[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"menstrual-pain\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:menstrual-pain":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,49,80,112,142,165,190,218],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":32,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100608750","the-good-pain-consultation-in-endometriosis-100608750",false,"NCT07205614","The Good Pain Consultation in Endometriosis.","Inclusion Criteria:\n\n* biological women\n\nExclusion Criteria:\n\n* not speaking norwegian","FEMALE","16 Years","50 Years",{"count":19,"type":20},110,"ESTIMATED","INTERVENTIONAL",[23],"NA","This PhD project investigates the effect of \"the good pain consultation\" and early integration of biopsychosocial pain education with current standard management of endometriosis. Our goal is to facilitate self-management of pain and improve health-related quality of life (HRQOL) using limited resources.\n\nOur research question is: Does a good pain consultation improve pain self-efficacy and HRQOL, compared to usual care at 3 months and 1 year.?\n\nResearchers will compare a good pain consultation to a control group that will receive usual care.\n\nParticipants will:\n\nAttend a consultation and biopsychososial pain education plus usual care or usual care alone.\n\nThey will answer questions in an internet-based questionnaires three times point during the study.",[26,27,28,29,30,31],"Pelvic Pain Syndrome","Endometriosis","Dysmenorrhea","Adenomyosis","Period Pain","Menstrual Pain",[33,34,35],"pain education","biopsychosocial","randomised controlled trial","RECRUITING","2026-04-22",{"date":39,"type":40},"2026-04-28","ACTUAL",{"date":42,"type":40},"2025-11-01",{"date":44,"type":20},"2028-06-01",{"name":46,"class":47},"Sorlandet Hospital HF","OTHER_GOV",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":15,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":21,"phases":60,"briefSummary":61,"conditions":62,"keywords":65,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":48},"100623076","high-intensity-interval-training-and-menstrual-health-experience-in-primary-dysmenorrhea-100623076","NCT07391930","High-Intensity Interval Training and Menstrual Health Experience in Primary Dysmenorrhea.","Efficacy of a High-Intensity Interval Training Program and Analysis of Menstrual Health Experience in Women With Primary Dysmenorrhea: A Mixed-Methods Randomized Controlled Trial.","Inclusion Criteria:\n\n* nulliparous\n* primary dysmenorrhea\n* body mass index between 18 and 30\n* menstrual pain \\>5 according to the Numeric Pain Scale\n* exercise \\>45 minutes\u002Fweek\n* understand Spanish and can freely read and sign the informed consent form\n\nExclusion Criteria:\n\n* amenorrhea or cycles \\>35 days\n* secondary dysmenorrhea\n* pelvic or abdominal surgical intervention\n* use of hormonal drugs\n* diagnosed with fibromyalgia, muscoloskeletal injuries or medical comorbidities that prevent them from performing intense exercise\n* receiving physiotherapy for pelvic floor disorders\n* intense exercise \\>75 minutes\u002Fweek","18 Years","40 Years",{"count":59,"type":20},60,[23],"The goal of this study is to evaluate whether a 12-week online supervised high-intensity interval training program can reduce menstrual pain and improve quality of life in women with primary dysmenorrhea. Participants will be divided into two groups: one receiving an educational workshop and the HIIT program, and a control group receiving only the workshop. Additionally, the study seeks to understand the personal experience of these women through weekly health diaries, exploring how the intervention affects their relationship with their bodies and their menstruation. The ultimate goal is to offer new, non-pharmacological evidence-based tools for managing menstrual pain.",[63,31,64],"Dysmenorrhea Primary","Pelvic Pain",[66,67,68,69],"High- Intensity Interval