[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"meniscus-lesion\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:meniscus-lesion":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,12,0,[8,46,71,96,120,150,181,207,238,261,284,307],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100556602","phase-3-meniscal-infiltration-of-corticosteroid-guided-with-ultra-sonography-100556602",false,"NCT06527235","Meniscal INfiltration of Corticosteroid Guided With Ultra Sonography","Efficacy of Ultrasound-monitored Meniscal Wall Betamethasone Infiltration on Pain in Relation to Degenerative Meniscal Injury: a Randomized, Double-blind, Placebo-controlled Multicenter Trial.","MINUS","Inclusion Criteria:\n\n* Localized knee pain with tenderness over the medial or lateral joint space reproduced on clinical examination\n* Pain assessed with a VAS score \\> 4\u002F10 despite first-line medical treatment including the use of tier I or II analgesics or NSAIDs.\n* An MRI of the knee performed in the 6 months preceding the operation as part of the pre-treatment assessment\n* Medial or lateral degenerative meniscal lesion on MRI consistent with pain, confirmed by an investigating physician\n* Affiliation to the Social Security\n* Free and informed consent signed by the patient\n\nExclusion Criteria:\n\n* Patient under curatorship, guardianship or safeguard of justice\n* Inability to speak, read or write French fluently\n* Patient deprived of liberty\n* Patients with psychiatric pathology\n* Patient who has had an MRI showing an unstable meniscal lesion: complete vertical tear of more than 10 mm in length, capsulomeniscal disinsertion of more than 10 mm in length, complex tear, T2 hypersignal tear of liquid type with passage of liquid testifying to the spreading of the edges, tear with displaced meniscal fragment, lesion of a posterior meniscal brake, lesion of the meniscotibial or meniscofemoral attachment\n* Patient with an MRI showing recent ligament injury(ies) (cruciate ligaments and\u002For collateral ligaments)\n* History of knee trauma less than 3 months\n* History of arthroscopy or open surgery of the involved knee,\n* History of corticosteroid injection in the knee concerned in the 3 months preceding inclusion,\n* Use of NSAIDs and oral corticosteroids during the 48 hours preceding inclusion\n* Use of tier 3 analgesics for gonalgia in the 3 months prior to inclusion\n* Episodes of knee instability or true locking\n* Radiographic gonarthrosis with a Kellgren Lawrence stage \\>1 authenticated on radiographic images taken within the last 6 months.\n* Known inflammatory rheumatism\n* Fibromyalgia as determined by the clinical investigator\n* Pregnancy and breastfeeding in progress\n* Contraindication to the use of injectable corticosteroids: septic arthritis, skin lesions at the injection site, severe coagulation disorders, hypersensitivity to one of the excipients\n* Contraindication to the use of systemic corticosteroids: acute infection, untreated and uncontrolled chronic infection, psychiatric or ophthalmological pathologies, unbalanced diabetes, uncontrolled hypertension\n* Contraindication to the use of lidocaine: known hypersensitivity to lidocaine hydrochloride, to local anaesthetics with an amide bond or to one of the excipients, patients with recurrent porphyrias\n* Patients on anticoagulants","ALL","18 Years",{"count":20,"type":21},152,"ESTIMATED","INTERVENTIONAL",[24],"PHASE3","The value of corticosteroid infiltration of the meniscus wall in the therapeutic strategy is not clearly defined: the data in the literature on the effectiveness of corticosteroid infiltration are heterogeneous and of low level of proof. We hypothesize that corticosteroid infiltration of the meniscal wall under ultrasound control would be effective for rapid relief of degenerative meniscal pain.