[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"meniscus-disorder\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:meniscus-disorder":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,41,73],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100556211","evaluation-of-clinical-functional-and-radiographic-outcomes-in-patients-who-underwent-meniscal-allograft-transplantation-mat-at-10-years-100556211",false,"NCT06522152","Evaluation of Clinical-functional and Radiographic Outcomes in Patients Who Underwent Meniscal Allograft Transplantation (MAT) at 10 Years.","MAT 10 Y","Inclusion Criteria:\n\n* Patients aged between 18 and 65 at the time of surgery\n* Both male and female\n* Patients who underwent meniscal transplantation at the Rizzoli Orthopedic Institute at least 10 years ago\n\nExclusion Criteria:\n\n* Patients who do not give consent to be included in the study\n* Patients who are no longer reachable\n* Presence of infection or hematologic, rheumatic, or coagulation disorders at the time of evaluation","ALL","18 Years","65 Years",{"count":20,"type":21},397,"ESTIMATED","10 Years","OBSERVATIONAL","Menisci are crescent-shaped cartilage structures that are fundamentally important for the biomechanics and physiology of the knee joint. They play a primary role in load transmission, assist the ligaments in ensuring knee stability, and thus protect against the onset of knee osteoarthritis. Meniscal injuries are the most frequently encountered joint pathology and can cause pain, mechanical blocks, and recurrent effusions. The treatment of these injuries has progressively evolved from meniscectomy (removal of damaged meniscal tissue) to the use of meniscal sutures (where possible) to allow the preservation of the greatest amount of meniscus: numerous studies have shown a correlation between the amount of meniscus removed and the future onset of osteoarthritis (Hutchinson AJSM 2014, Harston KSSTA 2012).\n\nHowever, in some cases, especially in the presence of complex and\u002For chronic lesions, meniscectomy remains the only viable surgical solution even today. Over time, months or years later, a subgroup of patients experiences symptoms such as pain, joint swelling, and mechanical overload of the compartment subjected to meniscectomy, a condition known as \"post-meniscectomy syndrome.\" Some of these patients will subsequently develop knee osteoarthritis, requiring invasive interventions such as partial or total knee replacement.\n\nMeniscal allograft transplantation (MAT) represents a valid therapeutic option for post-meniscectomy syndrome. This procedure aims to restore joint functionality and stability through the transplantation of a meniscus from a cadaver donor. MAT has been widely adopted in clinical practice, showing success in reducing pain and improving joint functionality.\n\nCurrent studies suggest that meniscal transplantation can offer significant protection against osteoarthritis, but the duration of this preventive effect is not yet fully understood. Furthermore, there are no studies that can demonstrate the state of osteoarthritis with radiographic controls pre- and post-treatment at a follow-up of over 10 years.",[26,27],"Meniscus Disorder","Arthritis Knee","RECRUITING","2025-08-01",{"date":31,"type":32},"2025-08-06","ACTUAL",{"date":34,"type":32},"2024-10-24",{"date":36,"type":21},"2030-07",{"name":38,"class":39},"Istituto Ortopedico Rizzoli","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":16,"minAge":48,"maxAge":49,"enrollmentInfo":50,"targetDuration":4,"studyType":52,"phases":53,"briefSummary":55,"conditions":56,"keywords":60,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":40},"100522431","effect-of-platelet-rich-plasma-prp-injection-on-knee-osteoarthritis-100522431","NCT06082531","Effect of Platelet-rich Plasma (PRP) Injection on Knee Osteoarthritis","Therapeutic Effect of Platelet-rich Plasma (PRP) Injection on Knee Osteoarthritis and Periarticular Tissue Injury","Inclusion Criteria:\n\n* The age range of the participants was 20 to 60 years old. Through a comprehensive clinical and imaging examination, it was conclusively determined that the individuals had knee osteoarthritis or experienced injuries to the cart, and meniscus surrounding the knee joint.\n* The preoperative routine tests and examinations revealed no contraindications.\n* Revised sentence: \"Informed consent of the patient\n\nExclusion Criteria:\n\n* The platelet count or function exhibits significant abnormalities、Systemic infection transmitted through the bloodstream.\n* Prolonged usage of anti-inflammatory drugs and systemic corticoid administration.\n* In injection site or damage to the skin.\n* Patients with tumors or undergoing radiotherapy and chemotherapy.\n* Pregnant or breastfeeding women.\n* Individuals with mental illnesses who are unable to cooperate with follow-up procedures.\n* Contraindications for MRI、Patients or their families do consent to participate in the study.\n* Other circumstances that render participation in the study unsuitable.","20 Years","60 Years",{"count":51,"type":21},300,"INTERVENTIONAL",[54],"NA","To evaluate the safety and effectiveness of PRP injection therapy in the repair of osteoarthritis and periarticular soft tissue injury through a single-center, exploratory clinical study, and to provide a more reliable basis for the treatment of joint injury.",[57,58,26,59],"Platelets-rich Plasma","Osteoarthritis Knees Both","Cartilage Injury",[61,62,59,63],"platelets-rich plasma","Osteoarthritis","Meniscus Injury","2025-04-06",{"date":66,"type":32},"2025-04-09",{"date":68,"type":32},"2023-09-01",{"date":70,"type":21},"2025-12-31",{"name":72,"class":39},"Xijing Hospital",{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":77,"acronym":4,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":79,"enrollmentInfo":80,"targetDuration":4,"studyType":52,"phases":82,"briefSummary":83,"conditions":84,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":40},"100507069","posteromedial-tibiofemoral-incongruence-pmtfi-treatment-100507069","NCT05882591","Posteromedial Tibiofemoral Incongruence (PMTFI) Treatment","Inclusion Criteria:\n\n* Pain, snapping or discomfort in posterior part of the knee in deep knee flexion during squat\n* Reduced concavity of the femoral metaphysis proximal to the medial femoral condyle confirmed on MRI\n* Impingement of posterior horn of medial meniscus with the metaphysis of femur during full knee flexion confirmed arthroscopically\n\nExclusion Criteria:\n\n* Active knee inflammation\n* Chondral injuries ICRS 3-4\n* Extraarticular reasons of pain, snapping or discomfort in posterior part of the knee in deep knee flexion during squat\n* Cyst or avascular changes within the femoral metaphysis adjacent to the planned localization of the procedure","70 Years",{"count":81,"type":21},10,[54],"The aim of this study is to assess outcomes of Posteromedial Tibiofemoral Incongruence (PMTFI) Treatment",[26,85,86,87],"Meniscus; Degeneration","Meniscus Tear","Meniscus Lesion","2023-05-20",{"date":90,"type":32},"2023-05-31",{"date":92,"type":32},"2020-10-09",{"date":94,"type":21},"2027-12-31",{"name":96,"class":39},"Artromedical Konrad Malinowski Clinic"]