Training","Quality of Life","Menstrual Health","Therapeutic Exercise","2026-04-19",{"date":72,"type":40},"2026-04-21",{"date":74,"type":40},"2026-02-18",{"date":76,"type":20},"2029-06",{"name":78,"class":79},"University of Alcala","OTHER",{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":86,"eligibilityCriteria":87,"healthyVolunteers":11,"sex":15,"minAge":56,"maxAge":88,"enrollmentInfo":89,"targetDuration":4,"studyType":21,"phases":91,"briefSummary":93,"conditions":94,"keywords":95,"overallStatus":102,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":48},"100632028","phase-1-vaginal-sildenafil-for-primary-dysmenorrhea-100632028","NCT07508358","Vaginal Sildenafil for Primary Dysmenorrhea","Vaginal Sildenafil for Primary Dysmenorrhea: A Randomized, Double-Blind, Placebo-Controlled, Two-Period Crossover Mechanistic Study","SILDYS","Inclusion Criteria:\n\n* Female sex assigned at birth\n* Age 18 to 35 years\n* History of moderate-to-severe primary dysmenorrhea\n* Regular menstrual cycles of approximately 21 to 35 days\n* Willing and able to complete 2 menstrual treatment visits in separate menstrual cycles\n* Able to provide informed consent\n* Able to comply with study procedures, including MRI procedures and vaginal self-administration of study product\n\nExclusion Criteria:\n\n* Known hypersensitivity to sildenafil or any formulation component\n* Current use of nitrates or nitric oxide donors\n* Current use of potent CYP3A4 inhibitors or potent CYP3A4 inducers\n* Current use of another phosphodiesterase type 5 inhibitor\n* Uncontrolled hypertension, near-hypotension, or other clinically significant hemodynamic instability\n* Clinically significant cardiovascular disease\n* Clinically significant electrocardiographic abnormality, as judged by the investigator\n* Clinically significant laboratory abnormality, as judged by the investigator\n* Severe hepatic impairment or severe renal impairment\n* Active pelvic infection\n* Contraindication to MRI or factors that would impair MRI safety or interpretability, including certain metallic implants, metallic injury, claustrophobia, or intrauterine device-related artifact\n* Pregnant or breastfeeding\n* Any condition that, in the opinion of the investigator, would increase risk or interfere with study participation","35 Years",{"count":90,"type":20},50,[92],"PHASE1","This phase 1 randomized, double-blind, placebo-controlled, two-period crossover trial will evaluate whether a single 100 mg vaginal sildenafil citrate suppository reduces uterine hypercontractility during menstruation in adults with moderate-to-severe dysmenorrhea. Uterine contractility will be measured using cine magnetic resonance imaging (MRI). Key secondary objectives are to evaluate acute menstrual pain reduction over 4 hours, characterize limited systemic exposure using a single 4-hour plasma sildenafil concentration, and assess short-term safety and tolerability.",[28,31],[96,97,98,99,100,101],"sildenafil","vaginal sildenafil","uterine contractility","cine MRI","dysmenorrhea","pelvic pain","NOT_YET_RECRUITING","2026-03-31",{"date":105,"type":40},"2026-04-02",{"date":107,"type":20},"2026-05",{"date":109,"type":20},"2027-10",{"name":111,"class":79},"Kevin Hellman",{"id":113,"slug":114,"hasResults":11,"nctId":115,"briefTitle":116,"officialTitle":117,"acronym":4,"eligibilityCriteria":118,"healthyVolunteers":119,"sex":15,"minAge":56,"maxAge":120,"enrollmentInfo":121,"targetDuration":4,"studyType":21,"phases":123,"briefSummary":124,"conditions":125,"keywords":128,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":136,"completionDateStruct":138,"leadSponsor":140,"locationsCount":48},"100624415","self-acupressure-for-primary-dysmenorrhea-and-premenstrual-symptoms-100624415","NCT07409337","Self-Acupressure for Primary Dysmenorrhea and Premenstrual Symptoms","Effects of Self-Acupressure on Primary Dysmenorrhea and Premenstrual Symptoms in Women Aged 18-30: A