\n\nThe main objective is to evaluate the efficacy of ultrasound-guided meniscal wall infiltration of betamethasone versus ultrasound-guided meniscal wall infiltration of placebo, at 1 month, on meniscal pain in the treatment of meniscal pain of degenerative origin in adult.",[27],"Meniscus Lesion",[29,30,31,32],"Betamethasone Injections","Meniscus","Ultrasonography","Randomized controlled Trial","RECRUITING","2025-11-26",{"date":36,"type":37},"2025-12-04","ACTUAL",{"date":39,"type":37},"2025-03-06",{"date":41,"type":21},"2028-06-01",{"name":43,"class":44},"University Hospital, Toulouse","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":53,"enrollmentInfo":54,"targetDuration":56,"studyType":57,"phases":4,"briefSummary":58,"conditions":59,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":45},"100555065","clinical-and-instrumental-assessment-of-meniscal-root-tears-treated-through-suture-to-the-posterior-cruciate-ligament-100555065","NCT06507241","Clinical and Instrumental Assessment of Meniscal ROOT Tears Treated Through Suture to the Posterior Cruciate Ligament","ROOT-PCL","Inclusion Criteria:\n\n1. Age between 18 and 50 years at the time of surgery;\n2. Male and female gender;\n3. Patients undergoing surgical treatment for at least one year for \"ROOT\" type meniscal lesions using arthroscopic suturing to the posterior cruciate ligament;\n4. Pre-operative MRI performed.\n\nExclusion Criteria:\n\n1. Patients no longer reachable;\n2. Patients who refuse consent to the study;\n3. Previous meniscectomy before surgery;\n4. Previous ligament injuries before surgery;\n5. New traumatic injuries after surgery;\n6. Advanced knee osteoarthritis (Outerbridge grade III-IV) at the time of surgery;\n7. Severe knee malalignment (\\> 5°) at the time of surgery;\n8. Severe obesity (BMI \\> 35);\n9. Lower limb conditions preventing full weight-bearing during evaluation;\n10. Infection or hematological\u002Frheumatic conditions at the time of evaluation.","50 Years",{"count":55,"type":21},59,"2 Years","OBSERVATIONAL","The menisci are crucial for knee stability and functionality. Composed of fibrocartilaginous structure, they have an anatomical and biomechanical arrangement that makes them essential for load transmission and the prevention of osteoarthritis. Meniscal root lesions, known as \"ROOT tears,\" compromise their protective function on the cartilage, leading to increased contact pressures between the tibia and femur and, over time, the development of osteoarthritis. Early diagnosis of these lesions is difficult and often the first detection is incidental. The subsequent challenges are significant due to a lack of pre-operative planning. A possible solution is a surgical technique involving arthroscopic suture of the posterior meniscal root along with the posterior cruciate ligament. This procedure does not require pre-operative planning and is applicable even in cases of incidental diagnosis.",[60,27,61],"Meniscus Tear","Knee Injuries","2025-11-18",{"date":64,"type":37},"2025-11-19",{"date":66,"type":37},"2024-10-18",{"date":68,"type":21},"2027-12",{"name":70,"class":44},"Istituto Ortopedico Rizzoli",{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":78,"targetDuration":4,"studyType":22,"phases":80,"briefSummary":82,"conditions":83,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":95},"100380036","juggerstitch-post-market-clinical-follow-up-study-100380036","NCT04228367","JuggerStitch Post Market Clinical Follow-up Study","JuggerStitch™ for Meniscal Repair Post Market Clinical Follow-up Study","Inclusion Criteria:\n\n* Subject qualifies for meniscal repair based on the physical exam and medical history and meets the approved indications for use of the study product;\n* Older than 18 years and skeletally mature;\n* Willing and able to comply with the study procedures;\n* Subject is capable of understanding the doctor's explanations, following his instructions and is able to participate in the follow-up program;\n* Subject is able to read and understand the informed consent form (ICF) and has voluntarily provided written informed consent.\n\nExclusion Criteria:\n\n* Meniscal tears in the avascular zone of meniscus;\n* Meniscal tears not suitable for repair because of the degree of damage(marked irregularity and complex tearing) to the meniscus body including degenerative, radial, horizontal cleavage and flap tears;\n* Presence of active infection;\n* If female, subject is pregnant;\n* Subject is vulnerable (prisoner, mentally incompetent or unable to understand what participation to the study entails, a known alcohol or drug abuser, anticipated to be non-compliant);\n* The subject is unwilling or unable to give consent or to comply with the follow-up program;\n* Subject meets any contraindications of the appropriate Instruction for Use.",{"count":79,"type":21},104,[81],"NA","This study is a post-market follow-up study. The data collected from this study will serve the purpose of confirming the safety and performance of the JuggerStitch Device used for meniscal repair according to the product labelling (Instruction For Use).",[84,27],"Meniscus