[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"menstruation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:menstruation":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,47,70,102,125,148,175,200],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100641443","hydration--female-life-stages-100641443",false,"NCT07653620","Hydration & Female Life Stages","Effect of Female Life Stage on Rehydration With Water vs. an Electrolyte Solution After Overnight Fast\u002FFluid Restriction","Inclusion Criteria:\n\n* • Sex assigned female at birth.\n\n  * Recreationally active (engaged in light to moderate-intensity, intermittent, or steady-state exercise at least 3 days per week for at least 30 min at a time)\n  * Age 18-60 years, within the following life stage ranges specified below:\n  * Premenopausal:\n\n    * 18-35 years\n    * Self-report regular spontaneous menstrual cycle length (21-35 days) for the past 2 menstrual cycles\n    * Menstrual cycle length \\\u003C 7 days variation in consecutive cycles\n  * Perimenopausal:\n\n    * Perimenopause: 35-55 years\n    * If tracking cycles: self reported cycle irregularity (≥7 day difference from usual cycle length) for the past 2 menstrual cycles, not due to known pathology\n    * If not tracking cycles: clinician diagnosis\n  * Postmenopausal:\n\n    * Postmenopause: 45-60 years\n    * If tracking cycles: ≥12 consecutive months of spontaneous amenorrhea not due to pregnancy, lactation, or pathology\n    * If not tracking cycles: clinician diagnosis\n  * Healthy, with no known renal, cardiovascular, metabolic, or endocrine disorders that affect hydration or fluid regulation.\n  * Not currently taking medications known to influence fluid balance (e.g., diuretics, laxatives, weight loss agents, or other relevant medications) or the hypothalamus-pituitary-gonadal axis (e.g., ovulation induction agents, gonadotropins, IVF stimulation medications, or other relevant medications)\n\n    o See appendix 13.8 for list of medications, drugs, and\u002For medical conditions that may impair cognitive functioning, alter physiological responses relevant to the study outcomes, or increase the risk associated with participation.\n  * Not receive any fertility treatments within the past 6 months\n  * No hormonal contraceptives use within the past 6 months\n  * If using a paraguard copper IUD, it must be inserted for ≥ 3 months (if applicable)\n  * BMI ≤ 30 kg\u002Fm²\n  * Are not participating in a weight loss program\n  * Are not allergic to adhesives, stevia, and strawberry lime flavoring\n  * Willing to avoid strenuous activity and alcohol consumption 24 hours prior to all visits\n  * Willing to fast overnight (\\~12 hours) prior to the medical screening\n  * For visit 2 and 4:\n\n    * Willing to fast overnight (\\~12 hours)\n    * Willing to consume a minimum of 2.7 L of water 24 hours prior to visits 2 and 4, then 500 mL 2 hours before the start of the visits 2 and 4\n  * For visits 3 and 5:\n  * Willing to restrict all fluids (\\~18 hours)\n  * Willing to limit fluid consumption to 1 L the morning\u002Fafternoon prior to the start of the fluid restriction\n  * Willing to restrict food (\\~12 hours) the day prior to each visit Willing to eat a consistent diet the day prior\n  * Fluent in English (able to read, understand, and provide informed consent).\n  * Willing and able to provide informed consent to participate in the study and comply with all study procedures and scheduled visits\n\nExclusion Criteria:\n\n* • Currently pregnant or breastfeeding\n\n  * \\\u003C 6 months since giving birth (even if experiencing 2 regular menstrual cycles in a row)\n  * Smoking within the last 5 years\n  * History of adverse events (e.g., fainting) with blood draws\n  * Participants with large amount of internal metal (e.g., spinal rod) will be excluded from the DXA scan only (Brandenton)\n  * Participant has participated in a clinical trial within the past 30 days\n  * Participant has participated in any PepsiCo trial within past 3 months\n  * Participant has a condition or is taking medication that the investigator believes would interfere with his\u002Fher ability to provide informed consent, comply with the study protocol, which might confound the interpretation of the study results, or put the person at undue risk\n  * Participant is employed by, or has a parent, guardian, or other immediate family member employed by a company that manufactures any products that compete with any Gatorade product. If participant is unsure if a company would be considered a competitor to Gatorade, they will be asked to please let the study investigator know the name of the other company and the nature of their relationship to that company before they sign the informed consent.",true,"FEMALE","18 Years","60 Years",{"count":21,"type":22},72,"ESTIMATED","INTERVENTIONAL",[25],"NA","Female life stages including premenopausal, perimenopausal, postmenopausal, are characterized by changing concentrations and patterns of hormones. The premenopause stage represents the reproductive years with normal menstrual cycles lasting between 21-35 days. The perimenopause stage is the beginning of the menopause transition and can last up to 10 years. During this transition, menstrual cycles become longer and irregular in length (7 days or longer). After 12 consecutive months with no period, the transition is complete into the postmenopause stage.