Randomized, Sham-Controlled, 6-Month Trial","Inclusion Criteria:\n\n* Female participants aged 18 to 30 years\n* Regular menstrual cycles (21-35 days)\n* Diagnosis of primary dysmenorrhea with moderate to severe menstrual pain\n* Presence of premenstrual symptoms consistent with premenstrual syndrome\n* Currently enrolled as a university student\n* Willingness to perform self-acupressure as instructed for approximately six menstrual cycles\n* Ability to understand the study procedures and provide written informed consent\n\nExclusion Criteria:\n\n* Secondary dysmenorrhea (e.g., endometriosis, uterine fibroids, pelvic inflammatory disease)\n* Current use of hormonal contraceptives or hormonal therapy within the past 3 months\n* Pregnancy or breastfeeding\n* Chronic gynecological, endocrine, or systemic disease that may affect menstrual pain or symptoms\n* Regular use of analgesic or anti-inflammatory medications outside menstruation\n* Prior formal training or regular practice of acupuncture or acupressure\n* Inability to comply with study procedures or follow-up schedule",true,"30 Years",{"count":122,"type":20},120,[23],"This randomized, sham-controlled trial aims to evaluate the effects of self-administered acupressure on menstrual pain severity and premenstrual symptoms in women aged 18-30 years with primary dysmenorrhea. Participants will be randomly assigned to either a self-acupressure intervention group or a sham self-acupressure control group. The intervention will be applied during the premenstrual and menstrual periods over approximately six months. The primary outcome is the change in menstrual pain severity, and secondary outcomes include changes in premenstrual symptom severity, analgesic use, and menstruation-related activity limitation.",[126,127,31],"Primary Dysmenorrhea","Premenstrual Syndrome",[129,28,130,131,132,133],"Self-acupressure","Premenstrual symptoms","Menstrual pain","Non-pharmacological treatment","Sham-controlled trial","2026-02-14",{"date":74,"type":40},{"date":137,"type":40},"2026-02-15",{"date":139,"type":20},"2026-08-15",{"name":141,"class":79},"Nigde Omer Halisdemir University",{"id":143,"slug":144,"hasResults":11,"nctId":145,"briefTitle":146,"officialTitle":147,"acronym":4,"eligibilityCriteria":148,"healthyVolunteers":119,"sex":15,"minAge":56,"maxAge":88,"enrollmentInfo":149,"targetDuration":4,"studyType":21,"phases":150,"briefSummary":151,"conditions":152,"keywords":154,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":156,"lastUpdatePostDateStruct":157,"startDateStruct":159,"completionDateStruct":161,"leadSponsor":163,"locationsCount":48},"100609054","a-research-study-exploring-how-musculoskeletal-function-and-the-autonomic-nervous-system-relate-to-visceral-pain-in-women-with-and-without-dysmenorrhea-painful-periods-100609054","NCT07209566","A Research Study Exploring How Musculoskeletal Function and the Autonomic Nervous System Relate to Visceral Pain in Women With and Without Dysmenorrhea (Painful Periods).","The Effect of Vaginal Somatovisceral Pain on Hip Extension Mobility and Strength in Women at Mid-cycle With Dysmenorrhea vs. Controls: A Case-control Study","Inclusion Criteria: Non-pregnant women, not taking hormonal birth control, between the ages of 18 and 36 who report regular menstrual cycles are eligible for the study Exclusion Criteria: Participants will be excluded if they are currently pregnant or, have given birth within the preceding six months, are breastfeeding, or are undergoing in-vitro fertilization treatments. Exclusions also include those who have had abdominal, lumbar, or pelvic surgery within the preceding 12 months, suffer from a chronic pain condition, have an active genitourinary infection, are incontinent of bowel or bladder, or have been diagnosed with prolapse of a pelvic organ, severe labral pathology, femoral acetabular impingement (FAI), interstitial cystitis, endometriosis, pelvic inflammatory disease, irritable bowel syndrome, or other pelvic pathology. Participants reporting a cycle length of less than 28 days or longer than 35 days, those with a history of sexual assault, and those who are anovulatory without hormonal BC or amenorrheic will also be excluded.