Tear, Tibial","2025-11-10",{"date":87,"type":37},"2025-11-12",{"date":89,"type":37},"2020-09-25",{"date":91,"type":21},"2026-04-30",{"name":93,"class":94},"Zimmer Biomet","INDUSTRY",6,{"id":97,"slug":98,"hasResults":11,"nctId":99,"briefTitle":100,"officialTitle":101,"acronym":102,"eligibilityCriteria":103,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":53,"enrollmentInfo":104,"targetDuration":4,"studyType":22,"phases":106,"briefSummary":107,"conditions":108,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":111,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":119},"100557718","fibrine-clot-augmented-repair-of-longitudinal-meniscus-tears-100557718","NCT06541756","Fibrine Clot-augmented Repair of Longitudinal Meniscus Tears","Fibrine Clot-augmented Repair of Longitudinal Meniscus Tears - A Prospectively Randomized Controlled Trial","FCAR","Inclusion Criteria:\n\n* Presenting with a painful meniscus (lateral or medial) longitudinal tear\n* Being between the ages of 18 and 50\n* Not having undergone surgery on the same knee before\n* Having an MRI taken at the end of the 1st year post-surgery\n\nExclusion Criteria:\n\n* Having additional collateral ligamentous damage along with the meniscus tear (such as MCL or LCL)\n* Incomplete clinical scores at the end of the study\n* A history of previous surgery on the same knee\n* Having an active infection\n* Not having a control MRI at the end of the 1st year",{"count":105,"type":21},120,[81],"Longitudinal meniscal tears are a type of meniscal injury characterized by a displaced fragment of the meniscus that flips over into the joint, often resembling a buckle or handle. These tears typically occur in the medial meniscus and are often associated with traumatic knee injuries, particularly in athletes.\n\nThe displaced meniscal fragment can cause mechanical symptoms such as locking, clicking, or catching of the knee, as well as pain and swelling. If not properly treated, buckle-handle meniscal tears can lead to further complications, including chronic knee instability, increased risk of osteoarthritis, and persistent joint pain.Repairing a longitudinal meniscal tear offers several advantages over partial meniscectomy, particularly in preserving knee function and preventing long-term complications.\n\nMeniscal repair aims to restore the integrity of the meniscus, which plays a crucial role in load distribution, shock absorption, and joint stability.\n\nUtilizing a fibrin clot during the repair of a buckle-handle meniscal tear can enhance the healing process and improve surgical outcomes. Fibrin clots act as a biological scaffold, promoting tissue regeneration by providing a matrix that facilitates cellular migration and proliferation.\n\nThe purpose of this study was to compare longitudinal meniscal tear repair reinforced with fibrin clot with routine end-to-end repair in a prospective randomized controlled trial.",[60,27,109,61],"Fibrin Blood Clot","2025-09-29",{"date":112,"type":37},"2025-10-02",{"date":114,"type":37},"2024-07-25",{"date":116,"type":21},"2029-07-31",{"name":118,"class":44},"Ankara City Hospital Bilkent",2,{"id":121,"slug":122,"hasResults":11,"nctId":123,"briefTitle":124,"officialTitle":125,"acronym":126,"eligibilityCriteria":127,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":128,"enrollmentInfo":129,"targetDuration":4,"studyType":22,"phases":131,"briefSummary":132,"conditions":133,"keywords":136,"overallStatus":141,"whyStopped":4,"lastUpdateSubmitDate":142,"lastUpdatePostDateStruct":143,"startDateStruct":144,"completionDateStruct":146,"leadSponsor":148,"locationsCount":45},"100608671","semitendinosus-autograft-vs-meniscal-allograft-in-post-meniscectomy-syndrome-100608671","NCT07204587","Semitendinosus Autograft vs Meniscal Allograft in Post-Meniscectomy Syndrome","A Stratified, Partially Randomized Study Comparing Autologous Semitendinosus Tendon Graft and Meniscal Allograft Transplantation in Young Adults With Post-Meniscectomy Syndrome","MAT","Inclusion Criteria:\n\n* Adults aged 18 to 45 years\n\nHistory of partial meniscectomy \\> 6 months prior to enrollment\n\nSymptomatic post-meniscectomy syndrome (knee pain, swelling, or functional decline)\n\nMRI showing cartilage status ≤ Outerbridge grade 2\n\nKnee joint stability (or stabilized during the index surgery)\n\nBody mass index (BMI) \\\u003C 30\n\nWillingness to provide written informed consent\n\nExclusion Criteria:\n\nTibial slope \\> 16°\n\nRadiographic or arthroscopic evidence of advanced cartilage degeneration (Outerbridge \\> 2 or ICRS ≥ 3)\n\nPresence of