[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"mental-health-issue\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:mental-health-issue":27},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,87,0,25,[9,46,75,105,129,160,186,208,228,252,275,301,328,350,371,397,422,445,469,497,526,558,579,602,620],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100644213","a-pre-post-pilot-of-a-smartphone-intervention-100644213",false,"NCT07665346","A Pre-post Pilot of a Smartphone Intervention","A Pre-post Pilot of Behavioral Interventions Delivered Through Smartphones","Inclusion Criteria:\n\n* age = 18 years\n* 0-5 years post-diagnosis of Stage I, II, or III female breast cancer\n* elevated symptoms of depression and\u002For anxiety as measured by the PHQ-8 (score \\> 9) or GAD-7 (score \\> 7).\n\nExclusion Criteria:\n\n* receiving individual (1 on 1) treatment for depression and\u002For anxiety to avoid treatment interference (note, individuals will be permitted to enroll if they are taking antidepressant medication and have not had an appointment to adjust the dosage over the past 2 weeks)\n* active suicidal ideation during the enrollment\u002Fscreening call based on a trained staff member orally administering the suicidality item from the PHQ-9 to individuals on the phone (\"In the last 2 weeks, have you had thoughts that you would be better off dead, or thoughts of hurting yourself in some way?\"). If an individual responds in any way other than \"not at all\" based on the available response options (i.e., either \"several days\", \"more than half the days\", or \"nearly every day\"), or if they mention having suicidal ideation or thoughts of death during the enrollment\u002Fscreening call, the Pitt-Optimum risk assessment tool will be administered. Only participants deemed low risk may proceed in enrollment; all will be given additional resources\n* do not have an app-compatible phone\n* cannot read and speak English (intervention and measures only available in English).","FEMALE","18 Years",{"count":20,"type":21},44,"ESTIMATED","INTERVENTIONAL",[24],"NA","Digital mental and behavioral health interventions have potential to significantly improve accessibility for the large number of breast cancer survivors who need treatments. However, the landscape of digital interventions tested in this population remains limited, with the few that have been tested primarily focused on reducing symptoms of mental disorders. This is problematic given the range of psychosocial needs among breast cancer survivors, including those who may not have active mental health symptoms, yet could benefit from learning effective coping skills.\n\nDigital health interventions delivered through smartphones have strong potential to improve access to care for the large number of breast cancer survivors who need mental and behavioral health support. There is a need to evaluate a range of supportive interventions that target different aspects of mental health, including negative thinking, coping skills, and knowledge. Our research team has previously tested individual digital interventions in relatively small samples, and found that they were effective in reducing mood symptoms among women with breast cancer.\n\nThe ultimate goal of this project is to evaluate how integrating these interventions into a single 8-week long app program affects mood and overall mental health in breast cancer survivors. The digital micro-interventions to be tested in this study are brief interventions that target specific behavioral and cognitive mechanisms of mental health. These include skills such as reducing negative thinking patterns, increasing knowledge of mental health factors, fostering a grateful outlook, promoting the practice of relaxation breathing, savoring positive memories, and acceptance-based mindfulness approaches.",[27,28],"Mental Health Issue","Breast Cancer",[30,31,32],"depression","anxiety","well-being","NOT_YET_RECRUITING","2026-06-18",{"date":36,"type":37},"2026-06-24","ACTUAL",{"date":39,"type":21},"2026-07",{"date":41,"type":21},"2026-09",{"name":43,"class":44},"University of Virginia","OTHER",1,{"id":47,"slug":48,"hasResults":12,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":54,"sex":55,"minAge":18,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":58,"briefSummary":59,"conditions":60,"keywords":62,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":45},"100478376","affirmative-psychotherapy-for-sexual-minority-womens-mental-and-behavioral-health-100478376","NCT05509166","Affirmative Psychotherapy for Sexual Minority Women's Mental and Behavioral Health","A Unified Protocol to Address Sexual Minority Women's Minority Stress, Mental Health and Hazardous Drinking","EQuIP","Inclusion Criteria:\n\n1. be 18 years of age or older\n2. be fluent in English\n3. self-identify as lesbian, bisexual, queer, pansexual, or other non-heterosexual identity\n\n3\\) report at ≥ 8 standard drinks\u002Fweek, on average, in the past 30 days, OR report at least 2 heavy drinking days ( ≥ 4 drinks in one day) in the past 30 days 4) currently experience a Diagnostic and Statistical Manual of Mental Disorders (DSM)-5 depression or anxiety disorder (screened initially using a cutoff of ≥ 2 on the Brief Symptom Inventory-4 and further confirmed by diagnostic interview via the DIAMOND) 5) report at least minimum motivation to reduce drinking (measured by the Readiness Ruler) 6) live in New York, New Jersey, and Pennsylvania and planning to stay for at least the next 4 months\n\nExclusion Criteria:\n\n1. report current mental health treatment ≥1 day\u002Fmo\n2. report having received any CBT in the past 3 months\n3. report current alcohol or drug abuse treatment, except mutual self-help (e.g., Alcoholics Anonymous)\n4. need alcohol detoxification indicated by ≥9 on Clinical Institute Withdrawal Assessment for Alcohol-Revised (CIWA-Ar)\n5. exhibit active psychosis or active mania, as assessed by the Structured Clinical Interviews for DSM-5 Disorders (SCID) Psych Screen\n6. exhibit active suicidality or active homicidality, as assessed by the SCID-Psych Screen\n7. be currently legally mandated to attend treatment\n8. demonstrate gross cognitive impairment, as assessed with the Telephone Interview for Cognitive Status",true,"ALL",{"count":57,"type":21},274,[24],"The purpose of this 2-arm randomized controlled trial is to assess the efficacy of a 10-session lesbian, gay, bisexual, transgender, and queer (LGBTQ)-affirmative cognitive-behavioral psychotherapy (CBT) delivered via telehealth in a large sample of sexual minority women (SMW) in New York, New Jersey and Pennsylvania. The investigators will assess whether the EQuIP (Empowering Queer Identities in Psychotherapy) treatment demonstrates significant reductions in heavy drinking (HD) and mental health symptoms (e.g., depression) compared to LGBTQ-affirmative treatment-as-usual.",[61,27],"Heavy Drinking",[63,64],"LGBTQ","Cognitive Behavioral Therapy","RECRUITING","2026-06-11",{"date":68,"type":37},"2026-06-15",{"date":70,"type":37},"2023-02-01",{"date":72,"type":21},"2027-10-01",{"name":74,"class":44},"Yale University",{"id":76,"slug":77,"hasResults":12,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":54,"sex":55,"minAge":18,"maxAge":4,"enrollmentInfo":83,"targetDuration":4,"studyType":22,"phases":85,"briefSummary":86,"conditions":87,"keywords":90,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":104},"100641701","projecte-benestar-2026-virtual-reality-program-for-healthcare-workers-100641701","NCT07649733","Projecte Benestar 2026: Virtual Reality Program for Healthcare Workers","Projecte Benestar 2026: Multicenter Study of the Effectiveness and Implementability of an Immersive Educational Program for Workers in Healthcare Settings","BENESTAR","Inclusion Criteria:\n\n* Active permanent or temporary staff member at a participating healthcare center where the program is implemented\n* Age 18 years or older\n* Able to understand, accept, and sign the informed consent form\n* Willing to complete the study procedures, attend the planned weekly sessions, and complete the study questionnaires\n\nExclusion Criteria:\n\n* Photosensitive epilepsy or history of seizures triggered by visual stimuli\n* Severe motion sickness or previous intolerance to immersive devices\n* Visual or hearing impairment that prevents adequate use of the virtual reality headset",{"count":84,"type":21},100,[24],"Projecte Benestar 2026 is a multicenter randomized controlled study evaluating a brief immersive educational program delivered through virtual reality for healthcare workers. The program is designed to support emotional well-being, self-care, mindfulness, and emotional regulation in professionals working in healthcare settings.