\n\n\\-",{"count":59,"type":20},[23],"The purpose of this clinical trial is to determine if women with dysmenorrhea demonstrate an increased musculoskeletal and autonomic nervous system response to a painful visceral stimulus compared to controls. A secondary aim is to determine if interoceptive awareness moderates this relationship. The designed methodology aims to elucidate the intricate connections between the interoceptive and musculoskeletal systems in pain perception among female participants, providing valuable insights into the underlying mechanisms of interoceptive pain and functional musculoskeletal changes.",[28,63,153,31],"Visceral Pain",[155],"Effect of visceral organ pain on musculoskeletal and autonomic nervous system","2025-09-29",{"date":158,"type":40},"2025-10-07",{"date":160,"type":40},"2025-08-01",{"date":162,"type":20},"2027-04-01",{"name":164,"class":79},"Azusa Pacific University",{"id":166,"slug":167,"hasResults":11,"nctId":168,"briefTitle":169,"officialTitle":170,"acronym":4,"eligibilityCriteria":171,"healthyVolunteers":11,"sex":15,"minAge":172,"maxAge":173,"enrollmentInfo":174,"targetDuration":4,"studyType":21,"phases":176,"briefSummary":177,"conditions":178,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":181,"lastUpdatePostDateStruct":182,"startDateStruct":184,"completionDateStruct":185,"leadSponsor":187,"locationsCount":48},"100598991","an-open-label-study-to-evaluate-the-effect-of-elix-cycle-balance--elix-daily-harmony-on-fibroid-related-symptoms-100598991","NCT07078682","An Open-Label Study to Evaluate the Effect of Elix Cycle Balance & Elix Daily Harmony on Fibroid-related Symptoms","An Open-Label, Single-Group Study to Evaluate the Effect of Elix Cycle Balance & Elix Daily Harmony on Fibroid-related Symptoms","Inclusion Criteria:\n\n* Be female.\n* Be aged 20-45.\n* BMI 18.5 - 24.9 kg\u002Fm2\n* Self-reported prior diagnosis of uterine fibroids.\n* Anyone who is generally healthy - does not live with any uncontrolled chronic disease.\n* Self-reported moderate to severe discomfort during menstruation, related to pelvic cramps, bloating, mood swings, or fatigue.\n* Self-reported menstrual cramps during their cycle, for the past six months minimum.\n* If taking hormonal birth control, has been doing so consistently for at least three months, and experiences a menstrual cycle with a period.\n* If taking other oral over-the-counter supplements or herbal remedies, has been consistently taking these for at least three months prior to starting the study, and is willing to maintain this routine for the study duration.\n* Willing to refrain from introducing any products or any new forms of medication or supplements for the study duration.\n* Willing to refrain from any other dietary supplements or herbal remedies targeting the menstrual cycle during the study period.\n* Willing to refrain from any new vaccines during the 6 month period.\n* Follows a stable, consistent exercise regimen and are willing, for the duration of the study, to not decrease or increase the amount of exercise in their regimen.\n* Agrees to refrain from any lifestyle changes that may affect their menstrual cycle for the duration of the study (for example, getting on or off hormonal birth control, reducing the amount of exercise).\n* If using any other interventions, such as massage, chiropractic medicine, or acupuncture, agrees not to increase or decrease the number of these other interventions during the study period.\n* Resides in the United States.\n\nExclusion Criteria:\n\n* Does not experience a regular menstrual cycle (21-35 days).\n* Does not experience menstrual cramping.\n* Follows an extreme diet intervention such as dry fasts, water fasts, or ketogenic diets.