inflammatory arthritis or systemic inflammatory joint disease\n\nHistory of cartilage repair surgery\n\nMalalignment \\> 5° not corrected\n\nUntreated ligamentous instability\n\nAny other condition judged by the investigator to compromise study participation or outcomes","45 Years",{"count":130,"type":21},40,[81],"This multicenter, stratified, partially randomized clinical trial aims to compare autologous semitendinosus tendon graft and meniscal allograft transplantation (MAT) in young adults with post-meniscectomy syndrome. The meniscus plays a critical role in load distribution, shock absorption, and joint stability. After meniscectomy, insufficient meniscal tissue often leads to persistent pain, swelling, and functional decline, increasing the risk of early osteoarthritis.\n\nTwo reconstructive strategies are clinically available: MAT provides immediate biomechanical function but requires donor matching and carries higher costs, while autologous tendon graft offers stable supply and no immunologic risk but lacks long-term clinical validation.\n\nIn this study, 40 patients aged 18-45 years will be enrolled. Participants will be allocated into four groups (randomized MAT, randomized autograft, patient-preference MAT, patient-preference autograft). All procedures will use a two-tunnel fixation technique with additional internal brace support.\n\nThe primary endpoint is the improvement in KOOS (Knee Injury and Osteoarthritis Outcome Score) at 24 months postoperatively. Secondary endpoints include MRI-based assessment of graft morphology and extrusion, reoperation rate, complications, patient satisfaction, and return-to-sport time.\n\nThis trial will provide critical evidence regarding the comparative effectiveness and feasibility of tendon autograft versus meniscal allograft in real-world clinical settings, potentially informing surgical decision-making and future treatment guidelines for post-meniscectomy syndrome.",[134,135,27],"Meniscal Injuries","Meniscal Tear",[137,138,139,140],"meniscal allograft","autologous tendon graft","Post-meniscectomy syndrome","Meniscus deficiency","NOT_YET_RECRUITING","2025-09-24",{"date":112,"type":37},{"date":145,"type":21},"2025-10-01",{"date":147,"type":21},"2029-09-30",{"name":149,"class":44},"Chang Gung Memorial Hospital",{"id":151,"slug":152,"hasResults":11,"nctId":153,"briefTitle":154,"officialTitle":155,"acronym":4,"eligibilityCriteria":156,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":157,"enrollmentInfo":158,"targetDuration":4,"studyType":22,"phases":159,"briefSummary":160,"conditions":161,"keywords":162,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":172,"lastUpdatePostDateStruct":173,"startDateStruct":175,"completionDateStruct":177,"leadSponsor":179,"locationsCount":45},"100545017","sterile-allogeneic-spongioflex-allograft-as-partial-meniscal-replacement-after-incomplete-meniscal-loss-100545017","NCT06376422","Sterile Allogeneic Spongioflex® Allograft as Partial Meniscal Replacement After Incomplete Meniscal Loss","Sterile Allogeneic Spongioflex® Allograft as Partial Meniscal Replacement After Incomplete Meniscal Loss, an Investigator-initiated Low Interventional Trial.","Inclusion Criteria:\n\n1. Patients (male and female) with:\n2. Partial loss of portions of the\n\n   * lateral meniscus and lateral joint line pain OR\n   * medial meniscus and medial joint line pain\n3. sufficient standing of the peripheral rim, so that the procedure can be performed\n4. Age: 18-60 years\n5. signed written informed consent to the study and to provide the scientific data in pseudonymized form\n\nExclusion Criteria:\n\n1. The presence of anterior cruciate ligament insufficiency which is not resolved by reconstruction of the anterior cruciate ligament within 16 weeks after partial meniscal implantation.\n2. Axial deviation (\\>2° varus or valgus)\n3. realignment osteotomy not performed within 12 weeks\n4. advanced cartilage damage (grade III according to ICRS) and osteoarthrosis in the affected compartment (grade III according to Kellgren and Lawrence \\[33\\])\n5. Extension deficit of more than 3° compared to the opposite side or a knee flexion of less than 125°\n6. inflammatory arthritis or synovitis on the treated knee\n7. BMI greater than 30 kg\u002Fm²\n8. \\\u003C18 years, \\>60 years\n9. Chronic pain patients\n10. only for patients who will be operated:\n\n    1. with increased anaesthesiologic risk, e.g., with known or predicted difficult airway\n    2. with increased risk of bleeding\n    3. with increased risk of infection\n    4. with necrotic, infected, or poorly perfused host sides\n    5. history of allergic reactions\n    6. acute hypersensitivity reactions to the IMP or any of its excipients\n    7. pregnant woman","60 Years",{"count":130,"type":21},[81],"The goal of this clinical trial is to learn if partial meniscal replacement can prevent or postpone total meniscal replacement, in adult patients (female\u002Fmale) with partial meniscal loss. The main questions it aims to answer are:\n\n* Can partial meniscal replacement improve knee function?