\n\nHormones that change across the lifespan are known to influence systems that regulate thirst, fluid balance, and sodium balance. Yet, fluid balance across life stages remains poorly understood, with no direct comparisons across all three life stages. The purpose of this study is to evaluate the effect of female life stage on rehydration with water and electrolyte solution after overnight fast and fluid restriction",[28,29,30,31,32,33],"Dehydration","Menstruation","Pre-menopause","Peri-menopausal Women","Post-menopausal Women","Hydration","RECRUITING","2026-06-12",{"date":37,"type":38},"2026-06-17","ACTUAL",{"date":40,"type":22},"2026-06",{"date":42,"type":22},"2026-12",{"name":44,"class":45},"PepsiCo Global R&D","INDUSTRY",2,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":23,"phases":57,"briefSummary":58,"conditions":59,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":69},"100636147","tampon-safety-in-use-study-100636147","NCT07561905","Tampon Safety-in-Use Study","An Open-Label Applicator Tampon Safety-in-Use Study","Key Inclusion Criteria:\n\n* Willing and able to read and provide written informed consent.\n* Female in good general health, age 18-49 (inclusive).\n* History of regular menstrual cycles during the previous 3months lasting approximately 21-35 days, including at least 4 days of menstruation, and expecting to menstruate during the study period.\n* History of use of applicator tampons within the past 12 months without discomfort.\n* Tracks menstruation and be able to confidently predict onset of menstruation\n* Normally use at least 6 tampons for protection during menstruation.\n* Normally uses regular, super, and\u002For super plus absorbency tampons for menstrual protection.\n* Agrees to the conduct of all study procedures, including gynecological exams and agrees to follow all study instructions and return for scheduled appointments.\n* Has used an acceptable form of birth control for at least one month prior to enrollment and for the duration of the study.\n\nKey Exclusion Criteria:\n\n* Pregnant, lactating or is trying to become pregnant.\n* Less than six (6) weeks post-partum.\n* Has a menstrual abnormality (such as oligomenorrhea or amenorrhea).\n* Has a known allergy or sensitivity to components of the investigational products\n* Any other medical condition or history, as determined by the Investigator that could compromise the study results or subject safety.","49 Years",{"count":56,"type":22},60,[25],"The goal of this clinical trial is to confirm the safety of a tampon in healthy female volunteers. Participants will use the study tampons as they normally would for one menstrual cycle. Gynecological exams will be conducted before and after the menstrual cycle.",[29],"2026-05-19",{"date":62,"type":38},"2026-05-22",{"date":64,"type":38},"2026-05-12",{"date":66,"type":22},"2026-06-08",{"name":68,"class":45},"Kimberly-Clark Corporation",1,{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":4,"eligibilityCriteria":76,"healthyVolunteers":16,"sex":17,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":4,"studyType":23,"phases":81,"briefSummary":82,"conditions":83,"keywords":85,"overallStatus":91,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":69},"100635543","hybrid-body-awareness-intervention-in-adolescent-girls-100635543","NCT07554053","HYBRID BODY AWARENESS INTERVENTION IN ADOLESCENT GIRLS","A RANDOMİZED CONTROLLED TRIAL","Inclusion Criteria:\n\n* Girls aged 11-16 years\n* Within 1-2 years after menarche\n* Able to participate in training and assessments\n* Written informed consent from participant and parent\u002Flegal guardian\n\nExclusion Criteria:\n\n* More than 2 years since menarche\n* Diagnosed psychiatric or gynecological disorder\n* Refusal to participate","11 Years","16 Years",{"count":80,"type":22},180,[25],"Menstruation after menarche is a multidimensional experience affecting adolescents' quality of life, school attendance, and psychological adjustment. Educational and awareness-based interventions improve menstrual knowledge, attitudes, and coping behaviors; however, randomized controlled trials evaluating hybrid body awareness-based interventions are limited.