\n\nParticipants will be active healthcare or healthcare-support workers from participating centers. They will be randomly assigned to one of two groups. One group will receive the virtual reality program at the beginning of the study, while the other group will continue usual activity and receive the same program later, after a wait-list period.\n\nThe main objective is to evaluate whether the program reduces emotional exhaustion, measured with the Maslach Burnout Inventory. Secondary objectives include evaluating changes in depersonalization, personal accomplishment, work engagement, usability, satisfaction, adherence, and tolerability of the virtual reality program.",[88,89,27],"Burnout, Healthcare Workers","Occupational Stress",[91,92,93,94],"Virtual Reality","Mindfulness","Healthcare workers","Burnout","2026-06-10",{"date":97,"type":37},"2026-06-16",{"date":99,"type":37},"2026-06-08",{"date":101,"type":21},"2027-12",{"name":103,"class":44},"Badalona Serveis Assistencials",2,{"id":106,"slug":107,"hasResults":12,"nctId":108,"briefTitle":109,"officialTitle":109,"acronym":110,"eligibilityCriteria":111,"healthyVolunteers":54,"sex":55,"minAge":112,"maxAge":113,"enrollmentInfo":114,"targetDuration":4,"studyType":22,"phases":116,"briefSummary":117,"conditions":118,"keywords":119,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":123,"completionDateStruct":125,"leadSponsor":127,"locationsCount":45},"100417190","implementation-supports-to-reduce-burnout-in-therapists-delivering-child-trauma-ebps-100417190","NCT04712461","Implementation Supports to Reduce Burnout in Therapists Delivering Child Trauma EBPs","SUPPORTS","Inclusion Criteria:\n\n* Therapists who have delivered a (or components of a) trauma EBP to a child in the past year.\n\nExclusion Criteria:\n\n* Therapists employed at their current agency for less than 6 months.","3 Years","99 Years",{"count":115,"type":21},60,[24],"The majority of children exposed to early adversity and trauma do not have access to sustainably delivered evidence-based mental health programs (EBPs), despite the growing prevalence of large-scale multiple-EBP implementation efforts aimed at increasing access to these services. The objective of this proposal is to develop and test a package of implementation strategies designed to promote the sustained delivery of child trauma EBPs by reducing provider turnover through targeting the associated mechanisms of provider burnout and organizational psychological safety climate. Findings will have a significant public health impact by informing efforts to increase the sustained availability of child trauma EBPs, thereby improving outcomes for children exposed to trauma.",[27],[120],"Mental Health","2026-06-04",{"date":99,"type":37},{"date":124,"type":37},"2023-01-01",{"date":126,"type":21},"2027-05-01",{"name":128,"class":44},"San Diego State University",{"id":130,"slug":131,"hasResults":12,"nctId":132,"briefTitle":133,"officialTitle":133,"acronym":134,"eligibilityCriteria":135,"healthyVolunteers":12,"sex":55,"minAge":136,"maxAge":137,"enrollmentInfo":138,"targetDuration":4,"studyType":140,"phases":4,"briefSummary":141,"conditions":142,"keywords":146,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":152,"lastUpdatePostDateStruct":153,"startDateStruct":154,"completionDateStruct":156,"leadSponsor":158,"locationsCount":45},"100616444","climate-anxiety-in-a-young-population-at-risk-of-suicide-100616444","NCT07305688","Climate Anxiety in a Young Population at Risk of Suicide","Anx-RS","Inclusion Criteria:\n\n* Men and women, boys and girls ;\n* Aged between 16 and 24;\n* Participants seen in adult or pediatric emergency departments, hospitalised in adult psychiatry or in child and adolescent psychiatry, or seen in outpatient consultation at Esquirol Hospital Center ;\n* Affiliated with a social security scheme or entitled to coverage under one ;\n* Having received full information about the study and having co-signed, together with the investigator, an informed consent form to participate in the study.\n* For minor participants: the consent to participate in the study must be signed by the holder(s) of parental authority, and the minor's assent will also be required.\n\nExclusion Criteria:\n\n* Participants will not be included in the study if their health condition is incompatible with understanding or completing the questionnaires used. This includes, in particular ;\n* Any chronic somatic pathology or major sensory impairment (for example : deafness or blindness) preventing reading, comprehension or communication with healthcare professionals ;\n* Any severe psychiatric pathology that significantly impairs cognitive or communication abilities, such as acute psychotic disorders, pervasive developmental disorders or confusional states ;\n* Participants hospitalised in units specialising in severe psychiatric disorders with major impairment of cognitive functions.\n* Adults under legal protection, in accordance with article L 1121-8 of the Public Health Code ;\n* Insufficient command of the French language","16 Years","24 Years",{"count":139,"type":21},108,"OBSERVATIONAL","Climate change has become a major source of concern, particularly among younger generations who are facing the progressive degradation of ecosystems, loss of biodiversity, and alarming environmental information disseminated through the media. The direct perception of climate-related disruptions has been shown to engender a profound sense of helplessness and loss. This distress, termed eco-anxiety, is characterised by feelings of fear, sadness and guilt regarding the planet's future.\n\nIn a context where there has been a marked increase in suicidal thoughts and attempts among young people over the past decade, it is essential to explore the psychological manifestations of eco-anxiety within this vulnerable population. The paucity of studies investigating this association underscores the significance of the present research.\n\nThe aims of this study is to examine the relationship between climate anxiety and suicidal risk among young people aged 16 to 24 years.\n\nThe study will encompass 108 young participants aged between 16 and 24 years, who are either hospitalised or receiving outpatient psychiatric care.\n\nEach participant will be required to complete one clinician-administered assessment, namely the Columbia Suicide Severity Rating Scale (C-SSRS), and two self-report questionnaires: the Climate Change Anxiety Scale - French version (CCAS-FR) and the State-Trait Anxiety Inventory (STAI-Y).\n\nFurthermore, a sociodemographic questionnaire will be administered in order to collect information regarding the subjects' age, sex, education level, living conditions, and psychiatric history.\n\nIt is hypothesised that there is a positive association between climate anxiety and suicidal risk, with the most eco-anxious participants showing higher C-SSRS scores. It is further predicted that eco-anxiety will correlate with elevated levels of state and trait anxiety, with the potential for modulating this relationship by sociodemographic factors, including gender.\n\nThis study will contribute to a better understanding of the psychological impacts of climate change on young people and help identify the most vulnerable profiles.",[143,144,27,145],"Anxiety","Suicidal Ideation","Environmental Exposure",[147,148,149,150,151],"Eco-anxiety","Anxiety disorders","Suicide risk","Mental health","Young adults","2026-06-02",{"date":121,"type":37},{"date":155,"type":37},"2025-12-15",{"date":157,"type":21},"2027-03-15",{"name":159,"class":44},"Centre Hospitalier Esquirol",{"id":161,"slug":162,"hasResults":12,"nctId":163,"briefTitle":164,"officialTitle":164,"acronym":4,"eligibilityCriteria":165,"healthyVolunteers":12,"sex":55,"minAge":166,"maxAge":137,"enrollmentInfo":167,"targetDuration":4,"studyType":22,"phases":169,"briefSummary":170,"conditions":171,"keywords":173,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":178,"lastUpdatePostDateStruct":179,"startDateStruct":180,"completionDateStruct":182,"leadSponsor":184,"locationsCount":45},"100637462","integrating-isyv-within-hiv-clinical-care-for-youth-living-with-hiv-in-tanzania-100637462","NCT07621510","Integrating iSYV Within HIV Clinical Care for Youth Living With HIV in Tanzania","Inclusion Criteria:\n\n1. youth living with HIV (YLWH) 15-24 years;\n2. have understanding of their HIV status;\n3. able to attend iSYV sessions if site is randomized to the intervention.