\n* Can partial meniscal replacement prevent\u002Fpostpone total meniscal replacement\u002Fknee prothesis? Researchers will compare the results of the operated group with patients not willing to be operated but with partial meniscal loss to see if the operation improves knee function.\n\nParticipants will be operated and have to attend follow-up visits with MRI after 6 months up to 5 years after surgery.",[27],[163,164,165,166,167,168,169,170,171],"meniscus deficiency","partial meniscus replacement","Spongioflex®","Allograft","International Knee Documentation Committee (IKDC) Score","Knee Injury and Osteoarthritis Outcome Score (KOOS)","Visuelle Analogskala (VAS) Score","Extrusion","magnetic resonance imaging (MRI)","2025-08-01",{"date":174,"type":37},"2025-08-06",{"date":176,"type":37},"2024-04-30",{"date":178,"type":21},"2031-04-30",{"name":180,"class":44},"Sven Behrendt",{"id":182,"slug":183,"hasResults":11,"nctId":184,"briefTitle":185,"officialTitle":186,"acronym":4,"eligibilityCriteria":187,"healthyVolunteers":11,"sex":17,"minAge":188,"maxAge":189,"enrollmentInfo":190,"targetDuration":4,"studyType":22,"phases":192,"briefSummary":193,"conditions":194,"keywords":195,"overallStatus":141,"whyStopped":4,"lastUpdateSubmitDate":198,"lastUpdatePostDateStruct":199,"startDateStruct":201,"completionDateStruct":203,"leadSponsor":205,"locationsCount":45},"100584223","comparison-of-the-effectiveness-of-single-and-dual-task-training-applied-to-individuals-with-knee-meniscus-lesion-100584223","NCT06886542","Comparison of the Effectiveness of Single and Dual Task Training Applied to Individuals With Knee Meniscus Lesion","Comparison of the Effectiveness of Single and Dual Task Training Applied to Individuals With Knee Meniscus Lesion: A Randomized Controlled, Single-Blind Study","Inclusion Criteria:\n\n* 40 to 65 years old\n* According to magnetic resonance imaging (MRI) results, there is a maximum of Grade 2 degenerative bilateral meniscus tear\n* Having a Standardized Mini Mental Test score of 24 and above\n* Volunteering\n* Know how to read and write\n* Not having vision or hearing problems that cannot be corrected with a device\n* Being able to walk independently in society\n\nExclusion Criteria:\n\n* Not meeting the inclusion criteria\n* Having compliance issues or emotional and cognitive problems that will prevent participation in the assessments and clinical practices to be used in the study\n* Having problems participating in exercises or follow-ups\n* Having had surgery related to the lower extremity\n* Having a neuromuscular disease\n* Having a history of systemic inflammatory joint disease\n* Having a rheumatic disease\n* Having an additional pathology in the knee\n* Receiving additional treatment","40 Years","65 Years",{"count":191,"type":21},32,[81],"The main function of the meniscus is to transfer and distribute femoral pressure to the tibia. Treatment of meniscus tears is divided into conservative and surgical treatment. The most preferred methods for patients with meniscus lesions include meniscectomy and exercise therapy. The anterior and posterior horns of the meniscus contain numerous mechanoreceptors, including Ruffini endings (slow adapting) and Pacinian corpuscles (fast adapting), which provide information about the position and movement of the joint. Reduced proprioception due to mechanoreceptor damage from meniscus tears may be associated with decreased postural stability, as sensory information associated with a patient's conscious perception of joint movement through mechanoreceptors in the meniscus may contribute to postural stability.