\n* Anyone who has experienced significant weight loss in the past three months prior to study participation.\n* Unwilling to stop the use of any medication or herbal remedies\u002Fsupplements that can affect the menstrual cycle.\n* Anyone with pre-existing chronic conditions that would prevent participants from adhering to the protocol, including oncological and psychiatric disorders.\n* Anyone with known severe allergic reactions.\n* Anyone with any allergies or sensitivities to any of the study product ingredients.\n* Any women who are pregnant, breastfeeding, or trying to conceive (or who will be at any point during the study period).\n* Anyone unwilling to follow the study protocol.\n* Has stopped, started, or changed hormonal birth control in the past three months.\n* Previous users of Elix Cycle Balance.\n* Anyone who is currently a smoker or has been a smoker in the past 3 months.\n* Anyone who has been diagnosed with the following conditions: PCOS, Endometriosis, PMDD, Adenomyosis, Hashimoto's thyroiditis, Grave's disease (and any other thyroid disorders), hyperprolactinemia, Cushing's disease, congenital adrenal hyperplasia, anorexia, bulimia, orthorexia, binge eating, any other eating disorder.\n* History of endocrine disorders such as thyroid disorder, Type 1 or 2 diabetes, or other.\n* History of hypertension, hyperlipidemia, or previous venous embolism.\n* Overweight\u002Fobesity (BMI \\> 25 kg\u002Fm2).\n* Women with other causes of chronic pelvic pain, including infectious disease, gastrointestinal, psychological disorders, fibromyalgia, and chronic fatigue syndrome.\n* Hysterectomy, myomectomy, or bilateral salpingo-oophorectomy or other gynecological medical or surgical treatment in the last 6 months.\n* History of an abnormal pap smear.\n* History of neoplasia of gynecological origin and\u002For existence of uterine malformations.\n* Chronic urinary tract infections or diagnosed functional gastrointestinal conditions like IBS, IBD, Crohn's disease, or ulcerative colitis.\n* Currently partaking in another research study or will be partaking in any other research study for the next 24 weeks, or at any point during this study's duration.\n* Consume more than 5 alcoholic drinks per week\n* Had a vaccine in the last 3 months","20 Years","45 Years",{"count":175,"type":20},42,[23],"This is a 24-week, single-arm, open-label, virtual study evaluating the effects of Elix Cycle Balance and Elix Daily Harmony on uterine fibroid-related symptoms and quality of life in 42 participants. Participants will self-administer the investigational herbal supplements daily and complete validated questionnaires at scheduled timepoints to assess symptom severity and quality of life.",[179,180,31],"Uterine Fibroids","Leiomyoma","2025-09-07",{"date":183,"type":40},"2025-09-12",{"date":160,"type":40},{"date":186,"type":20},"2026-01",{"name":188,"class":189},"Zenchi, Inc.","INDUSTRY",{"id":191,"slug":192,"hasResults":11,"nctId":193,"briefTitle":194,"officialTitle":195,"acronym":196,"eligibilityCriteria":197,"healthyVolunteers":11,"sex":15,"minAge":56,"maxAge":198,"enrollmentInfo":199,"targetDuration":4,"studyType":21,"phases":201,"briefSummary":202,"conditions":203,"keywords":206,"overallStatus":102,"whyStopped":4,"lastUpdateSubmitDate":209,"lastUpdatePostDateStruct":210,"startDateStruct":212,"completionDateStruct":214,"leadSponsor":216,"locationsCount":4},"100602959","abdominal-muscle-strengthening-for-menstrual-symptoms-in-primary-dysmenorrhea-100602959","NCT07130292","Abdominal Muscle Strengthening for Menstrual Symptoms in Primary Dysmenorrhea","Effects of Abdominal Muscle Strengthening Using Stabilizer Pressure Biofeedback on Menstrual Symptoms and Abdominal Muscle Strength in Young Women With Primary Dysmenorrhea: A Randomized Controlled Trial","STAMP","Inclusion Criteria:\n\n* Female participants aged 18-25 years\n* Regular menstrual cycles\n* Diagnosed