[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"mental-acuity\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:mental-acuity":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,45,67],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":4},"100641706","the-effect-of-water-temperature-on-heart-rate-variability-and-cognition-100641706",false,"NCT07654270","The Effect of Water Temperature on Heart Rate Variability and Cognition","Effects of Water Temperature on Heart Rate Variability During Cognitive Testing in Healthy Adult Women: A Randomized Crossover Trial","Inclusion Criteria:\n\n* Healthy women free of chronic disease (by self-report)\n* 18-30 years of age\n\nExclusion Criteria:\n\n* medication\u002Fdrug use that has not been consistent for the previous 3 months or will be discontinued during the trial\n* any acute illness\n* regular use of cigarettes or marijuana\n* pregnant or lactating women\n* not fluent in English\n* not willing to attend two in-person lab visits in downtown Phoenix and follow study protocol (including abstaining from caffeine in the 12 hours prior to testing)\n* not currently competing in sports or unusually high-intensity exercise protocols (e.g., high-intensity exercise greater than 30 minutes most days of the week)",true,"FEMALE","18 Years","30 Years",{"count":21,"type":22},30,"ESTIMATED","INTERVENTIONAL",[25],"NA","Heart rate variability (HRV) is a key indicator of fitness, and stress resilience. Previous research has shown that HRV decreases under mental workload, including during tasks that require strict attention. Studies also show that temperature exposure affects attention: cold increases the stress response while warm water has a calming effect. Very few studies combine thermal exposure with cognitive testing, and no controlled trials have investigated whether water temperature modulates HRV responses specifically during cognitive demand.",[28],"Mental Acuity",[30,31,32],"heart rate variability","water temperature","cognitive performance","NOT_YET_RECRUITING","2026-06-12",{"date":36,"type":37},"2026-06-17","ACTUAL",{"date":39,"type":22},"2026-07-13",{"date":41,"type":22},"2027-06-15",{"name":43,"class":44},"Arizona State University","OTHER",{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":16,"sex":52,"minAge":18,"maxAge":19,"enrollmentInfo":53,"targetDuration":4,"studyType":23,"phases":54,"briefSummary":55,"conditions":56,"keywords":57,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":66,"locationsCount":4},"100641622","effects-of-red-panax-ginseng-supplementation-on-cognitive-performance-and-emotional-well-being-in-young-healthy-adults-100641622","NCT07648316","Effects of Red Panax Ginseng Supplementation on Cognitive Performance and Emotional Well-Being in Young Healthy Adults","Effects of Red Panax Ginseng Supplementation on Cognitive Performance and Emotional Well-Being in Young Healthy Adults, a Randomized Controlled Trial","Inclusion Criteria:\n\n* Healthy young adults\n* 18-30 years of age\n\nExclusion Criteria:\n\n* medication\u002Fdrug use that has not been consistent for the previous 3 months or will be discontinued during the trial\n* unresolved chronic medical conditions (e.g., presence of persistent symptomology)\n* diagnosed clinical depression\n* acute illness\n* regular use of cigarettes or marijuana\n* pregnant or lactating women\n* not fluent in English\n* currently competing in sports or unusually high-intensity exercise protocols (e.g., high-intensity exercise greater than 30 minutes most days of the week)\n* current use of ginseng or adaptogenic supplements, or allergy to ginseng\n* any significant food allergies\n* not willing to attend two in-person lab visits in downtown Phoenix and follow study protocol (including abstaining from caffeine in the 12 hours prior to testing)","ALL",{"count":21,"type":22},[25],"College students face substantial and persistent mental health challenges that directly affect cognitive performance, stress regulation, and emotional well-being. Neurological functions such as working memory, attention regulation, executive control, and emotional processing are highly sensitive to stressors, leaving young adults vulnerable to daily fluctuations in cognitive efficiency. Recent findings from the Healthy Minds Network (2025) indicate that although rates of moderate to severe depression among college students declined from 44% in 2022 to 37% in 2025, and anxiety symptoms fell from 37% to 32%, levels of psychological flourishing also dropped, falling to 36% despite these improvements.\n\nGinseng contains bioactive compounds known as ginsenosides that favorably influence brain function and inflammatory cascades. Studies in stressed and moderately stressed adults demonstrated reduced perceived stress, improved emotional processing, enhanced cognitive performance, and beneficial changes to biomarkers with ginseng supplementation. In addition, randomized controlled trials reported improvements in mood regulation, fatigue resistance, and aspects of working memory and attention following short-term ginseng supplementation. This study will examine the effects of daily red panax ginseng supplementation (3000 mg\u002Fday; two 1500 mg Red Panax gummies) on cognitive performance and emotional well-being in healthy young adults.",[28],[58,59,60],"ginseng","mental health","cognitive performancd",{"date":62,"type":37},"2026-06-16",{"date":64,"type":22},"2026-06-22",{"date":41,"type":22},{"name":43,"class":44},{"id":68,"slug":69,"hasResults":11,"nctId":70,"briefTitle":71,"officialTitle":71,"acronym":4,"eligibilityCriteria":72,"healthyVolunteers":16,"sex":52,"minAge":73,"maxAge":74,"enrollmentInfo":75,"targetDuration":4,"studyType":23,"phases":76,"briefSummary":77,"conditions":78,"keywords":80,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},"100588039","effects-of-spirulina-supplementation-on-mental-health-in-healthy-adults-100588039","NCT06936202","Effects of Spirulina Supplementation on Mental Health in Healthy Adults","Inclusion Criteria:\n\n* healthy adults\n* ages 18-65\n* no underlying chronic disease or acute conditions\n* no autoimmune conditions\n* do not consume alcohol in excess, smoke, use recreational drugs\n* does not follow restrictive diets\n* will be recruited from the ASU university campus.\n\nExclusion Criteria:\n\n* not have been clinically diagnosed with depression\n* not taking antidepressants, anxiety, or stress medications, or any other medications\n* drugs, or supplements that could influence mental capacities\n* not pregnant or breastfeeding\n* not a competitive athlete","16 Years","65 Years",{"count":21,"type":22},[25],"Spirulina platensis is a form of cyanobacteria, a blue-green algae, and is a superfood most known for being rich in protein, vitamins and minerals, and healthful phytochemicals. Spirulina supports brain health through neuroprotection offered by its antioxidants, anti-inflammatory properties, and hormone regulation.\n\nThe aim of this study is to supplement healthy adults from a campus community with 3g of spirulina, daily, for 8 weeks to improve mood and mental acuity in comparison to receiving a placebo.",[79,28],"Depression",[81,82,83],"spirulina","depression","mental acuity","RECRUITING","2025-08-14",{"date":87,"type":37},"2025-08-19",{"date":89,"type":37},"2025-04-15",{"date":91,"type":22},"2026-05",{"name":43,"class":44},1]