[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"meniscal-injuries\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:meniscal-injuries":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,54,85],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100584741","impact-of-bone-marrow-aspirate-injections-in-knee-arthroscopy-100584741",false,"NCT06893302","Impact of Bone-Marrow Aspirate Injections in Knee Arthroscopy","Bone Marrow Aspirate Injections in Knee Arthroscopy: A Randomized, Single-Blind, Controlled Trial","BMA","Inclusion Criteria:\n\n1. Require a primary knee arthroscopy for a meniscal injury or focal chondral defect (knee debridement or meniscectomy)\n2. Have Kellgren-Lawrence grade 0 arthritis\n3. Have Outerbridge cartilage grade 2 or lower\n4. Ages 18-64\n\nExclusion Criteria:\n\n1. Have previously undergone ipsilateral knee surgery\n2. Have Kellegren-Lawrence grade 3 or greater\n3. Have received other OrthoBiologics within 3 mo of surgery\n4. Have ligament deficiencies\n5. Need meniscal repair\n6. Need a concomitant osteotomy or other realignment surgery\n7. Have used DMARDs within the last three months\n8. Have a hx of anemia, bleeding disorders, or inflammatory joint disease (rheumatoid arthritis, infectious arthritis, hemophilic arthropathy, Charcot's knee)\n9. Have a hx of metabolic bone disease (osteoporosis, osteomalacia, rickets, osteitis fibrosa cystica, Paget's disease of bone)\n10. Patients who are currently pregnant","ALL","18 Years","64 Years",{"count":21,"type":22},50,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study will examine whether using bone marrow aspirate (BMA) during knee arthroscopy surgery can improve patient outcomes. The investigators will enroll 50 patients who need knee arthroscopy surgery for meniscus injuries or cartilage damage. Like flipping a coin, patients will be randomly assigned to one of two groups of 25 patients each. One group will receive standard arthroscopic surgery plus an injection of bone marrow aspirate, while the other group will receive standard surgery plus a saline (salt water) injection. During surgery, for patients in the treatment group, approximately 4mL (less than one teaspoon) of bone marrow will be taken from their hip bone using a special needle system. A small amount (1mL) will be sent to the laboratory for testing. Patients will be followed for 12 months after surgery and will complete questionnaires about their pain levels and knee function at several time points: before surgery, 2 weeks, 6 weeks, 3 months, 6 months, and 12 months after surgery. These questionnaires will ask about pain, daily activities, and overall improvement.",[28,29,30,31],"Chondral Lesion of the Knee","Meniscal Injuries","Cartilage Defects of the Knee","Osteoarthritis (OA) of the Knee",[33,34,35,36,37,38,39,40,15],"knee arthroscopy","meniscal injury","knee debridement","meniscectomy","osteoarthritis","cartilage defect","chondral lesion","bone marrow aspirate","RECRUITING","2026-04-23",{"date":44,"type":45},"2026-04-27","ACTUAL",{"date":47,"type":22},"2026-06",{"date":49,"type":22},"2029-04",{"name":51,"class":52},"Hospital for Special Surgery, New York","OTHER",1,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":62,"enrollmentInfo":63,"targetDuration":4,"studyType":23,"phases":65,"briefSummary":66,"conditions":67,"keywords":70,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":53},"100608671","semitendinosus-autograft-vs-meniscal-allograft-in-post-meniscectomy-syndrome-100608671","NCT07204587","Semitendinosus Autograft vs Meniscal Allograft in Post-Meniscectomy Syndrome","A Stratified, Partially Randomized Study Comparing Autologous Semitendinosus Tendon Graft and Meniscal Allograft Transplantation in Young Adults With Post-Meniscectomy Syndrome","MAT","Inclusion Criteria:\n\n* Adults aged 18 to 45 years\n\nHistory of partial meniscectomy \\> 6 months prior to enrollment\n\nSymptomatic post-meniscectomy syndrome (knee pain, swelling, or functional decline)\n\nMRI showing cartilage status ≤ Outerbridge grade 2\n\nKnee joint stability (or stabilized during the index surgery)\n\nBody mass index (BMI) \\\u003C 30\n\nWillingness to provide written informed consent\n\nExclusion Criteria:\n\nTibial slope \\> 16°\n\nRadiographic or arthroscopic evidence of advanced cartilage degeneration (Outerbridge \\> 2 or ICRS ≥ 3)\n\nPresence of inflammatory arthritis or systemic inflammatory joint disease\n\nHistory of cartilage repair surgery\n\nMalalignment \\> 5° not corrected\n\nUntreated ligamentous instability\n\nAny other condition judged by the investigator to compromise study participation or outcomes","45 Years",{"count":64,"type":22},40,[25],"This multicenter, stratified, partially randomized clinical trial aims to compare autologous semitendinosus tendon graft and meniscal allograft transplantation (MAT) in young adults with post-meniscectomy syndrome. The meniscus plays a critical role in load distribution, shock absorption, and joint stability. After meniscectomy, insufficient meniscal tissue often leads to persistent pain, swelling, and functional decline, increasing the risk of early osteoarthritis.