\n\nExclusion Criteria:\n\n1. inability to provide informed consent\u002Fassent or participate meaningfully in the intervention due to cognitive impairment, psychosis, or other disability;\n2. enrollment in any other MH, stigma-related, or adherence intervention research study.","15 Years",{"count":168,"type":21},5000,[24],"Youth living with HIV (YLWH) experience mental health (MH) challenges that compromise their HIV care. Though the MH gap is well described, MH service delivery to YLWH is rare, especially in low resource settings. MH professionals are few and interventions tailored to the needs of this population are scarce. This project proposes a way to bridge the gap by streamlining the Sauti ya Vijana (SYV, The Voice of Youth) intervention redesigned to integrate into the differentiated HIV clinical care model in Tanzania. SYV is a peer-led, group-based treatment designed with and for YLWH to address their self-reported MH challenges and stressors living with HIV.",[172,27],"HIV -1 Infection",[174,175,176,177],"Youth","Adolescents","Tanzania","Cognitive behavioral therapy","2026-05-27",{"date":152,"type":37},{"date":181,"type":21},"2027-01-10",{"date":183,"type":21},"2030-09-30",{"name":185,"class":44},"Duke University",{"id":187,"slug":188,"hasResults":12,"nctId":189,"briefTitle":190,"officialTitle":191,"acronym":4,"eligibilityCriteria":192,"healthyVolunteers":12,"sex":55,"minAge":18,"maxAge":193,"enrollmentInfo":194,"targetDuration":4,"studyType":22,"phases":195,"briefSummary":196,"conditions":197,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":199,"lastUpdatePostDateStruct":200,"startDateStruct":202,"completionDateStruct":204,"leadSponsor":206,"locationsCount":45},"100602146","telehealth-to-improve-quality-of-life-in-persons-living-in-rural-texas-100602146","NCT07119710","Telehealth to Improve Quality of Life in Persons Living in Rural Texas","Improving Quality of Life in Persons Living in Rural Texas","Inclusion Criteria:\n\n* family caregiver of person with all forms of dementia\n\nExclusion Criteria:\n\n* not in another clinical intervention","110 Years",{"count":115,"type":21},[24],"The overarching goal of this project is to evaluate a current evidence-based practice, Cognitive Behavioral Therapy, for mental health conditions against Cognitive Behavioral Therapy plus two check-in calls a week for adults living in rural Texas.",[27,198],"Quality of Life","2026-05-13",{"date":201,"type":37},"2026-05-15",{"date":203,"type":37},"2023-03-24",{"date":205,"type":21},"2028-12-01",{"name":207,"class":44},"Texas Tech University",{"id":209,"slug":210,"hasResults":12,"nctId":211,"briefTitle":212,"officialTitle":213,"acronym":4,"eligibilityCriteria":214,"healthyVolunteers":12,"sex":55,"minAge":18,"maxAge":215,"enrollmentInfo":216,"targetDuration":4,"studyType":22,"phases":217,"briefSummary":218,"conditions":219,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":199,"lastUpdatePostDateStruct":222,"startDateStruct":223,"completionDateStruct":225,"leadSponsor":227,"locationsCount":45},"100492788","telehealth-to-reduce-mental-health-in-family-caregivers-100492788","NCT05696704","Telehealth to Reduce Mental Health in Family Caregivers","Utilizing Telehealth to Reduce Pre-Death Grief, Burden, and Stress in Family Caregivers","Inclusion Criteria:\n\n* Participants must be informal caregivers (e.g., spouse; child; close friend) of individuals with dementia\n* Informal caregivers can be family members or close friends\n* Adults (18 to 89 years old) who read, write, and speak in English\n* Mental Health Diagnosis (e.g., Generalized Anxiety Disorder; Major Depressive Disorder\n\nExclusion Criteria:\n\n* Formal caregivers (who are being paid to take care of the patient)\n* Any informal caregivers with cognitive impairment is identified during the assessment.","120 Years",{"count":115,"type":21},[24],"The overarching goal of this project is to evaluate if evidence-based interventions can reduce PDG, burden, and stress in informal caregivers of individuals with dementia when provided over telehealth.",[27,220,221],"Grief","Burden, Caregiver",{"date":201,"type":37},{"date":224,"type":37},"2023-01-30",{"date":226,"type":21},"2028-12-31",{"name":207,"class":44},{"id":229,"slug":230,"hasResults":12,"nctId":231,"briefTitle":232,"officialTitle":233,"acronym":234,"eligibilityCriteria":235,"healthyVolunteers":54,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":236,"targetDuration":4,"studyType":22,"phases":238,"briefSummary":239,"conditions":240,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":244,"lastUpdatePostDateStruct":245,"startDateStruct":247,"completionDateStruct":249,"leadSponsor":250,"locationsCount":45},"100456905","stress-phenotypes-and-preterm-birth-100456905","NCT05229666","Stress Phenotypes and Preterm Birth","Stress Phenotypes and Preterm Birth: Immune and Energetic Cellular Dysregulation and the Preventive Effect of Social Support","PTB","Inclusion Criteria\n\n* Pregnant women 18 years of age or older (based on self-report)\n* Not currently smoking, drinking alcohol, or taking drugs (based on self-report)\n* Planning to deliver at CUIMC\u002FNYP (based on self-report)\n* In the first or second trimester of pregnancy (prior to 28 weeks gestation) (based on self-report of estimated date of delivery)\n\nExclusion Criteria\n\n* Multi-fetal pregnancy (based on self-report)\n* Taking medications regularly that affect the cardiovascular and inflammatory systems, including NSAIDS and other anti-inflammatories, α blockers, β blockers, corticosteroids, chronic-use asthma medications (e.g. beta2- adrenoceptor agonists) (based on self-report)\n\n  * This does NOT include baby aspirin or low-dose aspirin, as baby aspirin \u002F low-dose aspirin is not normally considered to be an NSAID.\n* Inflammatory conditions including rheumatoid arthritis, lupus, and multiple sclerosis (based on self-report)",{"count":237,"type":21},200,[24],"Pregnancy ends in preterm birth (PTB) for approximately 1 in 10 women, though more often for Non-Hispanic Black women, 14.12% PTB rate, compared to 9.09% for Non-Hispanic White women. Psychosocial stress and childhood trauma each are associated with risk for PTB and PTB has an intergenerational impact: mothers born preterm are more likely to give birth preterm, especially amongst Black women. In this project, we will study mitochondria, which contain their own genome, the mitochondria DNA, and are inherited from the mother, as they represent a potential intersection point between psychosocial experiences and their biological embedding in underlying disease outcomes such as PTB",[241,242,243,27],"Preterm Birth","Inflammation","Stress","2026-05-12",{"date":246,"type":37},"2026-05-14",{"date":248,"type":37},"2021-12-09",{"date":101,"type":21},{"name":251,"class":44},"Columbia University",{"id":253,"slug":254,"hasResults":12,"nctId":255,"briefTitle":256,"officialTitle":257,"acronym":4,"eligibilityCriteria":258,"healthyVolunteers":54,"sex":55,"minAge":259,"maxAge":4,"enrollmentInfo":260,"targetDuration":4,"studyType":22,"phases":262,"briefSummary":263,"conditions":264,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":266,"lastUpdatePostDateStruct":267,"startDateStruct":269,"completionDateStruct":271,"leadSponsor":273,"locationsCount":45},"100602865","just-in-time-training-for-youth-mentors-100602865","NCT07129070","Just-in-Time Training for Youth Mentors","Just-in-Time Training for Youth Mentors: A Strategy for Implementing Evidence-Based Preventive Interventions for Youth in Rural Communities","Youth and Parent Inclusion Criteria:\n\n* student at a partnering rural middle school or high school\n* age 12-17\n* have English speaking\u002Freading\u002Fwriting ability at a level to participate in IPT-AST\n* youth's parent has English or Spanish-speaking\u002Freading\u002Fwriting ability at a level to participate in research activities.\n\nYouth and Parent Exclusion Criteria:\n\n* moderate or severe depression (PHQ-9 \\> 10)\n* active suicidal ideation with a plan and\u002For intent, requiring higher level of care\n* Youth does not have English-speaking ability at a level to participate in IPT-AST\n* youth's parent does not have English or Spanish-speaking\u002Freading\u002Fwriting ability at a level to participate in research activities.