\n\nThis study aims to evaluate the effect of a hybrid body awareness-based intervention on menstrual symptoms, menstrual attitudes, and self-regulation levels in post-menarche adolescent girls.",[29,84],"Adolescent Health",[86,29,87,88,89,90],"Adolescent","Body Awareness","Self-Regulation","Randomized Controlled Trial","Nursing","NOT_YET_RECRUITING","2026-04-27",{"date":94,"type":38},"2026-05-01",{"date":96,"type":22},"2026-05-15",{"date":98,"type":22},"2026-09-15",{"name":100,"class":101},"Kahramanmaras Sutcu Imam University","OTHER",{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":108,"eligibilityCriteria":109,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":110,"enrollmentInfo":111,"targetDuration":4,"studyType":23,"phases":113,"briefSummary":114,"conditions":115,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":123,"locationsCount":69},"100572128","influence-of-menstrual-cycle-phases-on-the-glycemic-control-of-aerobic-or-hiit-exercise-in-adult-women-with-type-1-diabetes-100572128","NCT06729242","Influence of Menstrual Cycle Phases on the Glycemic Control of Aerobic or HIIT Exercise in Adult Women With Type 1 Diabetes","Influence of Menstrual Cycle Phases on the Glycemic Control of Aerobic or HIIT Exercise in Adult Women With Type 1 Diabetes (DIABETEXX\u002F2)","DIABETEXX\u002F2","Inclusion Criteria:\n\nAge between 18-45 years T1D with a diabetes duration for more than 2 years Glycated hemoglobin (HbA1c) \\\u003C 8.5% (\\\u003C69 mmol mol-1) Stable insulin regimen in the past 6 months with less than 20% change in total insulin daily dose Multiple daily injections or insulin pump Weekly physical activity of 90 min or more, but no practicing any sport as amateur or professional.\n\nExclusion Criteria:\n\nClinical conditions or use of medications (other than insulin) known to affect glycemic control (e.g., oral\u002Fparenteral steroids or metformin, among others).","45 Years",{"count":112,"type":22},40,[25],"Continuous glucose monitors, as a technology that aims to improve glycaemic control in patients with type 1 diabetes, must always adjust to changes in blood glucose levels in these patients, e.g. during sporting activities. In women, in particular, menstruation and its different phases can affect blood glucose levels in different ways. Therefore, this study aims to determine whether there is a different behaviour of blood glucose levels during aerobic or high-intensity exercise in different phases of menstruation. If so, we will try to model this behaviour and create specific guidelines in this regard in terms of physical exercise programming in women. In addition, the information derived from this study will be used to design better artificial pancreas systems that take into account the effects of the menstrual cycle in women.",[116,29],"Diabetes Mellitus, Type I","2025-07-05",{"date":119,"type":38},"2025-07-08",{"date":121,"type":38},"2025-01-10",{"date":40,"type":22},{"name":124,"class":101},"University of Valencia",{"id":126,"slug":127,"hasResults":11,"nctId":128,"briefTitle":129,"officialTitle":130,"acronym":4,"eligibilityCriteria":131,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":132,"enrollmentInfo":133,"targetDuration":4,"studyType":134,"phases":4,"briefSummary":135,"conditions":136,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":139,"lastUpdatePostDateStruct":140,"startDateStruct":142,"completionDateStruct":144,"leadSponsor":146,"locationsCount":69},"100591822","the-effect-of-the-menstrual-cycle-on-immune-cell-activity-and-recovery-after-resistance-exercise-100591822","NCT06985420","The Effect of the Menstrual Cycle on Immune Cell Activity and Recovery After Resistance Exercise","The Impact of the Menstrual Cycle on Innate Immune Cell Activation, Recruitment, and Adhesion Dynamics During Recovery From Damaging Resistance Exercise: Role of Neutrophils and Systemic Chemokines.","Inclusion Criteria:\n\n* Women between the ages of 18 and 40.\n* Must weigh at least 110 pounds.\n* Healthy as determined by medical history, physical activity readiness, and menstrual cycle questionnaires.\n* Actively resistance training for at least 6 months (minimum of 3 resistance training sessions per week, with at least one lower body session).\n* Pre-menopausal and have a regular menstrual cycle (eumenorrheic), with a clear start of menses (early follicular phase).\n* Not currently pregnant or planning to become pregnant during the study.\n* Have not used hormonal birth control or intrauterine devices in the past 3 months (or three full menstrual cycles).\n* Able to recall approximate start dates of their last 6 menstrual cycles.\n* Willing to follow study instructions, including avoiding exercise, alcohol, and caffeine before testing visits.\n* Free from previous or current lower body injuries that could limit performance.\n* Not regularly taking any medications that could interfere with the study.\n* Determined to have a high likelihood of successful blood draws by a certified phlebotomist.