\n\nDual task is based on the simultaneous maintenance of motor-motor or cognitive-motor performance. Dual tasking is used to evaluate the simultaneous performance of a postural task and a motor or cognitive task to examine the interaction or effect of the secondary task on primary task performance. In a purposeful movement, it is necessary to have the ability to adapt to overcome environmental loads and achieve the goal. This also involves performing a cognitive task simultaneously while performing a motor task. In knee meniscus lesions, knee joint position sense and sensory input decrease, walking speed decreases, and attention devoted to walking increases.",[27],[196,197],"knee meniscus lesion","dual task training","2025-05-15",{"date":200,"type":37},"2025-05-20",{"date":202,"type":21},"2025-06-17",{"date":204,"type":21},"2026-08-17",{"name":206,"class":44},"Ankara Yildirim Beyazıt University",{"id":208,"slug":209,"hasResults":11,"nctId":210,"briefTitle":211,"officialTitle":212,"acronym":4,"eligibilityCriteria":156,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":157,"enrollmentInfo":213,"targetDuration":4,"studyType":22,"phases":214,"briefSummary":216,"conditions":217,"keywords":221,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":229,"lastUpdatePostDateStruct":230,"startDateStruct":232,"completionDateStruct":234,"leadSponsor":236,"locationsCount":45},"100575662","phase-4-partial-meniscal-replacement-with-spongioflex-100575662","NCT06775197","Partial Meniscal Replacement with Spongioflex®","Sterile Allogeneic Spongioflex® Allograft As Partial Meniscal Replacement After Incomplete Meniscal Loss, an Investigator-initiated Trial",{"count":130,"type":21},[215],"PHASE4","The purpose of this investigator-initiated trial is to evaluate whether the novel graft can prevent\u002Freduce the disadvantages of the previously used replacement materials and shows better results than the group of patients, which were not operated. Since there is currently no alternative made of biological material to this product, this investigator-initiated trial is of great medical and economic importance. The otherwise following arthrosis or knee prosthesis implantation (TKA ) could be prevented or at least postponed. Initial clinical results are promising.\n\nAn important and sensitive parameter for assessing the postoperative function of the meniscus is the MRI image. Genovese et al. 2007 were able to show in a categorization\u002Fclassification which magnetic resonance image can be expected in the case of successful incorporation. Several studies have shown that the known clinical knee scores (Lysholm, IKDC, KOOS, VAS pain) improve significantly after successful ingrowth of the meniscus implant.",[218,219,220,27,134,135],"Partial Meniscal Loss","Lateral Meniscus Partial Loss","Medial Meniscal Partial Loss",[222,166,165,223,224,225,226,227,228],"partial meniscal loss","IKDC","KOOS","return to sport","Outerbridge score","extrusion","VAS pain score","2025-01-09",{"date":231,"type":37},"2025-01-15",{"date":233,"type":37},"2024-11-05",{"date":235,"type":21},"2031-11-05",{"name":237,"class":44},"Maria-Josef-Hospital Greven",{"id":239,"slug":240,"hasResults":11,"nctId":241,"briefTitle":242,"officialTitle":243,"acronym":4,"eligibilityCriteria":244,"healthyVolunteers":11,"sex":17,"minAge":53,"maxAge":189,"enrollmentInfo":245,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":247,"conditions":248,"keywords":250,"overallStatus":141,"whyStopped":4,"lastUpdateSubmitDate":252,"lastUpdatePostDateStruct":253,"startDateStruct":255,"completionDateStruct":257,"leadSponsor":259,"locationsCount":4},"100570492","a-study-on-different-treatments-for-knee-osteoarthritis-caused-by-damaged-roots-of-the-medial-meniscus-100570492","NCT06707948","A Study on Different Treatments for Knee Osteoarthritis Caused by Damaged Roots of the Medial Meniscus.","Comparison of Different Treatment Strategies for Root Injury Behind the Medial Meniscus to Delay the Progression of Knee Osteoarthritis: a Prospective Cohort Study","Inclusion Criteria:\n\n1. Clinical diagnosis of posterior root tear of the medial meniscus;\n2. Patients with K-L classification ≤ grade II;\n3. The age range of 50-65 years old;\n4. International Cartilage Repair Society (ICRS) Modified Magnetic Resonance Imaging Grading System ≤ Grade 2;\n5. International Cartilage Repair Society (ICRS) arthroscopic grading system ≤ grade 2;\n6. Knee joint mobility ≥90°;\n7. Inversion deformity ≤10°;\n8. Must be able to complete follow-up MRI within 2 years after knee meniscus surgery;\n9. Must be able to complete clinical data;\n\nExclusion Criteria:\n\n1. Can not participate in this study;\n2. Patients with concomitant meniscal injuries elsewhere;\n3. knee joint infection disease;\n4. Osteoporosis disease;\n5. Patients with previous history of knee surgery;\n6. Knee joint