\n\nMentor and Mentor Supervisor Inclusion Criteria:\n\n* age 18 or older\n* have completed the typical mentor or mentor supervisor screening and selection process at partnering mentoring organization (including a background check)\n* are available to facilitate the program during after-school hours.","12 Years",{"count":261,"type":21},204,[24],"This study will evaluate the usability, feasibility, and acceptability of a novel multi-level Just-In-Time Training (JITT) implementation strategy (JITT-EBP) that aims to equip mentors and mentor supervisors to implement evidence-based practices (EBPs) with fidelity using methods that are sustainable in rural communities. JITT-EBP integrates (a) self-directed, on-demand, online training modules for mentors and mentor supervisors, (b) synchronous evidence-based supervision strategies, and (c) an apprenticeship delivery model in which EBPs are co-led by an experienced mentor and a novice mentor, providing opportunity for in-the-moment training and support. The study will conduct a pilot hybrid type 2 effectiveness-implementation trial to evaluate the use of JITT-EBP compared to usual training for implementing mentor-delivered Interpersonal Psychotherapy-Adolescent Skills Training (IPT-AST), an evidence-based depression prevention program. 96 adolescents (age 12-17) and their parents, 8-18 mentors (depending on amount of turnover), and 4 mentor supervisors will be enrolled in the trial.",[27,265,143],"Depression","2026-04-23",{"date":268,"type":37},"2026-04-24",{"date":270,"type":37},"2025-12-18",{"date":272,"type":21},"2028-05-31",{"name":274,"class":44},"University of Minnesota",{"id":276,"slug":277,"hasResults":12,"nctId":278,"briefTitle":279,"officialTitle":279,"acronym":280,"eligibilityCriteria":281,"healthyVolunteers":12,"sex":17,"minAge":282,"maxAge":4,"enrollmentInfo":283,"targetDuration":4,"studyType":22,"phases":285,"briefSummary":286,"conditions":287,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":291,"lastUpdatePostDateStruct":292,"startDateStruct":294,"completionDateStruct":296,"leadSponsor":298,"locationsCount":300},"100503502","family-spirit-strengths-100503502","NCT05836090","Family Spirit Strengths","FSS","Inclusion Criteria:\n\n* Self-identify as female; and\n* Pregnant or be a primary caregiver of a child that is 24 months or younger; and\n* 14 years or older at time of enrollment; and\n* Report a family history of high-risk substance use and\u002For report high-risk levels of personal substance use; and\n* Have elevated symptoms of depression and\u002For anxiety and\u002For risk of substance use disorder; and\n* Be part of the service population of one of the participating sites.\n\nExclusion Criteria:\n\n* Profound disability that limits the ability to participate in assessments or interventions; and\n* Unlikely to be residing in or near the research service area for the next 6 months.","14 Years",{"count":284,"type":21},188,[24],"This project addresses the disproportionate morbidity and mortality associated with mental and behavioral health problems in American Indian and Alaska Native communities. Access to culturally competent and effective behavioral health services is limited in many of these communities. The investigators aim to address this gap by testing the effectiveness of a trans-diagnostic secondary prevention program, Family Spirit Strengths (FSS) that can be embedded within home visiting services. The FSS program is a skills-based program that incorporates elements of evidence-based practice, the Common Elements Treatment Approach (CETA), and materials informed and developed based on an Indigenous advisory group. The FSS program aims to help participants build self-efficacy and coping skills, as well as build stronger connections to others, the participants' community, and cultural resources. The investigators will use a randomized controlled trial, whereby half of the participants will receive FSS and the other half will receive an evidence-based nutrition education program. The investigators' study is grounded in participatory processes and led by a team of Indigenous and allied researchers.",[288,289,290,27],"Depressive Symptoms","Anxiety Disorders and Symptoms","Substance Use","2026-04-10",{"date":293,"type":37},"2026-04-13",{"date":295,"type":37},"2023-04-20",{"date":297,"type":21},"2028-06-30",{"name":299,"class":44},"Johns Hopkins Bloomberg School of Public Health",3,{"id":302,"slug":303,"hasResults":12,"nctId":304,"briefTitle":305,"officialTitle":306,"acronym":307,"eligibilityCriteria":308,"healthyVolunteers":12,"sex":55,"minAge":18,"maxAge":309,"enrollmentInfo":310,"targetDuration":4,"studyType":22,"phases":311,"briefSummary":312,"conditions":313,"keywords":315,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":318,"lastUpdatePostDateStruct":319,"startDateStruct":321,"completionDateStruct":323,"leadSponsor":325,"locationsCount":45},"100634028","intensive-case-management-between-va-and-community-care-for-suicide-prevention-100634028","NCT07534358","Intensive Case Management Between VA and Community Care for Suicide Prevention","Improving Access to VA Mental Health and Suicide Prevention Services: A Randomized Clinical Trial of Intensive Case Management Between VA and Community Care (SUPERCEDE RCT)","SUPERCEDERCT","Inclusion Criteria: Veterans must be:\n\n* enrolled in the VA Eastern Colorado Health Care System (ECHCS)\n* able to complete an online questionnaire\n* age 18-80 years\n* able to comprehend and provide virtual informed consent\n* receiving both VA care and VA authorized community care, through the MISSION Act, which is related to any physical or mental health disorder\n* Veteran's non-VA care is authorized (i.e., non-VA care\u002Ftreatment approved in advance by the VA)\n* at risk for suicide, which is defined as any 1 of the following circumstances: a) prior lifetime suicide attempt; b) suicidal ideation in the past month; c) current mental health symptoms, defined as PHQ-9 \\>10, or PCL-5 \\>31\n* psychosocial challenges reported on the ACORN or Assessment of Needs measure\n* issues with VA community care coordination (i.e., Veteran reported challenges, consults canceled in medical record, appointments canceled or rescheduled in medical record, etc.)\n* receiving no or infrequent mental health services at the VA (e.g., seen less than once a month by a mental health provider).\n\nExclusion Criteria: Veterans must be:\n\n* not at imminent risk of suicide or homicide warranting crisis intervention (will be able to participate once stabilized)\n* unable or unwilling to participate in the intervention (e.g., unwilling to provide VA community care information, etc.)\n* without access to a device capable of telephone calls or video calls\n* presenting with any situation which the principal investigator deems this type of care is inappropriate for the Veteran.","80 Years",{"count":84,"type":21},[24],"The goal of this randomized clinical trial is to build the evidence base for SUPERCEDE, a suicide prevention focused intensive case management intervention to increase access, improve care coordination, provide suicide prevention monitoring, and procure a timely response of VA mental health and suicide prevention services among VA-enrolled veterans receiving VA authorized community care. This phase is a hybrid effectiveness Type 1 randomized control trial, which will include 2 arms: the treatment intervention, SUPERCEDE, and the control intervention, present centered therapy. The main questions it aims to answer are:• This RCT will continue to build the evidence base for effectiveness and determine feasibility and acceptability for the previously piloted SUPERCEDE. • This RCT will improve the understanding of implementation of this intervention, both in VA and VA authorized community care organizations in preparation for broader implementation. Researchers will compare SUPERCEDE and present centered therapy to see if SUPERCEDE results in improved functioning and a decrease in suicidal ideation. Participants will be randomized to either SUPERCEDE or present centered therapy (PCT) plus a safety plan if warranted. SUPERCEDE is a suicide prevention case management intervention that combines BCBT-SP, a Crisis Response Plan (CRP), intensive case management to alleviate suicide risk factors, and VA authorized community care coordination. PCT is an active control condition often used in clinical trials of posttraumatic stress disorder. The intervention focuses on the present moment and encouraging the client to find solutions to their problems. In this trial, investigators will mirror the sessions of PCT to SUPERCEDE. Thus, the control group will receive 3 sessions, with an optional 3 additional sessions.