with primary dysmenorrhea (no secondary dysmenorrhea or other gynecological disorders)\n* Menstrual pain intensity ≥ 4 on the Visual Analog Scale (VAS) during the menstrual cycle\n* Willingness to participate and ability to provide informed consent\n\nExclusion Criteria:\n\n* Diagnosis of secondary dysmenorrhea or other gynecological disorders (e.g., endometriosis, adenomyosis, uterine fibroids)\n* Current pregnancy or breastfeeding\n* History of abdominal or pelvic surgery in the past 6 months\n* Current use of hormonal therapy or analgesic medication that could affect menstrual pain assessment\n* Participation in regular abdominal or core strengthening exercise programs within the last 3 months\n* Any musculoskeletal, neurological, or systemic condition that could interfere with exercise performance or study participation","25 Years",{"count":200,"type":20},58,[23],"This randomized controlled trial aims to investigate the effects of abdominal muscle strengthening exercises using a stabilizer pressure biofeedback device on menstrual symptoms and abdominal muscle strength in young women with primary dysmenorrhea. Primary dysmenorrhea, characterized by painful menstrual cramps without underlying pelvic pathology, is common among women of reproductive age and can negatively affect quality of life.\n\nIn this study, 58 female participants aged 18-25 with regular menstrual cycles and a Visual Analog Scale (VAS) pain score of ≥4 will be randomly assigned to either an intervention group or a control group. The intervention group will perform abdominal strengthening and stretching exercises guided by a stabilizer pressure biofeedback device, three times per week for 6 weeks (excluding menstruation weeks).\n\nThe main outcomes include menstrual symptom severity (assessed by the Menstrual Symptom Scale), pain intensity (VAS), and abdominal muscle strength (measured using the stabilizer pressure biofeedback device). The results will help determine whether targeted abdominal muscle training can reduce menstrual symptoms and improve muscle strength in women with primary dysmenorrhea.",[31,204,205],"Menstrual Disorders","Muscle Strength",[126,207,208],"Abdominal Muscle Strengthening","Stabilizer Pressure Biofeedback","2025-08-12",{"date":211,"type":40},"2025-08-19",{"date":213,"type":20},"2025-08-13",{"date":215,"type":20},"2025-09-25",{"name":217,"class":79},"Bulent Ecevit University",{"id":219,"slug":220,"hasResults":11,"nctId":221,"briefTitle":222,"officialTitle":222,"acronym":4,"eligibilityCriteria":223,"healthyVolunteers":11,"sex":15,"minAge":172,"maxAge":88,"enrollmentInfo":224,"targetDuration":4,"studyType":21,"phases":225,"briefSummary":226,"conditions":227,"keywords":4,"overallStatus":102,"whyStopped":4,"lastUpdateSubmitDate":228,"lastUpdatePostDateStruct":229,"startDateStruct":231,"completionDateStruct":232,"leadSponsor":234,"locationsCount":48},"100589234","effect-of-myofascial-release-on-menstrual-pain-post-caesarean-section-100589234","NCT06951763","Effect of Myofascial Release on Menstrual Pain Post Caesarean Section","Inclusion Criteria:\n\n* Women complaining of menstrual pain post - caesarean section (CS).\n* Their age will range from 20 to 35 years.\n* Their body mass index will range from 20-30 kg\u002Fm2.\n* Women who gave birth once or twice.\n* Women who had C-section 6 weeks to 6 months ago.\n\nExclusion Criteria:\n\n* Active infection\u002F infectious skin disease, burn or scars.\n* Less than six weeks after CS.\n* Any abdominal surgeries other than CS.\n* Any spinal deformity as scoliosis or kyphosis.\n* History of cancer or radiation to the abdominopelvic region.",{"count":200,"type":20},[23],"The purpose of this study is to investigate the effect of myofascial release on menstrual pain post cesarean section.",[31],"2025-04-23",{"date":230,"type":40},"2025-04-30",{"date":230,"type":20},{"date":233,"type":20},"2025-08-15",{"name":235,"class":79},"Cairo University"]