\n\nTwo reconstructive strategies are clinically available: MAT provides immediate biomechanical function but requires donor matching and carries higher costs, while autologous tendon graft offers stable supply and no immunologic risk but lacks long-term clinical validation.\n\nIn this study, 40 patients aged 18-45 years will be enrolled. Participants will be allocated into four groups (randomized MAT, randomized autograft, patient-preference MAT, patient-preference autograft). All procedures will use a two-tunnel fixation technique with additional internal brace support.\n\nThe primary endpoint is the improvement in KOOS (Knee Injury and Osteoarthritis Outcome Score) at 24 months postoperatively. Secondary endpoints include MRI-based assessment of graft morphology and extrusion, reoperation rate, complications, patient satisfaction, and return-to-sport time.\n\nThis trial will provide critical evidence regarding the comparative effectiveness and feasibility of tendon autograft versus meniscal allograft in real-world clinical settings, potentially informing surgical decision-making and future treatment guidelines for post-meniscectomy syndrome.",[29,68,69],"Meniscal Tear","Meniscus Lesion",[71,72,73,74],"meniscal allograft","autologous tendon graft","Post-meniscectomy syndrome","Meniscus deficiency","NOT_YET_RECRUITING","2025-09-24",{"date":78,"type":45},"2025-10-02",{"date":80,"type":22},"2025-10-01",{"date":82,"type":22},"2029-09-30",{"name":84,"class":52},"Chang Gung Memorial Hospital",{"id":86,"slug":87,"hasResults":11,"nctId":88,"briefTitle":89,"officialTitle":90,"acronym":4,"eligibilityCriteria":91,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":92,"enrollmentInfo":93,"targetDuration":4,"studyType":23,"phases":94,"briefSummary":96,"conditions":97,"keywords":101,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":53},"100575662","phase-4-partial-meniscal-replacement-with-spongioflex-100575662","NCT06775197","Partial Meniscal Replacement with Spongioflex®","Sterile Allogeneic Spongioflex® Allograft As Partial Meniscal Replacement After Incomplete Meniscal Loss, an Investigator-initiated Trial","Inclusion Criteria:\n\n1. Patients (male and female) with:\n2. Partial loss of portions of the\n\n   * lateral meniscus and lateral joint line pain OR\n   * medial meniscus and medial joint line pain\n3. sufficient standing of the peripheral rim, so that the procedure can be performed\n4. Age: 18-60 years\n5. signed written informed consent to the study and to provide the scientific data in pseudonymized form\n\nExclusion Criteria:\n\n1. The presence of anterior cruciate ligament insufficiency which is not resolved by reconstruction of the anterior cruciate ligament within 16 weeks after partial meniscal implantation.\n2. Axial deviation (\\>2° varus or valgus)\n3. realignment osteotomy not performed within 12 weeks\n4. advanced cartilage damage (grade III according to ICRS) and osteoarthrosis in the affected compartment (grade III according to Kellgren and Lawrence \\[33\\])\n5. Extension deficit of more than 3° compared to the opposite side or a knee flexion of less than 125°\n6. inflammatory arthritis or synovitis on the treated knee\n7. BMI greater than 30 kg\u002Fm²\n8. \\\u003C18 years, \\>60 years\n9. Chronic pain patients\n10. only for patients who will be operated:\n\n    1. with increased anaesthesiologic risk, e.g., with known or predicted difficult airway\n    2. with increased risk of bleeding\n    3. with increased risk of infection\n    4. with necrotic, infected, or poorly perfused host sides\n    5. history of allergic reactions\n    6. acute hypersensitivity reactions to the IMP or any of its excipients\n    7. pregnant woman","60 Years",{"count":64,"type":22},[95],"PHASE4","The purpose of this investigator-initiated trial is to evaluate whether the novel graft can prevent\u002Freduce the disadvantages of the previously used replacement materials and shows better results than the group of patients, which were not operated. Since there is currently no alternative made of biological material to this product, this investigator-initiated trial is of great medical and economic importance. The otherwise following arthrosis or knee prosthesis implantation (TKA ) could be prevented or at least postponed. Initial clinical results are promising.\n\nAn important and sensitive parameter for assessing the postoperative function of the meniscus is the MRI image. Genovese et al. 2007 were able to show in a categorization\u002Fclassification which magnetic resonance image can be expected in the case of successful incorporation. Several studies have shown that the known clinical knee scores (Lysholm, IKDC, KOOS, VAS pain) improve significantly after successful ingrowth of the meniscus implant.",[98,99,100,69,29,68],"Partial Meniscal Loss","Lateral Meniscus Partial Loss","Medial Meniscal Partial Loss",[102,103,104,105,106,107,108,109,110],"partial meniscal loss","Allograft","Spongioflex®","IKDC","KOOS","return to sport","Outerbridge score","extrusion","VAS pain score","2025-01-09",{"date":113,"type":45},"2025-01-15",{"date":115,"type":45},"2024-11-05",{"date":117,"type":22},"2031-11-05",{"name":119,"class":52},"Maria-Josef-Hospital Greven"]