\n\nDetailed Description For hypothesis 3a: Overall, 100 participants will be randomized to either SUPERCEDE or present centered therapy (PCT) plus a safety plan if warranted. SUPERCEDE is a suicide prevention case management intervention that combines BCBT-SP, a Crisis Response Plan, intensive case management to alleviate suicide risk factors, and VA authorized community care coordination. PCT is an active control condition often used in clinical trials of posttraumatic stress disorder. The intervention focuses on the present moment and encouraging the client to find solutions to their problems. In this trial, investigators will mirror the sessions of PCT to SUPERCEDE. Thus, the control group will receive 3 sessions, with an optional 3 additional sessions. The study therapist is trained in both SUPERCEDE and PCT. Recruitment. Eligible participants will be identified through the VA Rocky Mountain Regional (RMR) Medical Center the VA Corporate Data Warehouse (CDW), flyers and advertisements, or through clinician or community referral. A recruitment letter will be sent to participants identified in the CDW. Investigators will attempt to contact potential participants with a warm call by telephone (up to 3 times) after the letter is sent.",[144,27,314],"Social Determinants of Health",[316,317],"suicide prevention","Veteran","2026-04-09",{"date":320,"type":37},"2026-04-16",{"date":322,"type":37},"2024-08-01",{"date":324,"type":21},"2027-06",{"name":326,"class":327},"VA Eastern Colorado Health Care System","FED",{"id":329,"slug":330,"hasResults":12,"nctId":331,"briefTitle":332,"officialTitle":333,"acronym":334,"eligibilityCriteria":335,"healthyVolunteers":12,"sex":55,"minAge":136,"maxAge":4,"enrollmentInfo":336,"targetDuration":4,"studyType":140,"phases":4,"briefSummary":338,"conditions":339,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":341,"lastUpdatePostDateStruct":342,"startDateStruct":343,"completionDateStruct":345,"leadSponsor":347,"locationsCount":45},"100606430","ibdminds---mapping-the-influence-of-anxiety-and-depression-on-ibd-100606430","NCT07175454","IBDminds - Mapping the Influence of aNxiety and DepreSsion on IBD","A Study to Describe the Burden of Mental Ill Health in Inflammatory Bowel Disease Patients Using Advanced Therapies, and to Identify Any Associations Between Common Mental Health Problems and the Efficacy of Such Advanced Therapies (IBDmind)","IBDminds","Inclusion Criteria:\n\n* Patients with a confirmed diagnosis of ulcerative colitis, or Crohn's disease, based upon either the outcome of the local multidisciplinary team, clinic documentation or in the opinion of the investigator\n* Patients receiving maintenance infliximab or vedolizumab by regular intravenous infusion\n* Patients willing and able to give informed consent\n* Patients aged 16 or over\n\nExclusion Criteria:\n\n* Patients cannot be recruited while receiving their loading dose of infusions, but may be included once complete.\n* Patients should not currently be planned for surgery within the next 12 months\n* Patients should not currently be planned to switch to another advanced therapy within the next 12 months\n* Patients should not currently be planned for a drug holiday within the next 12 months\n* Patients should not have a stoma (This would invalidate the PRO-2 outcome measure)\n* Patients should not currently be pregnant\n* Patient currently receiving subcutaneous infliximab or vedolizumab",{"count":337,"type":21},450,"People with Inflammatory bowel disease (IBD) can get challenging symptoms. Things like diarrhoea, tummy pain and being tired all the time are common. People often get IBD in their teens or twenties. They often find working, studying and relationships hard. IBD can't be cured, so it lasts for life.\n\nWhen IBD is hard to treat, we use advanced treatments, but these don't always work. When they do work the effect can wear off. This happens in 2 of 5 people within a year in research studies. There are some things that we know make them wear off. There are lots more reasons that we don't understand yet. We think anxiety, depression and stress make these treatments more likely to wear off. Previous research has suggested that people with IBD do worse if they have anxiety, depression or stress.\n\nThe investigators want people with IBD to complete questionnaires to see if they are affected by anxiety, depression or stress when they are taking advanced therapies. The investigators will follow those people to see if the effect of their treatment wears off.\n\nPeople living with IBD will contribute to the running and fine tuning of this research. Many of those that have engaged with us so far have said that their disease was worse when their mental health was worse. They were generally supportive of this study to see how anxiety, depression and stress effects IBD in people using advanced therapies.\n\nThe investigators have talked to a national charity about our work. They will help share the findings so that patients, care givers and other stakeholders will be able to read about them. The results will be published so that doctors and researchers can use them.",[340,27],"Inflammatory Bowel Diseases","2026-04-08",{"date":318,"type":37},{"date":344,"type":21},"2026-05",{"date":346,"type":21},"2028-05",{"name":348,"class":349},"The Royal Wolverhampton Hospitals NHS Trust","OTHER_GOV",{"id":351,"slug":352,"hasResults":12,"nctId":353,"briefTitle":354,"officialTitle":355,"acronym":4,"eligibilityCriteria":356,"healthyVolunteers":54,"sex":55,"minAge":18,"maxAge":4,"enrollmentInfo":357,"targetDuration":4,"studyType":22,"phases":359,"briefSummary":361,"conditions":362,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":363,"lastUpdatePostDateStruct":364,"startDateStruct":366,"completionDateStruct":368,"leadSponsor":370,"locationsCount":45},"100598714","phase-2-giiigoshimong-sitting-with-your-first-family-100598714","NCT07075081","Gii'Igoshimong: Sitting With Your First Family","The Protective Role of Ceremony Against Substance Use for American Indian Adults","Inclusion Criteria:\n\n* Are 18 years of age or older,\n* Self-identify as Ojibwe\u002FAnishinaabe\u002FChippewa,\n* Self-report using any kind of substances in the past 30 days,\n* Have no history of head injury with loss of consciousness,\n* Do not have a seizure disorder,\n* Do not currently have Type 2 Diabetes,\n* Are not currently pregnant\n\nExclusion Criteria:\n\n* Younger than18 years of age\n* Does not Self-identify as Ojibwe\u002FAnishinaabe\u002FChippewa,\n* Does not self-report using any kind of substances in the past 30 days,\n* Has history of head injury with loss of consciousness,\n* Has Type 2 Diabetes,\n* Has a seizure disorder,\n* Currently pregnant",{"count":358,"type":21},300,[360],"PHASE2","The goal of this randomized wait-list control study is to understand the relationship between ceremony and substance use (SU), SU risk (e.g., SU severity, depressive symptoms) and protective factors (e.g., spirituality, community support). The main questions it aims to answer are:\n\n* Will adults enrolled in Gii'igoshimong show improved SU outcomes compared to those in control groups?\n* Will self-relevant processing networks activated during stimulus engagement increase from pre- to post- engagement in ceremony and at 6-month follow-up?\n\nResearchers will compare adults that complete Gii'igoshimong with those that do not complete Gii'igoshimong to see if health outcomes are different.