\n\nExclusion Criteria:\n\n* Do not give consent to participate.\n* Have been determined unfit to participate based on medical or activity history (using health questionnaires).\n* Currently take prescription or over-the-counter medication that could affect the study results.\n* Have a chronic illness requiring medical care.\n* Not currently resistance-trained (don't meet the exercise requirement).\n* Pregnant or planning to become pregnant during the study.\n* Do not have regular periods or have been diagnosed as amenorrhoeic (absence of menstruation).\n* Currently taking any performance-enhancing drugs.\n* Currently using hormonal birth control or intrauterine devices (IUDs), or have used them in the past three months (or three full menstrual cycles).\n* Determined unlikely to have a successful blood draw by a trained phlebotomist.\n* Weigh less than 110 pounds.","40 Years",{"count":112,"type":22},"OBSERVATIONAL","The goal of this observational study is to learn how the menstrual cycle affects immune cell activation, recruitment, and recovery responses after resistance exercise in healthy, resistance-trained women aged 18-40. The main questions it aims to answer are:\n\nDoes the menstrual cycle influence neutrophil recruitment and adhesion after resistance exercise? Does the menstrual cycle affect markers of muscle damage and functional recovery? Researchers will compare three menstrual phases (early follicular, late follicular, and mid-luteal) to see if immune responses and recovery outcomes differ across these phases.\n\nParticipants will:\n\nComplete resistance exercise protocols across three different menstrual cycle phases.\n\nProvide blood samples to assess immune cell activation and muscle damage markers.\n\nTrack sleep, mood, and recovery with questionnaires and wear an accelerometer.",[137,29,138],"Healthy Women","Resistance Exercise","2025-05-14",{"date":141,"type":38},"2025-05-22",{"date":143,"type":38},"2024-08-16",{"date":145,"type":22},"2025-05",{"name":147,"class":101},"University of Central Florida",{"id":149,"slug":150,"hasResults":11,"nctId":151,"briefTitle":152,"officialTitle":153,"acronym":154,"eligibilityCriteria":155,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":156,"enrollmentInfo":157,"targetDuration":4,"studyType":23,"phases":159,"briefSummary":160,"conditions":161,"keywords":162,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":165,"lastUpdatePostDateStruct":166,"startDateStruct":168,"completionDateStruct":170,"leadSponsor":172,"locationsCount":69},"100470969","evolutive-and-functional-bases-of-menstruation-in-women---2-100470969","NCT05412771","Evolutive and Functional Bases of Menstruation in Women - 2","Bases Évolutives Et Fonctionnelles De La Menstruation Chez Les Femmes - 2","EVOMENS-2","Inclusion Criteria:\n\n* Be between 18 and 50 years old.\n* Have mensturation at the time of their participation\n* Have given their written consent\n* Have an indication for surgery of hysteroscopy for removal of a polyp and\u002For fibroid and\u002For endometrial, endometrialctomy for presumed benign pathology and\u002For management of a uterine malformation, scheduled between days 21 and 25 of their menstrual cycle\n* Covered by social security\n\nExclusion Criteria:\n\n* Using an intrauterine device contraceptive method during the study or within the previous three months\n* To be Pregnant at the time of collection\n* Have been pregnant in the three months prior to collection\n* Have had amenorrhoea in the three months prior to collection\n* Have received hormonal treatment within the three months prior to collection\n* Have participated in a clinical study within 3 months prior to collection\n* Have a personal history of breast, ovarian, body or cervical cancer\n* Have a diagnosis of endometriosis\n* Have a diagnosis of adenomyosis\n* Have a diagnosis of Lynch syndrome\n* Undergoing hysteroscopy for a condition other than those listed in the inclusion criteria\n* Women who have not given written consent\n* Women who are breastfeeding\n* Women with a body mass index (BMI) of less than 18.5 or more than 30","50 Years",{"count":158,"type":22},20,[25],"Menstruation corresponds to the shedding of the uterine lining when fecundation has not occurred. This is a recent evolutionary innovation in primates, and the cellular and genetic changes that led to the acquisition of menstruation are not well understood. Additionally, the uterine lining is poorly characterized in humans across the menstrual cycle, which hinders both evolutionary and medically-relevant analyses.\n\nIn this study, the research team are collecting uterine endometrial tissue samples from female donors undergoing uterine surgery for benign conditions, to profile gene expression and gene regulatory elements in the major cell types that compose the uterine lining during the secretive phase of the menstrual cycle. The investigators will compare this data to similar samples collected from other primates at the same time point in the female hormonal cycle.