instability disease;\n7. Severe KOA disease;\n8. Can not cooperate with MRI detection;\n9. Cannot tolerate the surgery;\n10. Those who cannot tolerate the arthroscopic knee surgery;\n11. Neuromuscular system pathology disease;",{"count":246,"type":21},69,"Medial meniscus posterior root tears (MMPRT) account for 20% or more of all meniscus tears, but the diagnosis and treatment of this condition continues to plague the general population due to the complexity of the diagnosis and uncertainty of the treatment. Early as well as timely diagnosis and treatment is one of the effective ways to avoid accelerated knee degeneration. Based on this study, our team is going to conduct a clinical study on posterior medial meniscus tear, combining Magnetic Resonance Imaging(MRI) to dynamically assess the changes of meniscus and articular cartilage surface after the injury, and selecting a specific patient group to carry out different therapeutic interventions, which mainly include conservative treatment, partial meniscectomy, and meniscal repair, in order to clarify the effects of different treatment modalities on the articular cartilage after the posterior meniscus tear, and to help to delay the degeneration of knee joints. This is to clarify the effects of different treatment modalities on the articular cartilage after posterior medial meniscus tears and to provide appropriate advice for delaying the progression of osteoarthritis of the knee.",[249,27],"Osteoarthritis",[251],"posterior meniscus root lesion;Osteoarthrotis","2024-11-26",{"date":254,"type":37},"2024-11-27",{"date":256,"type":21},"2024-11-30",{"date":258,"type":21},"2027-12-15",{"name":260,"class":44},"Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine",{"id":262,"slug":263,"hasResults":11,"nctId":264,"briefTitle":265,"officialTitle":266,"acronym":4,"eligibilityCriteria":267,"healthyVolunteers":11,"sex":17,"minAge":268,"maxAge":189,"enrollmentInfo":269,"targetDuration":4,"studyType":22,"phases":271,"briefSummary":272,"conditions":273,"keywords":4,"overallStatus":141,"whyStopped":4,"lastUpdateSubmitDate":275,"lastUpdatePostDateStruct":276,"startDateStruct":278,"completionDateStruct":280,"leadSponsor":282,"locationsCount":4},"100569328","pulsed-electromagnetic-field-therapy-pemt-in-patients-with-degenerative-meniscus-lesions-100569328","NCT06692816","Pulsed Electromagnetic Field Therapy (PEMT) in Patients With Degenerative Meniscus Lesions","Clinical Efficacy of Pulsed Electromagnetic Field Therapy (PEMT) in Patients With Degenerative Meniscus Lesions: Double-Blind Randomized Sham-Controlled Study","Inclusion Criteria:\n\n* Knee pain for at least 2 months\n* MRI findings of meniscus degeneration\n* The health condition is suitable for rehabilitation\n* Ability to understand commands\n\nExclusion Criteria:\n\n* Inability to cooperate fully and lack of literacy skills\n* NSAID use\n* Planning pregnancy during pregnancy or treatment process\n* A history of physical therapy and rehabilitation for the knee area in the last 6 months.\n* A history of local injection treatment to the knee area within the last 6 months,\n* A history of trauma, surgery, or fracture in the lower extremity on the side of pain in the last 6 months,\n* Lumbar radiculopathy\n* Presence of advanced gonarthrosis (Kellgren Lawrence stage 3-4)\n* Ligament injury or tear of the knee\n* Systemic inflammatory rheumatic disease (rheumatoid arthritis, systemic lupus erythematosus, ankylosing spondylitis, psoriatic arthritis, vasculitis etc.\n* Neurological diseases (multiple sclerosis, history of cerebrovascular disease, myopathic diseases, epilepsy, febrile convulsions, etc.),\n* Cardiac pacemaker,\n* Malignancy,\n* Bleeding diathesis,\n* An electronic or battery system body implant.\n* Acute infections, presence of tuberculosis","35 Years",{"count":270,"type":21},80,[81],"Pulse Electromagnetic Field Therapy (PEMT) is effective in the treatment of many diseases, especially musculoskeletal system diseases, due to its analgesic effect with the effect of induced currents, and also its anti-inflammatory , edema reducing, antispasmodic and blood flow accelerating effects with additional mechanisms. The aim of our study is to evaluate the effects of Pulsed Electromagnetic Field Therapy (PEMT) degenerative To investigate the effects on pain, quality of life and function in patients with meniscal lesions.",[27,274],"Pain","2024-11-15",{"date":277,"type":37},"2024-11-18",{"date":279,"type":21},"2024-12-01",{"date":281,"type":21},"2026-02-01",{"name":283,"class":44},"Afyonkarahisar