Lipase (\\> 2.0 - 5.0 x upper limit of normal \\[ULN\\] with signs or symptoms; \\> 5.0 x ULN and asymptomatic).\n* Persistent proteinuria \\> 3.5 g\u002F24 hours measured by urine protein creatinine ratio from a random urine sample (≥ Grade 3, CTCAE 5.0)\n* Have any malabsorbition condition\n* Any condition that could make the subject noncompliant with the study procedures and\u002For study requirements, as judged by the Investigator (for example: cognitive impairment, psychiatric illness, etc).",{"count":52,"type":21},104,[54],"PHASE2","The focus of this study will be to investigate whether Regorafenib demonstrates antitumor activity against recurrent meningiomas.\n\nSmall trials and case series suggest clinical relevant activity of several VEGF inhibitors such as sunitinib, bevacizumab and valatinib reporting a 6m-PFS rate of 42-64%. Indeed, VEGF and VEGF receptors (VEGFR) are regularly overexpressed in meningiomas and can correlate with outcome.\n\nRegorafenib inhibits angiogenic receptor tyrosine kinases (RTKs) and is highly selective for VEGFR1\u002F2\u002F3; moreover Regorafenib inhibits PDGFRB, FGFR1 and oncogenic intracellular signalling cascades involving c-RAF\u002FRAF1 and BRAF highly expressed in meningiomas.\n\nNoteworthy, Regorafenib showed antitumor activity in vitro and in vivo in a recent study; indeed, Regorafenib showed significant inhibition of meningioma cell motility and invasion and in vivo, mice with orthotopic meningioma xenografts showed a reduced volume of signal enhancement in MRI following Regorafenib therapy; this translated in a significantly increased overall survival time (p\\\u003C0.05) for Regorafenib treated mice.\n\nMoreover, Regorafenib showed good efficacy in different cancer types, such as colorectal cancer, GIST, hepatocellular carcinoma and glioblastoma (REGOMA trial) , maintainingmaintaining a good quality of life.",[28],"2026-05-12",{"date":59,"type":34},"2026-05-13",{"date":61,"type":34},"2024-09-23",{"date":63,"type":21},"2027-03",{"name":65,"class":41},"Istituto Oncologico Veneto IRCCS",17]