\n\nThe objective is to identify genes that have acquired novel regulation and\u002For expression patterns and which may be involved in menstruation, as well as better characterize the cellular and molecular pathways at work in the uterine lining of women for translational medicine purposes.",[29],[163,164],"endometrium","comparative genomics","2025-03-18",{"date":167,"type":38},"2025-03-19",{"date":169,"type":38},"2022-11-23",{"date":171,"type":22},"2027-10-25",{"name":173,"class":174},"Institut National de la Santé Et de la Recherche Médicale, France","OTHER_GOV",{"id":176,"slug":177,"hasResults":11,"nctId":178,"briefTitle":179,"officialTitle":180,"acronym":4,"eligibilityCriteria":181,"healthyVolunteers":16,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":182,"targetDuration":4,"studyType":23,"phases":184,"briefSummary":185,"conditions":186,"keywords":190,"overallStatus":91,"whyStopped":4,"lastUpdateSubmitDate":191,"lastUpdatePostDateStruct":192,"startDateStruct":194,"completionDateStruct":196,"leadSponsor":198,"locationsCount":4},"100584354","effectiveness-of-menstruation-education-to-secondary-school-students-100584354","NCT06888245","Effectiveness of Menstruation Education to Secondary School Students","Evaluation of the Effectiveness of Menstruation Education Given to Secondary School Students With and Without Animation","Inclusion Criteria:\n\n* Secondary school student\n* Open to communication and collaboration,\n* Female students who agreed to participate in the study and whose parents gave their consent were included in the study.\n\nExclusion Criteria:\n\n* Special education students from the research,\n* Female students who do not want to continue the research will be excluded.",{"count":183,"type":22},90,[25],"Supporting adolescents with education about the menstruation process is important in terms of managing the process physically and mentally healthy and gaining lifelong positive health behaviors. Various narrative techniques including visuals, slides and animations are utilized in menstruation education for adolescents. Within the scope of these narrative techniques, technological tools are frequently used for learning purposes in adolescence. In technology-supported education, training that includes visual materials such as animations and multimedia software is very important. Presentations supported by various visuals and texts can be effective in trainings on mentoring. Presentations can appeal to students' visual senses and attract their attention. Animation is one of the technology-based applications that are frequently used in the education of adolescents and support education. The presentation can be animated or non-animated.",[29,187,188,189],"Education","Student","Animation",[29,188,187,189],"2025-03-15",{"date":193,"type":38},"2025-03-21",{"date":195,"type":22},"2025-04-01",{"date":197,"type":22},"2025-08-01",{"name":199,"class":101},"Ordu University",{"id":201,"slug":202,"hasResults":11,"nctId":203,"briefTitle":204,"officialTitle":204,"acronym":4,"eligibilityCriteria":205,"healthyVolunteers":16,"sex":206,"minAge":18,"maxAge":4,"enrollmentInfo":207,"targetDuration":4,"studyType":134,"phases":4,"briefSummary":209,"conditions":210,"keywords":218,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":219,"lastUpdatePostDateStruct":220,"startDateStruct":222,"completionDateStruct":224,"leadSponsor":226,"locationsCount":69},"100377597","apple-womens-health-study-100377597","NCT04196595","Apple Women's Health Study","Inclusion Criteria:\n\n* Have menstruated at least once\n* Be at least 18 years old (at least 19 years old in Alabama and Nebraska, at least 21 years old in Puerto Rico)\n* Live in the United States of America\n* Be comfortable communicating in written and spoken English\n* Have installed the Apple Research app on your iPhone\n* Not share your iCloud account or iPhone with anyone else\n* Be willing and able to provide informed consent to participate in the study","ALL",{"count":208,"type":22},500000,"This is an observational longitudinal study to advance the understanding of menstrual cycle and gynecologic health conditions including PCOS, infertility and breast cancer.The study will be hosted within the Research app(available on App Store), which allows a user to find, enroll, and participate in Apple-supported health-related research studies.",[211,212,29,213,214,215,216,217],"Menstrual Cycle","Ovulation","Polycystic Ovary Syndrome","Infertility","Menopause","Reproduction","Reproductive Health",[29,211,212,213,214,215,216,217],"2024-07-01",{"date":221,"type":38},"2024-07-03",{"date":223,"type":38},"2019-11-14",{"date":225,"type":22},"2029-11",{"name":227,"class":45},"Apple Inc."]