\n\nAfter completing baseline assessments, participants will be randomized to complete Gii'igoshimong now (intervention) or after the participants have completed the 1 month and 6-month post assessments (waitlist control). All participants (intervention and waitlist control) within a cohort will complete 1 month and 6 month post assessments at the same time.",[290,27],"2026-03-30",{"date":365,"type":37},"2026-03-31",{"date":367,"type":37},"2025-09-09",{"date":369,"type":21},"2029-05-31",{"name":299,"class":44},{"id":372,"slug":373,"hasResults":12,"nctId":374,"briefTitle":375,"officialTitle":375,"acronym":4,"eligibilityCriteria":376,"healthyVolunteers":12,"sex":55,"minAge":377,"maxAge":4,"enrollmentInfo":378,"targetDuration":4,"studyType":22,"phases":380,"briefSummary":381,"conditions":382,"keywords":386,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":389,"lastUpdatePostDateStruct":390,"startDateStruct":392,"completionDateStruct":394,"leadSponsor":395,"locationsCount":45},"100502652","randomized-controlled-trial-on-precision-mental-health-100502652","NCT05825040","Randomized Controlled Trial on Precision Mental Health","Inclusion Criteria:\n\n* 17 years old or above\n* Able to read Chinese or English\n* With internet connection and able to access the internet\n* Does not register to Jockey Club TourHeart+ Project or participate in related research projects\n* With moderate-severe GAD-7 a\u002Fo moderate-severe PHQ-9\n\nExclusion Criteria:\n\n* People who are under 17 years old\n* Cannot access the internet\n* Existing users of Jockey Club TourHeart+ Project or participate in related research\n* Without moderate-severe depressive or anxiety symptoms\n* With suicidal risk","17 Years",{"count":379,"type":21},320,[24],"The current study aims to evaluate the effectiveness of different online psychological interventions, including guided and unguided transdiagnostic cognitive behavioural therapy, and unguided mindfulness-based intervention, on mental well-being in comparison to waitlist control. It is hypothesized that participants with the guided psychological intervention will show (H1) a greater reduction in mental health symptoms, and (H2) better mental well-being compared with participants with unguided psychological intervention and the control condition.",[383,27,384,385],"Mental Well-being","Mental Health Wellness 1","Precision Mental Health",[387,150,388,385],"Online Psychological Intervention","Mental well-being","2026-03-22",{"date":391,"type":37},"2026-03-25",{"date":393,"type":37},"2024-05-01",{"date":226,"type":21},{"name":396,"class":44},"Chinese University of Hong Kong",{"id":398,"slug":399,"hasResults":12,"nctId":400,"briefTitle":401,"officialTitle":402,"acronym":403,"eligibilityCriteria":404,"healthyVolunteers":54,"sex":55,"minAge":282,"maxAge":405,"enrollmentInfo":406,"targetDuration":408,"studyType":140,"phases":4,"briefSummary":409,"conditions":410,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":413,"lastUpdatePostDateStruct":414,"startDateStruct":416,"completionDateStruct":418,"leadSponsor":420,"locationsCount":45},"100630284","genesis-project-generating-evidence-on-the-needs-of-ecuadorian-adolescents-100630284","NCT07485673","GENESIS Project: Generating Evidence on the Needs of Ecuadorian Adolescents","Generating Evidence on the Needs of Ecuadorian Adolescents","GENESIS","Inclusion Criteria:\n\n* be between 14 and 19 years old\n\nExclusion Criteria:\n\n* have any disorder or treatment that contraindicated physical activity or that demanded special assistance\n* be under some pharmacological treatment;\n* not be authorized by parents, caregivers, or legal guardians to participate in the research project\n* do not agree to take part in the research project\n* for volunteering retirement.","19 Years",{"count":407,"type":21},1450,"5 Years","Background: Adolescence is a period of intensified emotional responses and occurs when mental health disorders commonly develop since adolescents are learning how to deal with powerful emotions. Globally, 15% of adolescents experience a mental disorder like depression or anxiety. However, adolescent mental health goes beyond mental disorders. It is state of mental well-being that allows individuals to deal with stressors, recognize their abilities, develop their activities well, and participate in society, providing a holistic approach that highlights the interplay between psychological well-being and other aspects of life. Given this perspective, a Lifestyle Medicine (LM) approach based on a multi-component framework is needed for assessing adolescents' mental health. This study aims to evaluate adolescents' (aged 14-19) mental health, identify and mitigate the risks of developing any mental health disorder as well as formulate comprehensive interventions to promote and increase their emotional wellbeing. Methods: Cross-sectional and longitudinal studies will be performed. Adolescents from Quito, Ecuador will be recruited using a simple random sampling technique. The minimum sample size is 385; however, to increase the precision of the estimates, a target sample of approximately 1000 participants will be established. Main outcome measure will be mental health using social determinants of health and lifestyle medicine factors. Conclusion: This research project will evaluate adolescents' mental health through a holistic and multiapproach evaluation and interrelate social determinants of health and lifestyle medicine variables to propose and design multidisciplinary strategies and interventions to prevent and mitigate mental health outcomes in adolescents. Additionally, the results will be useful in informing public health authorities to evaluate or modify current policies",[411,27,412],"Adolescent Development","Lifestyle Factors","2026-03-16",{"date":415,"type":37},"2026-03-20",{"date":417,"type":37},"2025-09-04",{"date":419,"type":21},"2030-08",{"name":421,"class":44},"Universidad de Especialidades Espiritu Santo",{"id":423,"slug":424,"hasResults":12,"nctId":425,"briefTitle":426,"officialTitle":427,"acronym":428,"eligibilityCriteria":429,"healthyVolunteers":12,"sex":55,"minAge":259,"maxAge":377,"enrollmentInfo":430,"targetDuration":4,"studyType":22,"phases":432,"briefSummary":433,"conditions":434,"keywords":435,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":413,"lastUpdatePostDateStruct":438,"startDateStruct":440,"completionDateStruct":442,"leadSponsor":443,"locationsCount":45},"100533969","help-healthy-lifestyles-project-for-youth-with-mental-distress-100533969","NCT06232733","HELP (HEalthy Lifestyles Project) for Youth With Mental Distress","HELP (HEalthy Lifestyles Project) for Youth With Mental Distress E-Health Intervention: Patient and Healthcare Impacts","HELP","Inclusion Criteria:\n\n* Youth 12-17 years of age seeking, waiting for or receiving support for emotional distress.\n* Able to provide informed consent to study participation.\n* Able to engage in the HELP e-intervention in English (French translation of the e-modules will not be available until intervention efficacy is established).\n* Willing to be randomized to a study group.\n* Willing to complete objective behaviour measures if selected (1 of 3 participants).\n* Willing to complete the study questionnaires.\n* Willing to provide consent for evaluation of mental healthcare system outcomes via their health record.\n\nExclusion Criteria:\n\n* Identified or suspected eating disorder\n* Youth whose health or family status is deemed to be inappropriate for the study as per their most responsible clinician.",{"count":431,"type":21},130,[24],"The goal of this clinical trial is to learn about how healthcare providers can support youths' mental health. The main question\\[s\\] it aims to answer are:\n\n* Do youth (12 to 17 years of age) who engage in the 6-month HELP e-intervention have a larger improvement in emotional health (measured by the Strengths and Difficulties Questionnaire) than youth who do not receive the intervention?\n* Does engagement in the HELP e-intervention improve lifestyle behaviour (physical activity, sleep or screen time)?\n* Do youth who engage in the 6-month HELP e-intervention utilize fewer mental healthcare resources, during and for 1 year following study participation, than youth who do not receive the intervention? Participants will receive the HELP intervention for 6 months, either immediately or after waiting 6 months from study enrollment. At 0, 3, 6, and 12 months, participants will answer a series of questionnaires to assess their emotional health and lifestyle behaviors. Researchers will compare the emotional health and lifestyle behaviors of youth who received HELP immediately to those who wait for 6 months prior to the intervention to see if their emotional health or lifestyle behaviors differ.",[27],[436,437],"adolescent","healthy lifestyle behavior",{"date":439,"type":37},"2026-03-17",{"date":441,"type":37},"2024-06-15",{"date":226,"type":21},{"name":444,"class":44},"Children's Hospital of Eastern Ontario",{"id":446,"slug":447,"hasResults":12,"nctId":448,"briefTitle":449,"officialTitle":449,"acronym":450,"eligibilityCriteria":451,"healthyVolunteers":12,"sex":55,"minAge":4,"maxAge":4,"enrollmentInfo":452,"targetDuration":454,"studyType":140,"phases":4,"briefSummary":455,"conditions":456,"keywords":458,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":461,"lastUpdatePostDateStruct":462,"startDateStruct":463,"completionDateStruct":465,"leadSponsor":467,"locationsCount":4},"100629550","psychiatric-care-and-education-for-adolescents-and-young-adults-in-the-ile-de-france-region-expectations-and-experiences-of-young-people-and-parents-concerned-100629550","NCT07476131","Psychiatric Care and Education for Adolescents and Young Adults in the Ile-de-France Region: Expectations and Experiences of Young People and Parents Concerned","Soins-Etude","Inclusion Criteria:\n\nQualitative study: Young people receiving psychiatric care in the four centers, either currently hospitalized (close to discharge) or discharged for more than one year (between one and two years); and for each of these young people, at least one of their parents will be interviewed during a single interview (two interviews will be conducted if both parents wish to testify but a joint interview is not possible).