Health Sciences University",{"id":285,"slug":286,"hasResults":11,"nctId":287,"briefTitle":288,"officialTitle":288,"acronym":4,"eligibilityCriteria":289,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":290,"enrollmentInfo":291,"targetDuration":4,"studyType":22,"phases":293,"briefSummary":294,"conditions":295,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":298,"lastUpdatePostDateStruct":299,"startDateStruct":301,"completionDateStruct":303,"leadSponsor":305,"locationsCount":45},"100507069","posteromedial-tibiofemoral-incongruence-pmtfi-treatment-100507069","NCT05882591","Posteromedial Tibiofemoral Incongruence (PMTFI) Treatment","Inclusion Criteria:\n\n* Pain, snapping or discomfort in posterior part of the knee in deep knee flexion during squat\n* Reduced concavity of the femoral metaphysis proximal to the medial femoral condyle confirmed on MRI\n* Impingement of posterior horn of medial meniscus with the metaphysis of femur during full knee flexion confirmed arthroscopically\n\nExclusion Criteria:\n\n* Active knee inflammation\n* Chondral injuries ICRS 3-4\n* Extraarticular reasons of pain, snapping or discomfort in posterior part of the knee in deep knee flexion during squat\n* Cyst or avascular changes within the femoral metaphysis adjacent to the planned localization of the procedure","70 Years",{"count":292,"type":21},10,[81],"The aim of this study is to assess outcomes of Posteromedial Tibiofemoral Incongruence (PMTFI) Treatment",[296,297,60,27],"Meniscus Disorder","Meniscus; Degeneration","2023-05-20",{"date":300,"type":37},"2023-05-31",{"date":302,"type":37},"2020-10-09",{"date":304,"type":21},"2027-12-31",{"name":306,"class":44},"Artromedical Konrad Malinowski Clinic",{"id":308,"slug":309,"hasResults":11,"nctId":310,"briefTitle":311,"officialTitle":312,"acronym":313,"eligibilityCriteria":314,"healthyVolunteers":315,"sex":17,"minAge":316,"maxAge":317,"enrollmentInfo":318,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":320,"conditions":321,"keywords":325,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":331,"lastUpdatePostDateStruct":332,"startDateStruct":334,"completionDateStruct":336,"leadSponsor":338,"locationsCount":45},"100409134","the-faroese-knee-cohort-etiology-and-long-term-implications-of-trochlear-dysplasia-and-patellar-dislocations-100409134","NCT04607538","The Faroese Knee Cohort: Etiology and Long-term Implications of Trochlear Dysplasia and Patellar Dislocations.","The Faroese Knee Cohort: An Investigation of Etiology and Long-term Implications of Trochlear Dysplasia and Patellar Dislocations","FKC","Inclusion Criteria:\n\n* Age between 15-20 years at the start of patient enrolment.\n* The feeling of patellar instability, or patellar dislocation\u002Fnear-dislocation.\n* The person has to be from the Faroe Islands.\n* All persons under the age of 18 must get written consent by their parents\n\nExclusion Criteria:\n\n* Terminal illness\n* Mental disabilities and illness, meaning that the patient cannot independently answer the PROM´s and cooperate to the clinical investigation.",true,"15 Years","20 Years",{"count":319,"type":21},100,"The investigators intend to establish a national cohort including all persons in the ages from 15-20 years old with patellar instability (PI) or a prior knee injury (ACL-ruptur or meniscus damage) . The cohort will be nicknamed \"The Faroese Knee Cohort\".\n\nThe overall aim is to investigate two groups.\n\n1. The patella instability group, in which we intend to investigate the following.\n\n   * Prevalence of patellar dislocation and trochlear dysplasia in the Faroe Islands.\n   * Risk factors for patellar dislocations-\n   * Heredity of trochlear dysplasia.\n   * If there is a specific gene responsible for the development of trochlear dysplasia.\n   * The development of retropatellar artrhosis, its onset and its impact on quality of life and function,\n2. Knee injury group (ACL-ruptur or meniscus injury)\n\n   * The prevalence of ACL-rupture and\u002For meniscus injury in this specific group in the Faroe Islands.\n   * The impact on quality of life and function.",[322,323,27,324],"Patellar Dislocation","ACL Injury","Trochlear Dysplasia",[326,327,328,329,330],"Patellar instability","Patellar dislocation","ACL-rupture","Meniscus lesion","Meniscus injury","2023-02-15",{"date":333,"type":37},"2023-02-17",{"date":335,"type":37},"2022-03-01",{"date":337,"type":21},"2051-12-01",{"name":339,"class":44},"Hvidovre University Hospital"]