\n\nData mining study: Young high school students receiving psychiatric care in the four centers in 2020, 2021,2022,2023,2024 and 2025\n\nExclusion Criteria:\n\nQualitative study: Refusal to participate Data mining study: Opposition to the use of data.",{"count":453,"type":21},600,"1 Day","Most chronic psychiatric disorders begin before the age of 18. In the most severe cases, prolonged hospitalization is essential, but this ultimately leads to harmful school dropout and social exclusion. \"Care-study\" hospitalizations offer comprehensive psychiatric, educational, and social care to prevent this. However, these programs have been largely under-evaluated ; only one limited and very old study has looked at the perspective of the young people concerned, and none at all has looked at their parents. Today, however, PREMS (Patient-Reported Experience Measures), which assess how users experience care (satisfaction, subjective and objective experiences, relationships with caregivers), are important indicators for improving care systems. the investigators therefore wish to gather young people's expectations regarding healthcare and education, as well as their opinions and those of their parents on their experiences in the current context, in order to evaluate and improve these systems by better meeting the expectations and needs of users.",[27,457],"Adolescent Behavior",[459,460],"teenagers and young adults","general practitioner","2026-03-11",{"date":439,"type":37},{"date":464,"type":21},"2026-03-01",{"date":466,"type":21},"2027-12-30",{"name":468,"class":44},"Fondation Santé des Étudiants de France",{"id":470,"slug":471,"hasResults":12,"nctId":472,"briefTitle":473,"officialTitle":474,"acronym":475,"eligibilityCriteria":476,"healthyVolunteers":12,"sex":55,"minAge":477,"maxAge":478,"enrollmentInfo":479,"targetDuration":4,"studyType":22,"phases":481,"briefSummary":482,"conditions":483,"keywords":486,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":489,"lastUpdatePostDateStruct":490,"startDateStruct":492,"completionDateStruct":493,"leadSponsor":495,"locationsCount":45},"100628036","development-and-validation-of-psycho-social-program-psp-100628036","NCT07456410","Development and Validation of Psycho-Social Program (PSP)","Development and Validation of Psycho-Social Program (PSP) for Mental Health Problems Among Patients With Type 2 Diabetes Mellitus (T2DM): A Randomised Controlled Trial","PSP-T2DM","Inclusion Criteria: Participants must be adults aged 30-40 years with Type 2 diabetes, experiencing mild-to-moderate mental health problems related to diabetes will be eligible.\n\nExclusion Criteria: Participants will be excluded if they have severe psychiatric disorders, serious medical comorbidities, are taking psychiatric medications that may affect outcomes, or are unable to participate in the intervention sessions.\n\n\\-","30 Years","40 Years",{"count":480,"type":21},80,[24],"The study aims to determine the effectiveness of a structured psycho-social program (PSP) in improving mental health outcomes among patients with Type 2 diabetes mellitus (T2DM). The intervention is designed to reduce symptoms of depression, anxiety, and diabetes-related distress (DD) by addressing maladaptive thoughts, emotional responses, and coping behaviors associated with chronic illness management. Through structured sessions incorporating cognitive restructuring, stress management techniques, behavioral activation, and adaptive coping strategies, participants will learn to manage emotional distress more effectively while improving treatment adherence and daily functioning. The intervention is expected to enhance psychological well-being, promote healthier coping mechanisms, and support better overall adjustment to living with T2DM.",[27,265,484,198,485],"Diabetes Distress","Medication Adherence",[487,488],"Type 2 Diabetes Mellitus","mental health problems","2026-03-04",{"date":491,"type":37},"2026-03-06",{"date":391,"type":21},{"date":494,"type":21},"2026-08-28",{"name":496,"class":44},"Government College University Faisalabad",{"id":498,"slug":499,"hasResults":12,"nctId":500,"briefTitle":501,"officialTitle":502,"acronym":503,"eligibilityCriteria":504,"healthyVolunteers":54,"sex":55,"minAge":505,"maxAge":405,"enrollmentInfo":506,"targetDuration":4,"studyType":22,"phases":508,"briefSummary":509,"conditions":510,"keywords":514,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":517,"lastUpdatePostDateStruct":518,"startDateStruct":520,"completionDateStruct":522,"leadSponsor":524,"locationsCount":45},"100539611","promoting-teenage-sleep-for-improved-mental-health-and-school-performance-100539611","NCT06306092","Promoting Teenage Sleep for Improved Mental Health and School Performance","Promoting Teenage Sleep - for Better Mental Health and School Performance","TeenSleep","Inclusion Criteria:\n\nStudents in Swedish high schools and upper secondary schools.\n\nExclusion Criteria:\n\n\\-","13 Years",{"count":507,"type":21},3000,[24],"The overall aim of this project is to evaluate the effectiveness of two school-based programs that have the potential to promote adolescent sleep and prevent future depressive symptoms. The programs will be offered to students aged 13-19 at Swedish high schools and upper secondary schools at the classroom level. The students will be compared to teaching as usual (control group).",[27,511,265,143,512,513],"Insomnia","Daytime Sleepiness","Wellness, Psychological",[515,150,175,516],"Sleep","School-based intervention","2026-03-03",{"date":519,"type":37},"2026-03-05",{"date":521,"type":37},"2024-08-17",{"date":523,"type":21},"2030-06-30",{"name":525,"class":44},"Kristianstad University",{"id":527,"slug":528,"hasResults":12,"nctId":529,"briefTitle":530,"officialTitle":531,"acronym":4,"eligibilityCriteria":532,"healthyVolunteers":12,"sex":55,"minAge":18,"maxAge":4,"enrollmentInfo":533,"targetDuration":4,"studyType":22,"phases":535,"briefSummary":536,"conditions":537,"keywords":542,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":550,"lastUpdatePostDateStruct":551,"startDateStruct":552,"completionDateStruct":554,"leadSponsor":556,"locationsCount":45},"100452068","evaluating-personalized-therapeutics-clinic-ptc-on-drug-drug-interactions-and-drug-gene-interactions-100452068","NCT05166694","Evaluating Personalized Therapeutics Clinic (PTC) on Drug-Drug Interactions and Drug-Gene Interactions","Evaluating the Effectiveness of a Personalized Therapeutics Clinic (PTC) Intervention on Drug-Drug Interactions (DDIs) and Drug-Gene Interactions (DGIs)","Inclusion Criteria:\n\n1. Adult participants cared for by a participating provider at University of Chicago Medical Center.\n2. Participants must be at least 18 years of age.\n3. Participants prescribed 5 or medication medications and taking a perpetrator drug or a drug with actionable pharmacogenomic information.\n\nExclusion Criteria for Participants\n\n1. Participants who have undergone, or are being actively considered for, liver or kidney transplantation.\n2. Participation in another pharmacogenomic study.\n3. Participants who have previously received genotyping from another source.\n4. Inability to understand and give informed consent to participate.\n\nInclusion of Women, Minorities, and Other Underrepresented Populations Individuals of all races and ethnic groups and genders are eligible for this trial.",{"count":534,"type":21},1300,[24],"The purpose of this study is to determine whether a consultation with a Personalized Therapeutics Clinic, or PTC, will help participants lower the risk for side effects (drug-drug interactions and drug-gene interactions) when taking many medications and help providers improve prescribing decisions for participants. A PTC is a clinical that will test your genes to gather information about your health that may help guide prescribing advice and offer you new information about your prescriptions. Doctors leading this study will look for variations (differences) in your genes that may suggest that you are at greater risk of having side effects or a greater chance of benefiting from certain medications. Individuals in this study will participate for roughly 9 months.",[538,539,540,27,541],"Cancer","Advanced Cancer","Advanced Solid Tumor","Behavior Disorders",[543,544,545,546,547,548,549],"tumor","advanced cancer","advanced solid tumor","cancer medication","prescriptions","inhibitor drug","inducer drug","2026-03-02",{"date":489,"type":37},{"date":553,"type":37},"2022-11-30",{"date":555,"type":21},"2027-11-01",{"name":557,"class":44},"University of Chicago",{"id":559,"slug":560,"hasResults":12,"nctId":561,"briefTitle":562,"officialTitle":562,"acronym":563,"eligibilityCriteria":564,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":565,"targetDuration":4,"studyType":140,"phases":4,"briefSummary":566,"conditions":567,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":570,"lastUpdatePostDateStruct":571,"startDateStruct":573,"completionDateStruct":575,"leadSponsor":577,"locationsCount":45},"100608343","prevalence-of-postpartum-depression-among-patients-of-the-chum-gare-clinic-100608343","NCT07200323","Prevalence of Postpartum Depression Among Patients of the CHUM GARE Clinic","PPD-GARE","Inclusion Criteria:\n\n* Patients aged 18 years or more\n* Patient who gave birth within the last 4 weeks to 6 months\n* Ability to understand French or English and complete the EPDS questionnaire\n* Physically present at their post-partum visit at the clinic\n\nExclusion Criteria:\n\n* Inability to comprehend and\u002For complete the EPDS\n* Declines participation or does not provide informed consent",{"count":84,"type":21},"Postpartum depression (PPD) is a frequent complication of the postnatal period but remains underdetected in routine clinical practice. This prospective clinical study, conducted at the high-risk pregnancy clinic of the CHUM, aims to estimate the prevalence of PPD among patients seen in postpartum follow-up. It also assesses the feasibility of implementing a standardized screening protocol that combines the administration of the Edinburgh Postnatal Depression Scale (EPDS) with a clinical decision-support algorithm to guide appropriate medical follow-up. The study also seeks to explore clinical characteristics associated with higher EPDS scores.",[568,569,27],"Post-partum Depression","Maternal Health","2026-02-19",{"date":572,"type":37},"2026-02-23",{"date":574,"type":37},"2025-10-20",{"date":576,"type":21},"2027-01",{"name":578,"class":44},"Centre hospitalier de l'Université de Montréal (CHUM)",{"id":580,"slug":581,"hasResults":12,"nctId":582,"briefTitle":583,"officialTitle":584,"acronym":4,"eligibilityCriteria":585,"healthyVolunteers":54,"sex":55,"minAge":136,"maxAge":4,"enrollmentInfo":586,"targetDuration":4,"studyType":22,"phases":588,"briefSummary":589,"conditions":590,"keywords":592,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":595,"lastUpdatePostDateStruct":596,"startDateStruct":598,"completionDateStruct":599,"leadSponsor":601,"locationsCount":104},"100555578","evaluating-the-impact-of-social-music-100555578","NCT06513910","Evaluating the Impact of Social Music","Evaluating the Impact of Community-Based Mindfulness and Musical Programs on Psychiatric Measures, Social Music Study 2b.","Inclusion Criteria:\n\n* ages 16 and older\n\nExclusion Criteria:\n\n* contraindications to functional Near Infrared Spectroscopy or Electroencephalography\n* ages 15 and younger",{"count":587,"type":21},48,[24],"Mental health vulnerability due to stress is increased in People of African Descent (PADs) in America due to disproportionate effects of racism, poverty, education, and criminal justice sentencing. Various meditation and mindfulness approaches have provided evidence of measured reductions in multiple negative dimensions of stress. However, the majority of these studies do not have an adequate representation of PADs or other marginalized groups and are not designed to be culturally relevant or community based. Music has been shown to alleviate multiple symptoms of stress and has been shown to be a preferred and effective support for meditation and mindfulness. However, its role in stress management in PADs engaged in meditation or mindfulness is seldom studied. This study aims to evaluate the effects of a virtual, community-based music mindfulness program on stress management in PAD community members with anxiety and depression during COVID19.\n\n2b. Social Music Study: Investigators will assess the neural mechanisms of feelings of subjective connectedness during communal music listening and creating between dyads of subjects who are both familiar and unfamiliar with each other.",[27,591],"COVID-19",[92,593,594],"Meditation","Music","2026-02-10",{"date":597,"type":37},"2026-02-12",{"date":322,"type":37},{"date":600,"type":21},"2026-03",{"name":74,"class":44},{"id":603,"slug":604,"hasResults":12,"nctId":605,"briefTitle":606,"officialTitle":607,"acronym":4,"eligibilityCriteria":608,"healthyVolunteers":54,"sex":55,"minAge":18,"maxAge":609,"enrollmentInfo":610,"targetDuration":4,"studyType":22,"phases":612,"briefSummary":613,"conditions":614,"keywords":615,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":595,"lastUpdatePostDateStruct":616,"startDateStruct":617,"completionDateStruct":618,"leadSponsor":619,"locationsCount":104},"100554910","music-mindfulness-study-2a-100554910","NCT06505226","Music Mindfulness Study 2a.","Evaluating the Impact of Community-Based Mindfulness and Musical Programs on Psychiatric Measures, Music Mindfulness Study 2a.","Inclusion Criteria:\n\n* symptoms of anxiety or depression assessed by PHQ9 (\\>9) and GAD7 (\\>9)\n\nExclusion Criteria:\n\n* Component 2a\n* PHQ-9 \\\u003C9, GAD7 \\\u003C 9\n* regular meditation practice of at least once a week\n* has taken meditation course or intervention in the past year\n* any hospitalizations in the last 6 months\n* suicidal ideation, self-injurious behavior, or homicidal ideation at screening\n* active audio-visual hallucinations or other signs of psychosis\n* diagnosis of a seizure disorder or other neurological disorder that precludes outpatient participation\n* history of thyroid or cardiovascular disease\n* current substance use disorder","65 Years",{"count":611,"type":21},70,[24],"Mental health vulnerability due to stress is increased in People of African Descent (PADs) in America due to disproportionate effects of racism, poverty, education, and criminal justice sentencing. Various meditation and mindfulness approaches have provided evidence of measured reductions in multiple negative dimensions of stress. However, the majority of these studies do not have an adequate representation of PADs or other marginalized groups and are not designed to be culturally relevant or community based. Music has been shown to alleviate multiple symptoms of stress and has been shown to be a preferred and effective support for meditation and mindfulness. However, its role in stress management in PADs engaged in meditation or mindfulness is seldom studied. This study aims to evaluate the effects of a virtual, community-based music mindfulness program on stress management in PAD community members with anxiety and depression during COVID19.\n\nMusic Mindfulness Study: Investigators will compare the effects of music-backed guided mindfulness mediation and guided mediation alone in alleviating anxiety and depression.",[27,591],[92,593,594],{"date":597,"type":37},{"date":322,"type":37},{"date":600,"type":21},{"name":74,"class":44},{"id":621,"slug":622,"hasResults":12,"nctId":623,"briefTitle":624,"officialTitle":625,"acronym":4,"eligibilityCriteria":214,"healthyVolunteers":12,"sex":55,"minAge":18,"maxAge":215,"enrollmentInfo":626,"targetDuration":4,"studyType":22,"phases":627,"briefSummary":628,"conditions":629,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":630,"lastUpdatePostDateStruct":631,"startDateStruct":632,"completionDateStruct":634,"leadSponsor":635,"locationsCount":45},"100464999","improving-mental-health-for-care-partners-of-persons-with-adadrd-100464999","NCT05334992","Improving Mental Health for Care Partners of Persons With AD\u002FADRD","Reducing Pre-Death Grief, Burden, and Stress in Informal Caregivers: A Group and Individual Therapy Approach",{"count":115,"type":21},[24],"The overarching goal of this project is to evaluate if evidence-based interventions can reduce PDG, burden, and stress in informal caregivers of individuals with dementia",[27,220,221],"2026-02-09",{"date":597,"type":37},{"date":633,"type":37},"2022-02-01",{"date":226,"type":21},{"name":207,"class":44}]